Cited by 172Functional Brain Connectivity StudiesAutism Spectrum Disorder ResearchAdvanced MRI Techniques and Applications

Sources of group differences in functional connectivity: An investigation applied to autism spectrum disorder

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Jones, Tyler B., Bandettini, Peter A., Kenworthy, Lauren, Case, Laura K., Milleville, Shawn C., Martin, Alex, Birn, Rasmus M.·2010·NeuroImage

Abstract

An increasing number of fMRI studies are using the correlation of low-frequency fluctuations between brain regions, believed to reflect synchronized variations in neuronal activity, to infer "functional connectivity". In studies of autism spectrum disorder (ASD), decreases in this measure of connectivity have been found by focusing on the response to task modulation, by using only the rest periods, or by analyzing purely resting-state data. This difference in connectivity, however, could result from a number of different mechanisms--differences in noise, task-related fluctuations, task performance, or spontaneous neuronal activity. In this study, we investigate the difference in functional connectivity between adolescents with high-functioning ASD and typically developing control subjects by examining the residual fluctuations occurring on top of the fMRI response to an overt verbal fluency task. We find decreased correlations of these residuals (a decreased "connectivity") in ASD subjects. Furthermore, we find that this decrease was not due to task-related effects, block-to-block variations in task performance, or increased noise, and the difference was greatest when primarily rest periods are considered. These findings suggest that the estimate of disrupted functional connectivity in ASD is likely driven by differences in task-unrelated neuronal fluctuations.

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Crossref · 10.1016/j.neuroimage.2009.07.051

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Research works printed but not linked: 2

  1. Murphy K Birn RM Handwerker DA Jones TB Bandettini PA 2009 The impact of global signal regression on resting state correlations: are anti-correlated networks introduced? Neuroimage 44 3 893 905 18976716 PMC2750906
  2. Tager-Flusberg H Prior M 2004 Language and communicative deficits and their effects on learning and behavior Asperger syndrome:Behavioral and educational aspects Guilford Press New York 85 103

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Authors
Jones, T. B., Bandettini, P. A., Kenworthy, L., Case, L. K., Milleville, S. C., Martin, A., & Birn, R. M.
Affiliations
National Institutes of Health (US)
Corresponding author
Birn, Rasmus M.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2010-01
Volume
49
Issue
1
Pages
401-414
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2061756585
Cited by
172
References
76
Citations by year
2025: 2 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 8 · 2020: 7 · 2019: 10 · 2018: 6 · 2017: 10 · 2016: 12 · 2015: 16 · 2014: 12 · 2013: 32 · 2012: 15
FWCI
6.61
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (ZIAMH002783, ZIAMH002920)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
autism spectrum disorder, functional connectivity, low-frequency fluctuations, resting-state fMRI, verbal fluency task, group differences
MeSH terms
Adolescent, Aging, Algorithms, Child, Child Development Disorders, Pervasive, Humans, Image Processing, Computer-Assisted, Language, Magnetic Resonance Imaging, Male, Neural Pathways, Neuropsychological Tests, Psychiatric Status Rating Scales, Regression Analysis, Social Behavior, Verbal Behavior, Executive Function

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