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Lessons for COVID-19 Immunity from Other Coronavirus Infections
Open accessAbstract
A key goal to controlling coronavirus disease 2019 (COVID-19) is developing an effective vaccine. Development of a vaccine requires knowledge of what constitutes a protective immune response and also features that might be pathogenic. Protective and pathogenic aspects of the response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are not well understood, partly because the virus has infected humans for only 6 months. However, insight into coronavirus immunity can be informed by previous studies of immune responses to non-human coronaviruses, common cold coronaviruses, and SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV). Here, we review the literature describing these responses and discuss their relevance to the SARS-CoV-2 immune response.
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“previous experience with the closely related SARS-CoV-1, showed that CD8+ and CD4+ memory T cells were detectable as late as 17 years post-infection, while neutralizing antibody titers had waned substantially by 1 year after infection [69,70]”
From The dawn of mRNA vaccines: the COVID-19 case (2021) · cites this paper as [69]
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Metadata
- Authors
- Sariol, A., & Perlman, S.
- Affiliations
- University of Iowa (US)
- Corresponding author
- Perlman, Stanley
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2020-08
- Volume
- 53
- Issue
- 2
- Pages
- 248-263
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC7359787
- OpenAlex
- W3041450977
- Cited by
- 317
- References
- 244
- Citations by year
- 2026: 4 · 2025: 15 · 2024: 17 · 2023: 29 · 2022: 68 · 2021: 138 · 2020: 46
- FWCI
- 3.34
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 383 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (PO1 AI060699, RO1 AI129269)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Keywords
- COVID-19 pandemic, SARS-CoV-2, protective immune response, SARS-CoV, MERS-CoV, common cold coronaviruses, vaccine development
- MeSH terms
- Betacoronavirus, COVID-19, SARS-CoV-2, Animals, Humans, Pneumonia, Viral, Viral Vaccines, Coronavirus Infections, CD8-Positive T-Lymphocytes, Severe Acute Respiratory Syndrome, Severe acute respiratory syndrome-related coronavirus, Adaptive Immunity, Pandemics, Middle East Respiratory Syndrome Coronavirus
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