Cited by 371Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital heart defects research

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Dlx1 and Dlx2 Control Neuronal versus Oligodendroglial Cell Fate Acquisition in the Developing Forebrain

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Petryniak, Magdalena A., Potter, Gregory B., Rowitch, David H., Rubenstein, John L.R.·2007·Neuron

DOI 10.1016/j.neuron.2007.06.036PMC PMC2039927

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Abstract

Progenitors within the ventral telencephalon can generate GABAergic neurons and oligodendrocytes, but regulation of the neuron-glial switch is poorly understood. We investigated the combinatorial expression and function of Dlx1&2, Olig2, and Mash1 transcription factors in the ventral telencephalon. We show that Dlx homeobox transcription factors, required for GABAergic interneuron production, repress oligodendrocyte precursor cell (OPC) formation by acting on a common progenitor to determine neuronal versus oligodendroglial cell fate acquisition. We demonstrate that Dlx1&2 negatively regulate Olig2-dependant OPC formation and that Mash1 promotes OPC formation by restricting the number of Dlx+ progenitors. Progenitors transplanted from Dlx1&2 mutant ventral telencephalon into newborn wild-type mice do not produce neurons but differentiate into myelinating oligodendrocytes that survive into adulthood. Our results identify another role for Dlx genes as modulators of neuron versus oligodendrocyte development in the ventral embryonic forebrain.

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Authors: Petryniak, M. A., Potter, G. B., Rowitch, D. H., & Rubenstein, J. L. R.
Affiliations: University of California, San Francisco (US)
Corresponding author: Potter, Gregory B.
Rubenstein, John L.R.
ORCID: Potter, Gregory B.
Rowitch, David H.
Rubenstein, John L.R.
Venue: Neuron
Publisher: Elsevier BV
Published: 2007-08
Volume: 55
Issue: 3
Pages: 417-433
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2007.06.036
PMC: PMC2039927
OpenAlex: W2031224620
Cited by: 371
References: 72
Citations by year: 2026: 15 · 2025: 19 · 2024: 10 · 2023: 15 · 2022: 27 · 2021: 26 · 2020: 24 · 2019: 17 · 2018: 11 · 2017: 19 · 2016: 16 · 2015: 19 · 2014: 19 · 2013: 34 · 2012: 9
FWCI: 7.06
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 2213 d)
Locations: Neuron (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R01 MH4942801, F32MH070211, K05MH065670, R01MH049428, R37MH049428)
National Institute of Neurological Disorders and Stroke (R01NS40511, L40 NS056772, R01NS040511)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-07162H, T32HD007162)
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
Keywords: DLX1, Dlx2, oligodendrocyte precursor cells, GABAergic interneurons, ventral telencephalon, Olig2, ASCL1, transcription factors, forebrain development, myelination
MeSH terms: Oligodendrocyte Transcription Factor 2, Animals, Animals, Newborn, Cell Differentiation, Cell Division, Cell Movement, Cerebral Ventricles, Myelin Basic Protein, Mutation, Nerve Tissue Proteins, Neurons, Oligodendroglia, Stem Cells, Telencephalon, Time Factors, Transcription Factors, Prosencephalon, Homeodomain Proteins, Stem Cell Transplantation, Mice, Basic Helix-Loop-Helix Proteins

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Dlx1 and Dlx2 Control Neuronal versus Oligodendroglial Cell Fate Acquisition in the Developing Forebrain

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