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The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks
Open accessAbstract
Starting with the beginning of the last century, a multitude of scientific studies has documented that the lunar cycle times behaviors and physiology in many organisms. It is plausible that even the first life forms adapted to the different rhythms controlled by the moon. Consistently, many marine species exhibit lunar rhythms, and also the number of documented "lunar-rhythmic" terrestrial species is increasing. Organisms follow diverse lunar geophysical/astronomical rhythms, which differ significantly in terms of period length: from hours (circalunidian and circatidal rhythms) to days (circasemilunar and circalunar cycles). Evidence for internal circatital and circalunar oscillators exists for a range of species based on past behavioral studies, but those species with well-documented behaviorally free-running lunar rhythms are not typically used for molecular studies. Thus, the underlying molecular mechanisms are largely obscure: the dark side of the moon. Here we review findings that start to connect molecular pathways with moon-controlled physiology and behaviors. The present data indicate connections between metabolic/endocrine pathways and moon-controlled rhythms, as well as interactions between circadian and circatidal/circalunar rhythms. Moreover, recent high-throughput analyses provide useful leads toward pathways, as well as molecular markers. However, for each interpretation, it is important to carefully consider the, partly substantially differing, conditions used in each experimental paradigm. In the future, it will be important to use lab experiments to delineate the specific mechanisms of the different solar- and lunar-controlled rhythms, but to also start integrating them together, as life has evolved equally long under rhythms of both sun and moon.
Overview
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Written from the paper’s full text.
TL;DR
This review synthesizes evidence that lunar-controlled rhythms, from circatidal to circalunar periods, are widespread and that molecular links are emerging with circadian clock genes, metabolic/endocrine pathways, and high-throughput markers. It argues that mechanisms remain largely obscure because species with well-documented behavioral free-running lunar rhythms are rarely used for molecular work and experimental conditions vary widely.
Key findings
- Lunar geophysical cycles span hours to days: lunidian ~24.8 h, semilunar ~14.8 days, synodic ~29.5 days; other lunar months include sidereal 27.32166 days, anomalistic 27.55 days, draconic 27.212220 days, and tropical 27.321582 days.
- Circadian clock genes interact with lunar rhythms but not uniformly: in *Platynereis dumerilii*, free-running FM showed significantly higher mRNA for *pdp1*, *period*, *clock*, and *tim*; the CK1δ/ε inhibitor PF-670462 rendered clock gene transcription and locomotor activity arrhythmic but left monthly spawning unaffected. In *Eurydice pulchra*, circatidal timekeeping was independent of PER and TIM cycles, no circatidal oscillations were found in core clock genes, only *tim* showed a clear circadian profile, and peroxiredoxin plus 10 of 11 detected mitochondrial genes followed circatidal patterns.
- Endocrine and metabolic pathways are implicated: melatonin levels were reduced around FM in several fish, melatonin receptors and *aanat* showed lunar-phase-dependent expression, and *Platynereis* GnRH-like/corazonin1 was differentially expressed across the circalunar cycle.
- High-throughput studies provide candidate markers: coral spawning transcriptomes showed downregulation of clock genes and upregulation of GPCR, calcium signaling, and respiratory genes; in *Platynereis* heads, about 25% of the analyzed proteome was differentially regulated between NM and free-running FM, a much higher circalunar regulation than at the transcript level.
Methods
- Narrative review, not a primary experimental study; it synthesizes behavioral, molecular, pharmacological, genetic linkage, transcriptomic, and proteomic findings across marine and terrestrial organisms.
- Data/sample: published literature on corals, *Platynereis dumerilii*, *Eurydice pulchra*, *Clunio marinus*, fish, mollusks, *Drosophila*, rodents, and humans, among others.
- Main analysis: compares experimental paradigms—natural versus artificial moonlight, free-running versus entrainment, field versus laboratory conditions—and highlights candidate pathways and molecular markers.
Limitations
- Stated: the underlying molecular mechanisms are largely obscure; species with well-documented behaviorally free-running lunar rhythms are not typically used for molecular studies; data variability likely arises from differing experimental regimes; current resolution may be insufficient to distinguish among different lunar cycles; laboratory versus field discrepancies exist; functional studies, knockouts, and transgenic models are needed.
- Stated: many interpretations require careful consideration of partly substantially differing experimental conditions, and some analyses, such as those on the HPG axis and lunar rhythmicity, are inconclusive.
- Evident: as a review, it reports no new primary data; cited studies show conflicting results, and many candidate mechanisms remain functionally untested.
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Figures
![Figure 1 Schematized representations of the known astronomical and geophysical rhythms dictated by the moon. (A) Lunidian rhythm, the period between two consecutive maximal heights of the moon in the sky (meridian transits). (B) Tidal rhythm: water levels increase twice every day in two opposite sites on earth, with one being the closest to our satellite. (C) Semilunar rhythm: the alignment of moon, earth and sun potentiate tidal variations, creating spring (during FM and NM) and neap (during FQM and LQM) tides cycles. (D) Synodic and sidereal months. The first gives rise to the known lunar phases: NM, FQM, FM, and LQM or third quarter moon. (E) Anomalistic month. (F) Draconic month. The plane described by moon's orbit is inclined (5.14°) compared to the plane on which the sun and the earth lay, and the two planes cross in two points called nodes (purple circles). (G) Tropical month: the clockwise rotation of earth's axis affects moon's relative trajectory in the sky (declination). Thus, periodically, the moon faces a more northern or southern portion of earth relative to the Equator, and this affects both moonlight intensity and tides. Moonlight depicted in the figure is a reflection of sunlight. The sun was purposely left away from the scheme for the sake of clarity. For further details, see text. Sources: [5,6]; https://en.wikipedia.org/wiki/Lunar_month;https://www.youtube.com/watch?v=jWCBhVfeAQU;https://www.youtube.com/watch?v=Z6DpPQ8QdLg;https://www.youtube.com/watch?v=adzx547ptck;http://www.antikythera-mechanism.gr/faq/astronomical-questions/what-are-the-different-months;https://moonblink.info/Eclipse/why/months;https://www.slideshare.net/RAFIULALAM006/month-57977849).](/paper-figures/1d23087421a74288bbc7367c677b3ca3/the-still-dark-side-of-the-moon-molecular-mechanisms-of-lunar-controlled-rhythms-figure-1.jpg)
![Figure 2 Circadian clock genes expression is affected by the lunar cycle or laboratory conditions mimicking moonlight cues. Gray areas on the left of each panel describe the environmental conditions or laboratory experimental settings employed. Green circles indicate experiments conducted under natural conditions, whereas orange circles refer to artificial (lab) experimental conditions. (A) The expression of A. millepora cry1, cry2, clk, and cyc is influenced by the lunar cycle. (B) Expression of a set of clock genes in P. dumerilii is regulated by an endogenous circalunar clock, as shown by experiments under lunar free-running conditions (absence of artificial moonlight cue at night). (C) Altered night illumination affect the expression of clock genes in a lunar phase-dependent manner in S. guttatus. For references, see [[26], [27], [28], [29]].](/paper-figures/4956229228e14d55b1403a4643b85f8c/the-still-dark-side-of-the-moon-molecular-mechanisms-of-lunar-controlled-rhythms-figure-2.jpg)
![Figure 3 Tidal activity rhythm in E. pulchra generates antisense tidal cycles of metabolism but is independent from classical clock genes oscillation. (A) Swimming activity pattern of Eurydice specimens shows a period of 12.5 h in free-running conditions, with maxima during predicted high water (HW). (B) Representative western blot of overoxidized peroxiredoxin. (C) Relative intensity of overoxidized head peroxiredoxin. (D and E) Relative expression of mitochondrially-encoded genes (ND = NADH dehydrogenase subunits, COX = cytochrome oxidase subunits; CYTB = cytochrome B) under free-running laboratory conditions. (F) None of Eurydice circadian clock genes exhibit a tidal rhythm at the transcript level, and curiously, only tim shows a clear circadian profile (red arrows show the time of expected high water). For references, see [10,54]. Orange circles: artificial (lab) conditions.](/paper-figures/33accdbf28ec425f91d98687195fa0e8/the-still-dark-side-of-the-moon-molecular-mechanisms-of-lunar-controlled-rhythms-figure-3.jpg)
![Figure 4 Summary table showing the experimental conditions, the main findings, and patterns of a sample of the high-throughput analysis reviewed. NM = new moon; FQM = first quarter moon; FM = full moon; LQM = last quarter moon; SP = spawning; NS = not spawning; T/L = regulated by the interaction between temperature and lunar cycle; D/L = regulated by the interaction between daily and lunar cycles; D/L/T = regulated by the interaction among daily, lunar, and temperature cues; TR = tidally regulated; T = transcript; P = protein. For references, see [57,79,86,89,91].](/paper-figures/a391c5c44d5e488aa50871b99aa31eea/the-still-dark-side-of-the-moon-molecular-mechanisms-of-lunar-controlled-rhythms-figure-4.jpg)
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Claims the paper makes
58 Not checked yet · 25 Own interpretation · 10 No basis given
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In the paper
“Thus, the underlying molecular mechanisms are largely obscure: the dark side of the moon.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Abstract
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“In line with this, it is not surprising that lunar rhythms are widespread among marine species [3], especially those living in relatively shallow waters and coastal reef habitats.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
What the sources say
- Not checked yetcites [3] Raible F. Takekata H. Tessmar-Raible K. An overview of monthly rhythms and clocks Front. Neurol. 8 2017 1 14 10.3389/fneur.2017.00189 28553258 PMC5428424 source
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In the paper
“Starting with the beginning of the last century, a multitude of scientific studies has documented that the lunar cycle times behaviors and physiology in many organisms.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Abstract
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In the paper
“However, it is interesting to report that potential effects of the anomalistic cycle on biological rhythmicity approximating the synodic month have been shown in Crassostrea gigas, both at the behavioral and reproductive levels [6,9].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
What the sources say
- Not checked yetcites [6] Tran D. Nadau A. Durrieu G. Ciret P. Parisot J.P. Massabuau J.C. Field chronobiology of a molluscan bivalve: how the moon and sun cycles interact to drive oyster activity rhythms Chronobiol. Int. 28 2011 307 317 10.3109/07420528.2011.565897 21539422 source
- Not checked yetcites [9] Bernard I. Massabuau J.C. Ciret P. Sow M. Sottolichio A. Pouvreau S. Tran D. In situ spawning in a marine broadcast spawner, the Pacific oyster Crassostrea gigas: timing and environmental triggers Limnol. Oceanogr. 61 2016 635 647 10.1002/lno.10240 source
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“As witnessed by the crew on Colombo's caravel, also in the Bermuda fireworm, Odontosyllis enopla, reproductive swarming occurs precisely during the first nights after FM in summer and early autumn [20].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
What the sources say
- Not checked yetcites [20] Fischer A. Fischer U. On the life-style and life-cycle of the luminescent polychaete Odontosyllis enopla (Annelida: Polychaeta) Invert. Biol. 114 2019 236 247 10.2307/3226878 source
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In the paper
“Like inside a shaken snow globe, once every year, the barrier reef explodes of eggs and sperms, few days after FM, during late spring/summer nights, a phenomenon even visible from the space [21,22].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
What the sources say
- Not checked yetcites [21] Babcock R.C. Bull G.D. Harrison P.L. Heyward A.J. Oliver J.K. Wallace C.C. Willis B.L. Synchronous spawnings of 105 scleractinian coral species on the Great Barrier Reef Mar. Biol. 90 1986 379 394 10.1007/BF00428562 source
- Not checked yetcites [22] Fogarty N.D. Marhaver K.L. Coral spawning, unsynchronized Science. 365 2019 987 988 10.1126/science.aay7457 31488677 source
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In the paper
“This cycle is defined as semilunar (~ 14.8 days, half a lunar synodic cycle) and is probably mostly related to tidal phenomena rather than moonlight intensity”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
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In the paper
“Evidence for internal circatital and circalunar oscillators exists for a range of species based on past behavioral studies”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Abstract
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In the paper
“as well as interactions between circadian and circatidal/circalunar rhythms.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Abstract
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“Since the beginning of the 20th century, detailed scientific studies have shown that the reproductive behavior and sexual maturation of animals as diverse as corals, polychaetes, echinoderms or fishes are synchronized by the lunar cycle, reviewed in [2,3].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Route to the Moon: From Popular Beliefs to Scientific Knowledge
What the sources say
- Not checked yetcites [2] Tessmar-Raible K. Raible F. Arboleda E. Another place, another timer: marine species and the rhythms of life BioEssays. 33 2011 165 172 10.1002/bies.201000096 21254149 PMC3182551 source
- Not checked yetcites [3] Raible F. Takekata H. Tessmar-Raible K. An overview of monthly rhythms and clocks Front. Neurol. 8 2017 1 14 10.3389/fneur.2017.00189 28553258 PMC5428424 source
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In the paper
“The present data indicate connections between metabolic/endocrine pathways and moon-controlled rhythms”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Abstract
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“Indeed, several environmental factors have been shown to change directly or indirectly in connection with the lunar cycle, like moonlight intensity, water levels, temperature, food availability, oxygen levels, and magnetic field.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
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“The potential interaction between the circadian and the circalunar clocks has been well documented in the marine bristleworm Platynereis dumerilii [28].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [28] Zantke J. Ishikawa-Fujiwara T. Arboleda E. Lohs C. Schipany K. Hallay N. Straw A.D. Todo T. Circadian and circalunar clock interactions in a marine annelid Cell Rep. 5 2013 99 113 10.1016/j.celrep.2013.08.031 24075994 PMC3913041 source
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“This monthly rhythm has been shown to rely on an endogenous circalunar oscillator, as it free-runs in absence of lunar cues [28].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [28] Zantke J. Ishikawa-Fujiwara T. Arboleda E. Lohs C. Schipany K. Hallay N. Straw A.D. Todo T. Circadian and circalunar clock interactions in a marine annelid Cell Rep. 5 2013 99 113 10.1016/j.celrep.2013.08.031 24075994 PMC3913041 source
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In the paper
“Furthermore, cry2 upregulation under artificial FM conditions was not reproduced by Brady et al. [27], although the sampling was conducted at a similar nighttime (see Figure 2).”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [27] Brady A.K. Willis B.L. Harder L.D. Vize P.D. Lunar phase modulates circadian gene expression cycles in the broadcast spawning coral Acropora millepora Biol. Bull. 230 2016 130 142 10.1086/BBLv230n2p130 27132135 source
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In the paper
“This annelid reproduces every month in specific lunar phases also in laboratory conditions [28,34], similarly to the field [35].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [28] Zantke J. Ishikawa-Fujiwara T. Arboleda E. Lohs C. Schipany K. Hallay N. Straw A.D. Todo T. Circadian and circalunar clock interactions in a marine annelid Cell Rep. 5 2013 99 113 10.1016/j.celrep.2013.08.031 24075994 PMC3913041 source
- Not checked yetcites [34] Hauenschild C. Lunar periodicity Cold Spring Harb. Symp. Quant. Biol. 25 1960 491 497 13712278 source
- Not checked yetcites [35] Ranzi S. Ricerche sulla biologia sessuale degli Anellidi Pubbl. Del Stn. Zool. Napoli. 11 1931 271 292
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“and interestingly, cry2 (but not the other investigated member, cry1) was found significantly upregulated during FM night compared to NM [26]”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [26] Levy O. Appelbaum L. Leggat W. Gothlif Y. Hayward D.C. Miller D.J. Hoegh-Guldberg O. Light-responsive cryptochromes from a simple multicellular animal, the coral Acropora millepora Science. 318 2007 467 470 10.1126/science.1145432 17947585 source
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In the paper
“In line with this, also the expression of the circadian clock gene, timeless (tim), was found significantly different between natural conditions and artificial illumination during NM nights [27].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [27] Brady A.K. Willis B.L. Harder L.D. Vize P.D. Lunar phase modulates circadian gene expression cycles in the broadcast spawning coral Acropora millepora Biol. Bull. 230 2016 130 142 10.1086/BBLv230n2p130 27132135 source
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In the paper
“Moreover, exposure to dark/dark (DD) flattened the expression of both genes also during the subjective light phase, with minor peaks occurring mostly during the subjective night phase [26].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [26] Levy O. Appelbaum L. Leggat W. Gothlif Y. Hayward D.C. Miller D.J. Hoegh-Guldberg O. Light-responsive cryptochromes from a simple multicellular animal, the coral Acropora millepora Science. 318 2007 467 470 10.1126/science.1145432 17947585 source
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In the paper
“The exposure to continuous nocturnal light (“constant FM”) or never showing the worms nocturnal light (“constant NM”) throughout their entire growth (no entrainment) results in arrhythmic spawning patterns.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [28] Zantke J. Ishikawa-Fujiwara T. Arboleda E. Lohs C. Schipany K. Hallay N. Straw A.D. Todo T. Circadian and circalunar clock interactions in a marine annelid Cell Rep. 5 2013 99 113 10.1016/j.celrep.2013.08.031 24075994 PMC3913041 source
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In the paper
“In the Caribbean reef coral Favia fragum, which in contrast to A. millipora reproduces monthly in precise lunar patterns, 4–5 days after FM [32], circadian clock transcripts for cry1, cry2, clk, and cyc showed differences between lunar phases, but without regular patterns [33].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [33] Hoadley K.D. Szmant A.M. Pyott S.J. Circadian clock gene expression in the coral Favia fragum over diel and lunar reproductive cycles PLoS One 6 2011 10.1371/journal.pone.0019755 PMC3089635 21573070 source
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In the paper
“It has to be noted that further studies employing artificial illumination mimicking both light/dark cycles and moonlight provided conflicting results for some of the above-mentioned data collected under natural light conditions.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [27] Brady A.K. Willis B.L. Harder L.D. Vize P.D. Lunar phase modulates circadian gene expression cycles in the broadcast spawning coral Acropora millepora Biol. Bull. 230 2016 130 142 10.1086/BBLv230n2p130 27132135 source
- Not checked yetcites [31] Brady A.K. Snyder K.A. Vize P.D. Circadian cycles of gene expression in the coral, Acropora millepora PLoS One 6 2011 10.1371/journal.pone.0025072 PMC3176305 21949855 source
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In the paper
“Interestingly, the spawning profile was found unaffected.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [28] Zantke J. Ishikawa-Fujiwara T. Arboleda E. Lohs C. Schipany K. Hallay N. Straw A.D. Todo T. Circadian and circalunar clock interactions in a marine annelid Cell Rep. 5 2013 99 113 10.1016/j.celrep.2013.08.031 24075994 PMC3913041 source
- Not checked yetcites [36] Eide E.J. Woolf M.F. Kang H. Woolf P. Hurst W. Camacho F. Vielhaber E.L. Giovanni A. Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation Mol. Cell. Biol. 25 2005 2795 2807 10.1128/MCB.25.7.2795-2807.2005 15767683 PMC1061645 source
- Not checked yetcites [37] Walton K.M. Fisher K. Rubitski D. Marconi M. Meng Q.-J. Sládek M. Adams J. Bass M. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period J. Pharmacol. Exp. Ther. 330 2009 430 439 10.1124/jpet.109.151415 19458106 source
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In the paper
“suggesting that, if there is a common denominator for circadian and circalunar timing adaptations in the midge, it is outside of the core circadian clock or conventional light input pathways.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
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“A deeper analysis of clock genes oscillations in diencephalon and pituitary gland over the lunar cycle revealed that moonlight interruption (by tank coverage) markedly impacted on the expression levels, cycle amplitude and daily pattern [29].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [29] Takeuchi Y. Kabutomori R. Yamauchi C. Miyagi H. Takemura A. Okano K. Okano T. Moonlight controls lunar-phase-dependency and regular oscillation of clock gene expressions in a lunar-synchronized spawner fish, Goldlined spinefoot Sci. Rep. 8 2018 1 12 10.1038/s41598-018-24538-1 29670140 PMC5906463 source
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In the paper
“However, the mapping of all known genes with key roles in circadian timing or light input pathways revealed their complete absence from these QTLs [46]”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [46] Kaiser T.S. Poehn B. Szkiba D. Preussner M. Sedlazeck F.J. Zrim A. Neumann T. Nguyen L.T. The genomic basis of circadian and circalunar timing adaptations in a midge Nature. 540 2016 69 73 10.1038/nature20151 27871090 PMC5133387 source
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In the paper
“Moreover, vibrations mimicking water turbulence were effective in re-entraining animals that became arrhythmic after spending more than a month in DD [10].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [10] Zhang L. Hastings M.H. Green E.W. Tauber E. Sladek M. Webster S.G. Kyriacou C.P. Wilcockson D.C. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra Curr. Biol. 23 2013 1863 1873 10.1016/j.cub.2013.08.038 24076244 PMC3793863 source
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In the paper
“In general, in spite of existing discrepancies that likely originate from comparisons between studies adopting different experimental conditions, the evidence reviewed here strongly suggests an interaction of circalunar rhythms and clocks with at least sets of core circadian clock genes.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
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In the paper
“RNAi experiments revealed that the circatidal timekeeping is at least independent from PER and TIM cycles.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [10] Zhang L. Hastings M.H. Green E.W. Tauber E. Sladek M. Webster S.G. Kyriacou C.P. Wilcockson D.C. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra Curr. Biol. 23 2013 1863 1873 10.1016/j.cub.2013.08.038 24076244 PMC3793863 source
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In the paper
“In the golden rabbitfish, Siganus guttatus, which spawns around FQM [47,48], cry1 and cry3 transcripts in both brain and ovaries were analyzed, exhibiting an overall increase in the brain (mesencephalon and diencephalon) during NM and especially FQM, and lower levels at LQM.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [49] Fukushiro M. Takeuchi T. Takeuchi Y. Hur S.P. Sugama N. Takemura A. Kubo Y. Okano K. Lunar phase-dependent expression of cryptochrome and a photoperiodic mechanism for lunar phase-recognition in a reef fish, goldlined spinefoot PLoS One 6 2011 10.1371/journal.pone.0028643 PMC3233589 22163321 source
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In the paper
“The marine midge, Clunio marinus, provides an interesting example of combined circadian and circalunar timing, which precisely orchestrates its adult emergence [[40], [41], [42]].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [40] Neumann D. Die lunare und tägliche Schlüpfperiodik der Mücke Clunio—Steuerung und Abstimmung auf die Gezeitenperiodik Z. Vgl. Physiol. 53 1966 1 61 10.1007/BF00343045 source
- Not checked yetcites [41] Neumann D. The timing of reproduction to distinct spring tide situations in the intertidal insect Clunio Behav Adapt. to Intertidal Life 1988 Springer USA 45 54 10.1007/978-1-4899-3737-7_4
- Not checked yetcites [42] Neumann D. Circadian components of semilunar and lunar timing mechanisms J. Biol. Rhythm. 4 1989 173 182 10.1177/074873048900400213 2519594 source
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In the paper
“In this species, the pharmacological inhibition of CK1δ/ε by PF-670462 altered both circadian cycles (pigment dispersion in chromatophores), as well as circatidal swimming rhythms [10].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [10] Zhang L. Hastings M.H. Green E.W. Tauber E. Sladek M. Webster S.G. Kyriacou C.P. Wilcockson D.C. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra Curr. Biol. 23 2013 1863 1873 10.1016/j.cub.2013.08.038 24076244 PMC3793863 source
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In the paper
“their normal cycling could still be required for circalunar entrainment.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
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In the paper
“While this experiment suggests the independence of the circalunar clock from classical circadian clock gene oscillations, their normal cycling could still be required for circalunar entrainment.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
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In the paper
“Interestingly, one of the two quantitative trait loci (QTLs) linked to circalunar timing overlaps largely with one of the two circadian QTLs [46]”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [46] Kaiser T.S. Poehn B. Szkiba D. Preussner M. Sedlazeck F.J. Zrim A. Neumann T. Nguyen L.T. The genomic basis of circadian and circalunar timing adaptations in a midge Nature. 540 2016 69 73 10.1038/nature20151 27871090 PMC5133387 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“In the pituitary, cry1a and cry2 levels were higher in almost all lunar phases in moonlight-deprived specimens, as well as per2a and per2b.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [29] Takeuchi Y. Kabutomori R. Yamauchi C. Miyagi H. Takemura A. Okano K. Okano T. Moonlight controls lunar-phase-dependency and regular oscillation of clock gene expressions in a lunar-synchronized spawner fish, Goldlined spinefoot Sci. Rep. 8 2018 1 12 10.1038/s41598-018-24538-1 29670140 PMC5906463 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“However, the circalunar expression pattern of cry3 in partial or complete absence of moonlight cues (partial, restricting moonlight exposure only to the first or second half of the night, or complete, covering the tank for the whole night), was similar to the profile found in more natural condition (tank not covered) [50], indicating the presence of an endogenous oscillator.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [50] Toda R. Okano K. Takeuchi Y. Yamauchi C. Fukushiro M. Takemura A. Okano T. Hypothalamic expression and moonlight-independent changes of Cry3 and Per4 implicate their roles in lunar clock oscillators of the lunar-responsive goldlined spinefoot PLoS One 9 2014 10.1371/journal.pone.0109119 PMC4182804 25272159 source
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In the paper
“Curiously, the most remarkable effects of moonlight deprivation reported in the diencephalon occurred counterintuitively during NM (Figure 2).”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [29] Takeuchi Y. Kabutomori R. Yamauchi C. Miyagi H. Takemura A. Okano K. Okano T. Moonlight controls lunar-phase-dependency and regular oscillation of clock gene expressions in a lunar-synchronized spawner fish, Goldlined spinefoot Sci. Rep. 8 2018 1 12 10.1038/s41598-018-24538-1 29670140 PMC5906463 source
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“The specific daily and lunar time point of adult emergence varies between strains from different geographic locations, presumably as an adaptation to the exact local lowest low tide occurrences.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [43] Kaiser T.S. Neumann D. Heckel D.G. Timing the tides: genetic control of diurnal and lunar emergence times is correlated in the marine midge Clunio marinus BMC Genet 12 2011 10.1186/1471-2156-12-49 PMC3124415 21599938 source
- Not checked yetcites [44] Kaiser T.S. Heckel D.G. Genetic architecture of local adaptation in lunar and diurnal emergence times of the marine midge Clunio marinus (Chironomidae, Diptera) PLoS One 7 2012 10.1371/journal.pone.0032092 PMC3285202 22384150 source
- Not checked yetcites [45] Neumann D. Genetic adaptation in emergence time of Clunio populations to different tidal conditions Helgoländer Meeresun. 15 1967 163 171 10.1007/BF01618620 source
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In the paper
“PRX, whose oxidation–reduction cycles constitute a marker for circadian rhythms from bacteria to animals [55], followed a circatidal pattern in E. pulchra (Figure 3).”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [54] O’Neill J.S. Lee K.D. Zhang L. Feeney K. Webster S.G. Blades M.J. Kyriacou C.P. Hastings M.H. Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra Curr. Biol. 25 2015 R326 R327 10.1016/j.cub.2015.02.052 25898100 PMC4406942 source
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In the paper
“It is interesting to note that activity peaks coincide with troughs in overoxidized PRX and mitochondrial genes expression.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [54] O’Neill J.S. Lee K.D. Zhang L. Feeney K. Webster S.G. Blades M.J. Kyriacou C.P. Hastings M.H. Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra Curr. Biol. 25 2015 R326 R327 10.1016/j.cub.2015.02.052 25898100 PMC4406942 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“and therefore likely affected by moonlight.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Circalunar Rhythms and Clocks: An Endocrine Perspective > Melatonin
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In the paper
“This indicates that these circadian clock genes are not involved in the circatidal oscillator.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
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In the paper
“Taken together, the accumulated evidence strongly suggests how dim nocturnal light (at moonlight intensities) might affect circadian entrainment and melatonin secretion in rodents.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Were-Rodents, Were-Flies, and Humans: The Effect of the Moon on Terrestrial Animals
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In the paper
“Furthermore, no circatidal oscillations have been found in Eurydice core clock genes.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [10] Zhang L. Hastings M.H. Green E.W. Tauber E. Sladek M. Webster S.G. Kyriacou C.P. Wilcockson D.C. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra Curr. Biol. 23 2013 1863 1873 10.1016/j.cub.2013.08.038 24076244 PMC3793863 source
plainSingle case- Asserted: passes — The authors put it forward as true.
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In the paper
“In this species “circadian” clock genes lose their 24-h periodic expression pattern under DD and exhibit a tidal frequency instead [53].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [53] Tran D. Perrigault M. Ciret P. Payton L. Bivalve mollusc circadian clock genes can run at tidal frequency Proc. Biol. Sci. 287 2020 20192440 10.1098/rspb.2019.2440 31910786 PMC7003461
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In the paper
“Remarkable changes in transcriptional dynamics occurred especially around the spawning event in the ambient treatment, but the same regulation was not observed under continuous NM, suggesting the crucial role of moonlight in driving gene expression.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > -omics under the Moon: Transcriptional Signatures and Protein Dynamics from High-Throughput Data > Corals
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In the paper
“Seemingly, flies interpreted moonlight conditions as longer photoperiods.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Were-Rodents, Were-Flies, and Humans: The Effect of the Moon on Terrestrial Animals
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In the paper
“This analysis shows that homologs of the GnRH-like/Corazonin/AKH supergroup are differentially expressed throughout the worm's circalunar cycle with the most significant expression changes in the transition from the week prior to the FM stimulus to the FM week [76].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Circalunar Rhythms and Clocks: An Endocrine Perspective > GnRH-like and other gonadotropic hormones
What the sources say
- Not checked yetcites [76] Andreatta G. Broyart C. Borghgraef C. Vadiwala K. Kozin V. Polo A. Bileck A. Beets I. Corazonin signaling integrates energy homeostasis and lunar phase to regulate aspects of growth and sexual maturation in Platynereis Proc. Natl. Acad. Sci. 117 2020 1097 1106 10.1073/pnas.1910262116 31843923 PMC6969523 source
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In the paper
“Moreover, also 10 out of the 11 detected mitochondrial genes (such as subunits of NADH dehydrogenase, cytochrome b, and cytochrome c oxidase, encoding components of the electron transport chain complexes I, III, and IV, respectively) were also expressed in a circatidal fashion.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [54] O’Neill J.S. Lee K.D. Zhang L. Feeney K. Webster S.G. Blades M.J. Kyriacou C.P. Hastings M.H. Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra Curr. Biol. 25 2015 R326 R327 10.1016/j.cub.2015.02.052 25898100 PMC4406942 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“However, it should be noted that apart from timeless, Eurydice circadian clock genes also do not show a circadian expression pattern [10] (Figure 3F).”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [10] Zhang L. Hastings M.H. Green E.W. Tauber E. Sladek M. Webster S.G. Kyriacou C.P. Wilcockson D.C. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra Curr. Biol. 23 2013 1863 1873 10.1016/j.cub.2013.08.038 24076244 PMC3793863 source
plainSingle case- Asserted: passes — The authors put it forward as true.
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In the paper
“These ambiguities likely are derived from differences in natural versus artificial moonlight conditions, like spectrum and intensity, moonrise/moonset timing, duration over the lunar month, or absence of additional cues (such as mechanosensory, thermal, magnetic).”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Perspectives
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In the paper
“XBP1 (an unfolded protein response transcription factor) is required for the maintenance of this rhythmicity.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Were-Rodents, Were-Flies, and Humans: The Effect of the Moon on Terrestrial Animals
What the sources say
- Not checked yetcites [134] Zhu B. Zhang Q. Pan Y. Mace E.M. York B. Antoulas A.C. Dacso C.C. O’Malley B.W. A cell-autonomous mammalian 12 hr clock coordinates metabolic and stress rhythms Cell Metab. 25 2017 1305 1319 10.1016/j.cmet.2017.05.004 28591634 PMC5526350 source
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In the paper
“P. dumerilii monthly spawning patterns are broader in the lab [28] compared to the field [35]”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Perspectives
What the sources say
- Not checked yetcites [28] Zantke J. Ishikawa-Fujiwara T. Arboleda E. Lohs C. Schipany K. Hallay N. Straw A.D. Todo T. Circadian and circalunar clock interactions in a marine annelid Cell Rep. 5 2013 99 113 10.1016/j.celrep.2013.08.031 24075994 PMC3913041 source
- Not checked yetcites [35] Ranzi S. Ricerche sulla biologia sessuale degli Anellidi Pubbl. Del Stn. Zool. Napoli. 11 1931 271 292
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In the paper
“studies in corals and D. melanogaster show discrepancies in gene expression data between field and laboratory samples [26,27,132]”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Perspectives
What the sources say
- Not checked yetcites [26] Levy O. Appelbaum L. Leggat W. Gothlif Y. Hayward D.C. Miller D.J. Hoegh-Guldberg O. Light-responsive cryptochromes from a simple multicellular animal, the coral Acropora millepora Science. 318 2007 467 470 10.1126/science.1145432 17947585 source
- Not checked yetcites [27] Brady A.K. Willis B.L. Harder L.D. Vize P.D. Lunar phase modulates circadian gene expression cycles in the broadcast spawning coral Acropora millepora Biol. Bull. 230 2016 130 142 10.1086/BBLv230n2p130 27132135 source
- Not checked yetcites [132] Vanin S. Bhutani S. Montelli S. Menegazzi P. Green E.W. Pegoraro M. Sandrelli F. Costa R. Unexpected features of Drosophila circadian behavioural rhythms under natural conditions Nature. 484 2012 371 375 10.1038/nature10991 22495312 source
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In the paper
“Although a direct connection with the lunar cycle is still elusive, it is interesting to note that a 12-h rhythm, reminiscent of circatidal oscillations, has been also found in transcriptional dynamics of mouse liver [134].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Were-Rodents, Were-Flies, and Humans: The Effect of the Moon on Terrestrial Animals
What the sources say
- Not checked yetcites [134] Zhu B. Zhang Q. Pan Y. Mace E.M. York B. Antoulas A.C. Dacso C.C. O’Malley B.W. A cell-autonomous mammalian 12 hr clock coordinates metabolic and stress rhythms Cell Metab. 25 2017 1305 1319 10.1016/j.cmet.2017.05.004 28591634 PMC5526350 source
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In the paper
“Unfortunately, reef corals are losing this critical reproductive synchrony, likely due to anthropogenic impact [22,23].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
What the sources say
- Not checked yetcites [22] Fogarty N.D. Marhaver K.L. Coral spawning, unsynchronized Science. 365 2019 987 988 10.1126/science.aay7457 31488677 source
- Not checked yetcites [23] Shlesinger T. Loya Y. Breakdown in spawning synchrony: a silent threat to coral persistence Science. 365 2019 1002 1007 10.1126/science.aax0110 31488683 source
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In the paper
“but those species with well-documented behaviorally free-running lunar rhythms are not typically used for molecular studies.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Abstract
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In the paper
“Consistently, many marine species exhibit lunar rhythms, and also the number of documented “lunar-rhythmic” terrestrial species is increasing.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Abstract
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In the paper
“As external fertilization is frequent among these animals, its synchronization with a reliable environmental cycle maximizes the probability that eggs and sperms encounter, and hence is critical for the survival of these species.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Route to the Moon: From Popular Beliefs to Scientific Knowledge
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In the paper
“In animals where the gonads contribute to a large proportion of the body mass, such as sea urchins or mussels, this effect is particularly prominent, leading indeed to significant changes in body mass”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Route to the Moon: From Popular Beliefs to Scientific Knowledge
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In the paper
“In this case, the spawning occurred 17–18 days after mating, in a precise lunar phase, between LQM and NM [19].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
What the sources say
- Not checked yetcites [19] A.M. Adamczewska, S. Morris, Ecology and behavior of Gecarcoidea natalis, the Christmas Island red crab, during the annual breeding migration, (2001) 305–320. 11441973 source
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In the paper
“Moreover, recent high-throughput analyses provide useful leads toward pathways, as well as molecular markers.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“The anomalistic cycle, modulating the proximity of our satellite to earth, can impact for instance on tides amplitude during the synodic month (spring–neap tides cycle, 14.76 days), although slightly out of phase (13.78 days from perigee to apogee) [5,7].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
What the sources say
- Not checked yetcites [5] Coughenour C.L. Archer A.W. Lacovara K.J. Tides, tidalites, and secular changes in the earth–moon system Earth-Science Rev. 97 2009 59 79 10.1016/j.earscirev.2009.09.002 source
- Not checked yetcites [7] Kvale E.P. The origin of neap–spring tidal cycles Mar. Geol. 235 2006 5 18 10.1016/j.margeo.2006.10.001 source
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In the paper
“Organisms follow diverse lunar geophysical/astronomical rhythms, which differ significantly in terms of period length: from hours (circalunidian and circatidal rhythms) to days (circasemilunar and circalunar cycles).”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Abstract
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In the paper
“While for short and long lunar period lengths marine examples are very well established, this is less clear for terrestrial organisms.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
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In the paper
“Most of the genes analyzed showed similar circadian expression profiles in the two different lunar phases, but significantly higher mRNA levels during FR-FM were found for pdp1, period, clock, and tim (see Figure 2), suggesting that a subset of circadian clock transcripts is affected by the circalunar clock, independently of nocturnal light cues.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [28] Zantke J. Ishikawa-Fujiwara T. Arboleda E. Lohs C. Schipany K. Hallay N. Straw A.D. Todo T. Circadian and circalunar clock interactions in a marine annelid Cell Rep. 5 2013 99 113 10.1016/j.celrep.2013.08.031 24075994 PMC3913041 source
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“These data suggest that the integration of multiple environmental features and/or the specific light spectrum of sunlight and moonlight might affect the expression of these genes.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“In spite of the increasing literature, the elucidation of the mechanisms underlying circalunar/circasemilunar and circatidal/circalunidian rhythms is still at an early stage.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections?
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In the paper
“In this species, the circalunar clock seems to also affect locomotor activity levels, with worms showing a weaker circadian rhythmicity during free-running FM (FR-FM) compared to NM.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [28] Zantke J. Ishikawa-Fujiwara T. Arboleda E. Lohs C. Schipany K. Hallay N. Straw A.D. Todo T. Circadian and circalunar clock interactions in a marine annelid Cell Rep. 5 2013 99 113 10.1016/j.celrep.2013.08.031 24075994 PMC3913041 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“Before this time, the scientific literature is rich in examples of other rhythms, including tidal and monthly. Those were mainly focused on behavioral observations and include many studies that provide evidence for free-running rhythms (for overviews, see [24,25]).”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
What the sources say
- Not checked yetcites [24] Fingerman M. Lunar rhythmicity in marine organisms Am. Nat. 91 1957 167 178 source
- Not checked yetcites [25] Numata H. Helm B. Annual, Lunar, and Tidal Clocks: Patterns and Mechanisms of Nature’s Enigmatic Rhythms 2014 Springer
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“In the reef-building coral Acropora millepora, which reproduces once every year integrating both seasonal, lunar and daily cues, natural FM, as well as artificial night illumination mimicking FM, have been shown to impact on clock genes expression.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [26] Levy O. Appelbaum L. Leggat W. Gothlif Y. Hayward D.C. Miller D.J. Hoegh-Guldberg O. Light-responsive cryptochromes from a simple multicellular animal, the coral Acropora millepora Science. 318 2007 467 470 10.1126/science.1145432 17947585 source
boosteddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Both cry1 and cry2 were expressed in the ectodermal layer of larvae and adults, and their mRNA levels peaked during daylight phases.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [26] Levy O. Appelbaum L. Leggat W. Gothlif Y. Hayward D.C. Miller D.J. Hoegh-Guldberg O. Light-responsive cryptochromes from a simple multicellular animal, the coral Acropora millepora Science. 318 2007 467 470 10.1126/science.1145432 17947585 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“For instance, only cry1 (but not cry2) was affected by exposure to DD, whereas, although not significantly, cry2 increased under natural moonlight compared to the artificial one during both LQM and FM [27,31].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [27] Brady A.K. Willis B.L. Harder L.D. Vize P.D. Lunar phase modulates circadian gene expression cycles in the broadcast spawning coral Acropora millepora Biol. Bull. 230 2016 130 142 10.1086/BBLv230n2p130 27132135 source
- Not checked yetcites [31] Brady A.K. Snyder K.A. Vize P.D. Circadian cycles of gene expression in the coral, Acropora millepora PLoS One 6 2011 10.1371/journal.pone.0025072 PMC3176305 21949855 source
hedgeddirect- Asserted: passes — The authors put it forward as true.
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In the paper
“This phenomenon threatens several species, not only corals, but entire reef communities.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“These and other data reported in this review suggest a high level of data variability, likely due to differences in experimental regimes, as well as strong environmental and possibly population variability.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“This intertidal isopod showed robust tidal rhythmicity after being caught in the wild and released in DD, suggesting the existence of a true circatidal endogenous oscillator.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [10] Zhang L. Hastings M.H. Green E.W. Tauber E. Sladek M. Webster S.G. Kyriacou C.P. Wilcockson D.C. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra Curr. Biol. 23 2013 1863 1873 10.1016/j.cub.2013.08.038 24076244 PMC3793863 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“Furthermore, circadian rhythm disruption through LL exposure affected neither the tidal swimming period nor overall activity levels [10].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [10] Zhang L. Hastings M.H. Green E.W. Tauber E. Sladek M. Webster S.G. Kyriacou C.P. Wilcockson D.C. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra Curr. Biol. 23 2013 1863 1873 10.1016/j.cub.2013.08.038 24076244 PMC3793863 source
plain- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Circatidal clocks and their relation with circadian clocks are particularly interesting, because in essence a 12.4 h period is just half of 24.8 h, i.e. a period covered by the conventional core circadian clock network.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
plaincorrelational- Asserted: passes — The authors put it forward as true.
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In the paper
“Genetic linkage analysis identified two specific chromosomal regions responsible for diurnal emergence and two related to lunar timing.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [46] Kaiser T.S. Poehn B. Szkiba D. Preussner M. Sedlazeck F.J. Zrim A. Neumann T. Nguyen L.T. The genomic basis of circadian and circalunar timing adaptations in a midge Nature. 540 2016 69 73 10.1038/nature20151 27871090 PMC5133387 source
plaindirect- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Thus, the data presented might actually suggest the presence of both a photo-repressive mechanism and an endogenous clock contributing together to the circalunar timing.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
hedgedconditional- Asserted: passes — The authors put it forward as true.
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In the paper
“In spite of the observed phase delay, the amplitude of tidal oscillations was robust and comparable to the untreated control.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [10] Zhang L. Hastings M.H. Green E.W. Tauber E. Sladek M. Webster S.G. Kyriacou C.P. Wilcockson D.C. Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra Curr. Biol. 23 2013 1863 1873 10.1016/j.cub.2013.08.038 24076244 PMC3793863 source
plain- Asserted: passes — The authors put it forward as true.
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In the paper
“Moreover, per4 showed a robust oscillation over the lunar cycle under all the light regimes, but in antiphase compared to cry3.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circalunar rhythms and clocks
What the sources say
- Not checked yetcites [50] Toda R. Okano K. Takeuchi Y. Yamauchi C. Fukushiro M. Takemura A. Okano T. Hypothalamic expression and moonlight-independent changes of Cry3 and Per4 implicate their roles in lunar clock oscillators of the lunar-responsive goldlined spinefoot PLoS One 9 2014 10.1371/journal.pone.0109119 PMC4182804 25272159 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These data potentially indicate the existence of a circatidal clock in the grass puffer brain, which, together with the circadian clock, might contribute to set the proper daily and lunar-related reproductive rhythms.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Circalunar Rhythms and Clocks: An Endocrine Perspective > Melatonin
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In the paper
“Thus, the authors suggested that peaks of PRX activity and mitochondrially encoded transcript levels might anticipate changes in the energy demand and reactive oxygen species production originating from the prevailing metabolic program, following in this case a circatidal rest/activity rhythm.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [54] O’Neill J.S. Lee K.D. Zhang L. Feeney K. Webster S.G. Blades M.J. Kyriacou C.P. Hastings M.H. Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra Curr. Biol. 25 2015 R326 R327 10.1016/j.cub.2015.02.052 25898100 PMC4406942 source
hedgedconditionalSingle case- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
None of the sources cited for this claim have been checked yet.
In the paper
“Moreover, melatonin synthesis is exquisitely light sensitive, inhibited by light exposure, and fueled in the dark [48,58,59]”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Circalunar Rhythms and Clocks: An Endocrine Perspective > Melatonin
What the sources say
- Not checked yetcites [48] Takemura A. Susilo E.S. Rahman M.D.S. Morita M. Perception and possible utilization of moonlight intensity for reproductive activities in a lunar-synchronized spawner, the golden rabbitfish J. Exp. Zool. Part A Comp. Exp. Biol. 301 2004 844 851 10.1002/jez.a.105 15449345 source
- Not checked yetcites [58] Rahman M.S. Kim B.H. Takemura A. Park C.B. Lee Y.D. Effects of moonlight exposure on plasma melatonin rhythms in the seagrass rabbitfish, Siganus canaliculatus J. Biol. Rhythm. 19 2004 325 334 10.1177/0748730404266712 15245651 source
- Not checked yetcites [59] Rahman M.S. Kim B.H. Takemura A. Park C.B. Lee Y.D. Influence of light-dark and lunar cycles on the ocular melatonin rhythms in the seagrass rabbitfish, a lunar-synchronized spawner J. Pineal Res. 37 2004 122 128 10.1111/j.1600-079X.2004.00147.x 15298671 source
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Given its role as an endocrine mediator of other light-dependent rhythms (daily/circadian, i.e. daily sleep–wake cycle) in vertebrates, also melatonin has been suggested as a potential component of the molecular mechanisms contributing to lunar-regulated rhythms.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Circalunar Rhythms and Clocks: An Endocrine Perspective > Melatonin
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
None of the sources cited for this claim have been checked yet.
In the paper
“The period of these oscillations was consistent with swimming activity and respiratory rate tidal cycles, which peak around high tides [54,56].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [54] O’Neill J.S. Lee K.D. Zhang L. Feeney K. Webster S.G. Blades M.J. Kyriacou C.P. Hastings M.H. Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra Curr. Biol. 25 2015 R326 R327 10.1016/j.cub.2015.02.052 25898100 PMC4406942 source
- Not checked yetcites [56] Hastings M.H. Semi-lunar variations of endogenous circa-tidal rhythms of activity and respiration in the isopod Eurydice pulchra Mar. Ecol Prog Ser. 4 1981 85 90 10.3354/meps004085 source
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
None of the sources cited for this claim have been checked yet.
In the paper
“Taking all above findings together might start to indicate that the circadian clockwork could be more plastic than previously thought and capable to adjust to the environmental cycle(s) most relevant for a given species [53,54,57].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
What the sources say
- Not checked yetcites [53] Tran D. Perrigault M. Ciret P. Payton L. Bivalve mollusc circadian clock genes can run at tidal frequency Proc. Biol. Sci. 287 2020 20192440 10.1098/rspb.2019.2440 31910786 PMC7003461
- Not checked yetcites [54] O’Neill J.S. Lee K.D. Zhang L. Feeney K. Webster S.G. Blades M.J. Kyriacou C.P. Hastings M.H. Metabolic molecular markers of the tidal clock in the marine crustacean Eurydice pulchra Curr. Biol. 25 2015 R326 R327 10.1016/j.cub.2015.02.052 25898100 PMC4406942 source
- Not checked yetcites [57] Schnytzer Y. Simon-Blecher N. Li J. Ben-Asher H.W. Salmon-Divon M. Achituv Y. Hughes M.E. Levy O. Tidal and diel orchestration of behaviour and gene expression in an intertidal mollusc Sci. Rep. 8 2018 1 13 10.1038/s41598-018-23167-y 29559663 PMC5861051 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This lack of both circatidal and circadian rhythmicity in clock gene expression is also conceivable with the idea that specific subsets of the core circadian clock might be differentially recruited in a tissue-dependent manner, and depending on cellular context form circadian, circatidal, or circalunidian clocks.”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Core Circadian Clock Genes and Lunar-Regulated Processes: Are There Connections? > Circatidal rhythms and clocks
hedgedconditionalSingle case- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Laboratory studies provide a better control of the multitude of environmental variables present in nature, allowing the investigation of the single contributions of a certain cue”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Perspectives
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“the generation of knockouts and transgenic animals clearly allow for a detailed functional dissection that is difficult to meet with other methods”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Perspectives
boosteddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
None of the sources cited for this claim have been checked yet.
In the paper
“complex chronobiological changes likely caused by anthropogenic impacts (i.e. light pollution, temperature changes, architectural barriers) that are endangering the world's ecosystems as we know them [22,23], and possibly human health”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Perspectives
What the sources say
- Not checked yetcites [22] Fogarty N.D. Marhaver K.L. Coral spawning, unsynchronized Science. 365 2019 987 988 10.1126/science.aay7457 31488677 source
- Not checked yetcites [23] Shlesinger T. Loya Y. Breakdown in spawning synchrony: a silent threat to coral persistence Science. 365 2019 1002 1007 10.1126/science.aax0110 31488683 source
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The paper relies on this without support.
Life has evolved equally long under both lunar and solar influences.
“As the moon formed about 4.51 billion years ago, life evolved equally long under both lunar and solar influences”
The paper relies on this without support.
The lunar cycle is a reliable and steady environmental cue.
“Animals exploit reliable and steady environmental cues to synchronize crucial events of their life”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“The Moon exhibits three different cycles that affect moonlight intensity and gravity on Earth and that are illustrated in Fig. 1 [see also figure 1 in the work by Andreatta and Tessmar-Raible (5)].”
From Women temporarily synchronize their menstrual cycles with the luminance and gravimetric cycles of the Moon (2021) · cites this paper as [5]
The cited source says what the claim attributes to it.
In the citing paper
“In many marine species (1–5) and some terrestrial species (6–9), reproductive behavior is synchronized with a particular phase of the lunar cycle (often full or new moon).”
From Women temporarily synchronize their menstrual cycles with the luminance and gravimetric cycles of the Moon (2021) · cites this paper as [5]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > Circalunar Rhythms and Clocks: An Endocrine Perspective > Melatonin
“arylalkylamine N-acetyltransferase (aanat, enzyme involved in melatonin synthesis) in the retina were reduced during FM nights compared to NM in the grass puffer [62,63].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > References
“62. Kashiwagi T. Park Y.J. Park J.G. Imamura S. Takeuchi Y. Hur S.P. Takemura A. Moonlight affects mRNA abundance of arylalkylamine N-acetyltransferase in the retina of a lunar-synchronized spawner, the goldlined spinefoot”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
“because of earth's axis clockwise rotation (Figure 1(f)).”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > The Moon Controls Rhythms of Physiology and Behavior
“(F) Draconic month. The plane described by moon's orbit is inclined (5.14°) compared to the plane on which the sun and the earth lay, and the two planes cross in two points called nodes (purple circles). (G) Tropical month:”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > -omics under the Moon: Transcriptional Signatures and Protein Dynamics from High-Throughput Data > Mollusks
“The intertidal limpet Cellana rota exhibits circatidal locomotor activity [57] and oxygen consumption [99].”
§ The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks > References
“99. Balaparameswara Rao M. Studies on the oxygen consumption of a tropical intertidal limpet Cellana radiata (Born): effect of body size and tidal rhythm”
Citations
Cites
Peroxiredoxins are conserved markers of circadian rhythms
Edgar, R. S., Green, E. W., Zhao, Y., Gerben Van Ooijen, A., Olmedo, M., Qin, X., Xu, Y. Q., Pan, M., Valekunja, U. K., Feeney, K. A., et al. (2012) · Nature · doi:10.1038/nature11088 · Cited by 915
Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase Shifting
Panda, S., Sato, T. K., Castrucci, A. M., Rollag, M. D., DeGrip, W. J., Hogenesch, J. B., Provencio, I., & Kay, S. A. (2002) · Science · doi:10.1126/science.1076848 · Cited by 861
Synchronous spawnings of 105 scleractinian coral species on the Great Barrier Reef
Babcock, R. C., Bull, G. D., Harrison, P. L., Heyward, A. J., Oliver, J. K., Wallace, C. C., & Willis, B. L. (1986) · Marine Biology · doi:10.1007/bf00428562 · Cited by 788
Morning and evening peaks of activity rely on different clock neurons of the Drosophila brain
Grima, B., Chélot, E., Xia, R., & Rouyer, F. (2004) · Nature · doi:10.1038/nature02935 · Cited by 684
Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation
Eide, E. J., Woolf, M. F., Kang, H., Woolf, P., Hurst, W., Camacho, F., Vielhaber, E. L., Giovanni, A., & Virshup, D. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2795-2807.2005 · Cited by 495
Smith, J. T., Coolen, L. M., Kriegsfeld, L. J., Sari, I. P., Jaafarzadehshirazi, M. R., Maltby, M., Bateman, K., Goodman, R. L., Tilbrook, A. J., Ubuka, T., et al. (2008) · Endocrinology · doi:10.1210/en.2008-0581 · Cited by 387
Zhu, H., Šauman, I., Yuan, Q., Casselman, A. L., Emery-Le, M., Emery, P., & Reppert, S. M. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060004 · Cited by 325
Nelson, D. E., & Takahashi, J. S. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018660 · Cited by 316
Distinct Contributions of Rod, Cone, and Melanopsin Photoreceptors to Encoding Irradiance
Lall, G. S., Revell, V. L., Momiji, H., al Enezi, J., Altimus, C. M., Güler, A. D., Aguilar, C., Cameron, M. A., Allender, S., Hankins, M. W., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.037 · Cited by 306
SPDEF regulates goblet cell hyperplasia in the airway epithelium
Park, K.-S., Korfhagen, T. R., Bruno, M. D., Kitzmiller, J. A., Wan, H., Wert, S. E., Hershey, G. K. K., Chen, G., & Whitsett, J. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29176 · Cited by 284
Research works printed but not linked: 3
- Szmant-Froelich, 1985, Sexual reproduction of Favia fragum (ESPER): lunar patterns of gametogenesis, embryogenesis and planulation in Puerto Rico, Bull. Mar. Sci., 37, 880
- Ranzi, 1931, Ricerche sulla biologia sessuale degli Anellidi, Pubbl. Del Stn. Zool. Napoli., 11, 271
- Decoursey, 1990, Circadian photoentrainment in nocturnal mammals—ecological overtones, Biol. Behav., 15, 213
Cited by
Sorted by citations
The Nereid on the rise: Platynereis as a model system
Özpolat, B. D., Randel, N., Williams, E. A., Bezares-Calderón, L. A., Andreatta, G., Balavoine, G., Bertucci, P. Y., Ferrier, D. E. K., Gambi, M. C., Gazave, E., et al. (2021) · EvoDevo · doi:10.1186/s13227-021-00180-3 · Cited by 88
Self-citationRhythms and Clocks in Marine Organisms
Häfker, N. S., Andreatta, G., Manzotti, A., Falciatore, A., Raible, F., & Tessmar‐Raible, K. (2022) · Annual Review of Marine Science · doi:10.1146/annurev-marine-030422-113038 · Cited by 73
Self-citationHelfrich-Förster, C., Monecke, S., Spiousas, I., Hovestadt, T., Mitesser, O., & Wehr, T. A. (2021) · Science Advances · doi:10.1126/sciadv.abe1358 · Cited by 70
“F. Raible, H. Takekata, K. Tessmar-Raible, An overview of monthly rhythms and clocks.”
BackgroundInfluentialMarine artificial light at night: An empirical and technical guide
Tidau, S., Smyth, T., McKee, D., Wiedenmann, J., D’Angelo, C., Wilcockson, D. C., Ellison, A., Grimmer, A. J., Jenkins, S. R., Widdicombe, S., et al. (2021) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.13653 · Cited by 45
Revealing the hidden reality of the mammalian 12-h ultradian rhythms
Ballance, H. I., & Zhu, B. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03730-5 · Cited by 39
Metadata
- Authors
- Andreatta, G., & Tessmar-Raible, K.
- Affiliations
- University of Vienna (AT)
- ORCID
- Andreatta, Gabriele
- Venue
- Journal of Molecular Biology
- Publisher
- Elsevier BV
- Published
- 2020-05
- Volume
- 432
- Issue
- 12
- Pages
- 3525-3546
- ISSN
- 0022-2836 (ISSN-L)
- PMC
- PMC7322537
- OpenAlex
- W3012359533
- Semantic Scholar
- b671c083737034100dfd60550f2e16af2f3a5b0a
- Cited by
- 111
- References
- 148
- Citations by year
- 2026: 16 · 2025: 22 · 2024: 20 · 2023: 17 · 2022: 20 · 2021: 12 · 2020: 4
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Molecular Biology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Padua Research Archive (University of Padova) (submittedVersion, cc-by-nc-nd)
- Funders
- Seventh Framework Programme
- Horizon 2020 Framework Programme (819952)
- European Research Council (337011)
- Austrian Science Fund (P28970, SFB F78)
- Universität Wien
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Physical Sciences › Environmental Science › Ecology › Physiological and biochemical adaptations
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Light effects on plants
- Keywords
- lunar rhythms, circatidal rhythm, circalunar rhythm, circadian rhythm, molecular clock mechanisms, metabolic pathways, endocrine pathways, molecular markers, free-running rhythm, marine organisms, terrestrial organisms
- MeSH terms
- Adaptation, Physiological, Animals, Circadian Rhythm, Light, Moon, Metabolic Networks and Pathways, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
A language model drew the claims from the paper on 2026-10-09, under version 3 of the claim definition (model deepseek-v4.1-flash, prompt extract-v3).
A second model labelled each claim on 2026-10-09 (model jev-1.13-20260917, definition revision gold-guideline-v0.2).
Statistics and arithmetic are recomputed, not judged.
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