The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Tumors as Organs: Complex Tissues that Interface with the Entire Organism
Open accessAbstract
Solid tumors are not simply clones of cancer cells. Instead, they are abnormal organs composed of multiple cell types and extracellular matrix. Some aspects of tumor development resemble processes seen in developing organs, while others are more akin to tissue remodeling. Some microenvironments, particularly those associated with tissue injury, are favorable for progression of mutant cells while others restrict it. Cancer cells can also instruct surrounding tissues to undergo changes that promote malignancy. Understanding the complex ways in which cancer cells interact with their surroundings, both locally in the tumor organ and systemically in the body as a whole, has implications for effective cancer prevention and therapy.
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Self-citation
Metadata
- Authors
- Egeblad, M., Nakasone, E. S., & Werb, Z.
- Venue
- Developmental Cell
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 18
- Issue
- 6
- Pages
- 884-901
- ISSN
- 1534-5807 (ISSN-L)
- OpenAlex
- W2082046119
- Cited by
- 1,234
- References
- 45
- FWCI
- 27.64
- Type
- journal article
- Language
- en
- Open access
- bronze
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