Cited by 156Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

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Morawski, M., Brückner, G., Jäger, C., Seeger, G., Arendt, T.·2010·Neuroscience

DOI 10.1016/j.neuroscience.2010.05.022

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Abstract

The biological basis for the selective vulnerability of neurons in Alzheimer's disease (AD) is elusive. Aggrecan-based perineuronal nets (PNs) of the extracellular matrix have been considered to contribute to neuroprotection in the cerebral cortex. In the present study, we investigated the organization of the aggrecan-based extracellular matrix in subcortical regions known to be preferentially affected by tau pathology in AD. Immunocytochemistry of aggrecan core protein was combined with detection of neurofibrillary degeneration. The results show that many regions affected by tau pathology in AD, such as the basal nucleus of Meynert, the dorsal thalamus, hypothalamic nuclei, raphe nuclei, and the locus coeruleus were devoid of a characteristic aggrecan-based extracellular matrix. Regions composed of nuclei with clearly different intensity of tau pathology, such as the amygdala, the thalamus and the oculomotor complex, showed largely complementary distribution patterns of neurofibrillary tangles and PNs. Quantification in the rostral interstitial nucleus of the longitudinal fascicle potentially affected by tau pathology in AD revealed that tau pathology was not accompanied by loss of aggrecan-based PNs. Neuro-fibrillary tangles in net-associated neurons extremely rarely occurred in the pontine reticular formation. We conclude that the low vulnerability of neurons ensheathed by PNs previously described for cortical areas in AD represents a more general phenomenon that also applies to subcortical regions. The aggrecan-based extracellular matrix of PNs may thus, be involved in neuroprotection.

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See all 156

Authors: Morawski, M., Brückner, G., Jäger, C., Seeger, G., & Arendt, T.
Affiliations: Leipzig University (DE)
ORCID: Morawski, M.
Arendt, T.
Venue: Neuroscience
Publisher: Elsevier BV
Published: 2010-09
Volume: 169
Issue: 3
Pages: 1347-1363
ISSN: 0306-4522 (ISSN-L)
DOI: 10.1016/j.neuroscience.2010.05.022
OpenAlex: W2035362565
Cited by: 156
References: 96
Citations by year: 2026: 10 · 2025: 10 · 2024: 12 · 2023: 9 · 2022: 13 · 2021: 11 · 2020: 12 · 2019: 5 · 2018: 18 · 2017: 8 · 2016: 6 · 2015: 8 · 2014: 13 · 2013: 5 · 2012: 6
FWCI: 4.54
Type: journal article
Language: en
Open access: green
zenodo.org
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neuroscience (publishedVersion)
PubMed (publishedVersion)
Zenodo (CERN European Organization for Nuclear Research) (submittedVersion, other-oa)
Funders: German Research Foundation
EU-Project “Neuropro” (223077)
Universität Leipzig
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: tau pathology, neurofibrillary tangles, Alzheimer's disease, subcortical structures, neuroprotection, extracellular matrix, nucleus basalis of Meynert, dorsal thalamus, hypothalamic nuclei, raphe nuclei, locus coeruleus, pontine reticular formation, amygdala
MeSH terms: Aged, Aged, 80 and over, Alzheimer Disease, Brain, Extracellular Matrix, Female, Humans, Male, Middle Aged, Neurons, Organ Specificity, Neurofibrillary Tangles, tau Proteins, Aggrecans

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Neurons associated with aggrecan-based perineuronal nets are protected against tau pathology in subcortical regions in Alzheimer's disease

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