Cited by 63Sleep and related disordersSleep and Wakefulness ResearchCircadian rhythm and melatonin

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Neuroscience-driven discovery and development of sleep therapeutics

Dresler, M., Spoormaker, V.I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., Holsboer, F.·2014·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2013.10.012

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Abstract

Until recently, neuroscience has given sleep research and discovery of better treatments of sleep disturbances little attention, despite the fact that disturbed sleep has overwhelming impact on human health. Sleep is a complex phenomenon in which specific psychological, electrophysiological, neurochemical, endocrinological, immunological and genetic factors are involved. The brain as both the generator and main object of sleep is obviously of particular interest, which makes a neuroscience-driven view the most promising approach to evaluate clinical implications and applications of sleep research. Polysomnography as the gold standard of sleep research, complemented by brain imaging, neuroendocrine testing, genomics and other laboratory measures can help to create composite biomarkers that allow maximizing the effects of individualized therapies while minimizing adverse effects. Here we review the current state of the neuroscience of sleep, sleep disorders and sleep therapeutics and will give some leads to promote the discovery and development of sleep medicines that are better than those we have today.

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Authors: Dresler, M., Spoormaker, V. I., Beitinger, P., Czisch, M., Kimura, M., Steiger, A., & Holsboer, F.
Affiliations: Max Planck Institute of Psychiatry (DE)
Max Planck Society (DE)
Corresponding author: Holsboer, F.
ORCID: Dresler, M.
Spoormaker, V.I.
Czisch, M.
Kimura, M.
Steiger, A.
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2014-03
Volume: 141
Issue: 3
Pages: 300-334
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2013.10.012
OpenAlex: W2065074889
Semantic Scholar: 8f84f6c1b91d3a60af74b2077877bb1add9b2cc1
Cited by: 63
References: 697
Citations by year: 2026: 2 · 2025: 3 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 3 · 2017: 4 · 2016: 7 · 2015: 10 · 2014: 5
FWCI: 1.27
Type: journal article
Language: en
Open access: closed
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Max Planck Digital Library (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion)
Radboud Repository (Radboud University) (submittedVersion)
Topics: Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Keywords: sleep disorders, polysomnography, neuroimaging, composite biomarker, personalized treatment, adverse effects
MeSH terms: Animals, Brain, Humans, Neurosciences, Sleep, Sleep Wake Disorders, Drug Design, Polysomnography, Biomedical Research, Neuroimaging

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