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Separate Neural Mechanisms Underlie Choices and Strategic Preferences in Risky Decision Making
Open accessAbstract
Adaptive decision making in real-world contexts often relies on strategic simplifications of decision problems. Yet, the neural mechanisms that shape these strategies and their implementation remain largely unknown. Using an economic decision-making task, we dissociate brain regions that predict specific choices from those predicting an individual's preferred strategy. Choices that maximized gains or minimized losses were predicted by functional magnetic resonance imaging activation in ventromedial prefrontal cortex or anterior insula, respectively. However, choices that followed a simplifying strategy (i.e., attending to overall probability of winning) were associated with activation in parietal and lateral prefrontal cortices. Dorsomedial prefrontal cortex, through differential functional connectivity with parietal and insular cortex, predicted individual variability in strategic preferences. Finally, we demonstrate that robust decision strategies follow from neural sensitivity to rewards. We conclude that decision making reflects more than compensatory interaction of choice-related regions; in addition, specific brain systems potentiate choices depending on strategies, traits, and context.
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“Indeed, activity in the AIC is a common feature in studies of cognitive control and inhibitory processing [7, 46–50] and reward sensitivity [8, 9].”
From The role of the anterior insula in adolescent decision making (2014) · cites this paper as [47]
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Metadata
- Authors
- Venkatraman, V., Payne, J. W., Bettman, J. R., Luce, M. F., & Huettel, S. A.
- Affiliations
- Duke University (US)
- Corresponding author
- Huettel, Scott A.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2009-05
- Volume
- 62
- Issue
- 4
- Pages
- 593-602
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC3213208
- OpenAlex
- W2151417045
- Cited by
- 222
- References
- 72
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 4 · 2023: 10 · 2022: 6 · 2021: 13 · 2020: 9 · 2019: 14 · 2018: 10 · 2017: 9 · 2016: 17 · 2015: 21 · 2014: 19 · 2013: 15 · 2012: 22
- FWCI
- 9.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1538 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Neuron (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Public Health Service (NIMH-70685, NINDS 41328)
- National Institute of Mental Health (R01MH070685)
- National Institute of Neurological Disorders and Stroke (P01NS041328)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Decision Sciences › General Decision Sciences › Decision-Making and Behavioral Economics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- risky decision making, strategic preferences, decision strategies, ventromedial prefrontal cortex, anterior insula, dorsomedial prefrontal cortex, parietal cortex, lateral prefrontal cortex, functional connectivity, individual differences, reward sensitivity
- MeSH terms
- Adolescent, Adult, Brain Mapping, Cerebral Cortex, Choice Behavior, Female, Gambling, Humans, Image Processing, Computer-Assisted, Individuality, Magnetic Resonance Imaging, Male, Nerve Net, Neuropsychological Tests, Oxygen, Predictive Value of Tests, Probability, Reward, Risk-Taking, Logistic Models, Young Adult
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