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Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function
Open accessAbstract
Intensive efforts are focused on identifying regulators of human pancreatic islet cell growth and maturation to accelerate development of therapies for diabetes. After birth, islet cell growth and function are dynamically regulated; however, establishing these age-dependent changes in humans has been challenging. Here, we describe a multimodal strategy for isolating pancreatic endocrine and exocrine cells from children and adults to identify age-dependent gene expression and chromatin changes on a genomic scale. These profiles revealed distinct proliferative and functional states of islet α cells or β cells and histone modifications underlying age-dependent gene expression changes. Expression of SIX2 and SIX3, transcription factors without prior known functions in the pancreas and linked to fasting hyperglycemia risk, increased with age specifically in human islet β cells. SIX2 and SIX3 were sufficient to enhance insulin content or secretion in immature β cells. Our work provides a unique resource to study human-specific regulators of islet cell maturation and function.
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“A DE study analyzing age-dependent gene regulation in human pancreas56 was used to get pancreas cell type specific priors.”
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Cites
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Self-citationDifferential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982
Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
Edgar, R. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.207 · Cited by 13,288
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422
Self-citationOpen source clustering software
de Hoon, M., Imoto, S., Nolan, J., & Miyano, S. (2004) · Bioinformatics · doi:10.1093/bioinformatics/bth078 · Cited by 3,047
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533
Generation of Functional Human Pancreatic β Cells In Vitro
Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025
Determination and Inference of Eukaryotic Transcription Factor Sequence Specificity
Weirauch, M. T., Yang, A. W. H., Albu, M., Coté, A. G., Montenegro‐Montero, A., Drewe, P., Najafabadi, H. S., Lambert, S. A., Mann, I. K., Cook, K. B., et al. (2014) · Cell · doi:10.1016/j.cell.2014.08.009 · Cited by 1,749
Reversal of diabetes with insulin-producing cells derived in vitro from human pluripotent stem cells
Rezania, A., Bruin, J. E., Arora, P., Rubin, A., Batushansky, I., Asadi, A., O'Dwyer, S., Quiskamp, N., Mojibian, M., Albrecht, T., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.3033 · Cited by 1,575
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Enge, M., Arda, H. E., Mignardi, M., Beausang, J., Bottino, R., Kim, S. K., & Quake, S. R. (2017) · Cell · doi:10.1016/j.cell.2017.09.004 · Cited by 568
Self-citationLawlor, N. T., George, J., Bolisetty, M. T., Kursawe, R., Sun, L., Vijayakumar, S., Kycia, I., Robson, P., & Stitzel, M. L. (2016) · Genome Research · doi:10.1101/gr.212720.116 · Cited by 543
Charting cellular identity during human in vitro β-cell differentiation
Veres, A., Faust, A. L., Bushnell, H. L., Engquist, E. N., Kenty, J. H.-R., Harb, G., Poh, Y.-C., Sintov, E., Gürtler, M., Pagliuca, F. W., et al. (2019) · Nature · doi:10.1038/s41586-019-1168-5 · Cited by 552
Chen, C., Cohrs, C. M., Stertmann, J., Bozsak, R., & Speier, S. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.06.019 · Cited by 506
Nair, G. G., Liu, J. S., Russ, H. A., Tran, S., Saxton, M. S., Chen, R., Juang, C., Li, M.-L., Nguyen, V. Q., Giacometti, S., et al. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0271-4 · Cited by 472
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Roe, J., Hwang, C., Somerville, T. D. D., Milazzo, J. P., Lee, E. J., Silva, B. D., Maiorino, L., Tiriac, H., Young, C. M., Miyabayashi, K., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.007 · Cited by 465
Balboa, D., Barsby, T., Lithovius, V., Saarimäki-Vire, J., Omar-Hmeadi, M., Dyachok, O., Montaser, H., Lund, P.-E., Yang, M., Ibrahim, H., et al. (2022) · Nature Biotechnology · doi:10.1038/s41587-022-01219-z · Cited by 433
Acquisition of Dynamic Function in Human Stem Cell-Derived β Cells
Velazco-Cruz, L., Song, J., Maxwell, K. G., Goedegebuure, M. M., Augsornworawat, P., Hogrebe, N. J., & Millman, J. R. (2019) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.12.012 · Cited by 399
Human islets contain four distinct subtypes of β cells
Dorrell, C., Schug, J., Canaday, P. S., Russ, H. A., Tarlow, B., Grompe, M. T., Horton, T., Hebrok, M., Streeter, P. R., Kaestner, K. H., et al. (2016) · Nature Communications · doi:10.1038/ncomms11756 · Cited by 389
Self-citationBao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 402
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Wu, C.-T., Lidsky, P. V., Xiao, Y., Lee, I. T., Cheng, R., Nakayama, T., Jiang, S., Demeter, J., Bevacqua, R. J., Chang, C., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.05.013 · Cited by 385
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Thompson, P. J., Shah, A., Ntranos, V., Van Gool, F., Atkinson, M., & Bhushan, A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.01.021 · Cited by 353
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Furuyama, K., Chera, S., van Gurp, L., Oropeza, D., Ghila, L., Damond, N., Vethe, H., Paulo, J. A., Joosten, A. M., Berney, T., et al. (2019) · Nature · doi:10.1038/s41586-019-0942-8 · Cited by 245
Self-citationSingle-nucleus and in situ RNA-sequencing reveal cell topographies in the human pancreas
Tosti, L., Hang, Y., Debnath, O., Tiesmeyer, S., Trefzer, T., Steiger, K., Ten, F. W., Lukassen, S., Ballke, S., Kühl, A. A., et al. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.11.010 · Cited by 228
Self-citationHohwieler, M., Illing, A., Hermann, P. C., Mayer, T., Stockmann, M., Perkhofer, L., Eiseler, T., Antony, J. S., Müller, M., Renz, S., et al. (2016) · Gut · doi:10.1136/gutjnl-2016-312423 · Cited by 226
Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx
Chakravarthy, H., Gu, X., Enge, M., Dai, X.-Q., Wang, Y., Damond, N., Downie, C. G., Liu, K., Wang, J., Xing, Y., et al. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.01.009 · Cited by 215
Self-citationXin, Y., Dominguez Gutierrez, G., Okamoto, H., Kim, J., Lee, A.-H., Adler, C., Ni, M., Yancopoulos, G. D., Murphy, A. J., & Gromada, J. (2018) · Diabetes · doi:10.2337/db18-0365 · Cited by 191
Maxwell, K. G., Augsornworawat, P., Velazco-Cruz, L., Kim, M. H., Asada, R., Hogrebe, N. J., Morikawa, S., Urano, F., & Millman, J. R. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax9106 · Cited by 183
Coate, K. C., Cha, J., Shrestha, S., Wang, W., Gonçalves, L. M., Almaça, J., Kapp, M., Fasolino, M., Morgan, A. R., Dai, C., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.006 · Cited by 182
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Puri, S., Roy, N., Russ, H. A., Leonhardt, L., French, E. K., Roy, R., Bengtsson, H. L., Scott, D. K., Stewart, A. F., & Hebrok, M. (2018) · Nature Communications · doi:10.1038/s41467-018-02939-0 · Cited by 148
Dai, C., Hang, Y., Shostak, A., Poffenberger, G., Hart, N. J., Prasad, N., Phillips, N., Levy, S., Greiner, D. L., Shultz, L. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci91761 · Cited by 148
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Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions
Hart, N. J., & Powers, A. C. (2018) · Diabetologia · doi:10.1007/s00125-018-4772-2 · Cited by 152
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Espinet, E., Gu, Z., Imbusch, C. D., Giese, N. A., Büscher, M., Safavi, M., Weisenburger, S., Klein, C., Vogel, V., Falcone, M., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1202 · Cited by 124
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Drucker, D. J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.08.006 · Cited by 117
Aghazadeh, Y., Poon, F., Sarangi, F., Wong, F., Khan, S. T., Sun, X., Hatkar, R., Cox, B., Nunes, S. S., & Nostro, M. C. (2021) · Cell stem cell · doi:10.1016/j.stem.2021.08.001 · Cited by 124
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“…accessible in the supplement of Chen et al. 2016 (https://doi.org/10.1016/j.cell.2016.10.026), Rendeiro et al. 2016 (https://doi.org/10.1038/ncomms11938), Moreno-Moral et al. 2018 (https://doi.org/10.1136/annrheumdis-2017-212454) and Arda et al, 2016 (https://doi.org/ 10.1016/j.cmet.2016.04.002).”
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Self-citationZhu, H., Wang, G., Nguyen-Ngoc, K.-V., Kim, D., Miller, M., Goss, G., Kovsky, J., Harrington, A. R., Saunders, D. C., Hopkirk, A. L., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.03.011 · Cited by 88
Self-citationWang, H., Bender, A. S., Wang, P., Karaköse, E., Inabnet, W. B., Libutti, S. K., Arnold, A., Lambertini, L., Stang, M., Chen, H., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00992-9 · Cited by 83
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Self-citationSinagoga, K. L., Stone, W. J., Schiesser, J. V., Schweitzer, J. I., Sampson, L. L., Zheng, Y., & Wells, J. M. (2017) · Development · doi:10.1242/dev.146316 · Cited by 48
Elbere, I., Silamiķelis, I., Ustinova, M., Kalniņa, I., Zaharenko, L., Pečulis, R., Konrāde, I., Ciuculete, D. M., Zhukovsky, C., Gudrā, D., et al. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0593-x · Cited by 48
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Sui, L., Xin, Y., Du, Q., Georgieva, D., Diedenhofen, G., Haataja, L., Su, Q., Zuccaro, M. V., Kim, J., Fu, J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.141553 · Cited by 47
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Maestas, M. M., Ishahak, M., Augsornworawat, P., Veronese-Paniagua, D., Maxwell, K. G., Velazco-Cruz, L., Marquez, E., Sun, J., Shunkarova, M., Gale, S. E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49724-w · Cited by 53
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Balboa, D., Iworima, D. G., & Kieffer, T. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.642152 · Cited by 49
Wortham, M., Benthuysen, J. R., Wallace, M., Savas, J. N., Mulas, F., Divakaruni, A. S., Liu, F., Albert, V., Taylor, B. L., Sui, Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.031 · Cited by 43
Gómez-Verján, J. C., Vázquez-Martínez, E. R., Rivero-Segura, N. A., & Medina-Campos, R. H. (2018) · Human Genetics · doi:10.1007/s00439-018-1955-3 · Cited by 46
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Jacobson, E. F., & Tzanakakis, E. S. (2017) · Journal of Biological Engineering · doi:10.1186/s13036-017-0066-3 · Cited by 43
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Characterization of stem-cell-derived islets during differentiation and after implantation
Cuesta-Gomez, N., Verhoeff, K., Jasra, I. T., Pawlick, R., Dadheech, N., & Shapiro, A. M. J. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111238 · Cited by 41
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López‐Beas, J., Capilla‐González, V., Aguilera, Y., Mellado-Damas, N., Lachaud, C. C., Martı́n, F., Smani, T., Soria, B., & Hmadcha, A. (2018) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2018.06.002 · Cited by 38
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Kim, H., Yoon, B.-H., Oh, C.-M., Lee, J., Lee, K., Song, H., Kim, E., Yi, K., Kim, M., Kim, H., et al. (2019) · Diabetes · doi:10.2337/db19-0685 · Cited by 37
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Abdelalim, E. M. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03710-9 · Cited by 38
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Kwak, S. H., Srinivasan, S., Chen, L., Todd, J. N., Mercader, J. M., Jensen, E. T., Divers, J., Mottl, A. K., Pihoker, C., Gandica, R., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00970-0 · Cited by 41
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Tremmel, D. M., Mitchell, S. A., Sackett, S. D., & Odorico, J. S. (2019) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000687 · Cited by 37
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Weitz, J., Menegaz, D., & Caicedo, A. (2020) · Diabetes · doi:10.2337/dbi19-0033 · Cited by 39
Repression of latent NF-κB enhancers by PDX1 regulates β cell functional heterogeneity
Weidemann, B. J., Marcheva, B., Kobayashi, M., Omura, C., Newman, M. V., Kobayashi, Y., Waldeck, N. J., Perelis, M., Lantier, L., McGuinness, O. P., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.11.018 · Cited by 41
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Spracklen, C. N., Shi, J., Vadlamudi, S., Wu, Y., Zou, M., Raulerson, C. K., Davis, J. P., Zeynalzadeh, M., Jackson, K. C., Yuan, W., et al. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007275 · Cited by 37
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Metadata
- Authors
- Arda, H. E., Li, L., Tsai, J., Torre, E. A., Rosli, Y., Peiris, H., Spitale, R. C., Dai, C., Gu, X., Qu, K., Wang, P., Wang, J., Grompe, M., Scharfmann, R., Snyder, M. S., Bottino, R., Powers, A. C., Chang, H. Y., & Kim, S. K.
- Affiliations
- Stanford Medicine (US)
- Vanderbilt University (US)
- Oregon Health & Science University (US)
- Allegheny Health Network (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Kim, Seung K.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 23
- Issue
- 5
- Pages
- 909-920
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC4864151
- OpenAlex
- W2343369957
- Cited by
- 222
- References
- 62
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 24 · 2023: 18 · 2022: 26 · 2021: 35 · 2020: 28 · 2019: 27 · 2018: 23 · 2017: 17 · 2016: 8
- FWCI
- 27.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 BX000666)
- Agricultural Research Development Agency
- National Institutes of Health (5p60dk020593-31)
- National Institute of Diabetes and Digestive and Kidney Diseases (UC4DK104143, U01DK089532, P60-DK020593, U01DK089572, UC4DK104211, U01DK072473, T32DK007217, P30DK020593)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- pancreatic islet development, beta cell maturation, age-related gene expression, histone modifications, chromatin regulation, Six2, Six3, insulin secretion, islet cell proliferation, diabetes treatment, fasting hyperglycemia
- MeSH terms
- Adult, Aging, Cell Differentiation, Cell Separation, Child, Child, Preschool, Chromatin, Diabetes Mellitus, Humans, Infant, Middle Aged, Transcription Factors, Homeodomain Proteins, Gene Expression Regulation, Developmental, Histone Code, Chromatin Immunoprecipitation, Insulin-Secreting Cells, Young Adult, Transcriptome
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