Sex differences in the brain: implications for explaining autism
Abstract
Empathizing is the capacity to predict and to respond to the behavior of agents (usually people) by inferring their mental states and responding to these with an appropriate emotion. Systemizing is the capacity to predict and to respond to the behavior of nonagentive deterministic systems by analyzing input-operation-output relations and inferring the rules that govern such systems. At a population level, females are stronger empathizers and males are stronger systemizers. The “extreme male brain” theory posits that autism represents an extreme of the male pattern (impaired empathizing and enhanced systemizing). Here we suggest that specific aspects of autistic neuroanatomy may also be extremes of typical male neuroanatomy.
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Elevated prenatal androgens have been strongly associated with ASD risk for more than a decade.
“For example, elevated prenatal androgens have been strongly associated with ASD risk for more than a decade (26–35) leading some to hypothesize that EDCs that alter androgen action may be contributory.”
From Endocrine Disruption of Vasopressin Systems and Related Behaviors (2017) · cites this paper as [26]
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“…neuropeptide signaling, neurogenesis, synaptic programming, and cell differentiation, migration, and death are in fl uenced by gonadal hormones during development and may be involved in the social and fear memory de fi cits (Baron-Cohen et al., 2005, 2011; Schaafsma et al., 2017; Ferri et al., 2018).”
- Authors
- Baron-Cohen, S., Knickmeyer, R. C., & Belmonte, M. K.
- Affiliations
- Autism Research Centre, Cambridge University, Department of Psychiatry, Douglas House, 18b Trumpington Road, Cambridge CB2 2AH, UK.
- University of Cambridge (GB)
- Venue
- Science
- Published
- 2005-11-04
- Volume
- 310
- Issue
- 5749
- Pages
- 819-823
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2141154555
- Cited by
- 1,145
- References
- 3
- Citations by year
- 2026: 20 · 2025: 42 · 2024: 50 · 2023: 47 · 2022: 51 · 2021: 52 · 2020: 45 · 2019: 71 · 2018: 63 · 2017: 67 · 2016: 67 · 2015: 80 · 2014: 69 · 2013: 63 · 2012: 54
- FWCI
- 3.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Nottingham Trent University's Institutional Repository (Nottingham Trent Repository) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Keywords
- autism spectrum disorder, sex differences, empathizing-systemizing theory, extreme male brain theory, empathizing, systemizing, brain structure, neuroanatomy, gender differences in autism
- MeSH terms
- Androgens, Animals, Autistic Disorder, Brain, Empathy, Estradiol, Female, Humans, Male, Models, Psychological, Receptors, Androgen, Sex Characteristics, Asperger Syndrome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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