Magnetic resonance imaging in Alzheimer’s disease neuroimaging initiative 2
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INTRODUCTION: Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. METHODS: We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. RESULTS: Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. DISCUSSION: Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.
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ADNI2 introduced dMRI as an additional approach for tracking AD progression.
“ADNI’s second phase (ADNI2) introduced to the initiative the use of diffusion-weighted MRI (dMRI) as an additional approach for tracking AD progression (Jack et al., 2015).”
From Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: The Updated Multi-protocol Approach in ADNI3 (2019) · cites this paper as Jack et al., 2015
The participants recruited for ADNI3 tend to be younger and healthier, on average, than those in ADNI2, as they were recruited with the intention of studying the transition from CN to AD.
“The participants recruited for ADNI3 tend to be younger and healthier, on average, than those in ADNI2, as they were recruited with the intention of studying the transition from CN to AD (Jack et al., 2015).”
From Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: The Updated Multi-protocol Approach in ADNI3 (2019) · cites this paper as Jack et al., 2015
The ADNI 3 MRI section (page not available in our copy) describes planned scans and imaging aims, but does not compare ADNI 3 recruits with ADNI 2 recruits. Searches for younger or healthier participants and recruitment to study the transition from cognitively normal to AD found no passage supporting those claims. (LLM, conf=0.77)
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Self-citationCerebral atrophy in mild cognitive impairment and Alzheimer disease
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Self-citationMulti-modal imaging predicts memory performance in normal aging and cognitive decline
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Self-citationVascular burden and Alzheimer disease pathologic progression
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Self-citationCognitive reserve and Alzheimer's disease biomarkers are independent determinants of cognition
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Increased brain atrophy rates in cognitively normal older adults with low cerebrospinal fluid Aβ1‐42
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Self-citationShapes of the Trajectories of 5 Major Biomarkers of Alzheimer Disease
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Self-citationIntensity non-uniformity correction using N3 on 3-T scanners with multichannel phased array coils
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Self-citationPreclinical AD predicts decline in memory and executive functions in subjective complaints
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Mild cognitive impairment with suspected nonamyloid pathology (SNAP): Prediction of progression
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Self-citation3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects
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Self-citationAmyloid-β–Associated Clinical Decline Occurs Only in the Presence of Elevated P-tau
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Self-citationContrast optimization of fluid‐attenuated inversion recovery (flair) imaging
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Self-citationRates of β-amyloid accumulation are independent of hippocampal neurodegeneration
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Self-citationAmyloid-β associated volume loss occurs only in the presence of phospho-tau
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Self-citationBiological heterogeneity in ADNI amnestic mild cognitive impairment
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Self-citationSpatial patterns of brain amyloid- burden and atrophy rate associations in mild cognitive impairment
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Self-citationNonlinear registration of longitudinal images and measurement of change in regions of interest
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Self-citationBrain connectivity and novel network measures for Alzheimer’s disease classification
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Self-citationBrain Atrophy in Healthy Aging Is Related to CSF Levels of Aβ1-42
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Self-citationRates of Decline in Alzheimer Disease Decrease with Age
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Self-citationNeuronal injury biomarkers and prognosis in ADNI subjects with normal cognition
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Self-citationReduced sample sizes for atrophy outcomes in Alzheimer's disease trials: baseline adjustment
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Self-citationUnbiased comparison of sample size estimates from longitudinal structural measures in ADNI
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Self-citationAccurate measurement of brain changes in longitudinal MRI scans using tensor-based morphometry
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Self-citationNonlinear time course of brain volume loss in cognitively normal and impaired elders
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Self-citationThe Role of Clusterin in Amyloid-β–Associated Neurodegeneration
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Self-citationAlgorithms, atrophy and Alzheimer's disease: Cautionary tales for clinical trials
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Emerging β-amyloid pathology and accelerated cortical atrophy
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Self-citationEnrichment and Stratification for Predementia Alzheimer Disease Clinical Trials
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Self-citationConsistent multi-time-point brain atrophy estimation from the boundary shift integral
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Self-citationFocal hemosiderin deposits and β‐amyloid load in the ADNI cohort
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Self-citationHomocysteine effects on brain volumes mapped in 732 elderly individuals
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Self-citationVentricular maps in 804 ADNI subjects: correlations with CSF biomarkers and clinical decline
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Self-citationAPOE ε4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD
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Self-citationDissociable Effects of Alzheimer Disease and White Matter Hyperintensities on Brain Metabolism
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Heart fatty acid binding protein and Aβ-associated Alzheimer’s neurodegeneration
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Self-citationComparison of phantom and registration scaling corrections using the ADNI cohort
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Self-citationHarmonized benchmark labels of the hippocampus on magnetic resonance: The EADC‐ADNI project
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Self-citationBrain structure and function as mediators of the effects of amyloid on memory
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Self-citationAlzheimer's disease disrupts rich club organization in brain connectivity networks
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Self-citationApplication of the National Institute on Aging-Alzheimer's Association AD criteria to ADNI
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Self-citationThe transitional association between β‐amyloid pathology and regional brain atrophy
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Self-citationFat-mass-related hormone, plasma leptin, predicts brain volumes in the elderly
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Self-citationVisual ratings of atrophy in MCI: prediction of conversion and relationship with CSF biomarkers
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Self-citationNeuroimaging Enrichment Strategy for Secondary Prevention Trials in Alzheimer Disease
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Self-citationPredicting Reduction of Cerebrospinal Fluid β-Amyloid 42 in Cognitively Healthy Controls
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Self-citationUsing Manifold Learning for Atlas Selection in Multi-Atlas Segmentation
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Self-citationNeuroimaging predictors of brain amyloidosis in mild cognitive impairment
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Self-citationTREM2 Risk Variant and Loss of Brain Tissue
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Self-citationMeasuring brain atrophy with a generalized formulation of the boundary shift integral
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Self-citationVariables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment
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Self-citationTractography density and network measures in Alzheimer’s disease
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Self-citationMackin, R. S., Insel, P. S., Tosun, D., Mueller, S. G., Schuff, N. W., Truran‐Sacrey, D., Raptentsetsang, S. T., Lee, J., Jack, C. R., Aisen, P. S. S., et al. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.021 · Cited by 34 · see citing works
Self-citationDistinct profiles of brain and cognitive changes in the very old with Alzheimer disease
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Self-citationConnectivity network measures predict volumetric atrophy in mild cognitive impairment
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Self-citationSerum cholesterol and variant in cholesterol-related gene CETP predict white matter microstructure
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Self-citationMultimodal MRI ‐based imputation of the A β + in early mild cognitive impairment
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Self-citationEmpowering Imaging Biomarkers of Alzheimer’s Disease
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Self-citationMultilocus genetic profiling to empower drug trials and predict brain atrophy
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Self-citationDoes MRI scan acceleration affect power to track brain change?
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Self-citationFlow-based network measures of brain connectivity in Alzheimer'S disease
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Self-citationPower Estimates for Voxel-Based Genetic Association Studies Using Diffusion Imaging
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Self-citationUnderstanding scanner upgrade effects on brain integrity & connectivity measures
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Self-citationEvaluation of diffusion imaging protocols for the Alzheimer's disease Neuroimaging Initiative
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Self-citationDisrupted Brain Connectivity in Alzheimer’s Disease: Effects of Network Thresholding
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Self-citationThe 20th Annual Meeting of ISMRM, Melbourne, Australia, 2012
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“…second phase (ADNI2) introduced to the initiative the use of diffusion-weighted MRI (dMRI) as an additional approach for tracking AD progression (Jack et al., 2015). dMRI has since been used in numerous studies to understand the effects of AD on white matter (WM) microstructure and brain…”
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- Authors
- Jack, C. R., Barnes, J., Bernstein, M. A., Borowski, B. J., Brewer, J., Clegg, S., Dale, A. M., Carmichael, O., Ching, C., DeCarli, C., Desikan, R. S., Fennema‐Notestine, C., Fjell, A. M., Fletcher, E., Fox, N. C., Gunter, J., Gutman, B. A., Holland, D., Hua, X., Insel, P., Kantarci, K., Killiany, R. J., Krueger, G., Leung, K. K., Mackin, S., Maillard, P., Malone, I. B., Mattsson, N., McEvoy, L., Modat, M., Mueller, S., Nosheny, R., Ourselin, S., Schuff, N., Senjem, M. L., Simonson, A., Thompson, P. M., Rettmann, D., Vemuri, P., Walhovd, K., Zhao, Y., Zuk, S., & Weiner, M.
- Affiliations
- Mayo Clinic (US)
- UCL Queen Square Institute of Neurology (GB)
- University of California San Diego (US)
- University of California, Davis (US)
- University of Southern California (US)
- University of Oslo (NO)
- San Francisco VA Medical Center (US)
- Department of Anatomy and Neurobiology Boston University School of Medicine Boston MA USA
- Siemens Medical Solutions Boston MA USA
- University College London (GB)
- University of Gothenburg (SE)
- Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology University College London London UK
- MR Applications and Workflow GE Healthcare Rochester MN USA
- Philips Healthcare Cleveland OH USA
- Corresponding author
- Jack, Clifford R.
- ORCID
- Jack, Clifford R.
- Barnes, Josephine
- Bernstein, Matt A.
- Clegg, Shona
- Dale, Anders M.
- Carmichael, Owen
- Ching, Christopher
- DeCarli, Charles
- Desikan, Rahul S.
- Fennema‐Notestine, Christine
- Fjell, Anders M.
- Fletcher, Evan
- Fox, Nick C.
- Gutman, Boris A.
- Holland, Dominic
- Hua, Xue
- Insel, Philip
- Kantarci, Kejal
- Maillard, Pauline
- Malone, Ian B.
- Mattsson, Niklas
- McEvoy, Linda
- Mueller, Susanne
- Nosheny, Rachel
- Senjem, Matthew L.
- Thompson, Paul M.
- Rettmann, Dan
- Vemuri, Prashanthi
- Walhovd, Kristine
- Zhao, Yansong
- Weiner, Michael
- Venue
- Alzheimer's & Dementia
- Publisher
- Wiley
- Published
- 2015-07
- Volume
- 11
- Issue
- 7
- Pages
- 740-756
- ISSN
- 1552-5260 (ISSN-L)
- 1552-5279
- PMC
- PMC4523217
- OpenAlex
- W2156450079
- Cited by
- 220
- References
- 185
- Citations by year
- 2026: 17 · 2025: 28 · 2024: 32 · 2023: 15 · 2022: 20 · 2021: 29 · 2020: 30 · 2019: 17 · 2018: 14 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 1
- FWCI
- 8.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Alzheimer s & Dementia (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0513-10134, NF-SI-0508-10123)
- National Institutes of Health (5u01ag024904-10)
- National Institute on Aging (U01-AG-024904, R01AG040060, R01AG011378, R01AG041851)
- National Institute of Mental Health (R01MH098062)
- National Institute of Biomedical Imaging and Bioengineering (P41EB015922)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- Alzheimer's disease, Alzheimer's Disease Neuroimaging Initiative
- MeSH terms
- Alzheimer Disease, Brain, Cognition Disorders, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Spin Labels, Biomarkers, Positron-Emission Tomography, History, 20th Century, History, 21st Century
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