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The Neurology of mTOR

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Lipton, Jonathan O., Sahin, Mustafa·2014·Neuron

DOI 10.1016/j.neuron.2014.09.034

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Abstract

The mechanistic target of rapamycin (mTOR) signaling pathway is a crucial cellular signaling hub that, like the nervous system itself, integrates internal and external cues to elicit critical outputs including growth control, protein synthesis, gene expression, and metabolic balance. The importance of mTOR signaling to brain function is underscored by the myriad disorders in which mTOR pathway dysfunction is implicated, such as autism, epilepsy, and neurodegenerative disorders. Pharmacological manipulation of mTOR signaling holds therapeutic promise and has entered clinical trials for several disorders. Here, we review the functions of mTOR signaling in the normal and pathological brain, highlighting ongoing efforts to translate our understanding of cellular physiology into direct medical benefit for neurological disorders.

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See all 736

Authors: Lipton, J. O., & Sahin, M.
Venue: Neuron
Publisher: Elsevier BV
Published: 2014-10
Volume: 84
Issue: 2
Pages: 275-291
ISSN: 0896-6273 (ISSN-L)
DOI: 10.1016/j.neuron.2014.09.034
OpenAlex: W2111444310
Cited by: 736
References: 62
FWCI: 16.79
Type: journal article
Language: en
Open access: bronze

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The Neurology of mTOR

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