Psychoneuroimmunology: psychological influences on immune function and health

Kiecolt-Glaser, Janice K.; McGuire, Lynanne; Robles, Theodore F.; Glaser, Ronald

doi:10.1037/0022-006x.70.3.537

Cited by 686Stress Responses and CortisolTryptophan and brain disordersCancer, Stress, Anesthesia, and Immune Response

Psychoneuroimmunology: psychological influences on immune function and health

Kiecolt-Glaser, Janice K., McGuire, Lynanne, Robles, Theodore F., Glaser, Ronald·2002·Journal of Consulting and Clinical Psychology

DOI 10.1037/0022-006x.70.3.537

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Abstract

This review focuses on human psychoneuroimmunology studies published in the past decade. Issues discussed include the routes through which psychological factors influence immune function, how a stressor's duration may influence the changes observed, individual difference variables, the ability of interventions to modulate immune function, and the health consequences of psychosocially mediated immune dysregulation. The importance of negative affect and supportive personal relationships are highlighted. Recent data suggest that immune dysregulation may be one core mechanism for a spectrum of conditions associated with aging, including cardiovascular disease, osteoporosis, arthritis, Type 2 diabetes, certain cancers, and frailty and functional decline; production of proinflammatory cytokines that influence these and other conditions can be stimulated directly by negative emotions and indirectly by prolonged infection.

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Negative HIV-specific expectancies and AIDS-related bereavement as predictors of symptom onset in asymptomatic HIV-positive gay men.
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Self-citation
Changes in cognitive coping strategies predict EBV-antibody titre change following a stressor disclosure induction
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Cytokine Antagonists in Aged Subjects and Their Relation With Cellular Immunity
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Depression in caregivers of demented patients is associated with altered immunity: impaired proliferative capacity, increased CD8+, and a decline in lymphocytes with surface signal transduction molecules (CD38+) and a cytotoxicity marker (CD56+ CD8+)
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Ontogeny and Senescence of Noradrenergic Innervation of the Rodent Thymus and Spleen
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Psychosocial stress moderates the relationship of cancer history with natural killer cell activity
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Psychoneuroimmunology : an interdisciplinary introduction
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International Review of Health Psychology
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Conditioning Allergic Skin Responses in Humans
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Chronic stress down-regulates growth hormone gene expression in peripheral blood mononuclear cells of older adults
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Effect of Hypnotic Suggestion on the Delayed-Type Hypersensitivity Response
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Psychoneuroimmunology and Immunotoxicology
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Developments in the Measurement of Subjective Well-Being
Kahneman, D., & Krueger, A. B. (2006) · Journal of Economic Perspectives · doi:10.1257/089533006776526030 · Cited by 3,177 · see citing works
Stress and Health: Psychological, Behavioral, and Biological Determinants
Schneiderman, N., Ironson, G., & Siegel, S. D. (2005) · Annual Review of Clinical Psychology · doi:10.1146/annurev.clinpsy.1.102803.144141 · Cited by 2,252 · see citing works
Stress, depression, the immune system, and cancer
Reiche, E. M. V., Nunes, S. O. V., & Morimoto, H. K. (2004) · The Lancet Oncology · doi:10.1016/s1470-2045(04)01597-9 · Cited by 1,364 · see citing works
Burnout and risk of cardiovascular disease: Evidence, possible causal paths, and promising research directions.
Melamed, S., Shirom, A., Toker, S., Berliner, S., & Shapira, I. (2006) · Psychological Bulletin · doi:10.1037/0033-2909.132.3.327 · Cited by 943 · see citing works
Mind matters: cognitive and physical effects of aging self-stereotypes
Levy, B. R. (2003) · The Journals of Gerontology: Series B · doi:10.1093/geronb/58.4.p203 · Cited by 908 · see citing works
The physiology of marriage: pathways to health.
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Self-citation
The effects of acute psychological stress on circulating and stimulated inflammatory markers: a systematic review and meta-analysis
Marsland, A. L., Walsh, C., Lockwood, K., & John-Henderson, N. A. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.01.011 · Cited by 691 · see citing works
Food insecurity is associated with adverse health outcomes among human infants and toddlers.
Cook, J. T., Frank, D. A., Meyers, A. F., Berkowitz, C., Black, M. M., Casey, P. H., Cutts, D. B., Zaldivar, N., Skalicky, A., Levenson, S., et al. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.6.1432 · Cited by 665 · see citing works
Positive social interactions and the human body at work: Linking organizations and physiology
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Hostility, Anger, Aggressiveness, and Coronary Heart Disease: An Interpersonal Perspective on Personality, Emotion, and Health
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Mindfulness meditation and reduced emotional interference on a cognitive task
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Psychological, behavioral, and immune changes after a psychological intervention: a clinical trial
Andersen, B. L., Farrar, W. B., Golden-Kreutz, D. M., Glaser, R., Emery, C. F., Crespin, T. R., Shapiro, C. L., & Carson, W. E. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.06.030 · Cited by 416 · see citing works
Self-citation
Psychosocial Aspects of Chronic Disease: ESRD as a Paradigmatic Illness
Cukor, D., Cohen, S. D., Peterson, R. A., & Kimmel, P. L. (2007) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007030345 · Cited by 385 · see citing works
How attributional ambiguity shapes physiological and emotional responses to social rejection and acceptance
Mendes, W. B., Major, B., McCoy, S., & Blascovich, J. (2008) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.94.2.278 · Cited by 346 · see citing works
Fecal Microbiota Composition and Frailty
van Tongeren, S. P., Slaets, J. P. J., Harmsen, H. J. M., & Welling, G. W. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.10.6438-6442.2005 · Cited by 333 · see citing works
Integrative Health Coaching for Patients With Type 2 Diabetes
Wolever, R. Q., Dreusicke, M., Fikkan, J., Hawkins, T. V., Yeung, S., Wakefield, J., Duda, L., Flowers, P., Cook, C., & Skinner, E. (2010) · The Diabetes Educator · doi:10.1177/0145721710371523 · Cited by 317 · see citing works
Emotion dysregulation as a mechanism linking peer victimization to internalizing symptoms in adolescents.
McLaughlin, K. A., Hatzenbuehler, M. L., & Hilt, L. M. (2009) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0015760 · Cited by 292 · see citing works
The Effects of Mind-Body Therapies on the Immune System: Meta-Analysis
Morgan, N., Irwin, M. R., Chung, M., & Wang, C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100903 · Cited by 294 · see citing works
“It has been well-established that psychological stress and depression impair anti-viral immune responses and activate innate immunity or markers of inflammation via effector pathways, such as the sympathetic nervous system and the hypothalamus-pituitaryadrenal (HPA) axis [23–28].”
Background
Stress‐related exhaustion disorder – clinical manifestation of burnout? A review of assessment methods, sleep impairments, cognitive disturbances, and neuro‐biological and physiological changes in clinical burnout
Grossi, G., Perski, A., Osika, W., & Savic, I. (2015) · Scandinavian Journal of Psychology · doi:10.1111/sjop.12251 · Cited by 273 · see citing works
Aging and the HPA axis: Stress and resilience in older adults
Gaffey, A. E., Bergeman, C. S., Clark, L. A., & Wirth, M. M. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.036 · Cited by 273 · see citing works
Social facilitation of wound healing
Detillion, C. E., Craft, T. K. S., Glasper, E. R., Prendergast, B. J., & DeVries, A. C. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2003.10.003 · Cited by 259 · see citing works
Stress and Diabetes: A Review of the Links
Lloyd, C., Smith, J., & Weinger, K. (2005) · Diabetes Spectrum · doi:10.2337/diaspect.18.2.121 · Cited by 248 · see citing works
Generalized unsafety theory of stress: unsafe environments and conditions, and the default stress response
Brosschot, J., Verkuil, B., & Thayer, J. (2018) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph15030464 · Cited by 244 · see citing works
Exposed to events that never happen: generalized unsafety, the default stress response, and prolonged autonomic activity
Brosschot, J. F., Verkuil, B., & Thayer, J. F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.019 · Cited by 178 · see citing works
Conscious and unconscious perseverative cognition: Is a large part of prolonged physiological activity due to unconscious stress?
Brosschot, J. F., Verkuil, B., & Thayer, J. F. (2010) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2010.02.002 · Cited by 176 · see citing works
2006 Curt P. Richter award winner
DeVries, A. C., Craft, T. K. S., Glasper, E. R., Neigh, G. N., & Alexander, J. K. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.04.007 · Cited by 153 · see citing works
A randomized controlled trial of a self-guided, multimedia, stress management and resilience training program
Rose, R. D., Buckey, J. C., Zbozinek, T. D., Motivala, S. J., Glenn, D. E., Cartreine, J. A., & Craske, M. G. (2013) · Behaviour Research and Therapy · doi:10.1016/j.brat.2012.11.003 · Cited by 153 · see citing works
Enhanced Psychosocial Well-Being Following Participation in a Mindfulness-Based Stress Reduction Program Is Associated with Increased Natural Killer Cell Activity
Fang, C. Y., Reibel, D. K., Longacre, M. L., Rosenzweig, S., Campbell, D. E., & Douglas, S. D. (2010) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2009.0018 · Cited by 130 · see citing works
Adverse childhood experiences are associated with spontaneous preterm birth: a case-control study
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Authors: Kiecolt-Glaser, J. K., McGuire, L., Robles, T. F., & Glaser, R.
Affiliations: The Ohio State University (US)
ORCID: Robles, Theodore F.
Venue: Journal of Consulting and Clinical Psychology
Publisher: American Psychological Association (APA)
Published: 2002-06
Volume: 70
Issue: 3
Pages: 537-547
ISSN: 0022-006X (ISSN-L)
1939-2117
DOI: 10.1037/0022-006x.70.3.537
OpenAlex: W2087461241
Semantic Scholar: 6fb5062c1ce3348c3401a5509b74c70f0ecc3a6f
Cited by: 686
References: 149
Citations by year: 2026: 18 · 2025: 21 · 2024: 15 · 2023: 17 · 2022: 20 · 2021: 27 · 2020: 31 · 2019: 34 · 2018: 24 · 2017: 42 · 2016: 36 · 2015: 26 · 2014: 36 · 2013: 34 · 2012: 43
FWCI: 9.22
Type: journal article
Language: en
Open access: closed
Locations: Journal of Consulting and Clinical Psychology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5k02mh001467-05, 5r37mh042096-15)
National Institute on Aging (P01AG016321, P01 AG-16321)
National Institute of Mental Health (T32MH18831, T32MH018831, K02 MH01467, R37 MH42096)
National Institute of Dental and Craniofacial Research (P50 DE17811)
National Center for Research Resources (M01-RR0034, M01RR000034)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Health Sciences › Medicine › Psychiatry and Mental health › Cancer, Stress, Anesthesia, and Immune Response
Keywords: psychoneuroimmunology, stress duration, individual differences, psychological intervention, immune dysregulation, negative affect, social support, aging, inflammatory cytokines, infection, cardiovascular disease, osteoporosis, arthritis, type 2 diabetes, cancer, frailty, functional decline
MeSH terms: Health Promotion, Health Status, Humans, Immune System, Interleukins, Psychoneuroimmunology, Stress, Psychological

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Psychoneuroimmunology: psychological influences on immune function and health

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