Evolutionary changes in promoter and enhancer activity during human corticogenesis
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Of mice, men, and macaque brains: The human brain represents a unique evolutionary trajectory. To better understand how the human brain came to be, Reilly et al. sought to identify changes in gene expression between mice, macaques, and humans. They compared epigenetic marks in the embryonic cortex, which revealed changes in gene regulation in biological pathways associated with cortical development. Science , this issue p. 1155
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Regulatory relationships between non-coding variants and their target genes vary across human cell types, tissues, developmental stages, and species.
“Such regulatory relationships show substantial heterogeneity across human cell types, tissues, and developmental stages (10), and are often highly species-specific (11).”
From Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder (2018) · cites this paper as [11]
Comparative epigenetic profiling of promoters and enhancers during human, rhesus macaque, and mouse corticogenesis identified many regions gained in humans.
“Comparative epigenetic profiling of promoters and enhancers present during human, rhesus macaque, and mouse corticogenesis has identified many regions that were gained in humans (Reilly et al., 2015).”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Reilly et al., 2015
These regions were significantly enriched in modules of co-expressed genes that function in neuronal proliferation, migration, and cortical-map organization.
“These regions were shown to be significantly enriched in modules of co-expressed genes that function in neuronal proliferation, migration, and cortical-map organization.”
From The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016) · cites this paper as Reilly et al., 2015
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- Authors
- Reilly, S. K., Yin, J., Ayoub, A. E., Emera, D., Leng, J., Cotney, J., Sarro, R., Rakic, P., & Noonan, J. P.
- Affiliations
- Yale University (US)
- Corresponding author
- Reilly, Steven K.
- Yin, Jun
- Noonan, James P.
- ORCID
- Venue
- Science
- Published
- 2015-03-06
- Volume
- 347
- Issue
- 6226
- Pages
- 1155-1159
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4426903
- OpenAlex
- W2053433605
- Cited by
- 297
- References
- 43
- Citations by year
- 2026: 21 · 2025: 22 · 2024: 30 · 2023: 34 · 2022: 27 · 2021: 26 · 2020: 24 · 2019: 19 · 2018: 31 · 2017: 21 · 2016: 28 · 2015: 14
- FWCI
- 13.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NSF
- NIH (GM094780, DA023999, NS014841, F32 GM106628)
- Wellcome Trust (099175/Z/12/Z)
- Medical Research Council
- Brown Coxe Fellowship in the Medical Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- cortical development, promoter activity, enhancer activity, epigenetic profiling, gene co-expression modules, transcription factor binding sites, neuronal proliferation, neuronal migration, rhesus monkeys, mice
- MeSH terms
- Animals, Cerebral Cortex, Enhancer Elements, Genetic, Humans, Macaca mulatta, Promoter Regions, Genetic, Gene Expression Regulation, Developmental, Evolution, Molecular, Organogenesis, Epigenesis, Genetic, Mice, Rats
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