Cited by 220Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsFunctional Brain Connectivity Studies

Magnetic resonance imaging in Alzheimer’s disease neuroimaging initiative 2

Open access
Jack, Clifford R., Barnes, Josephine, Bernstein, Matt A., Borowski, Bret J., Brewer, James, Clegg, Shona, Dale, Anders M., Carmichael, Owen +35 more·2015·Alzheimer's & Dementia

Abstract

INTRODUCTION: Alzheimer's Disease Neuroimaging Initiative (ADNI) is now in its 10th year. The primary objective of the magnetic resonance imaging (MRI) core of ADNI has been to improve methods for clinical trials in Alzheimer's disease (AD) and related disorders. METHODS: We review the contributions of the MRI core from present and past cycles of ADNI (ADNI-1, -Grand Opportunity and -2). We also review plans for the future-ADNI-3. RESULTS: Contributions of the MRI core include creating standardized acquisition protocols and quality control methods; examining the effect of technical features of image acquisition and analysis on outcome metrics; deriving sample size estimates for future trials based on those outcomes; and piloting the potential utility of MR perfusion, diffusion, and functional connectivity measures in multicenter clinical trials. DISCUSSION: Over the past decade the MRI core of ADNI has fulfilled its mandate of improving methods for clinical trials in AD and will continue to do so in the future.

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Crossref · 10.1016/j.jalz.2015.05.002

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  • ADNI2 introduced dMRI as an additional approach for tracking AD progression.

    “ADNI’s second phase (ADNI2) introduced to the initiative the use of diffusion-weighted MRI (dMRI) as an additional approach for tracking AD progression (Jack et al., 2015).”
  • The participants recruited for ADNI3 tend to be younger and healthier, on average, than those in ADNI2, as they were recruited with the intention of studying the transition from CN to AD.

    “The participants recruited for ADNI3 tend to be younger and healthier, on average, than those in ADNI2, as they were recruited with the intention of studying the transition from CN to AD (Jack et al., 2015).”

    From Diffusion MRI Indices and Their Relation to Cognitive Impairment in Brain Aging: The Updated Multi-protocol Approach in ADNI3 (2019) · cites this paper as Jack et al., 2015

    The ADNI 3 MRI section (page not available in our copy) describes planned scans and imaging aims, but does not compare ADNI 3 recruits with ADNI 2 recruits. Searches for younger or healthier participants and recruitment to study the transition from cognitively normal to AD found no passage supporting those claims. (LLM, conf=0.77)

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Research works printed but not linked: 6

  1. [14]The 15th International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI): 2012; Nice, France 2012
  2. [76]Mattsson N Insel P Donohue M Jagust W Sperling RA Aisen PS Weiner M Predicting reduction of CSF Aβ42 in cognitively healthy controls JAMA Neurol 25775167
  3. [114]Jack CR Jr Knopman DS Weigand SD Wiste HJ vemuri P Lowe V Kantarci K Gunter JL senjem ML Ivnik RJ An operational approach to NIA-AA crtiteria for preclinical Alzheimer's disease Ann Neurol 2012 71 6 765 775 22488240 PMC3586223
  4. [118]McKhann GM Knopman DS Chertkow H Hyman BT Jack CR Jr Kawas CH Klunk WE Koroshetz WJ Manly JJ Mayeux R The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging and the Alzheimer's Assocation Workgroup Alzheimers Dement 2011 7 3 263 269 21514250 PMC3312024
  5. [138]Rajagopalan P Hibar DP Thompson PM TREM2 and neurodegenerative disease N Engl J Med 2013 369 16 1565 1567 24131186 PMC4024453
  6. [178]2014 IEEE 11th International Symposium on Biomedical Imaging (ISBI): 2014 2014 Beijing, China IEEE 1027 1030

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Authors
Jack, C. R., Barnes, J., Bernstein, M. A., Borowski, B. J., Brewer, J., Clegg, S., Dale, A. M., Carmichael, O., Ching, C., DeCarli, C., Desikan, R. S., Fennema‐Notestine, C., Fjell, A. M., Fletcher, E., Fox, N. C., Gunter, J., Gutman, B. A., Holland, D., Hua, X., Insel, P., Kantarci, K., Killiany, R. J., Krueger, G., Leung, K. K., Mackin, S., Maillard, P., Malone, I. B., Mattsson, N., McEvoy, L., Modat, M., Mueller, S., Nosheny, R., Ourselin, S., Schuff, N., Senjem, M. L., Simonson, A., Thompson, P. M., Rettmann, D., Vemuri, P., Walhovd, K., Zhao, Y., Zuk, S., & Weiner, M.
Affiliations
  • Mayo Clinic (US)
  • UCL Queen Square Institute of Neurology (GB)
  • University of California San Diego (US)
  • University of California, Davis (US)
  • University of Southern California (US)
  • University of Oslo (NO)
  • San Francisco VA Medical Center (US)
  • Department of Anatomy and Neurobiology Boston University School of Medicine Boston MA USA
  • Siemens Medical Solutions Boston MA USA
  • University College London (GB)
  • University of Gothenburg (SE)
  • Department of Neurodegenerative Disease, Dementia Research Centre, Institute of Neurology University College London London UK
  • MR Applications and Workflow GE Healthcare Rochester MN USA
  • Philips Healthcare Cleveland OH USA
Corresponding author
Jack, Clifford R.
Venue
Alzheimer's & Dementia
Publisher
Wiley
Published
2015-07
Volume
11
Issue
7
Pages
740-756
ISSN
  • 1552-5260 (ISSN-L)
  • 1552-5279
OpenAlex
W2156450079
Cited by
220
References
185
Citations by year
2026: 17 · 2025: 28 · 2024: 32 · 2023: 15 · 2022: 20 · 2021: 29 · 2020: 30 · 2019: 17 · 2018: 14 · 2017: 8 · 2016: 6 · 2015: 3 · 2014: 1
FWCI
8.40
Type
journal article
Language
en
Open access
Locations
  • Alzheimer s & Dementia (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship (California Digital Library) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • National Institute for Health and Care Research (NF-SI-0513-10134, NF-SI-0508-10123)
  • National Institutes of Health (5u01ag024904-10)
  • National Institute on Aging (U01-AG-024904, R01AG040060, R01AG011378, R01AG041851)
  • National Institute of Mental Health (R01MH098062)
  • National Institute of Biomedical Imaging and Bioengineering (P41EB015922)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
Alzheimer's disease, Alzheimer's Disease Neuroimaging Initiative
MeSH terms
Alzheimer Disease, Brain, Cognition Disorders, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Spin Labels, Biomarkers, Positron-Emission Tomography, History, 20th Century, History, 21st Century

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