Oxidative Stress and Human Hypertension: Vascular Mechanisms, Biomarkers, and Novel Therapies

Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling

Ray, P. D., Huang, B.-W., & Tsuji, Y. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.008 · Cited by 4,373

A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress

Del Rio, D., Stewart, A. J., & Pellegrini, N. (2005) · Nutrition, Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2005.05.003 · Cited by 2,721

The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

Hayes, J. D., & Dinkova-Kostova, A. T. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.002 · Cited by 2,141

Superoxide Dismutases: Role in Redox Signaling, Vascular Function, and Diseases

Fukai, T., & Ushio-Fukai, M. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.3999 · Cited by 1,983

Redefining Oxidative Stress

Jones, D. P. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1865 · Cited by 1,726

Free radicals, reactive oxygen species, oxidative stress and its classification

Lushchak, V. I. (2014) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2014.10.016 · Cited by 1,649

Prevention of chronic disease in the 21st century: elimination of the leading preventable causes of premature death and disability in the USA

Bauer, U. E., Briss, P. A., Goodman, R. A., & Bowman, B. A. (2014) · The Lancet · doi:10.1016/s0140-6736(14)60648-6 · Cited by 1,394

Radical-free biology of oxidative stress

Jones, D. P. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00283.2008 · Cited by 1,213

Vascular NAD(P)H oxidases: specific features, expression, and regulation

Lassègue, B., & Clempus, R. E. (2003) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00758.2002 · Cited by 1,032

Bardoxolone Methyl in Type 2 Diabetes and Stage 4 Chronic Kidney Disease

de Zeeuw, D., Akizawa, T., Audhya, P., Bakris, G. L., Chin, M., Christ-Schmidt, H., Goldsberry, A., Houser, M., Krauth, M., Lambers Heerspink, H. J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1306033 · Cited by 1,030

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

Hybertson, B. M., Gao, B., Bose, S. K., & McCord, J. M. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.006 · Cited by 1,015

Xanthine oxidoreductase and cardiovascular disease: molecular mechanisms and pathophysiological implications

Berry, C. E., & Hare, J. M. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.055913 · Cited by 927

Combating oxidative stress in vascular disease: NADPH oxidases as therapeutic targets

Drummond, G. R., Selemidis, S., Griendling, K. K., & Sobey, C. G. (2011) · Nature Reviews Drug Discovery · doi:10.1038/nrd3403 · Cited by 899

Exercise is the real polypill.

Fiuza-Luces, C., Garatachea, N., Berger, N. A., & Lucia, A. (2013) · Physiology · doi:10.1152/physiol.00019.2013 · Cited by 791

QUANTIFICATION AND SIGNIFICANCE OF PROTEIN OXIDATION IN BIOLOGICAL SAMPLES*

SHACTER, E. (2000) · Drug Metabolism Reviews · doi:10.1081/dmr-100102336 · Cited by 747

Nox family NADPH oxidases: Molecular mechanisms of activation

Brandes, R. P., Weissmann, N., & Schröder, K. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.07.046 · Cited by 673

Effects of the Dietary Approach to Stop Hypertension (DASH) diet on cardiovascular risk factors: a systematic review and meta-analysis

Siervo, M., Lara, J., Chowdhury, S., Ashor, A., Oggioni, C., & Mathers, J. C. (2015) · British Journal of Nutrition · doi:10.1017/s0007114514003341 · Cited by 656

Evolution of nadph oxidase inhibitors: Selectivity and mechanisms for target engagement

Altenhöfer, S., Radermacher, K. A., Kleikers, P. W. M., Wingler, K., & Schmidt, H. H. H. W. (2015) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5814 · Cited by 521

Nox enzymes and new thinking on reactive oxygen: A double-edged sword revisited

Lambeth, J. D., & Neish, A. S. (2014) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104651 · Cited by 495

Angiotensin II, NADPH Oxidase, and Redox Signaling in the Vasculature

Nguyen Dinh Cat, A., Montezano, A. C., Burger, D., & Touyz, R. M. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4641 · Cited by 464

NADPH Oxidases in Vascular Pathology

Konior, A., Schramm, A., Czesnikiewicz-Guzik, M., & Guzik, T. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5607 · Cited by 452

Cysteine/cystine redox signaling in cardiovascular disease

Go, Y.-M., & Jones, D. P. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.029 · Cited by 447

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Sánchez-Aranguren, L. C., Prada, C. E., Riaño-Medina, C. E., & Lopez, M. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00372 · Cited by 438

Angiotensin II and Vascular Injury

Montezano, A. C., Nguyen Dinh Cat, A., Rios, F. J., & Touyz, R. M. (2014) · Current Hypertension Reports · doi:10.1007/s11906-014-0431-2 · Cited by 402

NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis

Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., de Haan, J. B., Koulis, C., El-Osta, A., Andrews, K. L., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.132159 · Cited by 386

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Baradaran, A., Nasri, H., & Rafieian‐Kopaei, M. (2014) · PubMed Central · Cited by 303

Biomarkers of lipid peroxidation in clinical material

Niki, E. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.03.020 · Cited by 297

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Juraschek, S. P., Guallar, E., Appel, L. J., & Miller, E. R. (2012) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.027995 · Cited by 294

Vascular Remodeling in Hypertension: Mechanisms and Treatment

Schiffrin, E. L. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.187021 · Cited by 276

Reactive Oxygen Species, Vascular Noxs, and Hypertension: Focus on Translational and Clinical Research

Montezano, A. C., & Touyz, R. M. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5302 · Cited by 270

c-Src Induces Phosphorylation and Translocation of p47phox: Role in Superoxide Generation by Angiotensin II in Human Vascular Smooth Muscle Cells

Touyz, R. M., Yao, G., & Schiffrin, E. L. (2003) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000069236.27911.68 · Cited by 270

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Spickett, C. M. (2013) · Redox Biology · doi:10.1016/j.redox.2013.01.007 · Cited by 267

Increased generation of superoxide by angiotensin II in smooth muscle cells from resistance arteries of hypertensive patients: role of phospholipase D-dependent NAD(P)H oxidase-sensitive pathways

Touyz, R. M., & Schiffrin, E. L. (2001) · Journal of Hypertension · doi:10.1097/00004872-200107000-00009 · Cited by 257

Pathophysiology of circulating xanthine oxidoreductase: New emerging roles for a multi-tasking enzyme

Battelli, M. G., Bolognesi, A., & Polito, L. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.05.022 · Cited by 256

Mitochondrial Redox Signaling: Interaction of Mitochondrial Reactive Oxygen Species with Other Sources of Oxidative Stress

Schulz, E., Wenzel, P., Münzel, T., & Daiber, A. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4609 · Cited by 251

Redox compartmentalization and cellular stress

Jones, D. P., & Go, Y. ‐. (2010) · Diabetes, Obesity and Metabolism · doi:10.1111/j.1463-1326.2010.01266.x · Cited by 246

Thiol/disulfide redox states in signaling and sensing

Go, Y.-M., & Jones, D. P. (2013) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2013.764840 · Cited by 241

Xanthine oxidoreductase-catalyzed reactive species generation: A process in critical need of reevaluation

Cantu-Medellin, N., & Kelley, E. E. (2013) · Redox Biology · doi:10.1016/j.redox.2013.05.002 · Cited by 237

Relationship between Oxidative Stress and Essential Hypertension

RODRIGO, R., PRAT, H., PASSALACQUA, W., ARAYA, J., GUICHARD, C., & BÄCHLER, J. P. (2007) · Hypertension Research · doi:10.1291/hypres.30.1159 · Cited by 235

Evaluating Oxidative Stress in Human Cardiovascular Disease: Methodological Aspects and Considerations

Lee, R., Margaritis, M., M. Channon, K., & Antoniades, C. (2012) · Current Medicinal Chemistry · doi:10.2174/092986712800493057 · Cited by 232

Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties

Zhou, S.-F., Wang, Y.-Y., Zhe, H., Yang, Y., & He, Z. (2014) · Drug Design, Development and Therapy · doi:10.2147/dddt.s68872 · Cited by 231

Hydrogen peroxide signaling in vascular endothelial cells

Bretón-Romero, R., & Lamas, S. (2014) · Redox Biology · doi:10.1016/j.redox.2014.02.005 · Cited by 215

Oxidative Stress-Related Biomarkers in Essential Hypertension and Ischemia-Reperfusion Myocardial Damage

Rodrigo, R., Libuy, M., Feliú, F., & Hasson, D. (2013) · Disease Markers · doi:10.1155/2013/974358 · Cited by 209

Evaluation of antioxidants: Scope, limitations and relevance of assays

Pinchuk, I., Shoval, H., Dotan, Y., & Lichtenberg, D. (2012) · Chemistry and Physics of Lipids · doi:10.1016/j.chemphyslip.2012.05.003 · Cited by 206

Role of mitochondrial oxidative stress in hypertension

Dikalov, S. I., & Ungvari, Z. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00089.2013 · Cited by 201

Angiotensin II and the vascular phenotype in hypertension

Savoia, C., Burger, D., Nishigaki, N., Montezano, A., & Touyz, R. M. (2011) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399411001815 · Cited by 198

Essential hypertension and oxidative stress: New insights

González, J. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i6.353 · Cited by 196

Oxidative stress, Noxs, and hypertension: Experimental evidence and clinical controversies

Montezano, A. C., & Touyz, R. M. (2012) · Annals of Medicine · doi:10.3109/07853890.2011.653393 · Cited by 193

Plasma and Dietary Antioxidant Status as Cardiovascular Disease Risk Factors: A Review of Human Studies

Wang, Y., Chun, O., & Song, W. (2013) · Nutrients · doi:10.3390/nu5082969 · Cited by 190

Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 5 (Nox5) Regulation by Angiotensin II and Endothelin-1 Is Mediated via Calcium/Calmodulin-Dependent, Rac-1-Independent Pathways in Human Endothelial Cells

Montezano, A. C., Burger, D., Paravicini, T. M., Chignalia, A. Z., Yusuf, H., Almasri, M., He, Y., Callera, G. E., He, G., Krause, K.-H., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.216036 · Cited by 188

Oxidative Stress in Hypertension: Role of the Kidney

Araujo, M., & Wilcox, C. S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5259 · Cited by 187

Nox NADPH Oxidases and the Endoplasmic Reticulum

Laurindo, F. R. M., Araujo, T. L. S., & Abrahão, T. B. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5605 · Cited by 185

Epicatechin lowers blood pressure, restores endothelial function, and decreases oxidative stress and endothelin-1 and NADPH oxidase activity in DOCA-salt hypertension

Gómez-Guzmán, M., Jiménez, R., Sánchez, M., Zarzuelo, M. J., Galindo, P., Quintela, A. M., López-Sepúlveda, R., Romero, M., Tamargo, J., Vargas, F., et al. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.015 · Cited by 179

Effect of Allopurinol on Blood Pressure: A Systematic Review and Meta‐Analysis

Agarwal, V., Hans, N., & Messerli, F. H. (2013) · The Journal of Clinical Hypertension · doi:10.1111/j.1751-7176.2012.00701.x · Cited by 173

Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals

Higashi, Y., Sasaki, S., Nakagawa, K., Fukuda, Y., Matsuura, H., Oshima, T., & Chayama, K. (2002) · American Journal of Hypertension · doi:10.1016/s0895-7061(01)02317-2 · Cited by 173

In vitro measurements and interpretation of total antioxidant capacity

Fraga, C. G., Oteiza, P. I., & Galleano, M. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.06.030 · Cited by 172

Nrf2 and Cardiovascular Defense

Howden, R. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/104308 · Cited by 162

New paradigms in inflammatory signaling in vascular endothelial cells

Xiao, L., Liu, Y., & Wang, N. (2014) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00182.2013 · Cited by 160

Reciprocal Relationship Between Reactive Oxygen Species and Cyclooxygenase-2 and Vascular Dysfunction in Hypertension

Martínez-Revelles, S., Avendaño, M. S., García-Redondo, A. B., Álvarez, Y., Aguado, A., Pérez-Girón, J. V., García-Redondo, L., Esteban, V., Redondo, J. M., Alonso, M. J., et al. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4335 · Cited by 158

F2-isoprostanes as an indicator and risk factor for coronary heart disease

Davies, S. S., & Roberts, L. J. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2010.11.023 · Cited by 155

p47phox Associates With the Cytoskeleton Through Cortactin in Human Vascular Smooth Muscle Cells

Touyz, R. M., Yao, G., Quinn, M. T., Pagano, P. J., & Schiffrin, E. L. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000154141.66879.98 · Cited by 155

4-Hydroxy-2-nonenal protects against cardiac ischemia–reperfusion injury via the Nrf2-dependent pathway

Zhang, Y., Sano, M., Shinmura, K., Tamaki, K., Katsumata, Y., Matsuhashi, T., Morizane, S., Ito, H., Hishiki, T., Endo, J., et al. (2010) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2010.05.011 · Cited by 152

Hypertension and Endothelial Dysfunction: Therapeutic Approach

Ghiadoni, L., Taddei, S., & Virdis, A. (2011) · Current Vascular Pharmacology · doi:10.2174/157016112798829823 · Cited by 149

Resveratrol Improves Vascular Function in Patients With Hypertension and Dyslipidemia by Modulating NO Metabolism

Carrizzo, A., Puca, A. A., Damato, A., Marino, M., Franco, E., Pompeo, F., Traficante, A., Civitillo, F., Santini, L., Trimarco, V., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.111.01009 · Cited by 145

Bioactive Eicosanoids: Role of Prostaglandin F2α and F2-Isoprostanes in Inflammation and Oxidative Stress Related Pathology

Basu, S. (2010) · Molecules and Cells · doi:10.1007/s10059-010-0157-1 · Cited by 144

Oxidative stress in human hypertension: association with antihypertensive treatment, gender, nutrition, and lifestyle

Ward, N. C., Hodgson, J. M., Puddey, I. B., Mori, T. A., Beilin, L. J., & Croft, K. D. (2003) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2003.10.021 · Cited by 142

Plasma Total Antioxidant Capacity in Hemodialyzed Patients and Its Relationships to other Biomarkers of Oxidative Stress and Lipid Peroxidation

Gerardi, G., Usberti, M., Martini, G., Albertini, A., Sugherini, L., Alfonso Pompella, C., & Lorenzo, D. D. (2002) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2002.019 · Cited by 135

Endothelin-1-induced oxidative stress in DOCA-salt hypertension involves NADPH-oxidase-independent mechanisms

Callera, G. E., Tostes, R. C., Yogi, Á., Montezano, A. C. I., & Touyz, R. M. (2006) · Clinical Science · doi:10.1042/cs20050307 · Cited by 121

Untitled work

(2014) · Dove Medical Press (Taylor and Francis Group) · Cited by 118

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Chen, J., Zhang, Z., & Cai, L. (2014) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2014.38.5.337 · Cited by 112

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston, M. C. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i2.38 · Cited by 111

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Chatterjee, S., & Fisher, A. B. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5624 · Cited by 110

Novel Nox homologues in the vasculature: focusing on Nox4 and Nox5

Montezano, A. C. I., Burger, D. E., Ceravolo, G. S., Yusuf, H., Montero, M. J., & Touyz, R. M. (2010) · Clinical Science · doi:10.1042/cs20100384 · Cited by 108

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Hernanz, R., Briones, A. M., Salaíces, M., & Alonso, M. J. (2013) · Clinical Science · doi:10.1042/cs20120651 · Cited by 105

Role of NADPH Oxidase in Endothelial Ischemia/Reperfusion Injury in Humans

Loukogeorgakis, S., van den Berg, J. M., Sofat, R., Nitsch, D., Charakida, M., Haiyee, B., de Groot, E., MacAllister, R. J., Kuijpers, T. W., & Deanfield, J. E. (2010) · Circulation · doi:10.1161/circulationaha.108.814731 · Cited by 104

Tetrahydrobiopterin: a novel antihypertensive therapy

Porkert, M., Sher, S., Reddy, U., Cheema, F. H., Niessner, C., Kolm, P., Jones, D. P., Hooper, C. W., Taylor, W. R., Harrison, D. G., et al. (2008) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1002329 · Cited by 100

Rationale and Trial Design of Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes: The Occurrence of Renal Events (BEACON)

de Zeeuw, D., Akizawa, T., Agarwal, R., Audhya, P., Bakris, G. L., Chin, M. P., Krauth, M., Heerspink, H. J. L., Meyer, C. J., McMurray, J. J. V., et al. (2013) · American Journal of Nephrology · doi:10.1159/000346948 · Cited by 98

Hypertension

Sliwa, K. S., Stewart, S., & Gersh, B. J. (2011) · Circulation · doi:10.1161/circulationaha.110.992362 · Cited by 97

Local ascorbate administration augments NO- and non-NO-dependent reflex cutaneous vasodilation in hypertensive humans

Holowatz, L. A., & Kenney, W. L. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00295.2007 · Cited by 96

NADPH oxidase inhibitors: a decade of discovery from Nox2ds to HTS

Cifuentes-Pagano, E., Csányi, G., & Pagano, P. J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1009-2 · Cited by 94

Antioxidants in Hypertension and Cardiovascular Disease

Schiffrin, E. L. (2010) · Molecular Interventions · doi:10.1124/mi.10.6.4 · Cited by 88

Effects of dietary mineral acids on voluntary food intake, digestion, mineral metabolism and acid-base balance of sheep

L’Estrange, J. L., & Murphy, F. (1972) · British Journal Of Nutrition · doi:10.1079/bjn19720003 · Cited by 87

The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls

Cifuentes-Pagano, E., Meijles, D. N., & Pagano, P. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5620 · Cited by 84

Selective Recapitulation of Conserved and Nonconserved Regions of Putative NOXA1 Protein Activation Domain Confers Isoform-specific Inhibition of Nox1 Oxidase and Attenuation of Endothelial Cell Migration

Ranayhossaini, D., Rodriguez, A. I., Sahoo, S., Chen, B. B., Mallampalli, R. K., Kelley, E. E., Csányi, G., Gladwin, M. T., Romero, G. G., & Pagano, P. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.521344 · Cited by 83

The role of the endogenous antioxidant enzymes and malondialdehyde in essential hypertension.

Ahmad, A., Singhal, U., Hossain, M. M., Islam, N., & Rizvi, I. (2013) · Journal of clinical and diagnostic research : JCDR · doi:10.7860/jcdr/2013/5829.3091 · Cited by 79

Redox biology: Interface of the exposome with the proteome, epigenome and genome

Go, Y., & Jones, D. P. (2014) · Redox Biology · doi:10.1016/j.redox.2013.12.032 · Cited by 78

Extracellular superoxide dismutase (ecSOD) in vascular biology: an update on exogenous gene transfer and endogenous regulators of ecSOD

Qin, Z., Reszka, K. J., Fukai, T., & Weintraub, N. L. (2007) · Translational research · doi:10.1016/j.trsl.2007.10.003 · Cited by 76

Endothelial Dysfunction in Diabetes and Hypertension: Cross Talk in RAS, BMP4, and ROS-dependent COX-2–derived Prostanoids

Wong, W. T., Tian, X. Y., & Huang, Y. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e31827fe46e · Cited by 72

NOX5 Expression Is Increased in Intramyocardial Blood Vessels and Cardiomyocytes after Acute Myocardial Infarction in Humans

Hahn, N. E., Meischl, C., Kawahara, T., Musters, R. J. P., Verhoef, V. M. J., van der Velden, J., Vonk, A. B. A., Paulus, W. J., van Rossum, A. C., Niessen, H. W. M., et al. (2012) · The American Journal of Pathology · doi:10.1016/j.ajpath.2012.02.018 · Cited by 67

Vascular signaling through G protein-coupled receptors: new concepts

Ushio‐Fukai, M. (2009) · Current Opinion in Nephrology & Hypertension · doi:10.1097/mnh.0b013e3283252efe · Cited by 67

Allopurinol, uric acid, and oxidative stress in cardiorenal disease

Riegersperger, M., Covic, A. C., & Goldsmith, D. J. A. (2011) · International Urology and Nephrology · doi:10.1007/s11255-011-9929-6 · Cited by 62

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Vikram, A., Kim, Y., Kumar, S., Naqvi, A., Hoffman, T. A., Kumar, A., Miller, F. J., Kim, C., & Irani, K. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304338 · Cited by 60

Oxidative stress in patients affected by primary aldosteronism

Petramala, L., Pignatelli, P., Carnevale, R., Zinnamosca, L., Marinelli, C., Settevendemmie, A., Concistrè, A., Tonnarini, G., Toma, G. D., Violi, F., et al. (2014) · Journal of Hypertension · doi:10.1097/hjh.0000000000000284 · Cited by 60

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Reuland, D. J., McCord, J. M., & Hamilton, K. L. (2013) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3182948a1e · Cited by 55

Adaptor Protein p66 Shc Mediates Hypertension-Associated, Cyclic Stretch–Dependent, Endothelial Damage

Spescha, R. D., Glanzmann, M., Simic, B., Witassek, F., Keller, S., Akhmedov, A., Tanner, F. C., Lüscher, T. F., & Camici, G. G. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02129 · Cited by 55

Oxidative Stress Is Associated With Increased Pulmonary Artery Systolic Pressure in Humans

Ghasemzadeh, N., Patel, R. S., Eapen, D. J., Veledar, E., Kassem, H. A., Manocha, P., Khayata, M., Zafari, A. M., Sperling, L. S., Jones, D. P., et al. (2014) · Hypertension · doi:10.1161/hypertensionaha.113.02360 · Cited by 54

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Wei, Z., Salmon, R. M., Upton, P. D., Morrell, N. W., & Li, W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.579771 · Cited by 53

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Vukelic, S., & Griendling, K. K. (2014) · Circulation Research · doi:10.1161/circresaha.114.303045 · Cited by 53

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Urinary biomarkers of oxidative/nitrosative stress in healthy smokers

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Mitogen-activated protein kinase activation by hydrogen peroxide is mediated through tyrosine kinase-dependent, protein kinase C-independent pathways in vascular smooth muscle cells: upregulation in spontaneously hypertensive rats

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Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor, decreases serum uric acid levels in type 2 diabetic patients partly by suppressing xanthine oxidase activity

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Endothelial Cells Negatively Modulate Reactive Oxygen Species Generation in Vascular Smooth Muscle Cells: Role of Thioredoxin

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c-Src, ERK1/2 and Rho kinase mediate hydrogen peroxide-induced vascular contraction in hypertension

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Experimental Antioxidant Biotherapy for Protection of the Vascular Wall by Modified Forms of Superoxide Dismutase and Catalase

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Assessment of Atherosclerosis in Chronic Granulomatous Disease

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Anti-oxidants - a protective role in cardiovascular disease?

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Changes in markers of oxidative stress and DNA damage in human visceral adipose tissue from subjects with obesity and type 2 diabetes

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Oxidative stress markers in hypertensive states of pregnancy: preterm and term disease

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Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells

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Modelling the impact on avoidable cardiovascular disease burden and costs of interventions to lower SBP in the England population

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Tetrahydrobiopterin Improves Endothelial Function in Cardiovascular Disease: A Systematic Review

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Antioxidant supplementation in hypertension.

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Redox Pioneer: Professor Helmut Sies

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Strategies Aimed at Nox4 Oxidase Inhibition Employing Peptides from Nox4 B‐Loop and C‐Terminus and p22 phox N‐Terminus: An Elusive Target

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C242T polymorphism of the NADPH oxidase p22PHOX gene and its association with endothelial dysfunction in asymptomatic individuals with essential systemic hypertension

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NADPH Oxidases: Progress and Opportunities

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G protein coupled-receptor signaling and reversible lysine acetylation

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Managing hypertension: evidence supporting the 2013/2014 recommendations of the Canadian Hypertension Education Program

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A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension

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Endothelial Dysfunction and Hypertension

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Targeting inflammation to reduce cardiovascular disease risk: A realistic clinical prospect?

Welsh, P., Grassia, G., Botha, S., Sattar, N., & Maffia, P. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13818 · Cited by 164

Redox signaling, Nox5 and vascular remodeling in hypertension

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