Cited by 109Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesComplex Network Analysis Techniques

Mapping putative hubs in human, chimpanzee and rhesus macaque connectomes via diffusion tractography

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Li, Longchuan, Hu, Xiaoping, Preuss, Todd M., Glasser, Matthew F., Damen, Frederick W., Qiu, Yuxuan, Rilling, James·2013·NeuroImage

Abstract

Mapping anatomical brain networks with graph-theoretic analysis of diffusion tractography has recently gained popularity, because of its presumed value in understanding brain function. However, this approach has seldom been used to compare brain connectomes across species, which may provide insights into brain evolution. Here, we employed a data-driven approach to compare interregional brain connections across three primate species: 1) the intensively studied rhesus macaque, 2) our closest living primate relative, the chimpanzee, and 3) humans. Specifically, we first used random parcellations and surface-based probabilistic diffusion tractography to derive the brain networks of the three species under various network densities and resolutions. We then compared the characteristics of the networks using graph-theoretic measures. In rhesus macaques, our tractography-defined hubs showed reasonable overlap with hubs previously identified using anterograde and retrograde tracer data. Across all three species, hubs were largely symmetric in the two hemispheres and were consistently identified in medial parietal, insular, retrosplenial cingulate and ventrolateral prefrontal cortices, suggesting a conserved structural architecture within these regions. However, species differences were observed in the inferior parietal cortex, polar and medial prefrontal cortices. The potential significance of these interspecies differences is discussed.

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Research works printed but not linked: 2

  1. Bailey P Bonin Gv McCulloch WS The isocortex of the chimpanzee 1950 Urbana, IL Univ. of Illionois Press
  2. Li L Rilling JK Preuss TM Glasser MF Hu X The effects of connection reconstruction method on the interregional connectivity of brain networks via diffusion tractography Hum Brain Mapp 2012b 33 1894 1913 21928316 PMC6414228

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Authors
Li, L., Hu, X., Preuss, T. M., Glasser, M. F., Damen, F. W., Qiu, Y., & Rilling, J.
Affiliations
  • Georgia Institute of Technology (US)
  • Emory University (US)
  • Washington University in St. Louis (US)
Corresponding author
Rilling, James
Venue
NeuroImage
Publisher
Elsevier BV
Published
2013-10
Volume
80
Pages
462-474
ISSN
1053-8119 (ISSN-L)
OpenAlex
W1979383653
Cited by
109
References
96
Citations by year
2026: 3 · 2025: 4 · 2024: 9 · 2023: 6 · 2022: 4 · 2021: 6 · 2020: 10 · 2019: 11 · 2018: 13 · 2017: 11 · 2016: 10 · 2015: 6 · 2014: 12 · 2013: 4
FWCI
8.28
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • NIH (5P01 AG026423-03, P50-MH100029)
  • National Center for Research Resources (P51RR165)
  • Office of Research Infrastructure Programs (P51OD11132)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Physical Sciences › Physics and Astronomy › Statistical and Nonlinear Physics › Complex Network Analysis Techniques
Keywords
brain connectome, diffusion tractography, primate brain evolution, human-brain comparison, chimpanzees, rhesus monkeys, probabilistic tractography, hemispheric symmetry, prefrontal cortex, parietal cortex, insula, retrosplenial cortex
MeSH terms
Animals, Brain, Pan troglodytes, Humans, Macaca mulatta, Models, Anatomic, Models, Neurological, Nerve Fibers, Myelinated, Nerve Net, Species Specificity, Diffusion Tensor Imaging, Connectome

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