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Cited by 1,234

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

Tumors as Organs: Complex Tissues that Interface with the Entire Organism

Open access
Egeblad, Mikala, Nakasone, Elizabeth S., Werb, Zena·2010·Developmental Cell
DOI 10.1016/j.devcel.2010.05.012
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Abstract

Solid tumors are not simply clones of cancer cells. Instead, they are abnormal organs composed of multiple cell types and extracellular matrix. Some aspects of tumor development resemble processes seen in developing organs, while others are more akin to tissue remodeling. Some microenvironments, particularly those associated with tissue injury, are favorable for progression of mutant cells while others restrict it. Cancer cells can also instruct surrounding tissues to undergo changes that promote malignancy. Understanding the complex ways in which cancer cells interact with their surroundings, both locally in the tumor organ and systemically in the body as a whole, has implications for effective cancer prevention and therapy.

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Crossref · 10.1016/j.devcel.2010.05.012

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Metadata

Authors
Egeblad, M., Nakasone, E. S., & Werb, Z.
Venue
Developmental Cell
Publisher
Elsevier BV
Published
2010-06
Volume
18
Issue
6
Pages
884-901
ISSN
1534-5807 (ISSN-L)
DOI
10.1016/j.devcel.2010.05.012
OpenAlex
W2082046119
Cited by
1,234
References
45
FWCI
27.64
Type
journal article
Language
en
Open access
bronze

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.