Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

Non-viral vectors for gene-based therapy

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Suppression of RNA Recognition by Toll-like Receptors: The Impact of Nucleoside Modification and the Evolutionary Origin of RNA

Karikó, K., Buckstein, M., Ni, H., & Weissman, D. (2005) · Immunity · doi:10.1016/j.immuni.2005.06.008 · Cited by 2,728 · see citing works

Gold nanoparticles in delivery applications☆

GHOSH, P., HAN, G., De, M., KIM, C., & Rotello, V. M. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.03.016 · Cited by 2,700 · see citing works

Progress and problems with the use of viral vectors for gene therapy

Thomas, C. E., Ehrhardt, A., & Kay, M. A. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1066 · Cited by 2,501 · see citing works

mRNA-based therapeutics--developing a new class of drugs

Sahin, U., Karikó, K., & Türeci, Ö. (2014) · Nature Reviews Drug Discovery · doi:10.1038/nrd4278 · Cited by 2,474 · see citing works

New-Concept Chemotherapy by Nanoparticles of Biodegradable Polymers: Where Are We Now?

Feng, S.-S. (2006) · Nanomedicine · doi:10.2217/17435889.1.3.297 · Cited by 1,951 · see citing works

Rational design of cationic lipids for siRNA delivery

Semple, S. C., Akinc, A., Chen, J., Sandhu, A. P., Mui, B. L., Cho, C. K., Sah, D. W. Y., Stebbing, D., Crosley, E. J., Yaworski, E., et al. (2010) · Nature Biotechnology · doi:10.1038/nbt.1602 · Cited by 1,822 · see citing works

Delivery materials for siRNA therapeutics

Kanasty, R., Dorkin, J. R., Vegas, A., & Anderson, D. (2013) · Nature Materials · doi:10.1038/nmat3765 · Cited by 1,800 · see citing works

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

Gilleron, J., Querbes, W., Zeigerer, A., Borodovsky, A., Marsico, G., Schubert, U., Manygoats, K., Seifert, S., Andree, C., Stöter, M., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2612 · Cited by 1,681 · see citing works

An Inverted Hexagonal Phase of Cationic Liposome-DNA Complexes Related to DNA Release and Delivery

Koltover, I., Salditt, T., Rädler, J. O., & Safinya, C. R. (1998) · Science · doi:10.1126/science.281.5373.78 · Cited by 1,336 · see citing works

Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo

Jayaraman, M., Ansell, S. M., Mui, B. L., Tam, Y. K., Chen, J., Du, X., Butler, D., Eltepu, L., Matsuda, S., Narayanannair, J. K., et al. (2012) · Angewandte Chemie International Edition · doi:10.1002/anie.201203263 · Cited by 1,267 · see citing works

Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform

Zhang, L., Chan, J. M., Gu, F., Rhee, J., Wang, A. Z., Radovic‐Moreno, A. F., Alexis, F., Langer, R., & Farokhzad, O. C. (2008) · ACS Nano · doi:10.1021/nn800275r · Cited by 1,042 · see citing works

Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes

Pardi, N., Tuyishime, S., Muramatsu, H., Kariko, K., Mui, B. L., Tam, Y. K., Madden, T. D., Hope, M. J., & Weissman, D. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.007 · Cited by 1,014 · see citing works

Chitosan-based formulations for delivery of DNA and siRNA

Mao, S., Sun, W., & Kissel, T. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.08.004 · Cited by 970 · see citing works

Cationic liposome-mediated RNA transfection.

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Therapeutic genome editing by combined viral and non-viral delivery of CRISPR system components in vivo

Yin, H., Song, C.-Q., Dorkin, J. R., Zhu, L. J., Li, Y., Wu, Q., Park, A., Yang, J., Suresh, S., Bizhanova, A., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3471 · Cited by 876 · see citing works

Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs

Kauffman, K. J., Dorkin, J. R., Yang, J. H., Heartlein, M. W., DeRosa, F., Mir, F. F., Fenton, O. S., & Anderson, D. G. (2015) · Nano Letters · doi:10.1021/acs.nanolett.5b02497 · Cited by 785 · see citing works

Expression of therapeutic proteins after delivery of chemically modified mRNA in mice

Kormann, M. S. D., Hasenpusch, G., Aneja, M. K., Nica, G., Flemmer, A. W., Herber-Jonat, S., Huppmann, M., Mays, L. E., Illenyi, M., Schams, A., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1733 · Cited by 733 · see citing works

Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown

Wittrup, A., Ai, A., Liu, X., Hamar, P., Trifonova, R., Charisse, K., Manoharan, M., Kirchhausen, T., & Lieberman, J. (2015) · Nature Biotechnology · doi:10.1038/nbt.3298 · Cited by 693 · see citing works

Nonviral delivery of self-amplifying RNA vaccines

Geall, A. J., Verma, A., Otten, G. R., Shaw, C. A., Hekele, A., Banerjee, K., Cu, Y., Beard, C. W., Brito, L. A., Krucker, T., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209367109 · Cited by 675 · see citing works

Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction

Zangi, L., Lui, K. O., von Gise, A., Ma, Q., Ebina, W., Ptaszek, L. M., Später, D., Xu, H., Tabebordbar, M., Gorbatov, R., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2682 · Cited by 646 · see citing works

Modification of antigen-encoding RNA increases stability, translational efficacy, and T-cell stimulatory capacity of dendritic cells

Holtkamp, S., Kreiter, S., Selmi, A., Simon, P., Koslowski, M., Huber, C., Türeci, O., & Sahin, U. (2006) · Blood · doi:10.1182/blood-2006-04-015024 · Cited by 625 · see citing works

Degradable lipid nanoparticles with predictable in vivo siRNA delivery activity

Whitehead, K. A., Dorkin, J. R., Vegas, A. J., Chang, P. H., Veiseh, O., Matthews, J., Fenton, O. S., Zhang, Y., Olejnik, K. T., Yesilyurt, V., et al. (2014) · Nature Communications · doi:10.1038/ncomms5277 · Cited by 615 · see citing works

Nucleic Acid Therapeutics Using Polyplexes: A Journey of 50 Years (and Beyond)

Lächelt, U., & Wagner, E. (2015) · Chemical Reviews · doi:10.1021/cr5006793 · Cited by 600 · see citing works

Cationic lipids, lipoplexes and intracellular delivery of genes.

Wasungu, L., & Hoekstra, D. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.06.024 · Cited by 575 · see citing works

Cationic lipid saturation influences intracellular delivery of encapsulated nucleic acids

Heyes, J., Palmer, L., Bremner, K., & MacLachlan, I. (2005) · Journal of Controlled Release · doi:10.1016/j.jconrel.2005.06.014 · Cited by 572 · see citing works

Cell cycle dependence of gene transfer by lipoplex, polyplex and recombinant adenovirus

Brunner, S., Sauer, T., Carotta, S., Cotten, M. L., Saltik, M., & Wagner, E. (2000) · Gene Therapy · doi:10.1038/sj.gt.3301102 · Cited by 534 · see citing works

Sequence-engineered mRNA without chemical nucleoside modifications enables an effective protein therapy in large animals

Thess, A., Grund, S., Mui, B. L., Hope, M. J., Baumhof, P., Fotin-Mleczek, M., & Schlake, T. (2015) · Molecular Therapy · doi:10.1038/mt.2015.103 · Cited by 513 · see citing works

Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates

Dong, Y., Love, K. T., Dorkin, J. R., Sirirungruang, S., Zhang, Y., Chen, D., Bogorad, R. L., Yin, H., Chen, Y., Vegas, A. J., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1322937111 · Cited by 488 · see citing works

Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial

Alton, E. W. F. W., Armstrong, D. K., Ashby, D., Bayfield, K. J., Bilton, D., Bloomfield, E. V., Boyd, A. C., Brand, J., Buchan, R., Calcedo, R., et al. (2015) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(15)00245-3 · Cited by 428 · see citing works

Folate-targeted, Anionic Liposome-entrapped Polylysine-condensed DNA for Tumor Cell-specific Gene Transfer

Lee, R. J., & Huang, L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8481 · Cited by 400 · see citing works

Materials for non-viral intracellular delivery of messenger RNA therapeutics

Kauffman, K. J., Webber, M. J., & Anderson, D. G. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.12.032 · Cited by 400 · see citing works

Characterization of cationic lipid-protamine–DNA (LPD) complexes for intravenous gene delivery

Li, S., Rizzo, M., Bhattacharya, S. S., & Huang, L. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300683 · Cited by 369 · see citing works

Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L

Anderson, B. R., Muramatsu, H., Jha, B. K., Silverman, R. H., Weissman, D., & Kariko, K. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr586 · Cited by 356 · see citing works

A Cationic Nanoemulsion for the Delivery of Next-generation RNA Vaccines

Brito, L. A., Chan, M., Shaw, C. A., Hekele, A., Carsillo, T., Schaefer, M., Archer, J., Seubert, A., Otten, G. R., Beard, C. W., et al. (2014) · Molecular Therapy · doi:10.1038/mt.2014.133 · Cited by 338 · see citing works

<i>In Vitro</i> and <i>in Vivo</i> mRNA Delivery Using Lipid-Enveloped pH-Responsive Polymer Nanoparticles

Su, X., Fricke, J., Kavanagh, D. G., & Irvine, D. J. (2011) · Molecular Pharmaceutics · doi:10.1021/mp100390w · Cited by 287 · see citing works

Increased erythropoiesis in mice injected with submicrogram quantities of pseudouridine-containing mRNA encoding erythropoietin

Karikó, K., Muramatsu, H., Keller, J. M., & Weissman, D. (2012) · Molecular Therapy · doi:10.1038/mt.2012.7 · Cited by 282 · see citing works

Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides

Nafee, N. A., Taetz, S., Schneider, M., Schaefer, U. F., & Lehr, C. (2007) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2007.03.006 · Cited by 264 · see citing works

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

Weide, B., Carralot, J.-P., Reese, A., Scheel, B., Eigentler, T. K., Hoerr, I., Rammensee, H.-G., Garbe, C., & Pascolo, S. (2008) · Journal of Immunotherapy · doi:10.1097/cji.0b013e31815ce501 · Cited by 261 · see citing works

Bioinspired Alkenyl Amino Alcohol Ionizable Lipid Materials for Highly Potent In Vivo mRNA Delivery

Fenton, O. S., Kauffman, K. J., McClellan, R. L., Appel, E. A., Dorkin, J. R., Tibbitt, M. W., Heartlein, M. W., DeRosa, F., Langer, R., & Anderson, D. G. (2016) · Advanced Materials · doi:10.1002/adma.201505822 · Cited by 254 · see citing works

Immunocompatibility properties of lipid–polymer hybrid nanoparticles with heterogeneous surface functional groups

Salvador-Morales, C., Zhang, L., Langer, R., & Farokhzad, O. C. (2009) · Biomaterials · doi:10.1016/j.biomaterials.2009.01.005 · Cited by 251 · see citing works

The regulation of mRNA stability in mammalian cells: 2.0

Wu, X., & Brewer, G. (2012) · Gene · doi:10.1016/j.gene.2012.03.021 · Cited by 239 · see citing works

mRNA as gene therapeutic: How to control protein expression

Tavernier, G., Andries, O., Demeester, J., Sanders, N. N., De Smedt, S. C., & Rejman, J. (2011) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.10.020 · Cited by 232 · see citing works

Non-Viral Gene Delivery Methods

Wang, W., Li, W., Ma, N., & Steinhoff, G. (2013) · Current Pharmaceutical Biotechnology · doi:10.2174/1389201011314010008 · Cited by 229 · see citing works

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

Rittig, S. M., Haentschel, M., Weimer, K. J., Heine, A., Muller, M. R., Brugger, W., Horger, M. S., Maksimovic, O., Stenzl, A., Hoerr, I., et al. (2011) · Molecular Therapy · doi:10.1038/mt.2010.289 · Cited by 226 · see citing works

Rapidly produced SAM ^® vaccine against H7N9 influenza is immunogenic in mice

Hekele, A., Bertholet, S., Archer, J., Gibson, D. G., Palladino, G., Brito, L. A., Otten, G. R., Brazzoli, M., Buccato, S., Bonci, A., et al. (2013) · Emerging Microbes &amp; Infections · doi:10.1038/emi.2013.54 · Cited by 226 · see citing works

Peptide-mediated RNA delivery: a novel approach for enhanced transfection of primary and post-mitotic cells

Bettinger, T. (2001) · Nucleic Acids Research · doi:10.1093/nar/29.18.3882 · Cited by 224 · see citing works

Enhancement of dendritic cells transfection in vivo and of vaccination against B16F10 melanoma with mannosylated histidylated lipopolyplexes loaded with tumor antigen messenger RNA

Perche, F., Benvegnu, T. J., Berchel, M., Lebegue, L., Pichon, C., Jaffrès, P., & Midoux, P. (2011) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2010.12.010 · Cited by 219 · see citing works

Noncytopathic Sindbis virus RNA vectors for heterologous gene expression

Agapov, E. V., Frolov, I. V., Lindenbach, B. D., Prágai, B. M., Schlesinger, S., & Rice, C. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.12989 · Cited by 214 · see citing works

Odd–Even Effect of Repeating Aminoethylene Units in the Side Chain of N-Substituted Polyaspartamides on Gene Transfection Profiles

Uchida, H., Miyata, K., Oba, M., Ishii, T., Suma, T., Itaka, K., Nishiyama, N., & Kataoka, K. (2011) · Journal of the American Chemical Society · doi:10.1021/ja204466y · Cited by 213 · see citing works

Biodegradable polyamino acid-based polycations as safe and effective gene carrier minimizing cumulative toxicity

Itaka, K., Ishii, T., Hasegawa, Y., & Kataoka, K. (2010) · Biomaterials · doi:10.1016/j.biomaterials.2009.11.072 · Cited by 211 · see citing works

Lipid-based mRNA vaccine delivery systems

Midoux, P., & Pichon, C. (2014) · Expert Review of Vaccines · doi:10.1586/14760584.2015.986104 · Cited by 209 · see citing works

A phase IB study on intravenous synthetic mRNA electroporated dendritic cell immunotherapy in pretreated advanced melanoma patients

Wilgenhof, S., Nuffel, A. M. T. V., Benteyn, D., Corthals, J., Aerts, C., Heirman, C., Riet, I. V., Bonehill, A., Thielemans, K., & Neyns, B. (2013) · Annals of Oncology · doi:10.1093/annonc/mdt245 · Cited by 204 · see citing works

Enhanced intranasal delivery of mRNA vaccine by overcoming the nasal epithelial barrier via intra- and paracellular pathways

Li, M., Zhao, M., Fu, Y., Li, Y., Gong, T., Zhang, Z., & Sun, X. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.02.043 · Cited by 201 · see citing works

Mammalian germ-line transgenesis by transposition

Dupuy, A. J., Clark, K. J., Carlson, C. M., Fritz, S., Davidson, A. E., Markley, K. M., Finley, K., Fletcher, C., Ekker, S. C., Hackett, P. B., et al. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.062630599 · Cited by 196 · see citing works

Current prospects for mRNA gene delivery

Yamamoto, A., Kormann, M., Rosenecker, J., & Rudolph, C. (2008) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2008.09.016 · Cited by 193 · see citing works

Systemic delivery of modified mRNA encoding herpes simplex virus 1 thymidine kinase for targeted cancer gene therapy.

Wang, Y.-H., Su, H.-H., Yang, Y., Hu, Y.-X., Zhang, L., Blancafort, P., & Huang, L. (2013) · Molecular Therapy · doi:10.1038/mt.2012.250 · Cited by 189 · see citing works

A Clinical Inflammatory Syndrome Attributable to Aerosolized Lipid–DNA Administration in Cystic Fibrosis

Ruiz, F. E., Clancy, J. P., Perricone, M. A., Bebok, Z. M., Hong, J. S., Cheng, S. H., Meeker, D. P., Young, K. R., Schoumacher, R., Weatherly, M. R., et al. (2001) · Human Gene Therapy · doi:10.1089/104303401750148667 · Cited by 184 · see citing works

Breaking the Bonds: Non-viral Vectors Become Chemically Dynamic

Wolff, J. A., & Rozema, D. B. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300326 · Cited by 163 · see citing works

Gene transfer to the lung: lessons learned from more than 2 decades of CF gene therapy.

Griesenbach, U., & Alton, E. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2008.09.010 · Cited by 163 · see citing works

Lipid-mediated delivery of RNA is more efficient than delivery of DNA in non-dividing cells

Zou, S., Scarfo, K. A., Nantz, M. H., & Hecker, J. G. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.01.019 · Cited by 161 · see citing works

mRNA-based cancer vaccine: prevention of B16 melanoma progression and metastasis by systemic injection of MART1 mRNA histidylated lipopolyplexes

Mockey, M., Bourseau, E., Voshavar, C., Chaudhuri, A., Lafosse, S., Cam, É. L., Quesniaux, V. F. J., Ryffel, B., Pichon, C., & Midoux, P. (2007) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7701072 · Cited by 161 · see citing works

Transposon-mediated BAC transgenesis in zebrafish and mice

Suster, M. L., Sumiyama, K., & Kawakami, K. (2009) · BMC Genomics · doi:10.1186/1471-2164-10-477 · Cited by 161 · see citing works

Therapeutic efficacy in a hemophilia B model using a biosynthetic mRNA liver depot system

DeRosa, F., Guild, B., Karve, S., Smith, L., Love, K., Dorkin, J. R., Kauffman, K. J., Zhang, J., Yahalom, B., Anderson, D. G., et al. (2016) · Gene Therapy · doi:10.1038/gt.2016.46 · Cited by 159 · see citing works

Polymer vectors via controlled/living radical polymerization for gene delivery

Xu, F., & Yang, W. (2011) · Progress in Polymer Science · doi:10.1016/j.progpolymsci.2010.11.005 · Cited by 157 · see citing works

Systemic delivery of messenger RNA for the treatment of pancreatic cancer using polyplex nanomicelles with a cholesterol moiety

Uchida, S., Kinoh, H., Ishii, T., Matsui, A., Tockary, T. A., Takeda, K. M., Uchida, H., Osada, K., Itaka, K., & Kataoka, K. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.031 · Cited by 150 · see citing works

Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**

Jayaraman, M., Ansell, S. M., Mui, B. L., Tam, Y. K., Chen, J., Du, X., Butler, D., Eltepu, L., Matsuda, S., Narayanannair, J. K., et al. (2012) · Angewandte Chemie · doi:10.1002/ange.201203263 · Cited by 150 · see citing works

Latest Developments in Gene Transfer Technology: Achievements, Perspectives, and Controversies over Therapeutic Applications

Romano, G., Micheli, P., Pacilio, C., & Giordano, A. (2000) · Stem Cells · doi:10.1634/stemcells.18-1-19 · Cited by 149 · see citing works

Modulated Protonation of Side Chain Aminoethylene Repeats in N-Substituted Polyaspartamides Promotes mRNA Transfection

Uchida, H., Itaka, K., Nomoto, T., Ishii, T., Suma, T., Ikegami, M., Miyata, K., Oba, M., Nishiyama, N., & Kataoka, K. (2014) · Journal of the American Chemical Society · doi:10.1021/ja506194z · Cited by 147 · see citing works

In vivo genome editing using nuclease-encoding mRNA corrects SP-B deficiency

Mahiny, A. J., Dewerth, A., Mays, L. E., Alkhaled, M., Mothes, B., Malaeksefat, E., Loretz, B., Rottenberger, J., Brosch, D. M., Reautschnig, P., et al. (2015) · Nature Biotechnology · doi:10.1038/nbt.3241 · Cited by 139 · see citing works

mRNA transfection of cervical carcinoma and mesenchymal stem cells mediated by cationic carriers

Rejman, J., Tavernier, G., Bavarsad, N., Demeester, J., & Smedt, S. C. D. (2010) · Journal of Controlled Release · doi:10.1016/j.jconrel.2010.07.124 · Cited by 133 · see citing works

In Vivo Messenger RNA Introduction into the Central Nervous System Using Polyplex Nanomicelle

Uchida, S., Itaka, K., Uchida, H., Hayakawa, K., Ogata, T., Ishii, T., Fukushima, S., Osada, K., & Kataoka, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056220 · Cited by 131 · see citing works

Multifunctional triblock copolymers for intracellular messenger RNA delivery

Cheng, C., Convertine, A. J., Stayton, P. S., & Bryers, J. D. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.020 · Cited by 123 · see citing works

Tumor vaccination using messenger RNA: prospects of a future therapy

Kreiter, S., Diken, M., Selmi, A., Türeci, Ö., & Şahin, U. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.03.007 · Cited by 120 · see citing works

A development that may evolve into a revolution in medicine: mRNA as the basis for novel, nucleotide-based vaccines and drugs

Kallen, K., & Theß, A. (2013) · Therapeutic Advances in Vaccines · doi:10.1177/2051013613508729 · Cited by 120 · see citing works

Viral and Non-viral Vectors in Gene Therapy: Technology Development and Clinical Trials

Lundstrom, K. H., & Boulikas, T. (2003) · Technology in Cancer Research & Treatment · doi:10.1177/153303460300200513 · Cited by 118 · see citing works

The potential of antigen and TriMix sonoporation using mRNA-loaded microbubbles for ultrasound-triggered cancer immunotherapy

Dewitte, H., Lint, S. V., Heirman, C., Thielemans, K., Smedt, S. C. D., Breckpot, K., & Lentacker, I. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.08.011 · Cited by 118 · see citing works

Efficient genetic modification of murine dendritic cells by electroporation with mRNA

Meirvenne, S. V., Straetman, L., Heirman, C., Dullaers, M., Greef, C. D., Tendeloo, V. F. V., & Thielemans, K. (2002) · Cancer Gene Therapy · doi:10.1038/sj.cgt.7700499 · Cited by 117 · see citing works

mRNA-Lipoplex loaded microbubble contrast agents for ultrasound-assisted transfection of dendritic cells

Temmerman, M. D., Dewitte, H., Vandenbroucke, R. E., Lucas, B., Libert, C., Demeester, J., Smedt, S. C. D., Lentacker, I., & Rejman, J. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.08.024 · Cited by 116 · see citing works

RNA as a Source of Transposase for Sleeping Beauty-Mediated Gene Insertion and Expression in Somatic Cells and Tissues

Wilber, A. C., Frandsen, J. L., Geurts, J. L., Largaespada, D. A., Hackett, P. B., & McIvor, R. S. (2005) · Molecular Therapy · doi:10.1016/j.ymthe.2005.10.014 · Cited by 115 · see citing works

Chemically modified RNA activated matrices enhance bone regeneration

Elangovan, S., Khorsand, B., Do, A., Hong, L., Dewerth, A., Kormann, M., Ross, R. D., Sumner, D. R., Allamargot, C., & Salem, A. K. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.09.050 · Cited by 114 · see citing works

Nonviral transfection of distinct types of human dendritic cells: high-efficiency gene transfer by electroporation into hematopoietic progenitor- but not monocyte-derived dendritic cells

Tendeloo, V. F. V., Snoeck, H.-W., Lardon, F., Vanham, G. L., Nijs, G., Lenjou, M., Hendriks, L., Broeckhoven, C. V., Moulijn, A. C., Rodrigus, I. R., et al. (1998) · Gene Therapy · doi:10.1038/sj.gt.3300626 · Cited by 112 · see citing works

Myocardial Delivery of Lipidoid Nanoparticle Carrying modRNA Induces Rapid and Transient Expression

Turnbull, I. C., Eltoukhy, A. A., Fish, K. M., Nonnenmacher, M. E., Ishikawa, K., Chen, J., Hajjar, R. J., Anderson, D. G., & Costa, K. D. (2015) · Molecular Therapy · doi:10.1038/mt.2015.193 · Cited by 112 · see citing works

Poly(glycoamidoamine) Brushes Formulated Nanomaterials for Systemic siRNA and mRNA Delivery in Vivo

Dong, Y., Dorkin, J. R., Wang, W., Chang, P., Webber, M. J., Tang, B. C., Yang, J., Ionita, I. A., Danino, D., DeRosa, F., et al. (2016) · Nano Letters · doi:10.1021/acs.nanolett.5b02428 · Cited by 111 · see citing works

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