Forced and voluntary exercise differentially affect brain and behavior

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880

Running enhances neurogenesis, learning, and long-term potentiation in mice

van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904

Plant-Derived Flavanol (−)Epicatechin Enhances Angiogenesis and Retention of Spatial Memory in Mice

van Praag, H., Lucero, M. J., Yeo, G. W., Stecker, K., Heivand, N., Zhao, C., Yip, E., Afanador, M., Schroeter, H., Hammerstone, J., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0914-07.2007 · Cited by 303

Exercise intensity influences the temporal profile of growth factors involved in neuronal plasticity following focal ischemia.

Ploughman, M., Granter-Button, S., Chernenko, G., Attwood, Z., Tucker, B. A., Mearow, K. M., & Corbett, D. (2007) · Brain Research · doi:10.1016/j.brainres.2007.02.065 · Cited by 170

Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats

Fediuc, S., Campbell, J. E., & Riddell, M. C. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01416.2005 · Cited by 148

Potential Therapeutic Effects of Exercise to the Brain

Ang, E., Gomez-Pinilla, F., Ang, E., & Gomez-Pinilla, F. (2007) · Current Medicinal Chemistry · doi:10.2174/092986707782023280 · Cited by 129

Activity wheel running reduces escape latency and alters brain monoamine levels after footshock

Dishman, R. K., Renner, K. J., Youngstedt, S. D., Reigle, T. G., Bunnell, B. N., Burke, K. A., Yoo, H. S., Mougey, E. H., & Meyerhoff, J. L. (1997) · Brain Research Bulletin · doi:10.1016/s0361-9230(96)00329-2 · Cited by 128

Extended voluntary running inhibits exercise-induced adult hippocampal progenitor proliferation in the spontaneously hypertensive rat.

Naylor, A. S., Persson, A. I., Eriksson, P. S., Jonsdottir, I. H., & Thorlin, T. (2005) · Journal of Neurophysiology · doi:10.1152/jn.01085.2004 · Cited by 127

Exercise and the brain: something to chew on

van Praag, H. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2008.12.007 · Cited by 599

The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: human and rodent perspectives

Garland, T., Schutz, H., Chappell, M. A., Keeney, B. K., Meek, T. H., Copes, L. E., Acosta, W., Drenowatz, C., Maciel, R. C., van Dijk, G., et al. (2011) · Journal of Experimental Biology · doi:10.1242/jeb.048397 · Cited by 444

Voluntary exercise induces anxiety‐like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis

Fuss, J., Ben Abdallah, N. M. ‐., Vogt, M. A., Touma, C., Pacifici, P. G., Palme, R., Witzemann, V., Hellweg, R., & Gass, P. (2010) · Hippocampus · doi:10.1002/hipo.20634 · Cited by 240

Potential Mechanisms Underlying Centralized Pain and Emerging Therapeutic Interventions

Eller-Smith, O. C., Nicol, A. L., & Christianson, J. A. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00035 · Cited by 227

Exercise prevents sleep deprivation-associated anxiety-like behavior in rats: Potential role of oxidative stress mechanisms

Vollert, C., Zagaar, M., Hovatta, I., Taneja, M., Vu, A., Dao, A., Levine, A., Alkadhi, K., & Salim, S. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.05.010 · Cited by 207

Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I

Liu, Y., Chen, H., Wu, C., Kuo, Y., Yu, L., Huang, A., Wu, F., Chuang, J., & Jen, C. J. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.173088 · Cited by 199

Exercise, Stress Resistance, and Central Serotonergic Systems

Greenwood, B. N., & Fleshner, M. (2011) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31821f7e45 · Cited by 183

Exercising the worry away: how inflammation, oxidative and nitrogen stress mediates the beneficial effect of physical activity on anxiety disorder symptoms and behaviours

Moylan, S., Eyre, H. A., Maes, M., Baune, B. T., Jacka, F. N., & Berk, M. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.003 · Cited by 155

Effects of voluntary and involuntary exercise on cognitive functions, and VEGF and BDNF levels in adolescent rats.

Uysal, N., Kiray, M., Sisman, A., Camsari, U., Gencoglu, C., Baykara, B., Cetinkaya, C., & Aksu, I. (2015) · Biotechnic & Histochemistry · doi:10.3109/10520295.2014.946968 · Cited by 154

Functional analysis of neurovascular adaptations to exercise in the dentate gyrus of young adult mice associated with cognitive gain.

Clark, P. J., Brzezinska, W. J., Puchalski, E. K., Krone, D. A., & Rhodes, J. S. (2009) · Hippocampus · doi:10.1002/hipo.20543 · Cited by 138

Ablating adult neurogenesis in the rat has no effect on spatial processing: evidence from a novel pharmacogenetic model

Groves, J. O., Leslie, I., Huang, G.-J., McHugh, S. B., Taylor, A., Mott, R., Munafò, M., Bannerman, D. M., & Flint, J. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003718 · Cited by 121

Running Changes the Brain: the Long and the Short of It

Vivar, C., & van Praag, H. (2017) · Physiology · doi:10.1152/physiol.00017.2017 · Cited by 114

Neuroprotective Effects of Exercise Treatments after Injury: The Dual Role of Neurotrophic Factors

Cobianchi, S., Arbat-Plana, A., Lopez-Alvarez, V. M., & Navarro, X. (2017) · Current Neuropharmacology · doi:10.2174/1570159x14666160330105132 · Cited by 94

Effects of acute treadmill running at different intensities on activities of serotonin and corticotropin-releasing factor neurons, and anxiety- and depressive-like behaviors in rats

Otsuka, T., Nishii, A., Amemiya, S., Kubota, N., Nishijima, T., & Kita, I. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.10.055 · Cited by 86

Adolescent voluntary exercise attenuated hippocampal innate immunity responses and depressive-like behaviors following maternal separation stress in male rats

Sadeghi, M., Peeri, M., & Hosseini, M.-J. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.05.017 · Cited by 83

Long-term physical exercise induces changes in sirtuin 1 pathway and oxidative parameters in adult rat tissues

Bayod, S., del Valle, J., Lalanza, J. F., Sanchez-Roige, S., de Luxán-Delgado, B., Coto-Montes, A., Canudas, A. M., Camins, A., Escorihuela, R. M., & Pallàs, M. (2012) · Experimental Gerontology · doi:10.1016/j.exger.2012.08.004 · Cited by 77

Beneficial effects of fluoxetine, reboxetine, venlafaxine, and voluntary running exercise in stressed male rats with anxiety- and depression-like behaviors

Lapmanee, S., Charoenphandhu, J., & Charoenphandhu, N. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.05.018 · Cited by 78

The benefits of exercise on structural and functional plasticity in the rodent hippocampus of different disease models.

Patten, A. R., Yau, S. Y., Fontaine, C. J., Meconi, A., Wortman, R. C., & Christie, B. R. (2015) · Brain Plasticity · doi:10.3233/bpl-150016 · Cited by 64

Use it and boost it with physical and mental activity.

Korol, D. L., Gold, P. E., & Scavuzzo, C. J. (2013) · Hippocampus · doi:10.1002/hipo.22197 · Cited by 45

Interplay between hormones and exercise on hippocampal plasticity across the lifespan

Bettio, L. E. B., Thacker, J. S., Rodgers, S. P., Brocardo, P. S., Christie, B. R., & Gil-Mohapel, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165821 · Cited by 40

Cardiac oxidative stress following maternal separation stress was mitigated following adolescent voluntary exercise in adult male rat

Sahafi, E., Peeri, M., Hosseini, M.-J., & Azarbyjani, M. A. (2018) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.10.022 · Cited by 32

Interaction between intensity and duration of acute exercise on neuronal activity associated with depression-related behavior in rats

Morikawa, R., Kubota, N., Amemiya, S., Nishijima, T., & Kita, I. (2021) · The Journal of Physiological Sciences · doi:10.1186/s12576-020-00788-5 · Cited by 22

Voluntary wheel running with and without follistatin overexpression improves NMJ transmission but not motor unit loss in late life of C57BL/6J mice

Chugh, D., Iyer, C. C., Bobbili, P., Blatnik, A. J., Kaspar, B. K., Meyer, K., Burghes, A. H., Clark, B. C., & Arnold, W. D. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.01.012 · Cited by 17

Exercise Does Not Protect against Peripheral and Central Effects of a High Cholesterol Diet Given Ad libitum in Old ApoE−/− Mice

Di Cataldo, V., Géloën, A., Langlois, J.-B., Chauveau, F., Thézé, B., Hubert, V., Wiart, M., Chirico, E. N., Rieusset, J., Vidal, H., et al. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00453 · Cited by 15