Cited by 64Functional Brain Connectivity StudiesNeural and Behavioral Psychology StudiesNeural dynamics and brain function

Brain state expression and transitions are related to complex executive cognition in normative neurodevelopment

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Medaglia, John D., Satterthwaite, Theodore D., Kelkar, Apoorva, Ciric, Rastko, Moore, Tyler M., Ruparel, Kosha, Gur, Ruben C., Gur, Raquel E. +1 more·2018·NeuroImage

Abstract

Adolescence is marked by rapid development of executive function. Mounting evidence suggests that executive function in adults may be driven by dynamic control of neurophysiological processes. Yet, how these dynamics evolve over adolescence and contribute to cognitive development is unknown. In a sample of 780 youth aged 8-22 yr (42.7% male) from the Philadelphia Neurodevelopment Cohort, we use a dynamic graph approach to extract activation states in BOLD fMRI data from 264 brain regions. We construct a graph in which each observation in time is a node and the similarity in brain states at two different times is an edge. Using this graphical approach, we identify two primary brain states reminiscent of intrinsic and task-evoked systems. We show that time spent in these two states is higher in older adolescents, as is the flexibility with which the brain switches between them. Increasing time spent in primary states and flexibility among states relates to increases in a complex executive accuracy factor score over adolescence. Flexibility is more positively associated with accuracy toward early adulthood. These findings suggest that brain state dynamics are associated with complex executive function across a critical period of adolescence.

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Crossref · 10.1016/j.neuroimage.2017.10.048

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  • Recent studies of executive control networks show changes in network expression and variability with development, interpreted as increased flexibility of frontoparietal brain regions with age.

    “Recent studies examining executive control networks demonstrate changes in network expression and variability with development, interpreted as increased flexibility of frontoparietal brain regions with age (56,57).”

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  1. Bassett DS Porter MA Wymbs NF Grafton ST Carlson JM Mucha PJ 2013b Robust detection of dynamic community structure in networks Chaos 23 013142 23556979 PMC3618100
  2. Mattar MG Cole MW Thompson-Schill SL Bassett DS 2015b A functional cartography of cognitive systems PLoS Comput Biol 11 e1004533 26629847 PMC4668064
  3. Power JD Cohen AL Nelson SM Wig GS Barnes KA Church JA Vogel AC Laumann TO Miezin FM Schlaggar BL 2011b Functional network organization of the human brain Neuron 72 665 678 22099467 PMC3222858

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Authors
Medaglia, J. D., Satterthwaite, T. D., Kelkar, A., Ciric, R., Moore, T. M., Ruparel, K., Gur, R. C., Gur, R. E., & Bassett, D. S.
Affiliations
  • Drexel University (US)
  • University of Pennsylvania (US)
Corresponding author
Bassett, Danielle S.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2018-02
Volume
166
Pages
293-306
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2767296169
Cited by
64
References
117
Citations by year
2026: 5 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 6 · 2020: 11 · 2019: 5 · 2018: 13
FWCI
4.55
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Army Research Office (R01-MH107703, R01-MH-107235, R01-HD-086888-01, R01-MH-109520, R21-MH-106799, W911NF-10-2-0022, R01-DC-009209-11, W911NF-14-1-0679, R01-NS-099348)
  • National Institute of Mental Health (R01MH112847, R01MH107703, R21MH106799, R01MH107235, MH089924, MH089983)
  • John D. and Catherine T. MacArthur Foundation
  • Perelman School of Medicine, University of Pennsylvania
  • National Institutes of Health (1-DP5-OD-021352-01, 1-R01-DC-014960-01)
  • Office of Naval Research
  • Army Research Laboratory
  • Alfred P. Sloan Foundation
  • National Science Foundation (BCS-1631550, CNS-1626008, BCS-1441502, PHY-1554488)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
brain state dynamics, executive function, adolescence, brain development, brain state transitions, intrinsic brain activity, cognitive development, Philadelphia Neurodevelopmental Cohort
MeSH terms
Adolescent, Adult, Brain, Child, Female, Humans, Magnetic Resonance Imaging, Male, Adolescent Development, Young Adult, Executive Function, Functional Neuroimaging

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