Early life stress impairs social recognition due to a blunted response of vasopressin release within the septum of adult male rats
Abstract
Early life stress poses a risk for the development of psychopathologies characterized by disturbed emotional, social, and cognitive performance. We used maternal separation (MS, 3h daily, postnatal days 1-14) to test whether early life stress impairs social recognition performance in juvenile (5-week-old) and adult (16-week-old) male Wistar rats. Social recognition was tested in the social discrimination test and defined by increased investigation by the experimental rat towards a novel rat compared with a previously encountered rat. Juvenile control and MS rats demonstrated successful social recognition at inter-exposure intervals of 30 and 60 min. However, unlike adult control rats, adult MS rats failed to discriminate between a previously encountered and a novel rat after 60 min. The social recognition impairment of adult MS rats was accompanied by a lack of a rise in arginine vasopressin (AVP) release within the lateral septum seen during social memory acquisition in adult control rats. This blunted response of septal AVP release was social stimulus-specific because forced swimming induced a rise in septal AVP release in both control and MS rats. Retrodialysis of AVP (1 μg/ml, 3.3 μl/min, 30 min) into the lateral septum during social memory acquisition restored social recognition in adult MS rats at the 60-min interval. These studies demonstrate that MS impairs social recognition performance in adult rats, which is likely caused by blunted septal AVP activation. Impaired social recognition may be linked to MS-induced changes in other social behaviors like aggression as shown previously.
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Social discrimination was impaired after daily maternal separation in male rats.
“Social discrimination (or preference for social novelty; i.e., the ability to discriminate between a familiar and unfamiliar conspecific) was impaired after daily maternal separation in male rats (Lukas et al., 2011)”
From Effects of Maternal Deprivation and Complex Housing on Rat Social Behavior in Adolescence and Adulthood (2018) · cites this paper as Lukas et al., 2011
Mice with reduced AVP release in the LS or lacking AVP V1aR have selective deficits in social memory, and re-introduction of AVP or V1aR in the LS rescues social memory.
“Mice with reduced AVP release in the LS, or that are lacking AVP V1aR entirely, have similarly selective deficits in social memory, and re-introduction of AVP or V1aR respectively in the LS results in rescue of social memory (Bielsky et al 2004; Bielsky et al 2005; Lukas et al 2011).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Lukas et al 2011
Cites
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Heim, C., & Nemeroff, C. B. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(01)01157-x · Cited by 2,791 · see citing works
Widom, C. S. (1989) · Science · doi:10.1126/science.2704995 · Cited by 1,976 · see citing works
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704 · see citing works
Plotsky, P. M., & Meaney, M. J. (1993) · Molecular Brain Research · doi:10.1016/0169-328x(93)90189-v · Cited by 1,638 · see citing works
Dynamic DNA methylation programs persistent adverse effects of early-life stress
Murgatroyd, C., Patchev, A. V., Wu, Y., Micale, V., Bockmühl, Y., Fischer, D., Holsboer, F., Wotjak, C. T., Almeida, O. F. X., & Spengler, D. (2009) · Nature Neuroscience · doi:10.1038/nn.2436 · Cited by 1,162 · see citing works
SÁNCHEZ, M. M., LADD, C. O., & PLOTSKY, P. M. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003029 · Cited by 1,003 · see citing works
Oxytocin, vasopressin, and human social behavior
Heinrichs, M., von Dawans, B., & Domes, G. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.05.005 · Cited by 799 · see citing works
Functional Cross‐Talk Between the Hypothalamic‐Pituitary‐Gonadal and ‐Adrenal Axes
Viau, V. (2002) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.2002.00798.x · Cited by 744 · see citing works
Long-term behavioral and neuroendocrine adaptations to adverse early experience
Ladd, C. O., Huot, R. L., Thrivikraman, K. V., Nemeroff, C. B., Meaney, M. J., & Plotsky, P. M. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62132-9 · Cited by 717 · see citing works
Goodson, J. L., & Bass, A. H. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(01)00043-1 · Cited by 632 · see citing works
Fries, A. B. W., Ziegler, T. E., Kurian, J. R., Jacoris, S., & Pollak, S. D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504767102 · Cited by 570 · see citing works
de Vries, G. J., & Buijs, R. M. (1983) · Brain Research · doi:10.1016/0006-8993(83)90855-7 · Cited by 524 · cited 1× · see citing works
“These can include altered input to the BNST and medial amygdala that send AVP fibers to the septum (De Vries and Buijs, 1983; Caffe et al., 1987).”
The vasopressinergic innervation of the brain in normal and castrated rats
DeVries, G. J., Buijs, R. M., van Leeuwen, F. W., Caffé, A. R., & Swaab, D. F. (1985) · Journal of Comparative Neurology · doi:10.1002/cne.902330206 · Cited by 522 · see citing works
Kalinichev, M., Easterling, K. W., Plotsky, P. M., & Holtzman, S. G. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(02)00781-5 · Cited by 484 · see citing works
Mechanisms of late-onset cognitive decline after early-life stress
Brunson, K. L., Kramár, E., Lin, B., Chen, Y., Colgin, L. L., Yanagihara, T. K., Lynch, G., & Baram, T. Z. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2281-05.2005 · Cited by 479 · see citing works
Engelmann, M., Landgraf, R., & Wotjak, C. T. (2004) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2004.09.001 · Cited by 450 · see citing works
Self-citationWigger, A., & Neumann, I. D. (1999) · Physiology & Behavior · doi:10.1016/s0031-9384(98)00300-x · Cited by 443 · see citing works
Self-citationVasopressin V1b receptor knockout reduces aggressive behavior in male mice
Wersinger, S. R., Ginns, E. I., O'Carroll, A.-M., Lolait, S. J., & Young III, W. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001195 · Cited by 397 · see citing works
Bielsky, I. F., Hu, S.-B., Ren, X., Terwilliger, E. F., & Young, L. J. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.031 · Cited by 367 · see citing works
Landgraf, R., Gerstberger, R., Montkowski, A., Probst, J., Wotjak, C., Holsboer, F., & Engelmann, M. (1995) · The Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04250.1995 · Cited by 341 · see citing works
Self-citationCentral vasopressin and oxytocin release: regulation of complex social behaviours
VEENEMA, A., & NEUMANN, I. (2008) · Progress in Brain Research · doi:10.1016/s0079-6123(08)00422-6 · Cited by 338 · see citing works
Self-citationNeumann, I., Russell, J. A., & Landgraf, R. (1993) · Neuroscience · doi:10.1016/0306-4522(93)90285-n · Cited by 337 · see citing works
Self-citationSex-specific influences of vasopressin on human social communication
Thompson, R. R., George, K., Walton, J. C., Orr, S. P., & Benson, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600406103 · Cited by 312 · see citing works
Caffé, A. R., van Leeuwen, F. W., & Luiten, P. G. M. (1987) · Journal of Comparative Neurology · doi:10.1002/cne.902610206 · Cited by 286 · see citing works
Romeo, R. D., Mueller, A., Sisti, H. M., Ogawa, S., McEwen, B. S., & Brake, W. G. (2003) · Hormones and Behavior · doi:10.1016/s0018-506x(03)00063-1 · Cited by 285 · see citing works
Brain vasopressin is an important regulator of maternal behavior independent of dams’ trait anxiety
Bosch, O. J., & Neumann, I. D. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807412105 · Cited by 280 · see citing works
Self-citationEngelmann, M., Wotjak, C. T., & Landgraf, R. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00053-l · Cited by 274 · see citing works
Self-citationEffects of early life stress on adult male aggression and hypothalamic vasopressin and serotonin.
Veenema, A. H., Blume, A., Niederle, D., Buwalda, B., & Neumann, I. D. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.05045.x · Cited by 271 · see citing works
Self-citationVeenema, A. H. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.03.003 · Cited by 268 · see citing works
Self-citationVeenema, A. H., Bredewold, R., & Neumann, I. D. (2007) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.02.008 · Cited by 263 · see citing works
Self-citationSeptal vasopressin modulates social memory in male rats
Dantzer, R., Koob, G. F., Bluthe´, R.-M., & Le Moal, M. (1988) · Brain Research · doi:10.1016/0006-8993(88)90066-2 · Cited by 262 · see citing works
Yirmiya, N., Rosenberg, C., Levi, S., Salomon, S., Shulman, C., Nemanov, L., Dina, C., & Ebstein, R. P. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001812 · Cited by 232 · see citing works
Engelmann, M., & Landgraf, R. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90022-1 · Cited by 225 · see citing works
Gonadal hormone actions on the morphology of the vasopressinergic innervation of the adult rat brain
De Vries, G. J., Buijs, R. M., & Sluiter, A. A. (1984) · Brain Research · doi:10.1016/0006-8993(84)91157-0 · Cited by 224 · see citing works
An intrinsic vasopressin system in the olfactory bulb is involved in social recognition
Tobin, V. A., Hashimoto, H., Wacker, D. W., Takayanagi, Y., Langnaese, K., Caquineau, C., Noack, J., Landgraf, R., Onaka, T., Leng, G., et al. (2010) · Nature · doi:10.1038/nature08826 · Cited by 213 · see citing works
Self-citationVeenema, A. H., & Neumann, I. D. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.10.017 · Cited by 191 · see citing works
Self-citationWeder, N., Yang, B. Z., Douglas-Palumberi, H., Massey, J., Krystal, J. H., Gelernter, J., & Kaufman, J. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.09.013 · Cited by 190 · see citing works
Lukas, M., Bredewold, R., Neumann, I. D., & Veenema, A. H. (2010) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.06.020 · Cited by 183 · see citing works
Self-citationVeenema, A. H., Beiderbeck, D. I., Lukas, M., & Neumann, I. D. (2010) · Hormones and Behavior · doi:10.1016/j.yhbeh.2010.03.006 · Cited by 180 · see citing works
Self-citationThe main olfactory system and social learning in mammals
Sánchez-Andrade, G., & Kendrick, K. M. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.12.021 · Cited by 166 · see citing works
Landgraf, R., Frank, E., Aldag, J. M., Neumann, I. D., Sharer, C. A., Ren, X., Terwilliger, E. F., Niwa, M., Wigger, A., & Young, L. J. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02750.x · Cited by 164 · see citing works
Self-citationAndrogen-dependent vasopressinergic neurons are involved in social recognition in rats
Bluthe, R.-M., Schoenen, J., & Dantzer, R. (1990) · Brain Research · doi:10.1016/0006-8993(90)90073-k · Cited by 164 · see citing works
Everts, H. G. J., & Koolhaas, J. M. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(98)00004-7 · Cited by 148 · see citing works
Beiderbeck, D. I., Neumann, I. D., & Veenema, A. H. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05974.x · Cited by 142 · see citing works
Self-citationInterleukin‐1β Stimulates both Central and Peripheral Release of Vasopressin and Oxytocin in the Rat
Landgraf, R., Neumann, I. D., Holsboer, F., & Pittman, Q. J. (1995) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1995.tb00663.x · Cited by 136 · see citing works
Self-citationZink, C. F., Stein, J. L., Kempf, L., Hakimi, S., & Meyer‐Lindenberg, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4899-09.2010 · Cited by 131 · see citing works
Intranasal Arginine Vasopressin Enhances the Encoding of Happy and Angry Faces in Humans
Guastella, A. J., Kenyon, A. R., Alvares, G. A., Carson, D. S., & Hickie, I. B. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.03.014 · Cited by 130 · see citing works
Ebner, K., Wotjak, C. T., Landgraf, R., & Engelmann, M. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02464-1 · Cited by 129 · see citing works
Self-citationThe involvement of the vasopressin system in stress-related disorders
Landgraf, R. (2006) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152706776359664 · Cited by 127 · cited 1× · see citing works
“In addition to its critical role in social recognition, AVP has been shown to regulate other social as well as emotional behaviors (Goodson and Bass, 2001; Engelmann et al., 2004; Landgraf, 2006; Bosch and Neumann, 2008; Veenema and Neumann, 2008; Heinrichs et al., 2009).”
Self-citationComplementary Roles of the Main and Accessory Olfactory Systems in Mammalian Mate Recognition
Baum, M. J., & Kelliher, K. R. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.010908.163137 · Cited by 127 · see citing works
Miller, M., DeVries, G., al-Shamma, H., & Dorsa, D. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-08-02881.1992 · Cited by 122 · see citing works
Social recognition memory requires two stages of protein synthesis in micePreprint
Richter, K., Wolf, G. L., & Engelmann, M. (2005) · Learning & Memory · doi:10.1101/lm.97505 · Cited by 121 · see citing works
Rhees, R. W., Lephart, E. D., & Eliason, D. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00381-8 · Cited by 118 · see citing works
Helmeke, C., Seidel, K., Poeggel, G., Bredy, T. W., Abraham, A., & Braun, K. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.07.008 · Cited by 98 · see citing works
Lateral septal vasopressin in rats: role in social and object recognition?
Everts, H. G. J., & Koolhaas, J. M. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00269-2 · Cited by 98 · see citing works
Ebner, K., Wotjak, C. T., Holsboer, F., Landgraf, R., & Engelmann, M. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00508.x · Cited by 85 · see citing works
Self-citationEngelmann, M., Ludwig, M., & Landgraf, R. (1994) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.1994.tb00598.x · Cited by 76 · see citing works
Self-citationBarnow, S., Lucht, M. J., & Freyberger, H. J. (2001) · Psychopathology · doi:10.1159/000049302 · Cited by 72 · see citing works
Engelmann, M., Bureš, J., & Landgraf, R. (1992) · Neuroscience Letters · doi:10.1016/0304-3940(92)90622-e · Cited by 52 · see citing works
Self-citationGreisen, M. H., Bolwig, T. G., Husum, H., Nedergaard, P., & Wörtwein, G. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.09.018 · Cited by 31 · see citing works
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Dumais, K. M., & Veenema, A. H. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.04.003 · Cited by 520 · see citing works
“Local VP release in the brain has been measured in male (Veenema et al., 2010; Lukas et al., 2011a) and female (Bosch & Neumann, 2010; Bosch et al., 2010) rats during the expression of social behavior; however, to our knowledge, there are no studies which have compared brain VP release in males and…”
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“Mice with reduced AVP release in the lateral septum (LS) or that are entirely lacking AVP V1aR have similarly selective deficits in social memory, and reintroduction of AVP or V1aR, respectively, in the LS results in rescue of social memory (Bielsky et al. 2004, 2005; Lukas et al. 2011).”
Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition
Gabor, C. S., Phan, A., Clipperton-Allen, A. E., Kavaliers, M., & Choleris, E. (2012) · Behavioral Neuroscience · doi:10.1037/a0026464 · Cited by 221 · see citing works
Lukas, M., Toth, I., Veenema, A. H., & Neumann, I. D. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.018 · Cited by 211 · see citing works
Sex-specific modulation of juvenile social play by vasopressin
Veenema, A. H., Bredewold, R., & De Vries, G. J. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.06.002 · Cited by 166 · see citing works
“Importantly, we do not find effects of surgery and cannula or probe implantation after two days on behavior in various behavioral tests (Beiderbeck et al., 2007; Veenema et al., 2010, 2012; Lukas et al., 2011, 2013).”
BackgroundMethodSelf-citationBredewold, R., Smith, C. J. W., Dumais, K. M., & Veenema, A. H. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00216 · Cited by 157 · see citing works
Self-citationSmith, C. J. W., Poehlmann, M. L., Li, S., Ratnaseelan, A. M., Bredewold, R., & Veenema, A. H. (2017) · Brain Structure and Function · doi:10.1007/s00429-016-1260-7 · Cited by 143 · see citing works
Self-citationVeenema, A. H., Bredewold, R., & De Vries, G. J. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.10.002 · Cited by 129 · see citing works
Self-citationSchneider, P., Bindila, L., Schmahl, C., Bohus, M., Meyer-Lindenberg, A., Lutz, B., Spanagel, R., & Schneider, M. (2016) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2016.00203 · Cited by 89 · see citing works
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Kompier, N. F., Keysers, C., Gazzola, V., Lucassen, P. J., & Krugers, H. J. (2019) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2019.00143 · Cited by 53 · see citing works
Song, Z., Larkin, T. E., Malley, M. O., & Albers, H. E. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.02.004 · Cited by 47 · see citing works
Qiao, X., Yan, Y., Wu, R., Tai, F., Hao, P., Cao, Y., & Wang, J. (2014) · Journal of Comparative Physiology A · doi:10.1007/s00359-013-0870-2 · Cited by 40 · see citing works
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Kentrop, J., Smid, C. R., Achterberg, E. J. M., van IJzendoorn, M. H., Bakermans-Kranenburg, M. J., Joëls, M., & van der Veen, R. (2018) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2018.00193 · Cited by 41 · see citing works
Borie, A. M., Dromard, Y., Guillon, G., Olma, A., Manning, M., Muscatelli, F., Desarménien, M. G., & Jeanneteau, F. (2021) · Journal of Clinical Investigation · doi:10.1172/jci144450 · Cited by 41 · see citing works
Bychowski, M. E., Mena, J. D., & Auger, C. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.04.047 · Cited by 37 · see citing works
Bredewold, R., Nascimento, N. F., Ro, G. S., Cieslewski, S. E., Reppucci, C. J., & Veenema, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0100-2 · Cited by 31 · see citing works
Self-citationSood, A., Pati, S., Bhattacharya, A., Chaudhari, K., & Vaidya, V. A. (2018) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2017.10.005 · Cited by 25 · see citing works
Hicks, C., Ramos, L., Reekie, T. A., Narlawar, R., Kassiou, M., & McGregor, I. S. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3902-5 · Cited by 23 · see citing works
Feng, T., An, S., Kinden, R., Zhang, X., Jia, R., & Tai, F. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.02.038 · Cited by 18 · see citing works
Bredewold, R., Washington, C., & Veenema, A. H. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-024-01987-z · Cited by 13 · see citing works
“Two hours later, fi ve or six consecutive 10-min dialysates were collected per rat according to [27, 39]: The fi rst two dialysates were taken under baseline (undisturbed) conditions.”
Self-citation
- Authors
- Lukas, M., Bredewold, R., Landgraf, R., Neumann, I. D., & Veenema, A. H.
- Affiliations
- University of Regensburg (DE)
- Max Planck Society (DE)
- Corresponding author
- Veenema, Alexa H.
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2011-07
- Volume
- 36
- Issue
- 6
- Pages
- 843-853
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2109345981
- Cited by
- 122
- References
- 61
- Citations by year
- 2026: 8 · 2025: 2 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 10 · 2020: 5 · 2019: 11 · 2018: 7 · 2017: 7 · 2016: 9 · 2015: 9 · 2014: 6 · 2013: 15 · 2012: 9
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
- Max Planck Institute for Plasma Physics (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institutes of Health
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- early life stress, maternal separation, social recognition, social memory, vasopressin, lateral septum, vasopressin release, forced swim test, retrodialysis, social discrimination, young rats, adult rats
- MeSH terms
- Age Factors, Animals, Arginine Vasopressin, Discrimination, Psychological, Exploratory Behavior, Male, Maternal Deprivation, Septum Pellucidum, Social Behavior, Swimming, Rats, Wistar, Microdialysis, Recognition, Psychology, Rats
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