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Origins and evolution of eukaryotic RNA interference
Open accessAbstract
Small interfering RNAs (siRNAs) and genome-encoded microRNAs (miRNAs) silence genes via complementary interactions with mRNAs. With thousands of miRNA genes identified and genome sequences of diverse eukaryotes available for comparison, the opportunity emerges for insights into origin and evolution of RNA interference (RNAi). The miRNA repertoires of plants and animals appear to have evolved independently. However, conservation of the key proteins involved in RNAi suggests that the last common ancestor of modern eukaryotes possessed siRNA-based mechanisms. Prokaryotes have a RNAi-like defense system that is functionally analogous but not homologous to eukaryotic RNAi. The protein machinery of eukaryotic RNAi seems to have been pieced together from ancestral proteins of archaeal, bacterial and phage origins that are involved in DNA repair and RNA-processing pathways.
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Metadata
- Authors
- SHABALINA, S., & KOONIN, E.
- Venue
- Trends in Ecology & Evolution
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 23
- Issue
- 10
- Pages
- 578-587
- ISSN
- 0169-5347 (ISSN-L)
- OpenAlex
- W2054268736
- Cited by
- 561
- References
- 86
- FWCI
- 8.07
- Type
- journal article
- Language
- en
- Open access
- green
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