Brain state expression and transitions are related to complex executive cognition in normative neurodevelopment
Open accessAbstract
Adolescence is marked by rapid development of executive function. Mounting evidence suggests that executive function in adults may be driven by dynamic control of neurophysiological processes. Yet, how these dynamics evolve over adolescence and contribute to cognitive development is unknown. In a sample of 780 youth aged 8-22 yr (42.7% male) from the Philadelphia Neurodevelopment Cohort, we use a dynamic graph approach to extract activation states in BOLD fMRI data from 264 brain regions. We construct a graph in which each observation in time is a node and the similarity in brain states at two different times is an edge. Using this graphical approach, we identify two primary brain states reminiscent of intrinsic and task-evoked systems. We show that time spent in these two states is higher in older adolescents, as is the flexibility with which the brain switches between them. Increasing time spent in primary states and flexibility among states relates to increases in a complex executive accuracy factor score over adolescence. Flexibility is more positively associated with accuracy toward early adulthood. These findings suggest that brain state dynamics are associated with complex executive function across a critical period of adolescence.
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Recent studies of executive control networks show changes in network expression and variability with development, interpreted as increased flexibility of frontoparietal brain regions with age.
“Recent studies examining executive control networks demonstrate changes in network expression and variability with development, interpreted as increased flexibility of frontoparietal brain regions with age (56,57).”
From Brain Mechanisms Supporting Flexible Cognition and Behavior in Adolescents With Autism Spectrum Disorder (2021) · cites this paper as [57]
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- Authors
- Medaglia, J. D., Satterthwaite, T. D., Kelkar, A., Ciric, R., Moore, T. M., Ruparel, K., Gur, R. C., Gur, R. E., & Bassett, D. S.
- Affiliations
- Drexel University (US)
- University of Pennsylvania (US)
- Corresponding author
- Bassett, Danielle S.
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2018-02
- Volume
- 166
- Pages
- 293-306
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC5747984
- OpenAlex
- W2767296169
- Cited by
- 64
- References
- 117
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 8 · 2022: 7 · 2021: 6 · 2020: 11 · 2019: 5 · 2018: 13
- FWCI
- 4.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- NeuroImage (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Army Research Office (R01-MH107703, R01-MH-107235, R01-HD-086888-01, R01-MH-109520, R21-MH-106799, W911NF-10-2-0022, R01-DC-009209-11, W911NF-14-1-0679, R01-NS-099348)
- National Institute of Mental Health (R01MH112847, R01MH107703, R21MH106799, R01MH107235, MH089924, MH089983)
- John D. and Catherine T. MacArthur Foundation
- Perelman School of Medicine, University of Pennsylvania
- National Institutes of Health (1-DP5-OD-021352-01, 1-R01-DC-014960-01)
- Office of Naval Research
- Army Research Laboratory
- Alfred P. Sloan Foundation
- National Science Foundation (BCS-1631550, CNS-1626008, BCS-1441502, PHY-1554488)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- brain state dynamics, executive function, adolescence, brain development, brain state transitions, intrinsic brain activity, cognitive development, Philadelphia Neurodevelopmental Cohort
- MeSH terms
- Adolescent, Adult, Brain, Child, Female, Humans, Magnetic Resonance Imaging, Male, Adolescent Development, Young Adult, Executive Function, Functional Neuroimaging
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