Mechanisms that Regulate Stem Cell Aging and Life Span

mTOR Signaling in Growth Control and Disease

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Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

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Signal integration in the endoplasmic reticulum unfolded protein response

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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The senescence-associated secretory phenotype: the dark side of tumor suppression

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Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836

The DNA Damage Response: Making It Safe to Play with Knives

Ciccia, A., & Elledge, S. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.019 · Cited by 4,368

β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

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A Cold-Inducible Coactivator of Nuclear Receptors Linked to Adaptive Thermogenesis

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Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

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ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931

Forging a signature of in vivo senescence

Sharpless, N. E., & Sherr, C. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3960 · Cited by 1,104

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

Mendelson, A., & Frenette, P. S. (2014) · Nature Medicine · doi:10.1038/nm.3647 · Cited by 819

The role of protein clearance mechanisms in organismal ageing and age-related diseases

Vı́lchez, D., Sáez, I., & Dillin, A. G. (2014) · Nature Communications · doi:10.1038/ncomms6659 · Cited by 710

Mitochondrial Dynamics Impacts Stem Cell Identity and Fate Decisions by Regulating a Nuclear Transcriptional Program

Khacho, M., Clark, A., Svoboda, D. S., Azzi, J., MacLaurin, J. G., Meghaizel, C., Sesaki, H., Lagace, D. C., Germain, M., Harper, M., et al. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.04.015 · Cited by 702

Haematopoietic stem cells require a highly regulated protein synthesis rate

Signer, R. A. J., Magee, J. A., Salic, A., & Morrison, S. J. (2014) · Nature · doi:10.1038/nature13035 · Cited by 674

Stem cells and the impact of ROS signaling

Bigarella, C. L., Liang, R. H.-S., & Ghaffari, S. (2014) · Development · doi:10.1242/dev.107086 · Cited by 662

Modulating the stem cell niche for tissue regeneration

Lane, S., Williams, D. A., & Watt, F. M. (2014) · Nature Biotechnology · doi:10.1038/nbt.2978 · Cited by 622

Mitochondria as signaling organelles

Chandel, N. S. (2014) · BMC Biology · doi:10.1186/1741-7007-12-34 · Cited by 576

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

Mohrin, M., Shin, J., Liu, Y., Brown, K., Luo, H., Xi, Y., Haynes, C. M., & Chen, D. (2015) · Science · doi:10.1126/science.aaa2361 · Cited by 490

A synopsis on aging—Theories, mechanisms and future prospects

da Costa, J. P., Vitorino, R. M. P., Silva, G. M., Vogel, C., Duarte, A. C., & Rocha‐Santos, T. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.06.005 · Cited by 505

Clonal Hematopoiesis and Evolution to Hematopoietic Malignancies

Bowman, R. L., Busque, L., & Levine, R. L. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.01.011 · Cited by 448

Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging

Mihaylova, M. M., Cheng, C.-W., Cao, A. Q., Tripathi, S., Mana, M. D., Bauer-Rowe, K. E., Abu-Remaileh, M., Clavain, L., Erdemir, A., Lewis, C. A., et al. (2018) · Cell Stem Cell · doi:10.1016/j.stem.2018.04.001 · Cited by 428

Aging and epigenetic drift: a vicious cycle

Issa, J.-P. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69735 · Cited by 419

Adrenergic nerve degeneration in bone marrow drives aging of the hematopoietic stem cell niche

Maryanovich, M., Zahalka, A. H., Pierce, H., Pinho, S., Nakahara, F., Asada, N., Wei, Q., Wang, X., Ciero, P., Xu, J., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0030-x · Cited by 411

Ultraviolet Radiation‐Induced Skin Aging: The Role of DNA Damage and Oxidative Stress in Epidermal Stem Cell Damage Mediated Skin Aging

Panich, U., Sittithumcharee, G., Rathviboon, N., & Jirawatnotai, S. (2016) · Stem Cells International · doi:10.1155/2016/7370642 · Cited by 374

Resolution of organ fibrosis

Jun, J.-I., & Lau, L. F. (2018) · Journal of Clinical Investigation · doi:10.1172/jci93563 · Cited by 358

Hallmarks of the ageing lung

Meiners, S., Eickelberg, O., & Königshoff, M. (2015) · European Respiratory Journal · doi:10.1183/09031936.00186914 · Cited by 340

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

Sáez, I., & Vı́lchez, D. (2014) · Current Genomics · doi:10.2174/138920291501140306113344 · Cited by 331

Age-Dependent Niche Signals from the Choroid Plexus Regulate Adult Neural Stem Cells

Silva-Vargas, V., Maldonado-Soto, A. R., Mizrak, D., Codega, P., & Doetsch, F. (2016) · Cell stem cell · doi:10.1016/j.stem.2016.06.013 · Cited by 306

The role of mitochondria in stem cell fate and aging

Zhang, H., Menzies, K. J., & Auwerx, J. H. (2018) · Development · doi:10.1242/dev.143420 · Cited by 291

An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate

Maryanovich, M., Zaltsman, Y., Ruggiero, A., Goldman, A., Shachnai, L., Levin‐Zaidman, S., Porat, Z., Golan, K., Lapidot, T., & Gross, A. (2015) · Nature Communications · doi:10.1038/ncomms8901 · Cited by 247

Identity Noise and Adipogenic Traits Characterize Dermal Fibroblast Aging

Salzer, M. C., Lafzi, A., Berenguer, A., Youssif, C., Castellanos‐Martín, A., Solanas, G., Peixoto, F. O., Attolini, C. S., Prats, N., Aguilera, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.10.012 · Cited by 246

A lifetime of neurogenesis in the olfactory system

Brann, J. H., & Firestein, S. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00182 · Cited by 238

Skin Structure–Function Relationships and the Wound Healing Response to Intrinsic Aging

Blair, M. J., Jones, J. D., Woessner, A. E., & Quinn, K. P. (2019) · Advances in Wound Care · doi:10.1089/wound.2019.1021 · Cited by 236

Epigenetic control of adult stem cell function

Avgustinova, A., & Benitah, S. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.76 · Cited by 222

Changes in Regenerative Capacity through Lifespan

Yun, M. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161025392 · Cited by 216

Cellular Aging Contributes to Failure of Cold-Induced Beige Adipocyte Formation in Old Mice and Humans

Berry, D. C., Jiang, Y., Arpke, R. W., Close, E. L., Uchida, A., Reading, D., Berglund, E. D., Kyba, M., & Graff, J. M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.023 · Cited by 214

Nrf2: Redox and Metabolic Regulator of Stem Cell State and Function

Dai, X., Yan, X., Wintergerst, K. A., Cai, L., Keller, B. B., & Tan, Y. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.09.007 · Cited by 209

Signaling in the stem cell niche: regulating cell fate, function and plasticity

Chacón‐Martínez, C. A., Koester, J., & Wickström, S. A. (2018) · Development · doi:10.1242/dev.165399 · Cited by 197

mTOR signaling in stem and progenitor cells

Meng, D., Frank, A. R., & Jewell, J. L. (2018) · Development · doi:10.1242/dev.152595 · Cited by 201

The aging skin microenvironment dictates stem cell behavior

Ge, Y., Miao, Y., Gur-Cohen, S., Gomez, N., Yang, H., Nikolova, M., Polak, L., Hu, Y., Verma, A., Elemento, O., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901720117 · Cited by 190

Adipose-Derived Mesenchymal Stem Cells from the Elderly Exhibit Decreased Migration and Differentiation Abilities with Senescent Properties

Liu, M., Lei, H., Dong, P., Fu, X., Yang, Z., Yang, Y., Ma, J., Liu, X., Cao, Y., & Xiao, R. (2017) · Cell Transplantation · doi:10.1177/0963689717721221 · Cited by 173

CD163+ Tumor-Associated Macrophages Correlated with Poor Prognosis and Cancer Stem Cells in Oral Squamous Cell Carcinoma

He, K., Zhang, L., Huang, C., Ma, S., Wang, Y.-F., Wang, W., Zhao, Z., Liu, B., Zhao, Y., Zhang, W., et al. (2014) · BioMed Research International · doi:10.1155/2014/838632 · Cited by 177

Adult neural stem cells and their niche: a dynamic duo during homeostasis, regeneration, and aging

Silva-Vargas, V., Crouch, E. E., & Doetsch, F. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.09.004 · Cited by 157

Is Chronic Obstructive Pulmonary Disease an Accelerated Aging Disease?

MacNee, W. (2016) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201602-124aw · Cited by 153

Dietary and Metabolic Control of Stem Cell Function in Physiology and Cancer

Mihaylova, M. M., Sabatini, D. M., & Yilmaz, Ö. H. (2014) · Cell stem cell · doi:10.1016/j.stem.2014.02.008 · Cited by 158

Epigenetic clock analyses of cellular senescence and ageing.

Lowe, D., Horvath, S., & Raj, K. (2016) · Oncotarget · doi:10.18632/oncotarget.7383 · Cited by 147

Proteostasis and aging of stem cells

Vı́lchez, D., Simic, M., & Dillin, A. G. (2013) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.09.002 · Cited by 142

Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process

Salminen, A., Kauppinen, A., Hiltunen, M. O., & Kaarniranta, K. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.05.004 · Cited by 145

Cancer and Aging - the Inflammatory Connection

Zinger, A., Cho, W. C. S., & Ben‐Yehuda, A. (2017) · Aging and Disease · doi:10.14336/ad.2016.1230 · Cited by 138

Oxidative Stress in Stem Cell Aging

Chen, F., Liu, Y., Wong, N.-K., Xiao, J., & So, K. (2017) · Cell Transplantation · doi:10.1177/0963689717735407 · Cited by 138

Inhibition of Akt/mTOR Attenuates Age-Related Changes in Mesenchymal Stem Cells

Gharibi, B., Farzadi, S., Ghuman, M. S., & Hughes, F. J. (2014) · Stem Cells · doi:10.1002/stem.1709 · Cited by 136

Targeting the mTOR Signaling Network for Alzheimer’s Disease Therapy

Wang, C., Yu, J., Miao, D., Wu, Z., Tan, M., & Tan, L. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8505-8 · Cited by 136

BCL-2 family proteins as regulators of mitochondria metabolism

Gross, A. (2016) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2016.01.017 · Cited by 133

Proteostatic and Metabolic Control of Stemness

García‐Prat, L., Sousa‐Victor, P., & Muñoz‐Cánoves, P. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.04.011 · Cited by 125

Cell Autonomous and non-autonomous effects of senescent cells in the skin

Demaria, M., Desprez, P. Y., Campisi, J., & Velarde, M. C. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.108 · Cited by 127

The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and Disease

Hadjiargyrou, M., & O’Keefe, R. J. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2373 · Cited by 127

Targeting Aging Pathways in Chronic Obstructive Pulmonary Disease

Easter, M., Bollenbecker, S., Barnes, J. W., & Krick, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186924 · Cited by 130

Age-Associated Methylation Suppresses SPRY1, Leading to a Failure of Re-quiescence and Loss of the Reserve Stem Cell Pool in Elderly Muscle

Bigot, A., Duddy, W. J., Ouandaogo, Z. G., Négroni, E., Mariot, V., Ghimbovschi, S. D., Harmon, B. T., Wielgosik, A., Loiseau, C., Devaney, J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.067 · Cited by 136

Genome Integrity in Aging: Human Syndromes, Mouse Models, and Therapeutic Options

Vermeij, W. P., Hoeijmakers, J. H. J., & Pothof, J. (2015) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010814-124316 · Cited by 125

Physiology of Sedentary Behavior and Its Relationship to Health Outcomes

Thyfault, J. P., Du, M., Kraus, W. E., Levine, J. A., & Booth, F. W. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000518 · Cited by 124

Dental Follicle Cells: Roles in Development and Beyond

Zhou, T., Pan, J., Wu, P., Huang, R., Du, W. T., Zhou, Y., Wan, M., Fan, Y., Xu, X., Zhou, X., et al. (2019) · Stem Cells International · doi:10.1155/2019/9159605 · Cited by 123

The role of melatonin, a multitasking molecule, in retarding the processes of ageing

Majidinia, M., Reiter, R. J., Shakouri, S. K., & Yousefi, B. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.010 · Cited by 126

Transient delivery of modified mRNA encoding TERT rapidly extends telomeres in human cells

Ramunas, J., Yakubov, E., Brady Jennifer, J., Corbel, S. Y., Holbrook, C., Brandt, M., Stein, J., Santiago, J. G., Cooke, J. P., & Blau, H. M. (2015) · The FASEB Journal · doi:10.1096/fj.14-259531 · Cited by 129

Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility

Koester, J., Miroshnikova, Y. A., Ghatak, S., Chacón-Martínez, C. A., Morgner, J., Li, X., Atanassov, I., Altmüller, J., Birk, D. E., Koch, M., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00705-x · Cited by 117

The neural stem cell secretome and its role in brain repair

Willis, C. M., Nicaise, A. M., Peruzzotti‐Jametti, L., & Pluchino, S. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146615 · Cited by 119

The role of TP53 in acute myeloid leukemia: Challenges and opportunities

Barbosa, K., Li, S., Adams, P. D., & Deshpande, A. J. (2019) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22796 · Cited by 118

Mesenchymal Stem Cells Secretory Responses: Senescence Messaging Secretome and Immunomodulation Perspective

Lunyak, V. V., Amaro-Ortiz, A., & Gaur, M. (2017) · Frontiers in Genetics · doi:10.3389/fgene.2017.00220 · Cited by 119

Nicotinamide mononucleotide promotes osteogenesis and reduces adipogenesis by regulating mesenchymal stromal cells via the SIRT1 pathway in aged bone marrow

Song, J., Li, J., Yang, F., Ning, G., Zhen, L., Wu, L., Zheng, Y., Zhang, Q., Lin, D., Xie, C., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1569-2 · Cited by 115

p53 on the crossroad between regeneration and cancer

Charni‐Natan, M., Aloni-Grinstein, R., Molchadsky, A., & Rotter, V. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.117 · Cited by 115

Autophagy promotes osteogenic differentiation of human bone marrow mesenchymal stem cell derived from osteoporotic vertebrae

Wan, Y., Zhuo, N., Li, Y., Zhao, W., & Jiang, D. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.004 · Cited by 108

Stem Cells, Redox Signaling, and Stem Cell Aging

Liang, R., & Ghaffari, S. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5300 · Cited by 106

MECHANISMS IN ENDOCRINOLOGY: Aging and anti-aging: a Combo-Endocrinology overview

Diamanti‐Kandarakis, E., Dattilo, M., Μacut, D., Duntas, L. H., Gonos, E. S., Goulis, D. G., Kanaka‐Gantenbein, C., Καπετάνου, Μ., Koukkou, E. G., Lambrinoudaki, I. V., et al. (2017) · European Journal of Endocrinology · doi:10.1530/eje-16-1061 · Cited by 105

Therapeutic Plasticity of Neural Stem Cells

Ottoboni, L., von Wunster, B., & Martino, G. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00148 · Cited by 105

Aging and Regeneration in Vertebrates

Sousounis, K., Baddour, J., & Tsonis, P. A. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-391498-9.00008-5 · Cited by 96

Developmental changes in hematopoietic stem cell properties

Copley, M. R., & Eaves, C. J. (2013) · Experimental & Molecular Medicine · doi:10.1038/emm.2013.98 · Cited by 97

Histone methylation and aging: Lessons learned from model systems

McCauley, B. S., & Dang, W. (2014) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2014.05.008 · Cited by 93

The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells

Baker, N., Wade, S., Triolo, M., Girgis, J., Chwastek, D., Larrigan, S., Feige, P., Fujita, R., Crist, C. G., Rudnicki, M. A., et al. (2022) · Cell stem cell · doi:10.1016/j.stem.2022.07.010 · Cited by 96

Biological ageing with HIV infection: evaluating the geroscience hypothesis

Montano, M. A., Oursler, K. K., Xu, K., Sun, Y. V., & Marconi, V. C. (2022) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00278-6 · Cited by 94

Red blood cells open promising avenues for longitudinal studies of ageing in laboratory, non-model and wild animals

Stier, A., Reichert, S., Criscuolo, F., & Bize, P. (2015) · Experimental Gerontology · doi:10.1016/j.exger.2015.09.001 · Cited by 93

Identification of long-lived proteins retained in cells undergoing repeated asymmetric divisions

Thayer, N. H., Leverich, C. K., Fitzgibbon, M., Nelson, Z. W., Henderson, K. A., Gafken, P. R., Hsu, J. J., & Gottschling, D. E. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1416079111 · Cited by 90

Metabolic regulation of somatic stem cells in vivo

Meacham, C. E., DeVilbiss, A. W., & Morrison, S. J. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00462-1 · Cited by 85

Stem cells: Aging and transcriptional fingerprints

Keyes, B. E., & Fuchs, E. V. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201708099 · Cited by 84

Thioredoxin-interacting protein regulates haematopoietic stem cell ageing and rejuvenation by inhibiting p38 kinase activity

Jung, H., Kim, D. O., Byun, J.-E., Kim, W. S., Kim, M. J., Song, H. Y., Kim, Y. K., Kang, D.-K., Park, Y.-J., Kim, T.-D., et al. (2016) · Nature Communications · doi:10.1038/ncomms13674 · Cited by 81

Conditional Loss of Pten in Myogenic Progenitors Leads to Postnatal Skeletal Muscle Hypertrophy but Age-Dependent Exhaustion of Satellite Cells

Yue, F., Bi, P., Wang, C., Li, J., Liu, X., & Kuang, S. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.11.002 · Cited by 81

SNAI2 Controls the Undifferentiated State of Human Epidermal Progenitor Cells

Mistry, D. S., Chen, Y., Wang, Y., Zhang, K., & Sen, G. L. (2014) · Stem Cells · doi:10.1002/stem.1809 · Cited by 81

Metabolic regulation of stem cell function

Burgess, R., Agathocleous, M., & Morrison, S. J. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12247 · Cited by 81

Klotho Deficiency Accelerates Stem Cells Aging by Impairing Telomerase Activity

Ullah, M., & Sun, Z. (2019) · The Journals of Gerontology: Series A · doi:10.1093/gerona/gly261 · Cited by 77

Pleiotropic age-dependent effects of mitochondrial dysfunction on epidermal stem cells

Velarde, M. C., Demaria, M., Melov, S., & Campisi, J. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1505675112 · Cited by 77

Sirtuins in Metabolic and Epigenetic Regulation of Stem Cells

Fang, Y., Tang, S., & Li, X. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2018.12.002 · Cited by 79

A comparative in vitro study of the osteogenic and adipogenic potential of human dental pulp stem cells, gingival fibroblasts and foreskin fibroblasts

Monterubbianesi, R., Bencun, M., Pagella, P., Woloszyk, A., Orsini, G., & Mitsiadis, T. A. (2019) · Scientific Reports · doi:10.1038/s41598-018-37981-x · Cited by 77

Ageing as developmental decay: insights from p16INK4a.

Martin, N., Beach, D., & Gil, J. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.09.008 · Cited by 76

Age-related decline in the matrix contents and functional properties of human periodontal ligament stem cell sheets

Wu, R., Bi, C., Yu, Y., Zhang, L., & Chen, F. (2015) · Acta Biomaterialia · doi:10.1016/j.actbio.2015.04.024 · Cited by 76

Hematopoietic stem cells preferentially traffic misfolded proteins to aggresomes and depend on aggrephagy to maintain protein homeostasis

Chua, B. A., Lennan, C., Sunshine, M. J., Dreifke, D., Chawla, A., Bennett, E. J., & Signer, R. A. J. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.02.010 · Cited by 74

Comparison of similar cells: Mesenchymal stromal cells and fibroblasts

Ugurlu, B., & Karaöz, E. (2020) · Acta Histochemica · doi:10.1016/j.acthis.2020.151634 · Cited by 73

Long-term culture of mesenchymal stem cells impairs ATM-dependent recognition of DNA breaks and increases genetic instability

Hladik, D., Höfig, I., Oestreicher, U., Beckers, J., Matjanovski, M., Bao, X., Scherthan, H., Atkinson, M. J., & Rosemann, M. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1334-6 · Cited by 72

Targeting senescent cells: possible implications for delaying skin aging: a mini-review

Velarde, M. C., & Demaria, M. (2016) · Gerontology · doi:10.1159/000444877 · Cited by 69

The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging

Farr, J. N., & Almeida, M. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3564 · Cited by 70

The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat

Stacpoole, P. W., & McCall, C. E. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.02.007 · Cited by 70

A stress-induced cellular aging model with postnatal neural stem cells

Cm, D., Xl, W., Gm, W., Wj, Z., Zhu, L., Gao, S., Dj, Y., Qin, Y., Qj, L., Yl, C., et al. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.82 · Cited by 73

A storm in the niche: Iron, oxidative stress and haemopoiesis

Pilo, F., & Angelucci, E. (2017) · Blood Reviews · doi:10.1016/j.blre.2017.08.005 · Cited by 69

Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis

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Strategies to expand the therapeutic potential of superoxide dismutase by exploiting delivery approaches

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Cellular Mechanisms of Somatic Stem Cell Aging

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Closing the Circle: Stem Cell Rejuvenation and Longevity

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How stem cells age and why this makes us grow old

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Cellular Mechanisms of Somatic Stem Cell Aging

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The Stem Cell Hypothesis of Aging

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