The human amygdala is involved in general behavioral relevance detection: evidence from an event-related functional magnetic resonance imaging Go-NoGo task
Open accessAbstract
The amygdala is classically regarded as a detector of potential threat and as a critical component of the neural circuitry mediating conditioned fear responses. However, it has been reported that the human amygdala responds to multiple expressions of emotions as well as emotionally neutral stimuli of a novel, uncertain or ambiguous nature. Thus, it has been proposed that the function of the amygdala may be of a more general art, i.e. as a detector of behaviorally relevant stimuli [Sander D, Grafman J, Zalla T (2003) The human amygdala: an evolved system for relevance detection. Rev Neurosci 14:303-316]. To investigate this putative function of the amygdala, we used event related functional magnetic resonance imaging (fMRI) and a modified Go-NoGo task composed of behaviorally relevant and irrelevant letter and number stimuli. Analyses revealed bilateral amygdala activation in response to letter stimuli that were behaviorally relevant as compared with letters with less behavioral relevance. Similar results were obtained for relatively infrequent NoGo relevant stimuli as compared with more frequent Go stimuli. Our findings support a role for the human amygdala in general detection of behaviorally relevant stimuli.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The amygdala is an important target of OT administration.
“Converging evidence from this field suggests the amygdalaa key brain region for emotion regulation (LeDoux, 2003), processing (Seeley et al., 2007), detection (Ousdal et al., 2008), and vigilance for social cues across sensory modalities (Whalen, 2007) is an important target of OT administration.”
From Low dose intranasal oxytocin delivered with Breath Powered device dampens amygdala response to emotional stimuli: A peripheral effect-controlled within-subjects randomized dose-response fMRI trial (2016) · cites this paper as Ousdal et al., 2008
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
LeDoux, J. E. (2000) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.23.1.155 · Cited by 8,444 · see citing works
A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data
Eickhoff, S. B., Stephan, K. E., Mohlberg, H., Grefkes, C., Fink, G. R., Amunts, K., & Zilles, K. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.12.034 · Cited by 4,033 · see citing works
Fears, phobias, and preparedness: toward an evolved module of fear and fear learning
Öhman, A., & Mineka, S. (2001) · Psychological Review · doi:10.1037/0033-295x.108.3.483 · Cited by 3,147 · see citing works
The amygdala: vigilance and emotion
Davis, M., & Whalen, P. J. (2001) · Molecular Psychiatry · doi:10.1038/sj.mp.4000812 · Cited by 2,882 · see citing works
Analysis of fMRI Time-Series Revisited
Friston, K. J., Holmes, A. P., Poline, J., Grasby, P. M., Williams, S., Frackowiak, R. S. J., & Turner, R. (1995) · NeuroImage · doi:10.1006/nimg.1995.1007 · Cited by 2,504 · see citing works
Adolphs, R., Tranel, D., Damasio, H., & Damasio, A. (1994) · Nature · doi:10.1038/372669a0 · Cited by 2,360 · see citing works
A differential neural response in the human amygdala to fearful and happy facial expressions
Morris, J. S., Frith, C. D., Perrett, D. I., Rowland, D., Young, A. W., Calder, A. J., & Dolan, R. J. (1996) · Nature · doi:10.1038/383812a0 · Cited by 2,013 · see citing works
Response and Habituation of the Human Amygdala during Visual Processing of Facial Expression
Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M., Hyman, S. E., & Rosen, B. R. (1996) · Neuron · doi:10.1016/s0896-6273(00)80219-6 · Cited by 1,711 · see citing works
LaBar, K. S., Gatenby, J. C., Gore, J. C., LeDoux, J. E., & Phelps, E. A. (1998) · Neuron · doi:10.1016/s0896-6273(00)80475-4 · Cited by 1,402 · see citing works
Dissociable neural responses to facial expressions of sadness and anger
Blair, R. J. R., Morris, J. S., Frith, C. D., Perrett, D. I., & Dolan, R. J. (1999) · Brain · doi:10.1093/brain/122.5.883 · Cited by 1,212 · see citing works
Encoding Predictive Reward Value in Human Amygdala and Orbitofrontal Cortex
Gottfried, J. A., O'Doherty, J., & Dolan, R. J. (2003) · Science · doi:10.1126/science.1087919 · Cited by 1,165 · see citing works
The human amygdala in social judgment
Adolphs, R., Tranel, D., & Damasio, A. R. (1998) · Nature · doi:10.1038/30982 · Cited by 1,125 · see citing works
Distinct spatial frequency sensitivities for processing faces and emotional expressions
Vuilleumier, P., Armony, J. L., Driver, J., & Dolan, R. J. (2003) · Nature Neuroscience · doi:10.1038/nn1057 · Cited by 1,117 · see citing works
The human amygdala and the emotional evaluation of sensory stimuli
Zald, D. H. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(02)00248-5 · Cited by 1,062 · see citing works
Rubia, K., Russell, T., Overmeyer, S., Brammer, M. J., Bullmore, E. T., Sharma, T., Simmons, A., Williams, S. C. R., Giampietro, V., Andrew, C. M., et al. (2001) · NeuroImage · doi:10.1006/nimg.2000.0685 · Cited by 999 · see citing works
Automatic and intentional brain responses during evaluation of trustworthiness of faces
Winston, J. S., Strange, B. A., O'Doherty, J., & Dolan, R. J. (2002) · Nature Neuroscience · doi:10.1038/nn816 · Cited by 993 · see citing works
The Human Amygdala: An Evolved System for Relevance Detection
Sander, D., Grafman, J., & Zalla, T. (2003) · Reviews in the Neurosciences · doi:10.1515/revneuro.2003.14.4.303 · Cited by 944 · cited 2× · see citing works
“According to Sander et al. (2003), “an event is relevant for an organism if it can significantly influence (positively or negatively) the attainment of his or her goals, or the maintenance of his or her own well-being.””
BackgroundThe Human Amygdala in Social Judgment
Adolphs, R., Tranel, D., & Damásio, A. R. (2002) · The MIT Press eBooks · doi:10.7551/mitpress/3077.003.0027 · Cited by 882 · see citing works
Representation of Pleasant and Aversive Taste in the Human Brain
O’Doherty, J. P., Rolls, E. T., Francis, S., Bowtell, R. W., & McGlone, F. P. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.85.3.1315 · Cited by 674 · see citing works
Amygdala circuitry in attentional and representational processes.
Holland, P., & Gallagher, M. (1999) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(98)01271-6 · Cited by 613 · see citing works
Perception without awareness: perspectives from cognitive psychology
Merikle, P. (2001) · Cognition · doi:10.1016/s0010-0277(00)00126-8 · Cited by 540 · see citing works
Inhibited and uninhibited infants “grown up”: adult amygdalar response to novelty
Schwartz, C. E., Wright, C. I., Shin, L. M., Kagan, J., & Rauch, S. L. (2003) · Science · doi:10.1126/science.1083703 · Cited by 528 · see citing works
Amygdala response to happy faces as a function of extraversion
Canli, T., Sivers, H., Whitfield, S. L., Gotlib, I. H., & Gabrieli, J. D. E. (2002) · Science · doi:10.1126/science.1068749 · Cited by 493 · see citing works
Role of the Amygdala in Decision‐Making
Bechara, A., Damasio, H., & Damasio, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07094.x · Cited by 475 · see citing works
Implicit Trustworthiness Decisions: Automatic Coding of Face Properties in the Human Amygdala
Engell, A. D., Haxby, J. V., & Todorov, A. T. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.9.1508 · Cited by 470 · see citing works
Effects of Gaze on Amygdala Sensitivity to Anger and Fear Faces
Adams, R. B., Gordon, H. L., Baird, A. A., Ambady, N., & Kleck, R. E. (2003) · Science · doi:10.1126/science.1082244 · Cited by 444 · see citing works
Comparative aspects of amygdala connectivity
PRICE, J. L. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07070.x · Cited by 442 · see citing works
Beyond threat: amygdala reactivity across multiple expressions of facial affect
Fitzgerald, D. A., Angstadt, M., Jelsone, L. M., Nathan, P. J., & Phan, K. L. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.003 · Cited by 427 · see citing works
Processing of Temporal Unpredictability in Human and Animal Amygdala
Herry, C., Bach, D. R., Esposito, F., Di Salle, F., Perrig, W. J., Scheffler, K., Lüthi, A., & Seifritz, E. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5218-06.2007 · Cited by 401 · see citing works
Brain systems for assessing facial attractiveness
Winston, J. S., O’Doherty, J. P., Kilner, J. M., Perrett, D. I., & Dolan, R. J. (2006) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2006.05.009 · Cited by 367 · see citing works
Classical fear conditioning in functional neuroimaging
Büchel, C. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00078-7 · Cited by 350 · see citing works
Amaral, D. G. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01307-5 · Cited by 349 · see citing works
Williams, L. M., Phillips, M. L., Brammer, M. J., Skerrett, D., Lagopoulos, J., Rennie, C., Bahramali, H., Olivieri, G., David, A. S., Peduto, A., et al. (2001) · NeuroImage · doi:10.1006/nimg.2001.0904 · Cited by 300 · see citing works
Emery, N. J., Capitanio, J. P., Mason, W. A., Machado, C. J., Mendoza, S. P., & Amaral, D. G. (2001) · Behavioral Neuroscience · doi:10.1037/0735-7044.115.3.515 · Cited by 273 · see citing works
Schwartz, C., Wright, C. I., Shin, L. M., Kagan, J., Whalen, P. J., McMullin, K. G., & Rauch, S. L. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01906-6 · Cited by 217 · see citing works
Kiehl, K. A., & Liddle, P. F. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(00)00117-1 · Cited by 215 · see citing works
Goldstein, M., Brendel, G., Tüscher, O., Pan, H., Epstein, J., Beutel, M. E., Yang, Y., Thomas, K. F., Levy, K. N., Silverman, M. E., et al. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.01.056 · Cited by 206 · see citing works
Rising Sound Intensity: An Intrinsic Warning Cue Activating the Amygdala
Bach, D. R., Schächinger, H., Neuhoff, J. G., Esposito, F., Salle, F. D., Lehmann, C., Herdener, M., Scheffler, K., & Seifritz, E. (2007) · Cerebral Cortex · doi:10.1093/cercor/bhm040 · Cited by 180 · see citing works
Impaired fear conditioning in Alzheimer’s disease
Hamann, S., Monarch, E. S., & Goldstein, F. C. (2002) · Neuropsychologia · doi:10.1016/s0028-3932(01)00223-8 · Cited by 129 · see citing works
Selective bilateral amygdala lesions in rhesus monkeys fail to disrupt object reversal learning
Izquierdo, A., & Murray, E. A. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3616-06.2007 · Cited by 121 · see citing works
Individual Differences in Amygdala Activity Predict Response Speed during Working Memory
Schaefer, A., Braver, T. S., Reynolds, J. R., Burgess, G. C., Yarkoni, T., & Gray, J. R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2567-06.2006 · Cited by 106 · see citing works
Schirmer, A., Escoffier, N., Zysset, S., Koester, D., Striano, T., & Friederici, A. D. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2008.01.018 · Cited by 95 · see citing works
Neutral faces activate the amygdala during identity matching
Wright, P. K., & Liu, Y. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.07.047 · Cited by 89 · see citing works
Preferential responses in amygdala and insula during presentation of facial contempt and disgust
Sambataro, F., Dimalta, S., Giorgio, A. D., Taurisano, P., Blasi, G., Scarabino, T., Giannatempo, G. M., Nardini, M., & Bertolino, A. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05120.x · Cited by 74 · see citing works
A supramodal limbic‐paralimbic‐neocortical network supports goal‐directed stimulus processing
Laurens, K. R., Kiehl, K. A., & Liddle, P. F. (2004) · Human Brain Mapping · doi:10.1002/hbm.20062 · Cited by 56 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The integration of negative affect, pain and cognitive control in the cingulate cortex
Shackman, A. J., Salomons, T. V., Slagter, H. A., Fox, A. S., Winter, J. J., & Davidson, R. J. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn2994 · Cited by 2,082 · see citing works
Frontal midline theta reflects anxiety and cognitive control: Meta-analytic evidence
Cavanagh, J. F., & Shackman, A. J. (2014) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2014.04.003 · Cited by 628 · see citing works
Implicit Trustworthiness Decisions: Automatic Coding of Face Properties in the Human Amygdala
Engell, A. D., Haxby, J. V., & Todorov, A. T. (2007) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2007.19.9.1508 · Cited by 470 · see citing works
Bzdok, D., Laird, A. R., Zilles, K., Fox, P. T., & Eickhoff, S. B. (2012) · Human Brain Mapping · doi:10.1002/hbm.22138 · Cited by 430 · see citing works
Criaud, M., & Boulinguez, P. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.003 · Cited by 368 · see citing works
Motivational Salience: Amygdala Tuning From Traits, Needs, Values, and Goals
Cunningham, W. A., & Brosch, T. (2012) · Current Directions in Psychological Science · doi:10.1177/0963721411430832 · Cited by 312 · see citing works
Doux, L. (2012) · doi:10.1016/b978-0-444-53860-4.00021-0 · Cited by 241 · see citing works
From high anxiety trait to depression: a neurocognitive hypothesis
Sandi, C., & Richter‐Levin, G. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.02.004 · Cited by 227 · see citing works
James, C. E., Oechslin, M. S., Van De Ville, D., Hauert, C.-A., Descloux, C., & Lazeyras, F. (2014) · Brain Structure and Function · doi:10.1007/s00429-013-0504-z · Cited by 180 · see citing works
ALE meta-analysis on facial judgments of trustworthiness and attractiveness
Bzdok, D., Langner, R., Caspers, S., Kurth, F., Habel, U., Zilles, K., Laird, A., & Eickhoff, S. B. (2011) · Brain Structure and Function · doi:10.1007/s00429-010-0287-4 · Cited by 183 · see citing works
Computing the Social Brain Connectome Across Systems and States
Alcalá-López, D., Smallwood, J., Jefferies, E., Overwalle, F. V., Vogeley, K. T., Mars, R. B., Turetsky, B. I., Laird, A. R., Fox, P. T., Eickhoff, S. B., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx121 · Cited by 177 · see citing works
Anosognosia for hemiplegia: a clinical-anatomical prospective study
Vocat, R., Staub, F., Stroppini, T., & Vuilleumier, P. O. (2010) · Brain · doi:10.1093/brain/awq297 · Cited by 171 · see citing works
Does it make a difference if I have an eye contact with you or with your picture? An ERP study
Pönkänen, L. M., Alhoniemi, A., Leppänen, J. M., & Hietanen, J. K. (2010) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq068 · Cited by 154 · see citing works
Uncertainty and Cognitive Control
Mushtaq, F., Bland, A. R., & Schaefer, A. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00249 · Cited by 157 · see citing works
Attentional capture by signals of threat
Schmidt, L. J., Belopolsky, A. V., & Theeuwes, J. (2015) · Cognition and Emotion · doi:10.1080/02699931.2014.924484 · Cited by 173 · see citing works
Pourtois, G., Vocat, R., N’Diaye, K., Spinelli, L., Seeck, M., & Vuilleumier, P. O. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.12.020 · Cited by 128 · see citing works
Evidence for a general face salience signal in human amygdala
Santos, A., Mier, D. U., Kirsch, P., & Meyer‐Lindenberg, A. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.11.024 · Cited by 120 · see citing works
Friederich, H.-C., Walther, S., Bendszus, M., Biller, A., Thomann, P., Zeigermann, S., Katus, T., Brunner, R., Zastrow, A., & Herzog, W. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.042 · Cited by 119 · see citing works
Murray, R. J., Brosch, T., & Sander, D. (2014) · Cortex · doi:10.1016/j.cortex.2014.06.010 · Cited by 105 · see citing works
Quintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102 · see citing works
Self-citationIndiscriminate Amygdala Response to Mothers and Strangers After Early Maternal Deprivation
Olsavsky, A. K., Telzer, E. H., Shapiro, M., Humphreys, K. L., Flannery, J., Goff, B., & Tottenham, N. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.025 · Cited by 99 · see citing works
Tottenham, N., Shapiro, M., Telzer, E. H., & Humphreys, K. L. (2012) · Developmental Science · doi:10.1111/j.1467-7687.2011.01128.x · Cited by 91 · see citing works
CACNA1C Risk Variant and Amygdala Activity in Bipolar Disorder, Schizophrenia and Healthy Controls
Tesli, M., Skåtun, K. C., Ousdal, O. T., Brown, A. A., Thoresen, C., Agartz, I., Melle, I. S., Djurovic, S., Jensen, J., & Andreassen, O. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056970 · Cited by 89 · see citing works
Self-citationThe amygdala and the relevance detection theory of autism: an evolutionary perspective
Zalla, T., & Sperduti, M. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00894 · Cited by 85 · see citing works
Neural networks related to dysfunctional face processing in autism spectrum disorder
Nickl‐Jockschat, T., Rottschy, C., Thommes, J., Schneider, F. W., Laird, A. R., Fox, P. T., & Eickhoff, S. B. (2014) · Brain Structure and Function · doi:10.1007/s00429-014-0791-z · Cited by 81 · see citing works
Autonomic reactions indicating positive affect during acoustic reward learning in domestic pigs
Zebunke, M., Langbein, J., Manteuffel, G., & Puppe, B. (2010) · Animal Behaviour · doi:10.1016/j.anbehav.2010.11.023 · Cited by 82 · see citing works
Amygdala involvement in human avoidance, escape and approach behavior
Schlund, M. W., & Cataldo, M. F. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.058 · Cited by 81 · see citing works
Mueller, S. C. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00327 · Cited by 79 · see citing works
A Multidimensional Approach to Apathy after Traumatic Brain Injury
Arnould, A., Rochat, L., Azouvi, P., & der Linden, M. V. (2013) · Neuropsychology Review · doi:10.1007/s11065-013-9236-3 · Cited by 79 · see citing works
Response of neural reward regions to food cues in autism spectrum disorders
Cascio, C. J., Foss-Feig, J. H., Heacock, J. L., Newsom, C. R., Cowan, R. L., Benningfield, M. M., Rogers, B. P., & Cao, A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-9 · Cited by 76 · see citing works
Liu, C., Dai, Z., Zhang, R., Zhang, M., Hou, Y., Qi, Z., Huang, Z., Lin, Y., Zhan, S., Yong He, A., et al. (2015) · Sleep Medicine · doi:10.1016/j.sleep.2014.12.029 · Cited by 64 · see citing works
Potential threat attracts attention and interferes with voluntary saccades.
Schmidt, L. J., Belopolsky, A. V., & Theeuwes, J. (2015) · Emotion · doi:10.1037/emo0000041 · Cited by 63 · see citing works
The amygdala, top-down effects, and selective attention to features.
Jacobs, R. H. A. H., Renken, R., Aleman, A., & Cornelissen, F. (2012) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.05.011 · Cited by 63 · see citing works
Altered inhibition-related frontolimbic connectivity in obsessive–compulsive disorder
van Velzen, L. S., de Wit, S. J., Ćurĉić‐Blake, B., Cath, D. C., de Vries, F. E., Veltman, D. J., van der Werf, Y. D., & van den Heuvel, O. A. (2015) · Human Brain Mapping · doi:10.1002/hbm.22898 · Cited by 50 · see citing works
Temporal dynamics of amygdala response to emotion- and action-relevance
Guex, R., Méndez‐Bértolo, C., Moratti, S., Strange, B. A., Spinelli, L., Murray, R. J., Sander, D., Seeck, M., Vuilleumier, P. O., & Domínguez‐Borràs, J. (2020) · Scientific Reports · doi:10.1038/s41598-020-67862-1 · Cited by 50 · see citing works
Wendt, J., Weike, A. I., Lotze, M., & Hamm, A. O. (2010) · Biological Psychology · doi:10.1016/j.biopsycho.2010.11.009 · Cited by 47 · see citing works
Current emotion research in behavioral neuroscience: the role(s) of the amygdala
Armony, J. L. (2013) · Emotion Review · doi:10.1177/1754073912457208 · Cited by 44 · see citing works
Effect of relevance on amygdala activation and association with the ventral striatum
Ousdal, O. T., Reckless, G. E., Server, A., Andreassen, O. A., & Jensen, J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.035 · Cited by 43 · see citing works
Self-citationThe Perception of Musical Spontaneity in Improvised and Imitated Jazz Performances
Engel, A., & Keller, P. E. (2011) · Frontiers in Psychology · doi:10.3389/fpsyg.2011.00083 · Cited by 44 · see citing works
Ousdal, O. T., Andreassen, O. A., Server, A., & Jensen, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096146 · Cited by 43 · see citing works
Self-citationStimulus arousal drives amygdalar responses to emotional expressions across sensory modalities
Lin, H., Müller-Bardorff, M., Gathmann, B., Brieke, J., Mothes‐Lasch, M., Bruchmann, M., Miltner, W. H. R., & Straube, T. (2020) · Scientific Reports · doi:10.1038/s41598-020-58839-1 · Cited by 44 · see citing works
Rahm, C., Liberg, B., Reckless, G. E., Ousdal, O. T., Melle, I. S., Andreassen, O. A., & Agartz, I. (2015) · Acta Neuropsychiatrica · doi:10.1017/neu.2015.11 · Cited by 36 · see citing works
Self-citationLong‐term cognitive enrichment affects opioid receptor expression in the amygdala of domestic pigs
Kalbe, C., & Puppe, B. (2009) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2009.00536.x · Cited by 36 · see citing works
Quintana, D. S., Westlye, L. T., Alnæs, D., Kaufmann, T., Mahmoud, R. A., Smerud, K. T., Djupesland, P. G., & Andreassen, O. A. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0241-3 · Cited by 33 · see citing works
Self-citationBasal forebrain moderates the magnitude of task-dependent amygdala functional connectivity.
Gorka, A., Knodt, A., & Hariri, A. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu080 · Cited by 25 · see citing works
Self-citationFunctionally distinct amygdala subregions identified using DTI and high-resolution fMRI
Balderston, N. L., Schultz, D. H., Hopkins, L. S., & Helmstetter, F. J. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsv055 · Cited by 33 · see citing works
Sicorello, M., Thome, J., Herzog, J., & Schmahl, C. G. (2020) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2020.10.009 · Cited by 33 · see citing works
Neuroanatomical substrates involved in true and false memories for face
Iidaka, T., Harada, T., Kawaguchi, J., & Sadato, N. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.04.044 · Cited by 35 · see citing works
Neural Circuitry of Emotional and Cognitive Conflict Revealed through Facial Expressions
Chiew, K. S., & Braver, T. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017635 · Cited by 31 · see citing works
James, C. E., Michel, C. M., Britz, J., Vuilleumier, P. O., & Hauert, C.-A. (2011) · Human Brain Mapping · doi:10.1002/hbm.21397 · Cited by 30 · see citing works
The influence of directed covert attention on emotional face processing
Brassen, S., Gamer, M., Rose, M., & Büchel, C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2009.12.073 · Cited by 29 · see citing works
Kim, H., Nanavaty, N., Ahmed, H., Mathur, V. A., & Anderson, B. A. (2021) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_01769 · Cited by 28 · see citing works
Dopamine-induced changes in neural network patterns supporting aversive conditioning
Diaconescu, A. O., Menon, M., Jensen, J., Kapur, S., & McIntosh, A. R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.11.064 · Cited by 28 · see citing works
Self-citationAmygdala response to faces parallels social behavior in Williams syndrome
Paul, B. M., Snyder, A. Z., Haist, F., Raichle, M. E., Bellugi, U., & Stiles, J. (2009) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsp023 · Cited by 28 · see citing works
Ousdal, O. T., Brown, A. A., Jensen, J., Nakstad, P., Melle, I. S., Agartz, I., Djurovic, S., Bogdan, R., Hariri, A. R., & Andreassen, O. A. (2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.5 · Cited by 25 · see citing works
Self-citationAttar, C. H., Müller, M. M., Andersen, . K., Büchel, C., & Rose, M. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5029-09.2010 · Cited by 25 · see citing works
de Borst, A. W., & de Gelder, B. (2022) · Brain Sciences · doi:10.3390/brainsci12030391 · Cited by 21 · see citing works
Amygdala Activation in Cognitive Task fMRI Varies with Individual Differences in Cognitive Traits
West, H. V., Burgess, G. C., Dust, J., Kandala, S., & Barch, D. M. (2021) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-021-00863-3 · Cited by 20 · see citing works
Haas, I. J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800935-2.00019-1 · Cited by 21 · see citing works
Discrimination of personally significant from nonsignificant sounds: A training study
Roye, A., Jacobsen, T., & Schröger, E. (2013) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-013-0173-7 · Cited by 18 · see citing works
The role of the amygdala in incongruity resolution: the case of humor comprehension
Nakamura, T., Matsui, T., Utsumi, A., Yamazaki, M. L., Makita, K., Harada, T., Tanabe, H. C., & Sadato, N. (2017) · Social Neuroscience · doi:10.1080/17470919.2017.1365760 · Cited by 17 · see citing works
Neurocognitive dynamics of near-threshold voice signal detection and affective voice evaluation
Swanborough, H., Staib, M., & Frühholz, S. (2020) · Science Advances · doi:10.1126/sciadv.abb3884 · Cited by 11 · see citing works
False memory for face in short-term memory and neural activity in human amygdala.
Iidaka, T., Harada, T., & Sadato, N. (2014) · Brain Research · doi:10.1016/j.brainres.2014.10.003 · Cited by 12 · see citing works
Wu, T., Fan, J., Chen, Y., Xiang, J., Zhu, D., Zhang, J., Shi, J., & Jiang, T. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00169 · Cited by 11 · see citing works
Trust and valence processing in the amygdala*
Vuilleumier, P. O., & Sander, D. (2008) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsn045 · Cited by 10 · see citing works
Context-prosody interaction in sarcasm comprehension: A functional magnetic resonance imaging study
Nakamura, T., Matsui, T., Utsumi, A., Sumiya, M., Nakagawa, E., & Sadato, N. (2022) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2022.108213 · Cited by 9 · see citing works
Reisch, L. M., Wegrzyn, M., Mielke, M., Mehlmann, A., Woermann, F. G., Kissler, J. M., & Bien, C. G. (2022) · Human Brain Mapping · doi:10.1002/hbm.25852 · Cited by 8 · see citing works
Arousal Modulates Activity in the Medial Temporal Lobe during a Short-Term Relational Memory Task
Thoresen, C., Jensen, J., Sigvartsen, N. P. B., Bolstad, I., Server, A., Nakstad, P., Andreassen, O. A., & Endestad, T. (2012) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2011.00177 · Cited by 7 · see citing works
Self-citationCarranza-Pinedo, V., Krohs, U., & Richter, S. H. (2025) · Neuroscience and Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106127 · Cited by 5 · see citing works
Baltezarević, R., & Baltezarević, V. (2022) · Megatrend revija · doi:10.5937/megrev2202013b · Cited by 6 · see citing works
Towards a neuroimaging biomarker of depression vulnerability
Farb, N. A. S., Segal, Z. V., & Anderson, A. K. (2011) · Translational Neuroscience · doi:10.2478/s13380-011-0033-2 · Cited by 6 · see citing works
Sicorello, M., Herzog, J. I., Wager, T., Ende, G., Müller-Engelmann, M., Herpertz, S. C., Bohus, M., Schmahl, C., Paret, C., & Niedtfeld, I. (2021) · medRxiv · doi:10.1016/j.ynirp.2021.100019 · Cited by 6 · see citing works
Bounoua, N., Spielberg, J. M., & Sadeh, N. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111507 · Cited by 5 · see citing works
Impulsivity in amphetamine use disorder: Examination of sex differences
Stewart, J. L., Burrows, K., Davis, C. B., Wilhelm, R. A., McNaughton, B. A., Kuplicki, R., Paulus, M. P., Khalsa, S. S., & White, E. J. (2023) · Addiction · doi:10.1111/add.16225 · Cited by 5 · see citing works
Changing role of the amygdala in affective and cognitive traits between early and late adulthood
Doucet, G. E., Kruse, J. A., Hamlin, N., Oleson, J., & White, S. F. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2023.1033543 · Cited by 4 · see citing works
Political neuroscience: Understanding how the brain makes political decisionsPreprint
Haas, I. J., Warren, C., & Lauf, S. J. (2020) · doi:10.31234/osf.io/kvzcf · Cited by 4 · see citing works
Functional states of prelimbic and related circuits during the acquisition of a GO/noGO task in rats
Muñoz-Redondo, C., Parras, G. G., Andreu-Sánchez, C., Martín-Pascual, M. Á., Delgado-Garcia, J. M., & Gruart, A. (2024) · Cerebral Cortex · doi:10.1093/cercor/bhae271 · Cited by 2 · see citing works
Constructing a Neuroscientific Pastoral Theology of Fear and Hope
Whitehead, J. C. (2012) · Process Studies · doi:10.5840/process201241129 · Cited by 2 · see citing works
A Cognitive Neuroscience View on Pointing: What is Special About Pointing with the Eyes and Hands?
Ulloa, J. L., & George, N. (2013) · Cited by 2 · see citing works
The functional neuro-anatomy of the human response to fear: A brief review
CASALE, A. D., Ferracuti, S., Kotzalidis, G. D., Rapinesi, C., Serata, D., Ambrosi, E., Simonetti, A., Savoja, V., Pompili, M., Angeletti, G., et al. (2011) · South African Journal of Psychiatry · doi:10.4102/sajpsychiatry.v17i1.270 · Cited by 1 · see citing works
Kim, H., Nanavaty, N., Ahmed, H., Mathur, V. A., & Anderson, B. A. (2021) · doi:10.31234/osf.io/adxwy · Cited by 1 · see citing works
Shekara, A., Ross, A., Soper, D. J., Paulk, A. C., Cash, S. S., Widge, A. S., Shear, P. K., Sheehy, J. P., & Basu, I. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.10.617540 · Cited by 1 · see citing works
On the influence of dopamine-related genetic variation on dopamine-related disorders
Bergman, O. (2009) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Emotional instability in borderline personality disorder
Schulze, L. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-18153
Neurophysiology and Neuropharmacology of Decision Making
Long, A. (2009)
On the role of the human amygdala : Mapping functions and individual variations using fMRI
Ousdal, O. T. (2012) · NORA - Norwegian Open Research Archives
Self-citationEvidence for Disturbances in the Processing and Regulation of Emotions
Schulze, L. (2011)
Exploring the Brain Mechanisms Involved in Reward Prediction Errors Using Conditioned Inhibition
Mollick, J. (2013) · CU Scholar (University of Colorado Boulder)
D’Alberto, N. (2018) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
The fearful face and beyond: fMRI studies of the human amygdala
Hardee, J. E. (2009) · doi:10.33915/etd.2933
Current Awareness in NMR in Biomedicine
(2009) · NMR in Biomedicine · doi:10.1002/nbm.1333
Dynamic Analysis of Emotional Causal Brain Network Based on Directed Transfer Function: 1
Wang, L. Z., Han, L., & Li, D. (2023) · International Conference on Bioinformatics and Biomedical Technology (ICBBT) · doi:10.1145/3608164.3608190
Joshi, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-820480-1.00077-2
Li, C., Peng, Y., Wang, R., He, X., Cai, Y. L., Ma, Y., Wu, D., Wang, M., & Zhang, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.30.596374
Stohr, G. M., Harrewijn, A., Morales, S., Zeytinoglu, S., Laky, Z. E., Khosravi, P., Cardinale, E. M., Lorenzo, N. E., Stoddard, J., Pine, D. S., et al. (2025) · Cognitive Affective & Behavioral Neuroscience · doi:10.3758/s13415-025-01293-1
- Authors
- Ousdal, O. T., Jensen, J., Server, A., Hariri, A. R., Nakstad, P. H., & Andreassen, O. A.
- Affiliations
- Oslo University Hospital (NO)
- University of Oslo (NO)
- University of Pittsburgh (US)
- Corresponding author
- Andreassen, O.A.
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 156
- Issue
- 3
- Pages
- 450-455
- ISSN
- 0306-4522 (ISSN-L)
- PMC
- PMC2755288
- OpenAlex
- W2004180312
- Cited by
- 102
- References
- 45
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 4 · 2020: 5 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 15
- FWCI
- 5.00
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Universitetet i Oslo
- Norges Forskningsråd (#167153/V50, #163070/V50, 167153)
- National Institute of Mental Health (K01MH072837)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- amygdala, go/no-go task, emotional salience, threat detection, stimulation frequency
- MeSH terms
- Adult, Amygdala, Decision Making, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Oxygen, Pattern Recognition, Visual, Photic Stimulation, Reaction Time, Signal Detection, Psychological, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
