Linking pattern completion in the hippocampus to predictive coding in visual cortex
Open accessAbstract
Models of predictive coding frame perception as a generative process in which expectations constrain sensory representations. These models account for expectations about how a stimulus will move or change from moment to moment, but do not address expectations about what other, distinct stimuli are likely to appear based on prior experience. We show that such memory-based expectations in human visual cortex are related to the hippocampal mechanism of pattern completion.
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A putative memory-based predictive-coding retrieval mechanism has been identified in the human hippocampus, where engrams of compound patterns are identified or completed and sent to cortex to construct perceptual predictions.
“A putative memory-based predictive-coding retrieval mechanism was recently identified in the human hippocampus, where engrams of compound patterns are identified (or completed, in situations in which the input is partial), and then sent to the cortex in order to construct perceptual predictions regarding the sensory inputs (Hindy et al., 2016).”
From The Transition to Minimal Consciousness through the Evolution of Associative Learning (2016) · cites this paper as Hindy et al., 2016
The Abstract describes hippocampal pattern completion as a candidate mechanism: partial input can activate a representation of an entire experience, which may support expectations in visual cortex. But the paper says its findings only suggest this mechanism and that fMRI cannot establish the direction of information transfer; the claim overstates it as an identified process in which representations are sent to cortex. (LLM, conf=0.86)
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- Authors
- Hindy, N. C., Ng, F. Y., & Turk-Browne, N. B.
- Affiliations
- Princeton University (US)
- Corresponding author
- Hindy, Nicholas C
- ORCID
- Hindy, Nicholas C
- Venue
- Nature Neuroscience
- Published
- 2016-04-11
- Volume
- 19
- Issue
- 5
- Pages
- 665-667
- ISSN
- 1097-6256 (ISSN-L)
- 1546-1726
- PMC
- PMC4948994
- OpenAlex
- W2325506870
- Cited by
- 246
- References
- 39
- Citations by year
- 2026: 20 · 2025: 28 · 2024: 28 · 2023: 29 · 2022: 22 · 2021: 29 · 2020: 25 · 2019: 25 · 2018: 18 · 2017: 13 · 2016: 8 · 2014: 1
- FWCI
- 13.44
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Princeton University
- National Institutes of Health (1s10od016277-01)
- National Eye Institute (F32EY023162, R01EY021755)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- pattern completion, predictive coding, hippocampus, visual cortex, perceptual expectations, prior experience, hippocampal subfields, visual perception
- MeSH terms
- Adolescent, Adult, Female, Hippocampus, Humans, Male, Memory, Photic Stimulation, Visual Cortex, Visual Perception, Young Adult
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