Cited by 263Stress Responses and CortisolNeuroendocrine regulation and behaviorWound Healing and Treatments

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Social facilitation of wound healing

Detillion, Courtney E, Craft, Tara K.S, Glasper, Erica R, Prendergast, Brian J, DeVries, A.Courtney·2004·Psychoneuroendocrinology

DOI 10.1016/j.psyneuen.2003.10.003

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Abstract

It is well documented that psychological stress impairs wound healing in humans and rodents. However, most research effort into influences on wound healing has focused on factors that compromise, rather than promote, healing. In the present study, we determined if positive social interaction, which influences hypothalamic-pituitary-adrenal (HPA) axis activity in social rodents, promotes wound healing. Siberian hamsters received a cutaneous wound and then were exposed to immobilization stress. Stress increased cortisol concentrations and impaired wound healing in isolated, but not socially housed, hamsters. Removal of endogenous cortisol via adrenalectomy eliminated the effects of stress on wound healing in isolated hamsters. Treatment of isolated hamsters with oxytocin (OT), a hormone released during social contact and associated with social bonding, also blocked stress-induced increases in cortisol concentrations and facilitated wound healing. In contrast, treating socially housed hamsters with an OT antagonist delayed wound healing. Taken together, these data suggest that social interactions buffer against stress and promote wound healing through a mechanism that involves OT-induced suppression of the HPA axis. The data imply that social isolation impairs wound healing, whereas OT treatment may ameliorate some effects of social isolation on health.

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Authors: Detillion, C. E., Craft, T. K. S., Glasper, E. R., Prendergast, B. J., & DeVries, A. C.
Affiliations: The Ohio State University (US)
Corresponding author: DeVries, A.Courtney
ORCID: Glasper, Erica R
Prendergast, Brian J
DeVries, A.Courtney
Venue: Psychoneuroendocrinology
Publisher: Elsevier BV
Published: 2004-09
Volume: 29
Issue: 8
Pages: 1004-1011
ISSN: 0306-4530 (ISSN-L)
DOI: 10.1016/j.psyneuen.2003.10.003
OpenAlex: W2097571882
Cited by: 259
References: 32
Citations by year: 2026: 2 · 2025: 10 · 2024: 10 · 2023: 3 · 2022: 16 · 2021: 13 · 2020: 7 · 2019: 7 · 2018: 16 · 2017: 16 · 2016: 12 · 2015: 14 · 2014: 16 · 2013: 11 · 2012: 17
FWCI: 2.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Psychoneuroendocrinology (publishedVersion)
PubMed (publishedVersion)
Funders: Ohio State University
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Keywords: wound healing, social facilitation, psychological stress, oxytocin, hypothalamic-pituitary-adrenal axis, cortisol, social isolation, Siberian hamster, adrenalectomy, social bonding, skin wounds
MeSH terms: Analysis of Variance, Animals, Cricetinae, Hydrocortisone, Immobilization, Oxytocin, Skin, Social Environment, Social Facilitation, Stress, Psychological, Wound Healing, Phodopus

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