Cited by 238Treatment of Major DepressionMicroRNA in disease regulationTryptophan and brain disorders

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Blood microRNA changes in depressed patients during antidepressant treatment

Bocchio-Chiavetto, Luisella, Maffioletti, Elisabetta, Bettinsoli, Paola, Giovannini, Caterina, Bignotti, Stefano, Tardito, Daniela, Corrada, Dario, Milanesi, Luciano, Gennarelli, Massimo·2013·European Neuropsychopharmacology

DOI 10.1016/j.euroneuro.2012.06.013

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Abstract

MicroRNAs (miRNAs) are potent modulators of protein expression that play key roles in brain pathways regulating neurogenesis and synaptic plasticity. These small RNAs may be critical for the pathophysiology of mental disorders and may influence the effectiveness of psychotropic drugs. To investigate the possible involvement of miRNAs in the mechanism of action of antidepressants (AD), we conducted a whole-miRNome quantitative analysis with qRT-PCR of the changes in the blood of 10 depressed subjects after 12 weeks of treatment with escitalopram. Thirty miRNAs were differentially expressed after the AD treatment: 28 miRNAs were up-regulated, and 2 miRNAs were strongly down-regulated. miRNA target gene prediction and functional annotation analysis showed that there was a significant enrichment in several pathways associated with neuronal brain function (such as neuroactive ligand-receptor interaction, axon guidance, long-term potentiation and depression), supporting the hypothesis that the differentially regulated miRNAs may be involved in the AD mechanism.

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Authors: Bocchio-Chiavetto, L., Maffioletti, E., Bettinsoli, P., Giovannini, C., Bignotti, S., Tardito, D., Corrada, D., Milanesi, L., & Gennarelli, M.
Affiliations: Centro San Giovanni di Dio Fatebenefratelli (IT)
University of Milan (IT)
Institute of Biomedical Technologies (IT)
ORCID: Maffioletti, Elisabetta
Bignotti, Stefano
Tardito, Daniela
Corrada, Dario
Milanesi, Luciano
Gennarelli, Massimo
Venue: European Neuropsychopharmacology
Publisher: Elsevier BV
Published: 2013-07
Volume: 23
Issue: 7
Pages: 602-611
ISSN: 0924-977X (ISSN-L)
DOI: 10.1016/j.euroneuro.2012.06.013
OpenAlex: W2075765362
Cited by: 238
References: 53
Citations by year: 2026: 2 · 2025: 10 · 2024: 19 · 2023: 13 · 2022: 19 · 2021: 22 · 2020: 24 · 2019: 23 · 2018: 16 · 2017: 23 · 2016: 26 · 2015: 16 · 2014: 13 · 2013: 10
FWCI: 9.64
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: European Neuropsychopharmacology (publishedVersion)
PubMed (publishedVersion)
BOA (University of Milano-Bicocca) (submittedVersion)
Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
IRIS eCampus Telematic University (Università degli Studi eCampus) (submittedVersion)
Funders: Cariplo Foundation (2009-2701)
Italian Ministry of Health (Ricerca Corrente) and Lombardy Region (17387 SAL-13)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: microRNA, depression, antidepressant treatment, escitalopram, blood microRNA, miRNome, neuroactive ligand-receptor interaction, axon guidance, long-term potentiation, neuronal function
MeSH terms: Adolescent, Adult, Aged, Major Depressive Disorder, Depressive Disorder, Major, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Citalopram, Signal Transduction, Antidepressive Agents, Second-Generation, Databases, Genetic, MicroRNAs

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Blood microRNA changes in depressed patients during antidepressant treatment

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