Sleep deprivation elevates expectation of gains and attenuates response to losses following risky decisions
Open accessAbstract
STUDY OBJECTIVES: Using a gambling task, we investigated how 24 hours of sleep deprivation modulates the neural response to the making of risky decisions with potentially loss-bearing outcomes. DESIGN: Two experiments involving sleep-deprived subjects were performed. In the first, neural responses to decision making and reward outcome were evaluated. A second control experiment evaluated responses to reward outcome only. PARTICIPANTS: Healthy right-handed adults participated in these experiments (26 [mean age 21.3 years] in Experiment 1 and 13 [mean age 21.7 years] in Experiment 2.) MEASUREMENTS AND RESULTS: Following sleep deprivation, choices involving higher relative risk elicited greater activation in the right nucleus accumbens, signifying an elevated expectation of the higher reward once the riskier choice was made. Concurrently, activation for losses in the insular and orbitofrontal cortices was reduced, denoting a diminished response to losses. This latter finding of reduced insular activation to losses was also true when volunteers were merely shown the results of the computer's decision, that is, without having to make their own choice. CONCLUSIONS: These results suggest that sleep deprivation poses a dual threat to competent decision making by modulating activation in nucleus accumbens and insula, brain regions associated with risky decision making and emotional processing.
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Sleep deprivation disrupts reward neural circuitry, usually enhancing brain reactivity to positive experiences.
“Sleep deprivation also disrupts reward neural circuitry, usually enhancing brain reactivity to positive experiences.”
From Impact of Sleep and Circadian Rhythms on Addiction Vulnerability in Adolescents (2018) · cites this paper as [87]
A lack of appropriate engagement of limbic-related PFC regions may contribute to altered positive emotional sensitivity and regulatory control under conditions of sleep loss, with cognition being driven more by subcortical affective circuits.
“A lack of appropriate engagement of these limbic-related PFC regions may therefore contribute to altered positive emotional sensitivity and regulatory control under conditions of sleep loss, with cognition being driven more by subcortical affective circuits (Killgore et al., 2006; Killgore et al., 2007; Venkatraman et al., 2007).”
From Sleep deprivation amplifies reactivity of brain reward networks, biasing the appraisal of positive emotional experiences (2011) · cites this paper as Venkatraman et al., 2007
Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · see citing works
The neural basis of economic decision-making in the Ultimatum Game.
Sanfey, A. G., Rilling, J. K., Aronson, J. A., Nystrom, L. E., & Cohen, J. D. (2003) · Science · doi:10.1126/science.1082976 · Cited by 3,375 · see citing works
Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173 · see citing works
Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens
Knutson, B., Adams, C. M., Fong, G. W., & Hommer, D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-16-j0002.2001 · Cited by 2,244 · see citing works
Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154 · see citing works
Abstract reward and punishment representations in the human orbitofrontal cortex
O'Doherty, J., Kringelbach, M. L., Rolls, E. T., Hornak, J., & Andrews, C. (2001) · Nature Neuroscience · doi:10.1038/82959 · Cited by 2,003 · see citing works
The somatic marker hypothesis: A neural theory of economic decision
Bechara, A., & Damasio, A. R. (2005) · Games and Economic Behavior · doi:10.1016/j.geb.2004.06.010 · Cited by 1,986 · see citing works
Effects of Sleep Deprivation on Performance: A Meta-Analysis
Pilcher, J. J., & Huffcutt, A. I. (1996) · Sleep · doi:10.1093/sleep/19.4.318 · Cited by 1,549 · see citing works
The impact of sleep deprivation on decision making: A review.
Harrison, Y., & Horne, J. A. (2000) · Journal of Experimental Psychology: Applied · doi:10.1037/1076-898x.6.3.236 · Cited by 1,238 · see citing works
The Neural Basis of Financial Risk Taking
Kuhnen, C. M., & Knutson, B. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.008 · Cited by 1,182 · see citing works
Thomas, M., Sing, H., Belenky, G., Holcomb, H., Mayberg, H., Dannals, R., Wagner JR., H., Thorne, D., Popp, K., Rowland, L., et al. (2000) · Journal of Sleep Research · doi:10.1046/j.1365-2869.2000.00225.x · Cited by 1,066 · see citing works
Rolls, E. T., Hornak, J., Wade, D., & McGrath, J. (1994) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.12.1518 · Cited by 1,005 · see citing works
Action sets and decisions in the medial frontal cortex
RUSHWORTH, M., WALTON, M., KENNERLEY, S., & BANNERMAN, D. (2004) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2004.07.009 · Cited by 1,004 · see citing works
Distributed Neural Representation of Expected Value
Knutson, B., Taylor, J., Kaufman, M., Peterson, R., & Glover, G. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0642-05.2005 · Cited by 955 · see citing works
Regret and its avoidance: a neuroimaging study of choice behavior
Coricelli, G., Critchley, H., Joffily, M., O’Doherty, J. P., Angela Sirigu, B., & Dolan, R. J. (2005) · Nature Neuroscience · doi:10.1038/nn1514 · Cited by 673 · see citing works
O'Doherty, J., Critchley, H., Deichmann, R., & Dolan, R. J. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-21-07931.2003 · Cited by 611 · see citing works
Neurobiology of Decision Making: A Selective Review from a Neurocognitive and Clinical Perspective
Monique Ernst, D., & Paulus, M. P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.06.004 · Cited by 567 · see citing works
Altered brain response to verbal learning following sleep deprivation
Drummond, S. P. A., Brown, G. G., Gillin, J. C., Stricker, J. L., Wong, E. C., & Buxton, R. B. (2000) · Nature · doi:10.1038/35001068 · Cited by 557 · see citing works
Development of “hot” executive function: The children’s gambling task
Kerr, A., & Zelazo, P. D. (2004) · Brain and Cognition · doi:10.1016/s0278-2626(03)00275-6 · Cited by 529 · see citing works
Elliott, R., Newman, J. L., Longe, O. A., & Deakin, J. F. W. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00303.2003 · Cited by 515 · see citing works
Functional Imaging of Working Memory after 24 Hr of Total Sleep Deprivation
Chee, M. W. L., & Choo, W. C. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.0007-04.2004 · Cited by 509 · see citing works
Self-citationThe Neural Basis of the Psychomotor Vigilance Task
Drummond, S. P. A., Bischoff‐Grethe, A., Dinges, D. F., Ayalon, L., Mednick, S. C., & Meloy, M. J. (2005) · SLEEP · doi:10.1093/sleep/28.9.1059 · Cited by 504 · see citing works
Walton, M. E., Bannerman, D. M., Alterescu, K., & Rushworth, M. F. S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-16-06475.2003 · Cited by 495 · see citing works
Huettel, S. A., Song, A. W., & McCarthy, G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.5070-04.2005 · Cited by 457 · see citing works
Self-citationDorsal striatum responses to reward and punishment: effects of valence and magnitude manipulations
DELGADO, M. R., LOCKE, H. M., STENGER, V. A., & FIEZ, J. A. (2003) · Cognitive, Affective, & Behavioral Neuroscience · doi:10.3758/cabn.3.1.27 · Cited by 431 · see citing works
Prospect theory on the brain? Toward a cognitive neuroscience of decision under risk
Trepel, C., Fox, C. R., & Poldrack, R. A. (2005) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2005.01.016 · Cited by 400 · see citing works
Rogers, R. D., Ramnani, N., Mackay, C. E., Wilson, J. L., Jezzard, P., Carter, C. S., & Smith, S. M. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.012 · Cited by 399 · see citing works
Choice selection and reward anticipation: an fMRI study
Ernst, M., Nelson, E. E., McClure, E. B., Monk, C. S., Munson, S., Eshel, N., Zarahn, E., Leibenluft, E., Zametkin, A., Towbin, K., et al. (2004) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2004.05.011 · Cited by 377 · see citing works
The Effects of Total Sleep Deprivation on Cerebral Responses to Cognitive Performance
Drummond, S. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(01)00325-6 · Cited by 306 · see citing works
The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation
Chuah, L. Y. M., Venkatraman, V., Dinges, D. F., & Chee, M. W. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0906-06.2006 · Cited by 301 · see citing works
Self-citationNeuroimaging of Performance Monitoring: Error Detection and Beyond
Ullsperger, M., & von Cramon, D. Y. (2004) · Cortex · doi:10.1016/s0010-9452(08)70155-2 · Cited by 220 · see citing works
Choo, W.-C., Lee, W.-W., Venkatraman, V., Sheu, F.-S., & Chee, M. W. L. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.11.029 · Cited by 203 · see citing works
Self-citationMu, Q., Mishory, A., Johnson, K. A., Nahas, Z. H., Kozel, F. A., Yamanaka, K., Bohning, D. E., & George, M. S. (2005) · SLEEP · doi:10.1093/sleep/28.4.433 · Cited by 199 · see citing works
Compensatory recruitment after sleep deprivation and the relationship with performance
Drummond, S. P. A., Meloy, M. J., Yanagi, M. A., Orff, H. J., & Brown, G. G. (2005) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2005.06.007 · Cited by 191 · see citing works
Risk-Taking Behavior: Effects of Ethanol, Caffeine, and Basal Sleepiness
Roehrs, T., Greenwald, M. K., & Roth, T. G. (2004) · SLEEP · doi:10.1093/sleep/27.5.887 · Cited by 53 · see citing works
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Neurocognitive consequences of sleep deprivation
Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154 · see citing works
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477 · see citing works
Effects of sleep deprivation on cognition
Killgore, W. D. S. (2010) · Progress in Brain Research · doi:10.1016/b978-0-444-53702-7.00007-5 · Cited by 1,421 · see citing works
The sleep-deprived human brain
Krause, A. J., Simon, E. B., Mander, B. A., Greer, S. M., Saletin, J. M., Goldstein-Piekarski, A. N., & Walker, M. P. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.55 · Cited by 1,200 · see citing works
Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease
Wulff, K., Gatti, S., Wettstein, J. G., & Foster, R. G. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2868 · Cited by 1,055 · see citing works
The role of sleep in emotional brain function
Goldstein, A. N., & Walker, M. P. (2014) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032813-153716 · Cited by 1,052 · see citing works
“One night of sleep deprivation elevates anticipatory activity within the reward-sensitive region of the striatum to monetary decisions that can lead to either future reward payoffs or losses – especially when those gambles are risky (Venkatraman et al 2007).”
BackgroundSleep and emotion regulation: An organizing, integrative review
Palmer, C. A., & Alfano, C. A. (2017) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2015.12.006 · Cited by 935 · see citing works
Risky business: the neuroeconomics of decision making under uncertainty
Platt, M. L., & Huettel, S. A. (2008) · Nature Neuroscience · doi:10.1038/nn2062 · Cited by 556 · see citing works
Self-citationGujar, N., Yoo, S.-S., Hu, P., & Walker, M. P. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.3220-10.2011 · Cited by 491 · see citing works
Circadian rhythms, sleep deprivation, and human performance
Goel, N., Basner, M., Rao, H., & Dinges, D. F. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00007-5 · Cited by 400 · see citing works
Minkel, J. D., Banks, S., Htaik, O., Moreta, M. C., Jones, C. W., McGlinchey, E. L., Simpson, N. S., & Dinges, D. F. (2012) · Emotion · doi:10.1037/a0026871 · Cited by 379 · see citing works
The impact of sleep deprivation on food desire in the human brain
Greer, S. M., Goldstein, A. N., & Walker, M. P. (2013) · Nature Communications · doi:10.1038/ncomms3259 · Cited by 375 · see citing works
Reduced Orbitofrontal and Parietal Gray Matter in Chronic Insomnia: A Voxel-Based Morphometric Study
Altena, E., Vrenken, H., Van Der Werf, Y. D., van den Heuvel, O. A., & Van Someren, E. J. W. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.003 · Cited by 330 · see citing works
The effects of poor quality sleep on brain function and risk taking in adolescence
Telzer, E. H., Fuligni, A. J., Lieberman, M. D., & Galván, A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.01.025 · Cited by 296 · see citing works
Grandner, M. A., Patel, N. P., Gehrman, P. R., Perlis, M. L., & Pack, A. I. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.08.001 · Cited by 291 · see citing works
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Tucker, A. M., Whitney, P., Belenky, G., Hinson, J. M., & Van Dongen, H. P. (2010) · SLEEP · doi:10.1093/sleep/33.1.47 · Cited by 287 · see citing works
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Holm, S. M., Forbes, E. E., Ryan, N. D., Phillips, M. L., Tarr, J. A., & Dahl, R. E. (2009) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2009.04.001 · Cited by 174 · see citing works
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Hasler, B. P., Dahl, R. E., Holm, S. M., Jakubcak, J. L., Ryan, N. D., Silk, J. S., Phillips, M. L., & Forbes, E. E. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2012.08.008 · Cited by 145 · see citing works
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Chuah, L. Y., & Chee, M. W. (2008) · Annals of the Academy of Medicine, Singapore · doi:10.47102/annals-acadmedsg.v37n8p669 · Cited by 96 · see citing works
Self-citationKILLGORE, W. D. S., KAMIMORI, G. H., & BALKIN, T. J. (2011) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2010.00893.x · Cited by 90 · see citing works
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Libedinsky, C., Smith, D. V., Teng, C. S., Namburi, P., Chen, V. W., Huettel, S. A., & Chee, M. W. L. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00070 · Cited by 79 · see citing works
Self-citationChee, M. W. L., Goh, C. S. F., Namburi, P., Parimal, S., Seidl, K. N., & Kastner, S. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.06.058 · Cited by 81 · see citing works
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Perogamvros, L., Dang-Vu, T. T., Desseilles, M., & Schwartz, S. (2013) · Frontiers in Psychology · doi:10.3389/fpsyg.2013.00474 · Cited by 77 · see citing works
“…and REM sleep deprivation on emotional and reward functions at the behavioral (Killgore et al., 2006; Banks and Dinges, 2007), neurobiological (Venkatraman et al., 2007; Yoo et al., 2007; Gujar et al., 2011b; Menz et al., 2012) and clinical (Riemann et al., 2002; Salvadore et al., 2010)…”
BackgroundMcKenna, B. S., & Eyler, L. T. (2012) · Clinical Psychology Review · doi:10.1016/j.cpr.2012.07.003 · Cited by 69 · see citing works
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Hasler, B. P., Casement, M. D., Sitnick, S. L., Shaw, D. S., & Forbes, E. E. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.02.024 · Cited by 59 · see citing works
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- Authors
- Venkatraman, V., Chuah, Y. L., Huettel, S. A., & Chee, M. W.
- Affiliations
- Duke-NUS Medical School (SG)
- Duke University (US)
- National University of Singapore (SG)
- Venue
- SLEEP
- Publisher
- Oxford University Press (OUP)
- Published
- 2007-05
- Volume
- 30
- Issue
- 5
- Pages
- 603-609
- ISSN
- 0161-8105 (ISSN-L)
- 1550-9109
- OpenAlex
- W2124519719
- Cited by
- 359
- References
- 35
- Citations by year
- 2026: 10 · 2025: 20 · 2024: 15 · 2023: 15 · 2022: 17 · 2021: 28 · 2020: 20 · 2019: 28 · 2018: 19 · 2017: 21 · 2016: 19 · 2015: 23 · 2014: 15 · 2013: 24 · 2012: 34
- FWCI
- 13.99
- Type
- journal article
- Language
- en
- Open access
- green
- papers.ssrn.com
- Locations
- SLEEP (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- SSRN Electronic Journal (submittedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- sleep deprivation, risky decision making, gambling task, nucleus accumbens, insula, orbitofrontal cortex, loss aversion, reward anticipation, emotional processing
- MeSH terms
- Adult, Affect, Brain Mapping, Cerebral Cortex, Choice Behavior, Decision Making, Dominance, Cerebral, Female, Frontal Lobe, Gambling, Humans, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Reaction Time, Reward, Set, Psychology, Sleep Deprivation
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