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The DNA Damage Response: Making It Safe to Play with Knives
Open accessAbstract
Damage to our genetic material is an ongoing threat to both our ability to faithfully transmit genetic information to our offspring as well as our own survival. To respond to these threats, eukaryotes have evolved the DNA damage response (DDR). The DDR is a complex signal transduction pathway that has the ability to sense DNA damage and transduce this information to the cell to influence cellular responses to DNA damage. Cells possess an arsenal of enzymatic tools capable of remodeling and repairing DNA; however, their activities must be tightly regulated in a temporal, spatial, and DNA lesion-appropriate fashion to optimize repair and prevent unnecessary and potentially deleterious alterations in the structure of DNA during normal cellular processes. This review will focus on how the DDR controls DNA repair and the phenotypic consequences of defects in these critical regulatory functions in mammals.
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In the citing paper
“Poly-ADP-ribose (PAR) chains are rapidly disassembled by poly (ADP-ribose) glycohydrolase (PARG), allowing the whole event to repeat [55,66].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [55]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“ATR (ATM and Rad3-related) is critical to UV DNA damage signaling (Ciccia and Elledge, 2010) and is intimately linked with NER”
From RETRACTED: PKA-Mediated Phosphorylation of ATR Promotes Recruitment of XPA to UV-Induced DNA Damage (2014) · cites this paper as Ciccia and Elledge, 2010
Experimental — accuracy not yet measuredIn the citing paper
“Poly-ADP-ribose chains act as a scaffold for repair proteins, ensuring effective recruitment of single-strand break repair (SSBR) and double-strand break repair (DSBR) machinery.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [55]
In the citing paper
“PARP1 and PARP2 are the main enzymes with a function in damage signaling.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [55]
In the citing paper
“In contrast, poly [ADP-ribose] polymerases (PARPs) work as signaling molecules in single-strand break repair.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [55]
In the citing paper
“PARPs catalyze an evolutionary conserved posttranslational modification in which ADP-ribose residues from nicotinamide adenine dinucleotide (NAD+) molecules are transferred onto amino acid moieties of various proteins, including histone proteins and PARP itself, leading to polymeric ADP-ribose chains formation.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [55]
In the citing paper
“In fact, PARP1 is responsible for the majority of ADP-ribosylation events in cell.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [55]
In the citing paper
“PARP binding is only temporary due to emerging electrostatic interactions.”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [55]
In the citing paper
“Double-strand break repair protein (MRE11), one of the components of MRN possess endo and exonucleolytic activity that enables single strand DNA (ssDNA) formation [55,118].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [55]
In the citing paper
“ssDNA is then coated with RPA protein that comprise to the stability of DNA fragments and form a platform for DNA repair protein RAD51 (RAD51) protein [55].”
From Focus on UV-Induced DNA Damage and Repair—Disease Relevance and Protective Strategies (2020) · cites this paper as [55]
In the citing paper
“The checkpoints also actively stimulate the repair processes [1–9] and, in higher eukaryotes, trigger the apoptotic response, if damage cannot be dealt with successfully [10–12].”
From Mind the gap: keeping UV lesions in check (2011) · cites this paper as [9]
In the citing paper
“These observations suggest that DDR pathways, evolved to safeguard genomic integrity and maximize survival of the organism13,44–46, may show reduced activity in stem cells with age.”
From Stem cell aging: mechanisms, regulators and therapeutic opportunities (2014) · cites this paper as [44]
In the citing paper
“It is estimated that oxidative stress may induce approximately 10,000 DNA alterations per cell per day, representing a major portion of endogenous DNA damage [17–20].”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [19]
In the citing paper
“Oxidative stress can induce a variety of different types of DNA damage or replication stress, such as base (purine and pyrimidine) damage, sugar moiety damage, Apurinic/apyrimidinic (AP) sites, DNA single-strand breaks (SSBs), DNA double-strand breaks (DSBs), tandem base modifications (e.g., DNA intrastrand crosslink), DNA interstrand crosslinks, protein–DNA crosslinks, mismatched pairs with dam”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [19]
In the citing paper
“In response to oxidative DNA damage, various DNA repair and DNA damage response (DDR) pathways are employed by cells to maintain genomic integrity [12, 18, 19, 31]”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [19]
In the citing paper
“To maintain genome stability, the DDR pathways are conserved surveillance mechanisms coordinating DNA repair, cell cycle progression, transcription, apoptosis, and senescence [19, 39–41].”
From Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stress (2014) · cites this paper as [19]
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Citations
Cites
The DNA-damage response in human biology and disease
Jackson, S. P., & Bartek, J. (2009) · Nature · doi:10.1038/nature08467 · Cited by 6,092
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S., & Bonner, W. M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5858 · Cited by 5,438
Radiobiology for the Radiologist.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498
The DNA damage response: putting checkpoints in perspective
Zhou, B.-B. S., & Elledge, S. J. (2000) · Nature · doi:10.1038/35044005 · Cited by 3,213
Self-citationATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Matsuoka, S., Ballif, B. A., Smogorzewska, A., McDonald, E. R., Hurov, K. E., Luo, J., Bakalarski, C. E., Zhao, Z., Solimini, N., Lerenthal, Y., et al. (2007) · Science · doi:10.1126/science.1140321 · Cited by 3,075
Self-citationSensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, L., & Elledge, S. J. (2003) · Science · doi:10.1126/science.1083430 · Cited by 2,693
Self-citationSomatic mutations affect key pathways in lung adenocarcinoma
Ding, L., Getz, G., Wheeler, D. A., Mardis, E. R., McLellan, M. D., Cibulskis, K., Sougnez, C., Greulich, H., Muzny, D. M., Morgan, M. B., et al. (2008) · Nature · doi:10.1038/nature07423 · Cited by 2,681
Genomic instability — an evolving hallmark of cancer
Negrini, S., Gorgoulis, V. G., & Halazonetis, T. D. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2858 · Cited by 2,397
Hoeijmakers, J. H. J. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0804615 · Cited by 2,239
Poly(ADP-ribose): novel functions for an old molecule
Schreiber, V., Dantzer, F., Amé, J., & de MURCIA, G. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1963 · Cited by 1,975
Transcriptional control of human p53-regulated genes
Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921
ATR: an essential regulator of genome integrity
Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798
PCNA, the Maestro of the Replication Fork
Moldovan, G.-L., Pfander, B., & Jentsch, S. (2007) · Cell · doi:10.1016/j.cell.2007.05.003 · Cited by 1,796
Principles of cancer therapy: oncogene and non-oncogene addiction
Luo, J., Solimini, N. L., & Elledge, S. J. (2009) · Cell · doi:10.1016/j.cell.2009.02.024 · Cited by 1,765
Self-citationCellular senescence in cancer and aging.
Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell · doi:10.1016/j.cell.2007.07.003 · Cited by 1,708
The DNA Damage Response: Ten Years After
Harper, J. W., & Elledge, S. J. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.11.015 · Cited by 1,705
Self-citationA comprehensive catalogue of somatic mutations from a human cancer genome
Pleasance, E. D., Cheetham, R. K., Stephens, P. J., McBride, D. J., Humphray, S. J., Greenman, C. D., Varela, I., Lin, M.-L., Ordóñez, G. R., Bignell, G. R., et al. (2010) · Nature · doi:10.1038/nature08658 · Cited by 1,696
53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks
Bunting, S. F., Callén, E., Wong, N., Chen, H.-T., Polato, F., Gunn, A., Bothmer, A., Feldhahn, N., Fernandez-Capetillo, O., Cao, L., et al. (2010) · Cell · doi:10.1016/j.cell.2010.03.012 · Cited by 1,671
Wold, M. S. (1997) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.66.1.61 · Cited by 1,445
ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex
Lee, J.-H., & Paull, T. T. (2005) · Science · doi:10.1126/science.1108297 · Cited by 1,424
Genomic Instability in Mice Lacking Histone H2AX
Celeste, A., Petersen, S., Romanienko, P. J., Fernandez-Capetillo, O., Chen, H. T., Sedelnikova, O. A., Reina-San-Martin, B., Coppola, V., Meffre, E., Difilippantonio, M. J., et al. (2002) · Science · doi:10.1126/science.1069398 · Cited by 1,385
The multifaceted mismatch-repair system
Jiricny, J. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1907 · Cited by 1,375
Regulation of DNA double-strand break repair pathway choice
Shrivastav, M., De Haro, L. P., & Nickoloff, J. A. (2008) · Cell Research · doi:10.1038/cr.2007.111 · Cited by 1,329
Base-excision repair of oxidative DNA damage
David, S. S., O'Shea, V. L., & Kundu, S. (2007) · Nature · doi:10.1038/nature05978 · Cited by 1,238
Mechanism and Regulation of Class Switch Recombination
Stavnezer, J., Guikema, J. E. J., & Schrader, C. E. (2008) · Annual Review of Immunology · doi:10.1146/annurev.immunol.26.021607.090248 · Cited by 1,195
RNF8 Ubiquitylates Histones at DNA Double-Strand Breaks and Promotes Assembly of Repair Proteins
Mailand, N., Bekker‐Jensen, S., Kildegaard, H. F., Melander, F., Bártek, J., Lukas, C., & Lukas, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.040 · Cited by 1,193
Single-strand break repair and genetic disease
Caldecott, K. W. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2380 · Cited by 1,097
Nordlund, P., & Reichard, P. A. (2006) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142443 · Cited by 1,082
Transcription-coupled DNA repair: two decades of progress and surprises
Hanawalt, P. C., & Spivak, G. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2549 · Cited by 1,081
A small-cell lung cancer genome with complex signatures of tobacco exposure
Pleasance, E., Stephens, P. J., O’Meara, S., McBride, D. J., Meynert, A. M., Jones, D., Lin, M., Beare, D. M., Lau, K. W., Greenman, C., et al. (2009) · Nature · doi:10.1038/nature08629 · Cited by 1,076
RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly
Huen, M. S. Y., Grant, R. A., Manke, I. A., Minn, K. T., Yu, X., Yaffe, M. B., & Chen, J. (2007) · Cell · doi:10.1016/j.cell.2007.09.041 · Cited by 1,068
Bouwman, P., Aly, A., Escandell, J. M., Pieterse, M., Bartkova, J., van der Gulden, H., Hiddingh, S., Thanasoula, M., Kulkarni, A., Yang, Q., et al. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1831 · Cited by 1,001
Doil, C., Mailand, N., Bekker‐Jensen, S., Ménard, P., Larsen, D. H., Pepperkok, R., Ellenberg, J., Panier, S., Durocher, D., Bártek, J., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.041 · Cited by 982
Molecular views of recombination proteins and their control
West, S. C. (2003) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1127 · Cited by 977
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis
Moynahan, M. E., & Jasin, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2851 · Cited by 959
The biology of infertility: research advances and clinical challenges
Matzuk, M. M., & Lamb, D. J. (2008) · Nature Medicine · doi:10.1038/nm.f.1895 · Cited by 948
Orchestration of the DNA-Damage Response by the RNF8 Ubiquitin Ligase
Kolas, N. K., Chapman, J. R., Nakada, S., Ylanko, J., Chahwan, R., Sweeney, F. D., Panier, S., Mendez, M., Wildenhain, J., Thomson, T. M., et al. (2007) · Science · doi:10.1126/science.1150034 · Cited by 932
PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
Wang, M., Wu, W., Wu, W., Rosidi, B., Zhang, L., Wang, H., & Iliakis, G. E. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl840 · Cited by 892
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880
DNA/RNA Helicase Gene Mutations in a Form of Juvenile Amyotrophic Lateral Sclerosis (ALS4)
Chen, Y.-Z., Bennett, C. L., Huynh, H. M., Blair, I. P., Puls, I., Irobi, J., Dierick, I., Abel, A., Kennerson, M. L., Rabin, B. A., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/421054 · Cited by 809
Accumulation of premutagenic DNA lesions in mice defective in removal of oxidative base damage
Klungland, A., Rosewell, I., Hollenbach, S., Larsen, E., Daly, G., Epe, B., Seeberg, E., Lindahl, T., & Barnes, D. E. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13300 · Cited by 807
Ruzankina, Y., Pinzon‐Guzman, C., Asare, A., Ong, T., Pontano, L. L., Cotsarelis, G., Zediak, V. P., Velez, M., Bhandoola, A., & Brown, E. J. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.03.002 · Cited by 803
TopBP1 Activates the ATR-ATRIP Complex
Kumagai, A., Lee, J., Yoo, H. Y., & Dunphy, W. G. (2006) · Cell · doi:10.1016/j.cell.2005.12.041 · Cited by 787
Maintaining genome stability at the replication fork
Branzei, D., & Foiani, M. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2852 · Cited by 786
Byun, T. S., Pacek, M., Yee, M.-C., Walter, J. C., & Cimprich, K. A. (2005) · Genes & Development · doi:10.1101/gad.1301205 · Cited by 767
Linking functional decline of telomeres, mitochondria and stem cells during ageing
Sahin, E., & DePinho, R. A. (2010) · Nature · doi:10.1038/nature08982 · Cited by 759
The RIDDLE Syndrome Protein Mediates a Ubiquitin-Dependent Signaling Cascade at Sites of DNA Damage
Stewart, G. S., Panier, S., Townsend, K., Al-Hakim, A., Kolas, N. K., Miller, E. S., Nakada, S., Ylanko, J., Olivarius, S., Mendez, M., et al. (2009) · Cell · doi:10.1016/j.cell.2008.12.042 · Cited by 757
Cancer. A Comprehensive Treatise
Becker, F. F. (1975) · Springer eBooks · doi:10.1007/978-1-4613-4449-0 · Cited by 748
How stem cells age and why this makes us grow old
Sharpless, N. E., & DePinho, R. A. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2241 · Cited by 743
ATM-Dependent Chromatin Changes Silence Transcription In cis to DNA Double-Strand Breaks
Shanbhag, N. M., Rafalska-Metcalf, I. U., Balane-Bolivar, C., Janicki, S. M., & Greenberg, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.04.038 · Cited by 737
Repair of ionizing radiation-induced DNA double-strand breaks by non-homologous end-joining
Mahaney, B. L., Meek, K., & Lees‐Miller, S. P. (2009) · Biochemical Journal · doi:10.1042/bj20080413 · Cited by 722
Identification of the FANCI Protein, a Monoubiquitinated FANCD2 Paralog Required for DNA Repair
Smogorzewska, A., Matsuoka, S., Vinciguerra, P., McDonald, E. R., Hurov, K. E., Luo, J., Ballif, B. A., Gygi, S. P., Hofmann, K., D’Andrea, A. D., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.009 · Cited by 718
Self-citationRepair of Endogenous DNA Damage
LINDAHL, T., & BARNES, D. E. (2000) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2000.65.127 · Cited by 714
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis.
Bienko, M., Green, C. M., Crosetto, N., Rudolf, F., Zapart, G., Coull, B., Kannouche, P., Wider, G., Peter, M., Lehmann, A. R., et al. (2005) · Science · doi:10.1126/science.1120615 · Cited by 712
Lou, Z., Minter‐Dykhouse, K., Franco, S., Gostissa, M., Rivera, M. A., Celeste, A., Manis, J. P., van Deursen, J., Nussenzweig, A., Paull, T. T., et al. (2006) · Molecular Cell · doi:10.1016/j.molcel.2005.11.025 · Cited by 668
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Sørensen, C. S., Hansen, L. T., Dziegielewski, J., Syljuåsen, R. G., Lundin, C., Bartek, J., & Helleday, T. (2005) · Nature Cell Biology · doi:10.1038/ncb1212 · Cited by 666
PARP1-dependent Kinetics of Recruitment of MRE11 and NBS1 Proteins to Multiple DNA Damage Sites
Haince, J.-F., McDonald, D., Rodrigue, A., Déry, U., Masson, J., Hendzel, M. J., & Poirier, G. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706734200 · Cited by 660
Central role of p53 in the suntan response and pathologic hyperpigmentation
Cui, R., Widlund, H. R., Feige, E., Lin, J. Y., Wilensky, D. L., Igras, V. E., D'Orazio, J., Fung, C. Y., Schanbacher, C. F., Granter, S. R., et al. (2007) · Cell · doi:10.1016/j.cell.2006.12.045 · Cited by 657
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
Bekker‐Jensen, S., Lukas, C., Kitagawa, R., Melander, F., Kastan, M. B., Bártek, J., & Lukas, J. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200510130 · Cited by 647
PARP is activated at stalled forks to mediate Mre11‐dependent replication restart and recombination
Bryant, H. E., Petermann, E., Schultz, N., Jemth, A., Loseva, O., Issaeva, N., Johansson, F., Fernandez, S., McGlynn, P., & Helleday, T. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.206 · Cited by 623
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
Dimitrova, N., Chen, Y.-C. M., Spector, D. L., & de Lange, T. (2008) · Nature · doi:10.1038/nature07433 · Cited by 604
How the Fanconi Anemia Pathway Guards the Genome
Moldovan, G., & D’Andrea, A. D. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134222 · Cited by 601
ATM and Artemis promote homologous recombination of radiation‐induced DNA double‐strand breaks in G2
Beucher, A., Birraux, J., Tchouandong, L., Barton, O., Shibata, A., Conrad, S., Goodarzi, A. A., Krempler, A., Jeggo, P. A., & Löbrich, M. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.276 · Cited by 595
Poly(ADP-ribose)–Dependent Regulation of DNA Repair by the Chromatin Remodeling Enzyme ALC1
Ahel, D., Hořejší, Z., Wiechens, N., Polo, S. E., Garcia-Wilson, E., Ahel, I., Flynn, H., Skehel, M., West, S. C., Jackson, S. P., et al. (2009) · Science · doi:10.1126/science.1177321 · Cited by 588
Paulsen, R. D., Soni, D. V., Wollman, R., Hahn, A. T., Yee, M., Guan, A. S., Hesley, J., Miller, S. C., Cromwell, E. F., Solow-Cordero, D. E., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.021 · Cited by 564
CtIP-BRCA1 modulates the choice of DNA double-strand-break repair pathway throughout the cell cycle
Yun, M. H., & Hiom, K. (2009) · Nature · doi:10.1038/nature07955 · Cited by 556
Principles of ubiquitin and SUMO modifications in DNA repair
Bergink, S., & Jentsch, S. (2009) · Nature · doi:10.1038/nature07963 · Cited by 554
Crosstalk between histone modifications during the DNA damage response
van Attikum, H., & Gasser, S. M. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.03.001 · Cited by 542
Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
Galanty, Y., Belotserkovskaya, R., Coates, J., Polo, S. E., Miller, K. M., & Jackson, S. P. (2009) · Nature · doi:10.1038/nature08657 · Cited by 536
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
Cook, P. J., Ju, B. G., Telese, F., Wang, X., Glass, C. K., & Rosenfeld, M. G. (2009) · Nature · doi:10.1038/nature07849 · Cited by 534
Chou, D. M., Adamson, B., Dephoure, N. E., Tan, X., Nottke, A. C., Hurov, K. E., Gygi, S. P., Colaiácovo, M. P., & Elledge, S. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1012946107 · Cited by 529
Self-citationThe Fanconi Anemia Pathway Promotes Replication-Dependent DNA Interstrand Cross-Link Repair
Knipscheer, P., Räschle, M., Smogorzewska, A., Enoiu, M., Ho, T. V., Schärer, O. D., Elledge, S. J., & Walter, J. C. (2009) · Science · doi:10.1126/science.1182372 · Cited by 525
Self-citationDNA damage signalling guards against activated oncogenes and tumour progression
Bartek, J., Bartkova, J., & Lukas, J. (2007) · Oncogene · doi:10.1038/sj.onc.1210881 · Cited by 521
BRCA1 and its toolbox for the maintenance of genome integrity
Huen, M. S. Y., Sy, S. M.-H., & Chen, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2831 · Cited by 517
The emerging role of nuclear architecture in DNA repair and genome maintenance
Misteli, T., & Soutoglou, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2651 · Cited by 501
RecQ helicases: multifunctional genome caretakers
Chu, W. K., & Hickson, I. D. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2682 · Cited by 498
Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
Fackenthal, J. D., & Olopade, O. I. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2054 · Cited by 497
Ten Genes for Inherited Breast Cancer
Walsh, T., & King, M.-C. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.01.010 · Cited by 477
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
Esashi, F., Christ, N., Gannon, J., Liu, Y., Hunt, T., Jasin, M., & West, S. C. (2005) · Nature · doi:10.1038/nature03404 · Cited by 473
Wang, B., & Elledge, S. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710061104 · Cited by 464
Self-citationHistone H3 methylation links DNA damage detection to activation of the tumour suppressor Tip60
Sun, Y., Jiang, X., Xu, Y., Ayrapetov, M. K., Moreau, L. A., Whetstine, J. R., & Price, B. D. (2009) · Nature Cell Biology · doi:10.1038/ncb1982 · Cited by 454
Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair
Svendsen, J. M., Smogorzewska, A., Sowa, M. E., O’Connell, B. C., Gygi, S. P., Elledge, S. J., & Harper, J. W. (2009) · Cell · doi:10.1016/j.cell.2009.06.030 · Cited by 450
Self-citationGagné, J., Isabelle, M., Lo, K. S., Bourassa, S., Hendzel, M. J., Dawson, V. L., Dawson, T. M., & Poirier, G. G. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn771 · Cited by 443
Replication protein A-mediated recruitment and activation of Rad17 complexes
Zou, L., Liu, D., & Elledge, S. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336100100 · Cited by 431
Self-citationWSTF regulates the H2A.X DNA damage response via a novel tyrosine kinase activity
Xiao, A., Li, H., Shechter, D., Ahn, S. H., Fabrizio, L. A., Erdjument‐Bromage, H., Ishibe-Murakami, S., Wang, B., Tempst, P., Hofmann, K., et al. (2008) · Nature · doi:10.1038/nature07668 · Cited by 430
Self-citationPoly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins
Ahel, I., Ahel, D., Matsusaka, T., Clark, A. J., Pines, J., Boulton, S. J., & West, S. C. (2008) · Nature · doi:10.1038/nature06420 · Cited by 429
Fekairi, S., Scaglione, S., Chahwan, C., Taylor, E. R., Tissier, A., Coulon, S., Dong, M., Ruse, C. I., Yates, J. R., Russell, P. R., et al. (2009) · Cell · doi:10.1016/j.cell.2009.06.029 · Cited by 418
Clarifying the mechanics of DNA strand exchange in meiotic recombination
Neale, M. J., & Keeney, S. (2006) · Nature · doi:10.1038/nature04885 · Cited by 417
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
Timinszky, G., Till, S., Hassa, P. O., Hothorn, M., Kustatscher, G., Nijmeijer, B., Colombelli, J., Altmeyer, M., Stelzer, E. H. K., Scheffzek, K., et al. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1664 · Cited by 416
Identification of Holliday junction resolvases from humans and yeast
Ip, S. C. Y., Rass, U., Blanco, M. G., Flynn, H. R., Skehel, M. J., & West, S. C. (2008) · Nature · doi:10.1038/nature07470 · Cited by 416
Rydberg, B., & Lindahl, T. L. (1982) · The EMBO Journal · doi:10.1002/j.1460-2075.1982.tb01149.x · Cited by 410
Williams, R. S., Williams, J. S., & Tainer, J. A. (2007) · Biochemistry and Cell Biology · doi:10.1139/o07-069 · Cited by 399
TopBP1 activates ATR through ATRIP and a PIKK regulatory domainPreprint
Mordes, D. A., Glick, G. G., Zhao, R., & Cortez, D. (2008) · Genes & Development · doi:10.1101/gad.1666208 · Cited by 398
Mechanisms of double-strand break repair in somatic mammalian cells
Hartlerode, A. J., & Scully, R. (2009) · Biochemical Journal · doi:10.1042/bj20090942 · Cited by 395
Hanada, K., Budzowska, M., Davies, S. L., van Drunen, E., Onizawa, H., Beverloo, H. B., Maas, A., Essers, J., Hickson, I. D., & Kanaar, R. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1313 · Cited by 392
O'Hagan, H. M., Mohammad, H. P., & Baylin, S. B. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000155 · Cited by 386
The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress
Morris, J. R., Boutell, C., Keppler, M., Densham, R., Weekes, D., Alamshah, A., Butler, L., Galanty, Y., Pangon, L., Kiuchi, T., et al. (2009) · Nature · doi:10.1038/nature08593 · Cited by 375
Polo, S. E., Kaidi, A., Baskcomb, L., Galanty, Y., & Jackson, S. P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.188 · Cited by 374 · cited 3×
“…22, 2010 ª2010 Elsevier Inc. 181 182 Molecular Cell 40, October 22, 2010 ª2010 Elsevier Inc. recruitment of DNA repair and chromatin modifying complexes, such as polycomb and histone deacetylase (HDAC) complexes, at DNA damage sites (Polo et al., 2010; Schreiber et al., 2006; Chou et al., 2010).”
BackgroundRTEL1 Maintains Genomic Stability by Suppressing Homologous Recombination
Barber, L. J., Youds, J. L., Ward, J. D., McIlwraith, M. J., O'Neil, N. J., Petalcorin, M. I. R., Martin, J. S., Collis, S. J., Cantor, S. B., Auclair, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.08.016 · Cited by 369
Ellison, V., & Stillman, B. (2003) · PLoS Biology · doi:10.1371/journal.pbio.0000033 · Cited by 363
Defective DNA Repair and Neurodegenerative Disease
Rass, U., Ahel, I., & West, S. C. (2007) · Cell · doi:10.1016/j.cell.2007.08.043 · Cited by 358
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler
Gottschalk, A. J., Timinszky, G., Kong, S. E., Jin, J., Cai, Y., Swanson, S. K., Washburn, M. P., Florens, L. A., Ladurner, A. G., Conaway, J. W., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906920106 · Cited by 358
Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
Nakada, S., Tai, I., Panier, S., Al-Hakim, A., Iemura, S.-I., Juang, Y.-C., O’Donnell, L., Kumakubo, A., Munro, M., Sicheri, F., et al. (2010) · Nature · doi:10.1038/nature09297 · Cited by 357
A UAF1-Containing Multisubunit Protein Complex Regulates the Fanconi Anemia Pathway
Cohn, M. A., Kowal, P., Yang, K., Haas, W., Huang, T. T., Gygi, S. P., & D’Andrea, A. D. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.09.031 · Cited by 355
Radiobiology for the Radiologist
Hendry, J. H. (1979) · British Journal of Cancer · doi:10.1038/bjc.1979.88 · Cited by 341
Noon, A. T., Shibata, A., Rief, N., Löbrich, M., Stewart, G. S., Jeggo, P. A., & Goodarzi, A. A. (2010) · Nature Cell Biology · doi:10.1038/ncb2017 · Cited by 339
Origin of Chromosomal Translocations in Lymphoid Cancer
Nussenzweig, A., & Nussenzweig, M. C. (2010) · Cell · doi:10.1016/j.cell.2010.03.016 · Cited by 337
Identification of FAAP24, a Fanconi Anemia Core Complex Protein that Interacts with FANCM
Ciccia, A., Ling, C., Coulthard-Graf, R., Yan, Z., Xue, Y., Meetei, A. R., Laghmani, E. H., Joenje, H., McDonald, N. Q., de Winter, J. P., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.003 · Cited by 335
Self-citationCoordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair
Munoz, I. M., Hain, K. O., Déclais, A., Gardiner, M., Toh, G. W. ‐., Sánchez‐Pulido, L., Heuckmann, J. M., Toth, R. L., Macartney, T., Eppink, B., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.020 · Cited by 334
Smogorzewska, A., Desetty, R. D., Saito, T. T., Schlabach, M. R., Lach, F. P., Sowa, M. E., Clark, A. B., Kunkel, T. A., Harper, J. W., Colaiácovo, M. P., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.023 · Cited by 332
Self-citationMutant chromatin remodeling protein SMARCAL1 causes Schimke immuno-osseous dysplasia
Boerkoel, C. F., Takashima, H., John, J., Yan, J., Stankiewicz, P., Rosenbarker, L., André, J., Bogdanović, R., Burguet, A., Cockfield, S. M., et al. (2002) · Nature Genetics · doi:10.1038/ng821 · Cited by 329
A Role for the Deubiquitinating Enzyme USP28 in Control of the DNA-Damage Response
Zhang, D., Zaugg, K., Mak, T. W., & Elledge, S. J. (2006) · Cell · doi:10.1016/j.cell.2006.06.039 · Cited by 328
Self-citationBreak-induced replication: What is it and what is it for?
Llorente, B., Smith, C. E., & Symington, L. S. (2008) · Cell Cycle · doi:10.4161/cc.7.7.5613 · Cited by 325
Simsek, D., & Jasin, M. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1773 · Cited by 321
MacKay, C., Déclais, A., Lundin, C., Agostinho, A., Deans, A. J., Macartney, T., Hofmann, K., Gartner, A., West, S. C., Helleday, T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.021 · Cited by 319
Bothmer, A., Robbiani, D. F., Feldhahn, N., Gazumyan, A., Nussenzweig, A., & Nussenzweig, M. C. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100244 · Cited by 315
Correlation of DNA adduct levels in human lung with cigarette smoking
Phillips, D. H., Hewer, A. J., Martin, C. N., et al. (1988) · Nature · doi:10.1038/336790a0 · Cited by 309
The combined status of ATM and p53 link tumor development with therapeutic responsePreprint
Jiang, H., Reinhardt, H. C., Bártková, J., Tommiska, J., BLOMQVIST, C. P., Nevanlinna, H. A., Bártek, J., Yaffe, M. B., & Hemann, M. T. (2009) · Genes & Development · doi:10.1101/gad.1815309 · Cited by 306
The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks
Kruhlak, M., Crouch, E. E., Orlov, M., Montaño, C., Gorski, S. A., Nussenzweig, A., Misteli, T., Phair, R. D., & Casellas, R. (2007) · Nature · doi:10.1038/nature05842 · Cited by 305
53BP1 facilitates long-range DNA end-joining during V(D)J recombination
Difilippantonio, S., Gapud, E. J., Wong, N., Huang, C., Mahowald, G. K., Chen, H. T., Kruhlak, M. J., Callén, E., Livák, F., Nussenzweig, M. C., et al. (2008) · Nature · doi:10.1038/nature07476 · Cited by 302
Activation of the Cellular DNA Damage Response in the Absence of DNA Lesions
Soutoglou, E., & Misteli, T. (2008) · Science · doi:10.1126/science.1159051 · Cited by 299
Chapman, J. R., & Jackson, S. P. (2008) · EMBO Reports · doi:10.1038/embor.2008.103 · Cited by 299
Preventing Nonhomologous End Joining Suppresses DNA Repair Defects of Fanconi Anemia
Adamo, A., Collis, S. J., Adelman, C. A., Silva, N., Hořejšı́, Z., Ward, J. D., Martínez-Pérez, E., Boulton, S. J., & Volpe, A. L. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.06.026 · Cited by 297
Structural and Functional Relationships of the XPF/MUS81 Family of Proteins
Ciccia, A., McDonald, N. Q., & West, S. C. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.070306.102408 · Cited by 294
Self-citationMutations in PNKP cause microcephaly, seizures and defects in DNA repair
Shen, J., Gilmore, E. C., Marshall-Walker, C. A., Haddadin, M. H., Reynolds, J. J., Eyaid, W., Bodell, A., Barry, B. J., Gleason, D., Allen, K., et al. (2010) · Nature Genetics · doi:10.1038/ng.526 · Cited by 294
Parp‐1 protects homologous recombination from interference by Ku and Ligase IV in vertebrate cells
Hochegger, H., Dejsuphong, D., Fukushima, T., Morrison, C. G., Sonoda, E., Schreiber, V., Zhao, G., Saberi, A., Masutani, M., Adachi, N., et al. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601015 · Cited by 290
Meek, K., Dang, V. D., & Lees‐Miller, S. P. (2008) · Advances in immunology · doi:10.1016/s0065-2776(08)00602-0 · Cited by 289
Genetics of familial amyotrophic lateral sclerosis
Valdmanis, P. N., & Rouleau, G. A. (2008) · Neurology · doi:10.1212/01.wnl.0000296811.19811.db · Cited by 286
Blastyák, A., Pintér, L., Unk, I., Prakash, L., Prakash, S., & Haracska, L. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.07.030 · Cited by 285
Karras, G. I., & Jentsch, S. (2010) · Cell · doi:10.1016/j.cell.2010.02.028 · Cited by 282
Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein A
Davies, A. A., Huttner, D., Daigaku, Y., Chen, S., & Ulrich, H. D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.12.016 · Cited by 281
Inherited Mitochondrial Diseases of DNA Replication
Copeland, W. C. (2007) · Annual Review of Medicine · doi:10.1146/annurev.med.59.053006.104646 · Cited by 281
Ubiquitin signalling in DNA replication and repair
Ulrich, H. D., & Walden, H. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2921 · Cited by 280
Human RAD50 Deficiency in a Nijmegen Breakage Syndrome-like Disorder
Waltes, R., Kalb, R., Gatei, M. H., Kijas, A. W., Stümm, M., Sobeck, A., Wieland, B., Varon, R., Lerenthal, Y., Lavin, M. F., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.04.010 · Cited by 277
HERC2 coordinates ubiquitin-dependent assembly of DNA repair factors on damaged chromosomes
Bekker‐Jensen, S., Danielsen, J. M. R., Fugger, K., Gromova, I., Nerstedt, A., Lukas, C., Bártek, J., Lukas, J., & Mailand, N. (2009) · Nature Cell Biology · doi:10.1038/ncb2008 · Cited by 277
Kratz, K., Schöpf, B., Kaden, S., Sendoel, A., Eberhard, R., Lademann, C. A., Cannavò, E., Sartori, A. A., Hengartner, M. O., & Jiricny, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.022 · Cited by 271
Lee, H.-S., Park, J., Kim, S., Kwon, S.-J., & Kwon, J. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.27 · Cited by 269
Age to survive: DNA damage and aging
Schumacher, B., Garinis, G. A., & Hoeijmakers, J. H. J. (2008) · Trends in Genetics · doi:10.1016/j.tig.2007.11.004 · Cited by 266
Haince, J.-F., Kozlov, S., Dawson, V. L., Dawson, T. M., Hendzel, M. J., Lavin, M. F., & Poirier, G. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608406200 · Cited by 261
Spycher, C., Miller, E. S., Townsend, K., Pavic, L., Morrice, N. A., Janščák, P., Stewart, G. S., & Stucki, M. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200709008 · Cited by 259
Ubiquitin-dependent DNA damage bypass is separable from genome replication
Daigaku, Y., Davies, A. A., & Ulrich, H. D. (2010) · Nature · doi:10.1038/nature09097 · Cited by 259
Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance
Bohr, V. A. (2008) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2008.09.003 · Cited by 257
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair
Liu, T., Ghosal, G., Yuan, J., Chen, J., & Huang, J. (2010) · Science · doi:10.1126/science.1192656 · Cited by 255
The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forksPreprint
Bansbach, C. E., Betous, R., Lovejoy, C. A., Glick, G. G., & Cortez, D. (2009) · Genes & Development · doi:10.1101/gad.1839909 · Cited by 254
The ups and downs of p53: understanding protein dynamics in single cells
Batchelor, E., Loewer, A., & Lahav, G. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2604 · Cited by 250
Ku70 Corrupts DNA Repair in the Absence of the Fanconi Anemia Pathway
Pace, P., Mosedale, G., Hodskinson, M. R. G., Rosado, I. V., Sivasubramaniam, M., & Patel, K. J. (2010) · Science · doi:10.1126/science.1192277 · Cited by 248
FANCM Connects the Genome Instability Disorders Bloom's Syndrome and Fanconi Anemia
Deans, A. J., & West, S. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.12.006 · Cited by 245
Yan, Z., Delannoy, M., Chen, L., Daee, D. L., Osman, F., Muniandy, P. A., Shen, X. H., Oostra, A. B., Du, H., Steltenpool, J., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.039 · Cited by 242
Site-specific Phosphorylation Dynamics of the Nuclear Proteome during the DNA Damage Response
Bennetzen, M. V., Larsen, D. H., Bunkenborg, J., Bártek, J., Lukas, J., & Andersen, J. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900616-mcp200 · Cited by 240
Melander, F., Bekker‐Jensen, S., Falck, J., Bártek, J., Mailand, N., & Lukas, J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708210 · Cited by 231
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
Ishiai, M., Kitao, H., Smogorzewska, A., Tomida, J., Kinomura, A., Uchida, E., Saberi, A., Kinoshita, E., Kinoshita‐Kikuta, E., Koike, T., et al. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1504 · Cited by 230
Self-citationTip60: Connecting chromatin to DNA damage signaling
Sun, Y., Jiang, X., & Price, B. D. (2010) · Cell Cycle · doi:10.4161/cc.9.5.10931 · Cited by 230
Tel2 Regulates the Stability of PI3K-Related Protein Kinases
Takai, H., Wang, R. C., Takai, K., Yang, H., & de Lange, T. (2007) · Cell · doi:10.1016/j.cell.2007.10.052 · Cited by 226
Mitochondrial DNA repair in aging and disease
Druzhyna, N., Wilson, G. L., & LeDoux, S. P. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.03.002 · Cited by 225
Ciccia, A., Bredemeyer, A. L., Sowa, M. E., Terret, M., Jallepalli, P. V., Harper, J. W., & Elledge, S. J. (2009) · Genes & Development · doi:10.1101/gad.1832309 · Cited by 224
Self-citationPARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development
Huber, A., Bai, P., Murcia, J. M. D., & Murcia, G. D. (2004) · DNA Repair · doi:10.1016/j.dnarep.2004.06.002 · Cited by 222
Replication fork reversal and the maintenance of genome stability
Atkinson, J., & McGlynn, P. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp244 · Cited by 221
Collis, S. J., Ciccia, A., Deans, A. J., Hořejšı́, Z., Martin, J. S., Maslen, S., Skehel, M. J., Elledge, S. J., West, S. C., & Boulton, S. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.10.014 · Cited by 220
Self-citationRegulation of DNA Repair through DeSUMOylation and SUMOylation of Replication Protein A Complex
Dou, H., Huang, C., Singh, M. M., Carpenter, P. B., & Yeh, E. T. H. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.07.021 · Cited by 212
Hurov, K. E., Cotta-Ramusino, C., & Elledge, S. J. (2010) · Genes & Development · doi:10.1101/gad.1934210 · Cited by 210
Self-citationMartin, S. A., McCabe, N., Mullarkey, M. J., Cummins, R., Burgess, D. J., Nakabeppu, Y., Oka, S., Kay, E. W., Lord, C. J., & Ashworth, A. (2010) · Cancer Cell · doi:10.1016/j.ccr.2009.12.046 · Cited by 205
Singh, T. R., Saro, D., Ali, A. M., Zheng, X.-F., Du, C.-H., Killen, M. W., Sachpatzidis, A., Wahengbam, K., Pierce, A. J., Xiong, Y., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.036 · Cited by 200
Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks
Bolderson, E., Tomimatsu, N., Richard, D. J., Boucher, D., Kumar, R., Pandita, T. K., Burma, S., & Khanna, K. K. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp1164 · Cited by 200
Cell cycle–dependent chromatin loading of the Fanconi anemia core complex by FANCM/FAAP24
Kim, J. M., Kee, Y., Gurtan, A. M., & D’Andrea, A. D. (2008) · Blood · doi:10.1182/blood-2007-09-113092 · Cited by 199
Gu, Y., Sekiguchi, J., Gao, Y., Dikkes, P., Frank, K. M., Ferguson, D. O., Hasty, P., Chun, J. J. M., & Alt, F. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.6.2668 · Cited by 198
Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexesPreprint
Takai, H., Xie, Y., de Lange, T., & Pavletich, N. P. (2010) · Genes & Development · doi:10.1101/gad.1956410 · Cited by 197
Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA
Blastyák, A., Hajdú, I., Unk, I., & Haracska, L. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00863-09 · Cited by 197
Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends
Roberts, S. A., Strande, N. T., Burkhalter, M. D., Strom, C. N., Havener, J. M., Hasty, P., & Ramsden, D. A. (2010) · Nature · doi:10.1038/nature08926 · Cited by 196
Recent Advances in Cancer Therapy Targeting Proteins Involved in DNA Double-Strand Break Repair
Bolderson, E., Richard, D. J., Zhou, B. S., & Khanna, K. K. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-0096 · Cited by 194
DNA damage and decisions: CtIP coordinates DNA repair and cell cycle checkpoints
You, Z., & Bailis, J. M. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.04.002 · Cited by 189
RIDDLE immunodeficiency syndrome is linked to defects in 53BP1-mediated DNA damage signaling
Stewart, G. S., Stanković, T., Byrd, P. J., Wechsler, T., Miller, E. S., Huissoon, A., Drayson, M. T., West, S. C., Elledge, S. J., & Taylor, A. M. R. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708408104 · Cited by 183
Self-citationThe DNA Damage Response Arouses the Immune System
Gasser, S., & Raulet, D. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4603 · Cited by 182
RecQ helicases: guardian angels of the DNA replication fork
Bachrati, C. Z., & Hickson, I. D. (2008) · Chromosoma · doi:10.1007/s00412-007-0142-4 · Cited by 180
Identification of a novel, widespread, and functionally important PCNA-binding motif
Gilljam, K. M., Feyzi, E., Aas, P. A., de Sousa, M. M. L., Müller, R., Vågbø, C. B., Catterall, T., Liabakk, N., Slupphaug, G., Drabløs, F., et al. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200903138 · Cited by 179
Role of yeast Rad5 and its human orthologs, HLTF and SHPRH in DNA damage tolerance
Unk, I., Hajdú, I., Blastyák, A., & Haracska, L. (2010) · DNA repair · doi:10.1016/j.dnarep.2009.12.013 · Cited by 178
Andersen, S. L., Bergstralh, D. T., Kohl, K. P., LaRocque, J. R., Moore, C. B., & Sekelsky, J. J. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.06.019 · Cited by 175
Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination
Bienko, M., Green, C., Sabbioneda, S., Crosetto, N., Matić, I., Hibbert, R. G., Begovic, T., Niimi, A., Mann, M., Lehmann, A. R., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2009.12.039 · Cited by 172
DNA Repair Defects in Stem Cell Function and Aging
Park, Y., & Gerson, S. L. (2004) · Annual Review of Medicine · doi:10.1146/annurev.med.56.082103.104546 · Cited by 172
Wang, B., Hurov, K., Hofmann, K., & Elledge, S. J. (2009) · Genes & Development · doi:10.1101/gad.1770309 · Cited by 172
Self-citationMERIT40 facilitates BRCA1 localization and DNA damage repairPreprint
Feng, L., Huang, J., & Chen, J. (2009) · Genes & Development · doi:10.1101/gad.1770609 · Cited by 163
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
Wu, L., Luo, K., Lou, Z., & Chen, J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802885105 · Cited by 162
ATR activation and replication fork restart are defective in FANCM‐deficient cells
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Metadata
- Authors
- Ciccia, A., & Elledge, S. J.
- Affiliations
- Brigham and Women's Hospital (US)
- Corresponding author
- Elledge, Stephen J.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 40
- Issue
- 2
- Pages
- 179-204
- ISSN
- 1097-2765 (ISSN-L)
- PMC
- PMC2988877
- OpenAlex
- W2077436902
- Cited by
- 4,368
- References
- 246
- Citations by year
- 2026: 198 · 2025: 240 · 2024: 246 · 2023: 301 · 2022: 292 · 2021: 335 · 2020: 343 · 2019: 308 · 2018: 292 · 2017: 303 · 2016: 329 · 2015: 289 · 2014: 288 · 2013: 269 · 2012: 201
- FWCI
- 16.84
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Molecular Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R37GM044664)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Health Sciences › Medicine › Oncology › PARP inhibition in cancer therapy
- Keywords
- DNA damage response, DNA repair, signal transduction, DNA damage recognition, DNA repair regulation, mammalian cells, genetic stability, genome stability
- MeSH terms
- Animals, DNA, DNA Damage, DNA Repair, Models, Genetic, Recombination, Genetic, Signal Transduction, DNA Breaks, Double-Stranded, Eukaryota
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