Cited by 315Neuroinflammation and Neurodegeneration MechanismsFlavonoids in Medical ResearchPhytochemicals and Antioxidant Activities

The DOI matches its Crossref record; 157 of the 159 references it cites were found in a registry or an index.

Neuroinflammation: Modulation by flavonoids and mechanisms of action

Spencer, Jeremy P.E., Vafeiadou, Katerina, Williams, Robert J., Vauzour, David·2012·Molecular Aspects of Medicine

DOI 10.1016/j.mam.2011.10.016

Open this paper in CoChat — free account

Abstract

Neuroinflammatory processes are known to contribute to the cascade of events culminating in the neuronal damage that underpins neurodegenerative disorders such as Parkinson's and Alzheimer's disease. Recently, there has been much interest in the potential neuroprotective effects of flavonoids, a group of plant secondary metabolites known to have diverse biological activity in vivo. With respect to the brain, flavonoids, such as those found in cocoa, tea, berries and citrus, have been shown to be highly effective in preventing age-related cognitive decline and neurodegeneration in both animals and humans. Evidence suggests that flavonoids may express such ability through a multitude of physiological functions, including an ability to modulate the brains immune system. This review will highlight the evidence for their potential to inhibit neuroinflammation through an attenuation of microglial activation and associated cytokine release, iNOS expression, nitric oxide production and NADPH oxidase activity. We will also detail the current evidence indicting that their regulation of these immune events appear to be mediated by their actions on intracellular signaling pathways, including the nuclear factor-κB (NF-κB) cascade and mitogen-activated protein kinase (MAPK) pathway. As such, flavonoids represent important precursor molecules in the quest to develop of a new generation of drugs capable of counteracting neuroinflammation and neurodegenerative disease.

Integrity signals

Registry

Crossref · 10.1016/j.mam.2011.10.016

Cites

157 of 157 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families
Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429
Structure-antioxidant activity relationships of flavonoids and phenolic acids
Rice-Evans, C. A., Miller, N. J., & Paganga, G. (1996) · Free Radical Biology and Medicine · doi:10.1016/0891-5849(95)02227-9 · Cited by 9,085
Mammalian MAP kinase signalling cascades
Chang, L., & Karin, M. (2001) · Nature · doi:10.1038/35065000 · Cited by 5,118
Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases
Barnes, P. J., & Karin, M. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704103361506 · Cited by 4,622
Microglia: a sensor for pathological events in the CNS
Kreutzberg, G. W. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10049-7 · Cited by 4,396
Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies
Manach, C., Williamson, G., Morand, C., Scalbert, A., & Rémésy, C. (2005) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.230s · Cited by 4,219 · cited 1×
“…pivotal in controlling neuronal resistance to neurotoxins, including oxidants (‘indirect’ antioxidant nature) (Levites et al., 2001) and inflammatory mediators (Spencer, 2009a), or through their chelation of transition metal ions such as iron (Levites et al., 2002; Mandel et al., 2005, 2006).”
Background
Interaction of Estrogenic Chemicals and Phytoestrogens with Estrogen Receptor β
Kuiper, G. G. J. M., Lemmen, J. G., Carlsson, B., Corton, J. C., Safe, S. H., van der Saag, P. T., van der Burg, B., & Gustafsson, J.-Å. (1998) · Endocrinology · doi:10.1210/endo.139.10.6216 · Cited by 4,203
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580
A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).
Vlahos, C. J., Matter, W. F., Hui, K. Y., & Brown, R. F. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37680-9 · Cited by 3,248

Show all 159 references

Sorted by citations

Important Flavonoids and Their Role as a Therapeutic Agent
Ullah, A., Munir, S., Badshah, S. L., Khan, N., Ghani, L., Poulson, B. G., Emwas, A.-H., & Jaremko, M. (2020) · Molecules · doi:10.3390/molecules25225243 · Cited by 1,696
Bioactive flavonoids in medicinal plants: Structure, activity and biological fate
Wang, T.-Y., Li, Q., & Bi, K.-S. (2017) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2017.08.004 · Cited by 1,022
Low-grade inflammation, diet composition and health: current research evidence and its translation
Minihane, A. M., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M. F., Vauzour, D., et al. (2015) · British Journal Of Nutrition · doi:10.1017/s0007114515002093 · Cited by 962
Bioavailability, bioactivity and impact on health of dietary flavonoids and related compounds: an update
Rodriguez‐Mateos, A., Vauzour, D., Krueger, C. G., Shanmuganayagam, D., Reed, J. D., Calani, L., Mena, P. R., Rio, D. D., & Crozier, A. (2014) · Archives of Toxicology · doi:10.1007/s00204-014-1330-7 · Cited by 623
The Bioavailability, Transport, and Bioactivity of Dietary Flavonoids: A Review from a Historical Perspective
Williamson, G., Kay, C. D., & Crozier, A. (2018) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12351 · Cited by 620
Anti-inflammatory Effects of Flavonoids in Neurodegenerative Disorders
Spagnuolo, C., Moccia, S., & Russo, G. L. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.09.001 · Cited by 458
Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects
Vauzour, D. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/914273 · Cited by 449
A survey of modulation of gut microbiota by dietary polyphenols
Dueñas, M., Muñoz-González, I., Cueva, C., Jiménez-Girón, A., Sánchez-Patán, F., Santos-Buelga, C., Moreno-Arribas, M. V., & Bartolomé, B. (2015) · BioMed Research International · doi:10.1155/2015/850902 · Cited by 396
LPS-induced Murine Neuroinflammation Model: Main Features and Suitability for Pre-clinical Assessment of Nutraceuticals
Catorce, M. N., & Gevorkian, G. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666151204122017 · Cited by 368
Damage to dopaminergic neurons by oxidative stress in Parkinson's disease (Review)
Guo, J., Zhao, X., Li, Y., Li, G., & Liu, X. (2018) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2018.3406 · Cited by 353
Neuroinflammation in Alzheimer’s disease
Zhang, F., & Jiang, L. (2015) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s75546 · Cited by 276
Current evidence on the effect of dietary polyphenols intake on chronic diseases
Costa, C., Tsatsakis, A. M., Mamoulakis, C., Teodoro, M., Briguglio, G., Caruso, E., Tsoukalas, D., Margina, D. M., Dardiotis, E., Kouretas, D., et al. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.10.023 · Cited by 262
The neuroprotective effects of cocoa flavanol and its influence on cognitive performance
Nehlig, A. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04378.x · Cited by 258
Novel Insights into the Pharmacology of Flavonoids
Romano, B., Pagano, E., Montanaro, V., Fortunato, A. L., Milić, N., & Borrelli, F. (2013) · Phytotherapy Research · doi:10.1002/ptr.5023 · Cited by 248
Marine Algae-Derived Bioactive Compounds: A New Wave of Nanodrugs?
Menaa, F., Wijesinghe, U., Thiripuranathar, G., Althobaiti, N. A., Albalawi, A. E., Khan, B. A., & Menaa, B. (2021) · Marine Drugs · doi:10.3390/md19090484 · Cited by 254
Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
Sairazi, N. S. M., & Sirajudeen, K. N. S. (2020) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2020/6565396 · Cited by 260
The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation
Çalış, Z., Moğulkoç, R., & Baltacı, A. K. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190617150051 · Cited by 221
Higher dietary anthocyanin and flavonol intakes are associated with anti-inflammatory effects in a population of US adults
Cassidy, A., Rogers, G. T., Peterson, J. J., Dwyer, J. T., Lin, H., & Jacques, P. F. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.108555 · Cited by 204
The Neuroprotective Potentiality of Flavonoids on Alzheimer’s Disease
Calderaro, A., Patanè, G. T., Tellone, E., Barreca, D., Ficarra, S., Misiti, F., & Laganà, G. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314835 · Cited by 208
Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences
Teles, R. B. D. A., Diniz, T. C., Pinto, T. C. C., Júnior, R. G. D. O., Silva, M. G. E., de Lavor, É. M., Fernandes, A. W. C., de Oliveira, A. P., Ribeiro, F. P. R. D. A., da Silva, A. A. M., et al. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/7043213 · Cited by 200
Chronic consumption of flavanone-rich orange juice is associated with cognitive benefits: an 8-wk, randomized, double-blind, placebo-controlled trial in healthy older adults
Kean, R., Lamport, D. J., Dodd, G. F., Freeman, J. E., Williams, C. M., Ellis, J. A., Butler, L. T., & Spencer, J. P. E. (2015) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.088518 · Cited by 187
Neuroprotective Effects of Bioavailable Polyphenol-Derived Metabolites against Oxidative Stress-Induced Cytotoxicity in Human Neuroblastoma SH-SY5Y Cells
González-Sarrías, A., Núñez-Sánchez, M. A., Tomás-Barberán, F. A., & Espín, J. C. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b04538 · Cited by 174
Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer’s and Parkinson’s Disease
Caruana, M., Cauchi, R. J., & Vassallo, N. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00031 · Cited by 164
Anti-Inflammatory Activities of Marine Algae in Neurodegenerative Diseases
Barbalace, M. C., Malaguti, M., Giusti, L., Lucacchini, A., Hrelia, S., & Angeloni, C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20123061 · Cited by 163
Wine Polyphenols: Potential Agents in Neuroprotection
Basli, A., Soulet, S., Chaher, N., Mérillon, J., Chibane, M., Monti, J., & Richard, T. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/805762 · Cited by 162
Neuroinflammation in Alzheimer's Disease
Sawikr, Y., Yarla, N. S., Peluso, I., Kamal, M. A., Aliev, G., & Bishayee, A. (2017) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2017.02.001 · Cited by 161
The Role of Dietary Polyphenols on Adult Hippocampal Neurogenesis: Molecular Mechanisms and Behavioural Effects on Depression and Anxiety
Dias, G. P., Cavegn, N., Nix, A., do Nascimento Bevilaqua, M. C., Stangl, D., Zainuddin, M. S. A., Nardi, A. E., Gardino, P. F., & Thuret, S. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/541971 · Cited by 153
Carbon monoxide: Mechanisms of action and potential clinical implications
Rochette, L., Cottin, Y., Zeller, M., & Vergely, C. (2012) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2012.09.007 · Cited by 149
Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging
Sarubbo, F., Esteban, S., Miralles, A., & Moranta, D. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170703113212 · Cited by 146
The genetic aspects of berries: from field to health
Mazzoni, L., Pérez-López, P., Giampieri, F., Álvarez-Suárez, J. M., Gasparrini, M., Forbes-Hernández, T. Y., Quiles, J. L., Mezzetti, B., & Battino, M. A. (2015) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.7216 · Cited by 139
Neuroinflammation in epileptogenesis: from pathophysiology to therapeutic strategies
Li, W., Wu, J., Zeng, Y., & Zheng, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1269241 · Cited by 144
Effect of flavonoids on learning, memory and neurocognitive performance: relevance and potential implications for Alzheimer's disease pathophysiology
Vauzour, D. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6473 · Cited by 139
Astilbin inhibits Th17 cell differentiation and ameliorates imiquimod-induced psoriasis-like skin lesions in BALB/c mice via Jak3/Stat3 signaling pathway
Di, T., Ruan, Z.-T., Zhao, J., Wang, Y., Liu, X., Wang, Y., & Li, P. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2015.12.035 · Cited by 133
Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease
Uddin, M. S., Kabir, M. T., Niaz, K., Jeandet, P., Clément, C., Mathew, B., Rauf, A., Rengasamy, K. R. R., Sobarzo‐Sánchez, E., Ashraf, G. M., et al. (2020) · Molecules · doi:10.3390/molecules25061267 · Cited by 135
Dietary polyphenols: A novel strategy to modulate microbiota-gut-brain axis
Serra, D., Almeida, L. M., & Dinis, T. C. P. (2018) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2018.06.007 · Cited by 136
Multitarget drug discovery for Alzheimer's disease: triazinones as BACE-1 and GSK-3β inhibitors
Prati, F., De Simone, A., Bisignano, P., Armirotti, A., Summa, M., Pizzirani, D., Scarpelli, R., Perez, D. I., Andrisano, V., Perez‐Castillo, A., et al. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201410456 · Cited by 128
Bioactive Polyphenols and Neuromodulation: Molecular Mechanisms in Neurodegeneration
Meo, F. D., Valentino, A., Petillo, O., Peluso, G., Filosa, S., & Crispi, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21072564 · Cited by 131
Modulation of nitric oxide by flavonoids
Duarte, J., Francisco, V., & Pérez‐Vizcaíno, F. (2014) · Food & Function · doi:10.1039/c4fo00144c · Cited by 131
Anti-inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-Activated N13 Microglial Cells
Candiracci, M., Piatti, E., Dominguez-Barragán, M., García-Antrás, D., Rodríguez-Morgado, B., Ruano, D., Gutiérrez, J. F., Parrado, J., & Castaño, A. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf302468h · Cited by 122
Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation
Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125
Polyphenols and the Human Brain: Plant “Secondary Metabolite” Ecologic Roles and Endogenous Signaling Functions Drive Benefits
Kennedy, D. O. (2014) · Advances in Nutrition · doi:10.3945/an.114.006320 · Cited by 128
Map kinase signaling as therapeutic target for neurodegeneration
Ahmed, T., Zulfiqar, A., Argüelles, S., Rasekhian, M., Nabavi, S. F., Sanches-Silva, A. T., & Nabavi, S. M. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105090 · Cited by 123
Flavonoid-rich orange juice is associated with acute improvements in cognitive function in healthy middle-aged males
Alharbi, M. H., Lamport, D. J., Dodd, G. F., Saunders, C., Harkness, L., Butler, L. T., & Spencer, J. P. E. (2015) · European Journal of Nutrition · doi:10.1007/s00394-015-1016-9 · Cited by 118
Impact of Flavonoids on Cellular and Molecular Mechanisms Underlying Age-Related Cognitive Decline and Neurodegeneration
Flanagan, E. C., Müller, M. M., Hornberger, M., & Vauzour, D. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0226-1 · Cited by 119
Therapeutic Potential of Baicalein in Alzheimer’s Disease and Parkinson’s Disease
Li, Y., Zhao, J., & Hölscher, C. (2017) · CNS Drugs · doi:10.1007/s40263-017-0451-y · Cited by 114
Natural product biosynthesis in Medicago species
Gholami, A., Geyter, N. D., Pollier, J., Goormachtig, S., & Goossens, A. (2014) · Natural Product Reports · doi:10.1039/c3np70104b · Cited by 109
The Human Tripeptide GHK-Cu in Prevention of Oxidative Stress and Degenerative Conditions of Aging: Implications for Cognitive Health
Pickart, L., Vasquez-Soltero, J. M., & Margolina, A. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/324832 · Cited by 112
Cognitive and mood improvements following acute supplementation with purple grape juice in healthy young adults
Haskell‐Ramsay, C. F., Stuart, R. C., Okello, E. J., & Watson, A. W. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1454-7 · Cited by 106
Role of Plant-Derived Flavonoids and Their Mechanism in Attenuation of Alzheimer’s and Parkinson’s Diseases: An Update of Recent Data
Hussain, G., Zhang, L., Rasul, A., Anwar, H., Sohail, M. U., Razzaq, A., Aziz, N., Shabbir, A., Ali, M. Z., & Sun, T. (2018) · Molecules · doi:10.3390/molecules23040814 · Cited by 110
Concord grape juice, cognitive function, and driving performance: a 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children
Lamport, D. J., Lawton, C. L., Merat, N., Jamson, H., Myrissa, K., Hofman, D. L., Chadwick, H. K., Quadt, F., Wightman, J. D., & Dye, L. (2016) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.115.114553 · Cited by 105
The effects of flavonoid and other polyphenol consumption on cognitive performance: A systematic research review of human experimental and epidemiological studies
Lamport, D. J., Dye, L., Wightman, J. D., & Lawton, C. L. (2012) · Nutrition and Aging · doi:10.3233/nua-2012-0002 · Cited by 101
Effects of a mixed berry beverage on cognitive functions and cardiometabolic risk markers; A randomized cross-over study in healthy older adults
Nilsson, A. C., Salo, I., Plaza, M., & Björck, I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0188173 · Cited by 105
Metal Complexes of Flavonoids: Their Synthesis, Characterization and Enhanced Antioxidant and Anticancer Activities
Khater, M. A., Ravishankar, D., Greco, F., & Osborn, H. M. I. (2019) · Future Medicinal Chemistry · doi:10.4155/fmc-2019-0237 · Cited by 101
Role of Cytosolic Phospholipase A2 in Oxidative and Inflammatory Signaling Pathways in Different Cell Types in the Central Nervous System
Sun, G. Y., Chuang, D. Y., Zong, Y., Jiang, J., Lee, J. C., Gu, Z., & Simonyi, Á. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8662-4 · Cited by 99
Beneficial Effects of Spirulina Consumption on Brain Health
Trotta, T., Porro, C., Cianciulli, A., & Panaro, M. A. (2022) · Nutrients · doi:10.3390/nu14030676 · Cited by 98
Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation
Pan, Y., Sun, X., Jiang, L., Hu, L., Kong, H., Han, Y., Cheng, Q., Song, C., Qian, Y., & Liu, W. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0754-9 · Cited by 98
Baicalein attenuates α-synuclein aggregation, inflammasome activation and autophagy in the MPP+-treated nigrostriatal dopaminergic system in vivo
Hung, K.-C., Huang, H.-J., Wang, Y.-T., & Lin, A. M.-Y. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.10.040 · Cited by 96
The Anti-Neuroinflammatory Role of Anthocyanins and Their Metabolites for the Prevention and Treatment of Brain Disorders
Henriques, J. F., Serra, D., Dinis, T. C. P., & Almeida, L. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228653 · Cited by 95
Tiliroside, a dietary glycosidic flavonoid, inhibits TRAF-6/NF-κB/p38-mediated neuroinflammation in activated BV2 microglia
Velagapudi, R., Aderogba, M. A., & Olajide, O. A. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.08.008 · Cited by 94
Cognitive impairments in type 2 diabetes, risk factors and preventive strategies
Sharma, G., Parihar, A., Talaiya, T., Dubey, K., Porwal, B., & Parihar, M. S. (2020) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2019-0105 · Cited by 94
Activation of the astrocytic Nrf2/ARE system ameliorates the formation of demyelinating lesions in a multiple sclerosis animal model: Astrocytic Nrf2 Hyperactivation Prevents the Formation of Demyelinating Lesions
Draheim, T., Liessem, A., Scheld, M., Wilms, F., Weißflog, M., Denecke, B., Kensler, T. W., Zendedel, A., Beyer, C., Kipp, M., et al. (2016) · Glia · doi:10.1002/glia.23058 · Cited by 95
Role of Quercetin Benefits in Neurodegeneration
Elumalai, P., & Lakshmi, S. (2016) · Advances in neurobiology · doi:10.1007/978-3-319-28383-8_12 · Cited by 88
7-O-Esters of taxifolin with pronounced and overadditive effects in neuroprotection, anti-neuroinflammation, and amelioration of short-term memory impairment in vivo
Gunesch, S., Hoffmann, M., Kiermeier, C., Fischer, W. H., Pinto, A. F. M., Maurice, T., Maher, P. A., & Decker, M. W. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101378 · Cited by 89
Astragaloside IV Attenuates Experimental Autoimmune Encephalomyelitis of Mice by Counteracting Oxidative Stress at Multiple Levels
He, Y., Du, M., Gao, Y. L., Liu, H., Wang, H., Wu, X., & Wang, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076495 · Cited by 87
The effect of a high-polyphenol Mediterranean diet (Green-MED) combined with physical activity on age-related brain atrophy: the Dietary Intervention Randomized Controlled Trial Polyphenols Unprocessed Study (DIRECT PLUS)
Kaplan, A., Zelicha, H., Meir, A. Y., Rinott, E., Tsaban, G., Levakov, G., Prager, O., Salti, M., Yovell, Y., Ofer, J., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac001 · Cited by 91
The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
Sarubbo, F., Cavallucci, V., & Pani, G. (2022) · Cells · doi:10.3390/cells11030382 · Cited by 89
Mechanisms of dietary flavonoid action in neuronal function and neuroinflammation
Jaeger, B. N., Parylak, S., & Gage, F. H. (2017) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2017.11.003 · Cited by 83
Dietary Flavonoids in the Management of Huntington’s Disease: Mechanism and Clinical Perspective
Khan, H. Z., Ullah, H., Tundis, R., Belwal, T., Devkota, H. P., Daglia, M., Çetin, Z., Saygılı, E. İ., Campos, M. G., Çapanoğlu, E., et al. (2020) · eFood · doi:10.2991/efood.k.200203.001 · Cited by 78
Dietary polyphenols and neurogenesis: Molecular interactions and implication for brain ageing and cognition
Sarubbo, F., Moranta, D., & Pani, G. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.05.011 · Cited by 77
Pelargonidin improves memory deficit in amyloid β25-35 rat model of Alzheimer’s disease by inhibition of glial activation, cholinesterase, and oxidative stress
Sohanaki, H., Baluchnejadmojarad, T., Nikbakht, F., & Roghani, M. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.06.021 · Cited by 77
Cocoa Agronomy, Quality, Nutritional, and Health Aspects
Badrie, N., Bekele, F. L., Sikora, E., & Sikora, M. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.669428 · Cited by 81
Therapeutic benefits of flavonoids against neuroinflammation: a systematic review
Hamsalakshmi, Alex, A. M., Marappa, M. A., Joghee, S., & Chidambaram, S. B. (2022) · Inflammopharmacology · doi:10.1007/s10787-021-00895-8 · Cited by 79
Neuroprotection comparison of chlorogenic acid and its metabolites against mechanistically distinct cell death-inducing agents in cultured cerebellar granule neurons
Taram, F., Winter, A. N., & Linseman, D. A. (2016) · Brain Research · doi:10.1016/j.brainres.2016.07.028 · Cited by 73
Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes
Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73
Methylated flavonoids as anti-seizure agents: Naringenin 4′,7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models
Copmans, D., Orellana-Paucar, A. M., Steurs, G., Zhang, Y., Ny, A., Foubert, K., Exarchou, V., Siekierska, A., Kim, Y., Borggraeve, W. M. D., et al. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.11.011 · Cited by 73
(+)-Catechin Attenuates NF-κB Activation Through Regulation of Akt, MAPK, and AMPK Signaling Pathways in LPS-Induced BV-2 Microglial Cells
Hussein, S. S. S., Kamarudin, M. N. A., & Kadir, H. A. (2015) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x15500548 · Cited by 70
Role of microglia in ethanol-induced neurodegenerative disease: Pathological and behavioral dysfunction at different developmental stages
Yang, J., Xue, X., Tian, H., Wang, X., Dong, Y., Wang, F., Zhao, Y., Yao, X., Cui, W., & Wu, C. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.07.002 · Cited by 74
Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice
Burton, M. D., Rytych, J. L., Amin, R., & Johnson, R. W. (2016) · Rejuvenation Research · doi:10.1089/rej.2015.1708 · Cited by 69
Optimization of Astilbin Extraction from the Rhizome of Smilax glabra, and Evaluation of Its Anti-Inflammatory Effect and Probable Underlying Mechanism in Lipopolysaccharide-Induced RAW264.7 Macrophages
Lu, C., Zhu, Y. P., Hu, M.-M., Wang, D., Xiao-jie, X., Lu, C., & Zhu, W. (2015) · Molecules · doi:10.3390/molecules20010625 · Cited by 69
Systems Biology Approaches to Understand the Host–Microbiome Interactions in Neurodegenerative Diseases
Rosário, D., Borén, J., Uhlén, M., Proctor, G., Aarsland, D., Mardinoğlu, A., & Shoaie, S. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00716 · Cited by 66
Radioprotective Effect of Flavonoids on Ionizing Radiation-Induced Brain Damage
Wang, Q., Xie, C., Xi, S.-J., Qian, F., Peng, X., Huang, J., & Tang, F.-R. (2020) · Molecules · doi:10.3390/molecules25235719 · Cited by 73
Colonic fermentation of polyphenolics from Sea buckthorn ( Hippophae rhamnoides ) berries: Assessment of effects on microbial diversity by Principal Component Analysis
Attri, S., Sharma, K., Raigond, P., & Goel, G. (2017) · Food Research International · doi:10.1016/j.foodres.2017.11.032 · Cited by 68
Citrus bergamia Juice Extract Attenuates β-Amyloid-Induced Pro-Inflammatory Activation of THP-1 Cells Through MAPK and AP-1 Pathways
Currò, M., Risitano, R., Ferlazzo, N., Cirmi, S., Gangemi, C. M. A., Caccamo, D., Ientile, R., & Navarra, M. (2016) · Scientific Reports · doi:10.1038/srep20809 · Cited by 68
Effects of Polyphenol-Rich Interventions on Cognition and Brain Health in Healthy Young and Middle-Aged Adults: Systematic Review and Meta-Analysis
Ammar, A., Trabelsi, K., Boukhris, O. F., Bouaziz, B., Müller, P., Glenn, J. M., Bott, N. T., Müller, N. G., Chtourou, H., Driss, T., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051598 · Cited by 71
Antidepressant-like effects of rosmarinic acid through mitogen-activated protein kinase phosphatase-1 and brain-derived neurotrophic factor modulation
Kondo, S., Omri, A. E., Han, J., & Isoda, H. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.03.001 · Cited by 63
Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from oxidative stress and attenuate microglia activation
Garcia, G., Nanni, S., Figueira, I., Ivanov, I., McDougall, G. J., Stewart, D., Ferreira, R. B., Pinto, P., Silva, R. F. M., Brites, D. M. T. O., et al. (2016) · Food Chemistry · doi:10.1016/j.foodchem.2016.07.128 · Cited by 62
Luteolin protects microglia against rotenone-induced toxicity in a hormetic manner through targeting oxidative stress response, genes associated with Parkinson’s disease and inflammatory pathways
Elmazoğlu, Z., Sağlam, A. S. Y., Sonmez, C., & Karasu, Ç. (2018) · Drug and Chemical Toxicology · doi:10.1080/01480545.2018.1504961 · Cited by 63
The neuromodulatory effects of flavonoids and gut Microbiota through the gut-brain axis
Wang, H., Zhao, T., Liu, Z., Danzengquzhen, Cisangzhuoma, Ma, J., Li, X., Huang, X., & Li, B. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1197646 · Cited by 66
Agathisflavone, a flavonoid derived from Poincianella pyramidalis (Tul.), enhances neuronal population and protects against glutamate excitotoxicity
Souza, C. D. S., Grangeiro, M. S., Pereira, É. P. L., dos Santos, C. C., da Silva, A. B., Sampaio, G. P., Figueiredo, D. D. R., David, J. M., David, J. P., da Silva, V. D. A., et al. (2018) · NeuroToxicology · doi:10.1016/j.neuro.2018.02.001 · Cited by 64
LC-MS/MS Screening of Phenolic Compounds in Wild and Cultivated Grapes Vitis amurensis Rupr.
Razgonova, M. P., Zakharenko, A. M., Pikula, K., Манаков, Ю. А., Erċışlı, S., Derbush, I. V., Kislin, E. I., Seryodkin, I. V., Sabitov, A., Kalenik, T. K., et al. (2021) · Molecules · doi:10.3390/molecules26123650 · Cited by 61
Low Levels of a Urinary Biomarker of Dietary Polyphenol Are Associated with Substantial Cognitive Decline over a 3‐Year Period in Older Adults: The Invecchiare in Chianti Study
Rabassa, M., Cherubini, A., Zamora‐Ros, R., Urpí-Sardà, M., Bandinelli, S., Ferrucci, L., & Andrés‐Lacueva, C. (2015) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13379 · Cited by 62
Astragaloside IV inhibits microglia activation via glucocorticoid receptor mediated signaling pathway
Liu, H., Shi, H., Huang, F., Peterson, K. E., Wu, H., Lan, Y., Zhang, B., He, Y., Woods, T. A., Du, M., et al. (2016) · Scientific Reports · doi:10.1038/srep19137 · Cited by 58
Effect of Light- and Dark-Germination on the Phenolic Biosynthesis, Phytochemical Profiles, and Antioxidant Activities in Sweet Corn (Zea mays L.) Sprouts
Xiang, N., Guo, X., Liu, F., Li, Q., Hu, J., & Brennan, C. S. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061246 · Cited by 58
Targeting the NLRP3 Inflammasome in Neuroinflammation: Health Promoting Effects of Dietary Phytochemicals in Neurological Disorders
Hung, W., Ho, C., & Pan, M. (2019) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201900550 · Cited by 57
Chrysin alleviates imiquimod-induced psoriasis-like skin inflammation and reduces the release of CCL20 and antimicrobial peptides
Li, H., Wu, N., Pu, C., Hsiao, C., Chang, D., & Hung, C. (2020) · Scientific Reports · doi:10.1038/s41598-020-60050-1 · Cited by 59
Traditional uses, phytochemistry, transformation of ingredients and pharmacology of the dried seeds of Raphanus sativus L. (Raphani Semen), A comprehensive review
Gao, L., Li, H., Li, B., Shao, H., Yu, X., Miao, Z., Zhang, L., Zhu, L., & Sheng, H. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115387 · Cited by 60
Phytonutrient intakes in relation to European fruit and vegetable consumption patterns observed in different food surveys
Tennant, D. R., Davidson, J., & Day, A. J. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514001950 · Cited by 55
Flavones from Erythrina falcata are modulators of fear memory
de Oliveira, D. R., Zamberlam, C. R., Gaiardo, R. B., Rêgo, G. M., Cerutti, J. M., Cavalheiro, A. J., & Cerutti, S. M. (2014) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-14-288 · Cited by 55
Active constituents of saffron (Crocus sativus L.) and their prospects in treating neurodegenerative diseases (Review)
Yang, W., Qiu, X., Wu, Q., Chang, F., Zhou, T., Zhou, M., & Pei, J. (2023) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2023.11934 · Cited by 60
Contribution of the phenolic composition to the antioxidant, anti-inflammatory and antitumor potential of Equisetum giganteum L. and Tilia platyphyllos Scop.
Jabeur, I., Martins, N. A., Barros, L., Calhelha, R. C., Vaz, J. A., Achour, L., Santos‐Buelga, C., & Ferreira, I. C. F. R. (2017) · Food & Function · doi:10.1039/c6fo01778a · Cited by 57

Authors: Spencer, J. P. E., Vafeiadou, K., Williams, R. J., & Vauzour, D.
Affiliations: University of Reading (GB)
University of Bath (GB)
University of East Anglia (GB)
Corresponding author: Spencer, Jeremy P.E.
ORCID: Vauzour, David
Venue: Molecular Aspects of Medicine
Publisher: Elsevier BV
Published: 2012-02
Volume: 33
Issue: 1
Pages: 83-97
ISSN: 0098-2997 (ISSN-L)
DOI: 10.1016/j.mam.2011.10.016
OpenAlex: W1977122148
Cited by: 315
References: 159
Citations by year: 2026: 7 · 2025: 13 · 2024: 21 · 2023: 29 · 2022: 23 · 2021: 20 · 2020: 30 · 2019: 25 · 2018: 18 · 2017: 26 · 2016: 27 · 2015: 21 · 2014: 25 · 2013: 13 · 2012: 17
FWCI: 1.55
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Molecular Aspects of Medicine (publishedVersion)
PubMed (publishedVersion)
UEA Digital Repository (University of East Anglia) (submittedVersion)
University of Hertfordshire Research Archive (University of Hertfordshire) (submittedVersion)
Funders: Biotechnology and Biological Sciences Research Council (BB/G005702/1, BB/E023185/1, BB/F008953/1, BB/C518222/1)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
Keywords: neuroinflammation, flavonoids, neuroprotection, neurodegenerative diseases, Parkinson's disease, Alzheimer's disease, microglial activation, cytokine production, nitric oxide, NADPH oxidase, inducible nitric oxide synthase, NF-κB signaling, MAPK signaling, intracellular signaling, age-related cognitive decline, Theobroma cacao, tea, berries, citrus
MeSH terms: Animals, Flavonoids, Humans, Inflammation, Nervous System Diseases, Signal Transduction, Neuroprotective Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Neuroinflammation: Modulation by flavonoids and mechanisms of action

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks