Mechanisms that Regulate Stem Cell Aging and Life Span

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The DNA Damage Response: Making It Safe to Play with Knives

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β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes

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Protein aggregation and neurodegenerative disease

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Molecular chaperones in protein folding and proteostasis

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Premature ageing in mice expressing defective mitochondrial DNA polymerase

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Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA

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Adapting Proteostasis for Disease Intervention

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Inherent toxicity of aggregates implies a common mechanism for protein misfolding diseases

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Hypoxia-inducible factors and the response to hypoxic stress

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

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Rejuvenation of aged progenitor cells by exposure to a young systemic environment

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

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Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

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DNA damage, aging, and Cancer

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Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators

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Telomere Shortening and Tumor Formation by Mouse Cells Lacking Telomerase RNA

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Autophagy and Aging

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Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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Gene regulation and DNA damage in the ageing human brain

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Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells.

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How Shelterin Protects Mammalian Telomeres

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Recognition and Processing of Ubiquitin-Protein Conjugates by the Proteasome

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The ageing systemic milieu negatively regulates neurogenesis and cognitive function

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A Mutant Drosophila Insulin Receptor Homolog That Extends Life-Span and Impairs Neuroendocrine Function

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Role of the INK4a Locus in Tumor Suppression and Cell Mortality

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The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

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Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19

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FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress

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Wnt signalling regulates adult hippocampal neurogenesis

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daf-16 : An HNF-3/forkhead Family Member That Can Function to Double the Life-Span of Caenorhabditis elegans

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Ink4a/Arf expression is a biomarker of aging

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Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1

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p53 mutant mice that display early ageing-associated phenotypes

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Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells.

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Astroglia induce neurogenesis from adult neural stem cells

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Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein

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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

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Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice

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The Endocrine Regulation of Aging by Insulin-like Signals

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Telomere dysfunction induces metabolic and mitochondrial compromise

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Essential role of mouse telomerase in highly proliferative organs

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Gatekeepers and caretakers

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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

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Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study

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Rates of Behavior and Aging Specified by Mitochondrial Function During Development

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Notch-Mediated Restoration of Regenerative Potential to Aged Muscle

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Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

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Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells

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Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

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Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.

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The nucleolus under stress

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The Role of Hemocytes in Anopheles gambiae Antiplasmodial Immunity

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Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice

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Rationalization of the effects of mutations on peptide andprotein aggregation rates

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The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity

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p16INK4a induces an age-dependent decline in islet regenerative potential

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Molecular mechanisms of translational control

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FOXO3A genotype is strongly associated with human longevity

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p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis

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Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

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Stems Cells and the Pathways to Aging and Cancer

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Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

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Foxo3a is essential for maintenance of the hematopoietic stem cell pool

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Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

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In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics

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PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention

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Lifespan extension by conditions that inhibit translation in Caenorhabditis elegans

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Aging Hematopoietic Stem Cells Decline in Function and Exhibit Epigenetic Dysregulation

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