The Impact of Neuroimmune Alterations in Autism Spectrum Disorder

Gottfried, Carmem; Bambini-Junior, Victorio; Francis, Fiona; Riesgo, Rudimar; Savino, Wilson

doi:10.3389/fpsyt.2015.00121

Cited by 143Autism Spectrum Disorder ResearchTryptophan and brain disordersGenetics and Neurodevelopmental Disorders

The Impact of Neuroimmune Alterations in Autism Spectrum Disorder

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Gottfried, Carmem, Bambini-Junior, Victorio, Francis, Fiona, Riesgo, Rudimar, Savino, Wilson·2015·Frontiers in Psychiatry

DOI 10.3389/fpsyt.2015.00121PMC PMC4563148

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Abstract

Autism spectrum disorder (ASD) involves a complex interplay of both genetic and environmental risk factors, with immune alterations and synaptic connection deficiency in early life. In the past decade, studies of ASD have substantially increased, in both humans and animal models. Immunological imbalance (including autoimmunity) has been proposed as a major etiological component in ASD, taking into account increased levels of pro-inflammatory cytokines observed in postmortem brain from patients, as well as autoantibody production. Also, epidemiological studies have established a correlation of ASD with family history of autoimmune diseases; associations with major histocompatibility complex haplotypes and abnormal levels of immunological markers in the blood. Moreover, the use of animal models to study ASD is providing increasing information on the relationship between the immune system and the pathophysiology of ASD. Herein, we will discuss the accumulating literature for ASD, giving special attention to the relevant aspects of factors that may be related to the neuroimmune interface in the development of ASD, including changes in neuroplasticity.

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Numerous studies show that a significant risk factor for autism is a family history of autoimmune disease.
“Further lending credence to this association are numerous studies showing that a significant risk factor for autism is a family history of autoimmune disease (Brimberg et al, 2013;Gesundheit et al, 2013;Gottfried et al, 2015;Wu et al, 2015)”
From The Role of the Immune System in Autism Spectrum Disorder (2017) · cites this paper as Gottfried et al, 2015

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Regional Alterations in Purkinje Cell Density in Patients with Autism
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Self-citation
Phosphatidylinositol 3-kinase (PI3K) pathway activation in bladder cancer
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Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model
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“Animal models of maternal infection have also been used to study behavioral impairments and brain alterations, such as maternal influenza infection (166), maternal immune activation (110, 167, 169–171, 173, 174, 177, 178), and prenatal exposure to antibodies (168, 172).”
Background
Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohorts
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Distinct Genetic Risk Based on Association of <i>MET</i> in Families With Co-occurring Autism and Gastrointestinal Conditions
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Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism
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Maternal immune activation and autism spectrum disorder: interleukin-6 signaling as a key mechanistic pathway
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Mast cells, brain inflammation and autism
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Resveratrol prevents social deficits in animal model of autism induced by valproic acid
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Self-citation
Glutathione-Related Factors and Oxidative Stress in Autism, A Review
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Decreased serum levels of transforming growth factor-β1 in patients with autism
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Maternal Autoantibodies in Autism
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The emerging role of microRNAs in schizophrenia and autism spectrum disorders
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Neuronal migration disorders: Focus on the cytoskeleton and epilepsy
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Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors
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Neuropathological and Genetic Findings in Autism: The Significance of a Putative Minicolumnopathy
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Maternal immune activation leads to activated inflammatory macrophages in offspring
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Increased IgG4 levels in children with autism disorder
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Neurobehavioral alterations in autoimmune mice
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Regional Callosal Morphology in Autism and Macrocephaly
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Are Neuronotrophic Neuron ‐ Astrocyte Interactions Regionally Specified?a
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[121]Enstrom AM Onore CE Van de Water JA Ashwood P. Differential monocyte responses to TLR ligands in children with autism spectrum disorders. Brain Behav Immun (2009) 24: 64– 71. 10.1016/j.bbi.2009.08.001 19666104 PMC3014091 · DOI · Paper page

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Authors: Gottfried, C., Bambini-Junior, V., Francis, F., Riesgo, R., & Savino, W.
Affiliations: Universidade Federal do Rio Grande do Sul (BR)
Inserm (FR)
Instituto Oswaldo Cruz (BR)
Corresponding author: Gottfried, Carmem
Savino, Wilson
ORCID: Gottfried, Carmem
Francis, Fiona
Riesgo, Rudimar
Savino, Wilson
Venue: Frontiers in Psychiatry
Publisher: Frontiers Media SA
Published: 2015-09-09
Volume: 6
Pages: 121-121
ISSN: 1664-0640 (ISSN-L)
DOI: 10.3389/fpsyt.2015.00121
PMC: PMC4563148
OpenAlex: W1887549719
Cited by: 143
References: 180
Citations by year: 2026: 2 · 2025: 9 · 2024: 11 · 2023: 14 · 2022: 12 · 2021: 14 · 2020: 19 · 2019: 20 · 2018: 18 · 2017: 14 · 2016: 9 · 2015: 1
FWCI: 1.38
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
Locations: Frontiers in Psychiatry (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
Americanae (AECID Library) (submittedVersion, other-oa)
Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
Arca - Repositório Institucional da Fiocruz (submittedVersion, other-oa)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Lancaster EPrints (Lancaster University) (submittedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders: Institut National de la Santé et de la Recherche Médicale
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Hospital de Clínicas de Porto Alegre
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
Centre National de la Recherche Scientifique
Fundação Oswaldo Cruz
Fundação Instituto de Pesquisas Econômicas
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords: autism spectrum disorder, autoimmunity, inflammatory cytokines, autoantibodies, animal models of autism, neuroplasticity, synaptic dysfunction, ASD etiology

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The Impact of Neuroimmune Alterations in Autism Spectrum Disorder

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