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Cited by 981

The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.

Insights into Secondary Metabolism from a Global Analysis of Prokaryotic Biosynthetic Gene Clusters

Open access
Cimermancic, Peter, Medema, Marnix H., Claesen, Jan, Kurita, Kenji, Wieland Brown, Laura C., Mavrommatis, Konstantinos, Pati, Amrita, Godfrey, Paul A., Koehrsen, Michael, Clardy, Jon, Birren, Bruce W., Takano, Eriko, Sali, Andrej, Linington, Roger G., Fischbach, Michael A.·2014·Cell
DOI 10.1016/j.cell.2014.06.034
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Abstract

Summary Although biosynthetic gene clusters (BGCs) have been discovered for hundreds of bacterial metabolites, our knowledge of their diversity remains limited. Here, we used a novel algorithm to systematically identify BGCs in the extensive extant microbial sequencing data. Network analysis of the predicted BGCs revealed large gene cluster families, the vast majority uncharacterized. We experimentally characterized the most prominent family, consisting of two subfamilies of hundreds of BGCs distributed throughout the Proteobacteria; their products are aryl polyenes, lipids with an aryl head group conjugated to a polyene tail. We identified a distant relationship to a third subfamily of aryl polyene BGCs, and together the three subfamilies represent the largest known family of biosynthetic gene clusters, with more than 1,000 members. Although these clusters are widely divergent in sequence, their small molecule products are remarkably conserved, indicating for the first time the important roles these compounds play in Gram-negative cell biology.

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Metadata

Authors
Cimermancic, P., Medema, M. H., Claesen, J., Kurita, K., Wieland Brown, L. C., Mavrommatis, K., Pati, A., Godfrey, P. A., Koehrsen, M., Clardy, J., Birren, B. W., Takano, E., Sali, A., Linington, R. G., & Fischbach, M. A.
Venue
Cell
Publisher
Elsevier BV
Published
2014-07
Volume
158
Issue
2
Pages
412-421
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2014.06.034
OpenAlex
W2009257824
Cited by
981
References
100
FWCI
42.86
Type
journal article
Language
en
Open access
bronze

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