CoChat
Sign Up
Cited by 223Neuroscience and Neuropharmacology ResearchCell Adhesion Molecules ResearchGenetics and Neurodevelopmental Disorders

The DOI matches its Crossref record; 69 of the 70 references it cites were found in a registry or an index.

Activity-Dependent Regulation of Synaptic AMPA Receptor Composition and Abundance by β3 Integrins

Open access
Cingolani, Lorenzo A., Thalhammer, Agnes, Yu, Lily M.Y., Catalano, Myriam, Ramos, Timothy, Colicos, Michael A., Goda, Yukiko·2008·Neuron
DOI 10.1016/j.neuron.2008.04.011PMC PMC2446609
Open this paper in CoChat — free accountOpen PDF

Abstract

At synapses, cell adhesion molecules (CAMs) provide the molecular framework for coordinating signaling events across the synaptic cleft. Among synaptic CAMs, the integrins, receptors for extracellular matrix proteins and counterreceptors on adjacent cells, are implicated in synapse maturation and plasticity and memory formation. However, little is known about the molecular mechanisms of integrin action at central synapses. Here, we report that postsynaptic beta3 integrins control synaptic strength by regulating AMPA receptors (AMPARs) in a subunit-specific manner. Pharmacological perturbation targeting beta3 integrins promotes endocytosis of GluR2-containing AMPARs via Rap1 signaling, and expression of beta3 integrins produces robust changes in the abundance and composition of synaptic AMPARs without affecting dendritic spine structure. Importantly, homeostatic synaptic scaling induced by activity deprivation elevates surface expression of beta3 integrins, and in turn, beta3 integrins are required for synaptic scaling. Our findings demonstrate a key role for integrins in the feedback regulation of excitatory synaptic strength.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.neuron.2008.04.011

Cites

69 of 69 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Cited by

Sorted by citations

See all 223

Related

See all

Metadata

Authors
Cingolani, L. A., Thalhammer, A., Yu, L. M. Y., Catalano, M., Ramos, T., Colicos, M. A., & Goda, Y.
Affiliations
  • MRC Laboratory for Molecular Cell Biology (GB)
  • University College London (GB)
  • University of Calgary (CA)
Corresponding author
  • Cingolani, Lorenzo A.
  • Goda, Yukiko
ORCID
Venue
Neuron
Publisher
Elsevier BV
Published
2008-06
Volume
58
Issue
5
Pages
749-762
ISSN
0896-6273 (ISSN-L)
DOI
10.1016/j.neuron.2008.04.011
PMC
PMC2446609
OpenAlex
W1983897183
Cited by
223
References
70
Citations by year
2026: 6 · 2025: 7 · 2024: 7 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 9 · 2019: 7 · 2018: 9 · 2017: 6 · 2016: 17 · 2015: 12 · 2014: 19 · 2013: 18 · 2012: 18
FWCI
8.50
Type
journal article
Language
en
Open access
Licence
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • ArTS Archivio della ricerca di Trieste (University of Trieste https://www.units.it/) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (R01MH066676, R01MH66676)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
CD61, AMPA receptors, GluR2, Rap1 signaling, synaptic scaling, homeostatic plasticity, activity-dependent regulation, synaptic efficacy, receptor internalization, dendritic spines, excitatory synapses
MeSH terms
Animals, Chelating Agents, Egtazic Acid, Endocytosis, Gene Expression Regulation, Hippocampus, Neural Inhibition, Neurons, Peptides, Platelet Aggregation Inhibitors, Synapses, Time Factors, Transfection, Presynaptic Terminals, Receptors, AMPA, Mice, Knockout, Patch-Clamp Techniques, Excitatory Amino Acids, Bridged Bicyclo Compounds, Heterocyclic, Excitatory Postsynaptic Potentials, rap1 GTP-Binding Proteins, Intercellular Signaling Peptides and Proteins, Integrin beta3, Mice, Rats, Thiazolidines, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review