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Intranasal oxytocin in the treatment of autism spectrum disorders: A multilevel meta-analysis
Abstract
Intranasal oxytocin has been shown to promote social functioning and has recently been applied as a treatment for autism spectrum disorders (ASD). The current meta-analysis aims to assess the crucial question of oxytocin's efficacy in the treatment of ASD. We performed a systematic literature search, including randomized, single- or double-blind/open-label and placebo-controlled clinical trials as well as single-arm, non-randomized and uncontrolled studies investigating exogenous oxytocin effect on ASD. A total of 28 studies (N = 726 ASD patients) met our predefined inclusion criteria. We used a multilevel meta-analytic model and found that oxytocin had beneficial effects on social functioning, but did not find strong evidence for symptoms improvement in the non-social domain. Our findings suggest that oxytocin administration can be regarded as an effective treatment for some core aspects of ASD, especially in the domain of social functioning, highlighting the promise of using oxytocin as a new-generation therapeutic to address core social impairments in ASD.
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“It is also likely that the effects of OXT in ASD are modulated by age, gender, and possibly genetic factors [77, 79, 90].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [90]
In the citing paper
“Nonetheless, as illustrated by a recent meta-analysis, there does seem to be overall beneficial effects of OXT on social symptoms of ASD, although this review included both children and adults [90].”
From An Update on Psychopharmacological Treatment of Autism Spectrum Disorder (2022) · cites this paper as [90]
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Metadata
- Authors
- Huang, Y., Huang, X., Ebstein, R. P., & Yu, R.
- Affiliations
- Lingnan University (HK)
- Peking University (CN)
- Southwestern University of Finance and Economics (CN)
- Hong Kong Baptist University (HK)
- Corresponding author
- Yu, Rongjun
- Venue
- Neuroscience & Biobehavioral Reviews
- Publisher
- Elsevier BV
- Published
- 2021-03
- Volume
- 122
- Pages
- 18-27
- ISSN
- 0149-7634 (ISSN-L)
- OpenAlex
- W3120256748
- Semantic Scholar
- f48f0f3b5ee61a8b063bae805b9f9d5c343c51ac
- Cited by
- 119
- References
- 80
- Citations by year
- 2026: 19 · 2025: 19 · 2024: 21 · 2023: 24 · 2022: 31 · 2021: 5
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience & Biobehavioral Reviews (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Human-Animal Interaction Studies
- Keywords
- intranasal oxytocin, autism spectrum disorder, social functioning, social dysfunction, autism treatment
- MeSH terms
- Autism Spectrum Disorder, Administration, Intranasal, Double-Blind Method, Humans, Oxytocin, Randomized Controlled Trials as Topic, Treatment Outcome
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