Development of a Crohn's Disease Activity Index

A Phase I Trial With Transgenic Bacteria Expressing Interleukin-10 in Crohn’s Disease

Braat, H., Rottiers, P., Hommes, D. W., Huyghebaert, N., Remaut, E., Remon, J., van Deventer, S. J. H., Neirynck, S., Peppelenbosch, M. P., & Steidler, L. (2006) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2006.03.028 · Cited by 786

Trichuris suis therapy in Crohn’s disease

Summers, R. W., Elliott, D. E., Urban, J. F., Thompson, R., & Weinstock, J. V. (2005) · Gut · doi:10.1136/gut.2004.041749 · Cited by 762

A pilot randomized trial of a human anti-interleukin-6 receptor monoclonal antibody in active Crohn’s disease☆

Ito, H., Takazoe, M., Fukuda, Y., Hibi, T., Kusugami, K., Andoh, A., Matsumoto, T., Yamamura, T., Azuma, J., & Nishimoto, N. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.012 · Cited by 636

Intestinal permeability and the prediction of relapse in Crohn's disease

Wyatt, J., Vogelsang, H., Hübl, W., Waldhoer, T., & Lochs, H. (1993) · The Lancet · doi:10.1016/0140-6736(93)90882-h · Cited by 626

Impact of depressive mood on relapse in patients with inflammatory bowel disease: A prospective 18-month follow-up study

Mittermaier, C., Dejaco, C., Waldhoer, T., Oefferlbauer-Ernst, A., Miehsler, W., Beier, M., Tillinger, W., Gangl, A., & Moser, G. (2004) · Psychosomatic Medicine · doi:10.1097/01.psy.0000106907.24881.f2 · Cited by 532

Increased Proportions of Bifidobacterium and the Lactobacillus Group and Loss of Butyrate-Producing Bacteria in Inflammatory Bowel Disease

Wang, W., Chen, L., Zhou, R., Wang, X., Song, L., Huang, S., Wang, G., & Xia, B. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.01500-13 · Cited by 509

Influence of dietary factors on the clinical course of ulcerative colitis: a prospective cohort study

Jowett, S. L., Seal, C. J., Pearce, M. S., Phillips, E., Gregory, W., Barton, J. R., & Welfare, M. R. (2004) · Gut · doi:10.1136/gut.2003.024828 · Cited by 462

Symptoms of depression and anxiety are independently associated with clinical recurrence of inflammatory bowel disease

Mikocka-Walus, A., Pittet, V., Rossel, J.-B., von Känel, R., Anderegg, C., Bauerfeind, P., Beglinger, C., Begré, S., Belli, D., Bengoa, J. M., et al. (2016) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2015.12.045 · Cited by 348

Relationship between disease activity indices and colonoscopic findings in patients with colonic inflammatory bowel disease.

Gomes, P., du Boulay, C., Smith, C. L., & Holdstock, G. (1986) · Gut · doi:10.1136/gut.27.1.92 · Cited by 339

Decreased abundance of Faecalibacterium prausnitzii in the gut microbiota of Crohn's disease

Fujimoto, T., Imaeda, H., Takahashi, K., Kasumi, E., Bamba, S., Fujiyama, Y., & Andoh, A. (2013) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.12073 · Cited by 304

Effectiveness of an ‘half elemental diet’ as maintenance therapy for Crohn's disease: a randomized-controlled trial

TAKAGI, S., UTSUNOMIYA, K., KURIYAMA, S., YOKOYAMA, H., TAKAHASHI, S., IWABUCHI, M., TAKAHASHI, H., TAKAHASHI, S., KINOUCHI, Y., HIWATASHI, N., et al. (2006) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2006.03120.x · Cited by 292

Efficacy and Safety of MEDI2070, an Antibody Against Interleukin 23, in Patients With Moderate to Severe Crohn’s Disease: A Phase 2a Study

Sands, B. E., Chen, J., Feagan, B. G., Penney, M., Rees, W. A., Danese, S., Higgins, P. D. R., Newbold, P., Faggioni, R., Patra, K., et al. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.03.049 · Cited by 279

Predicting relapse in Crohn’s disease: a biopsychosocial model

Bitton, A., Dobkin, P. L., Edwardes, M. D., Sewitch, M. J., Meddings, J. B., Rawal, S., Cohen, A., Vermeire, S., Dufresne, L., Franchimont, D., et al. (2008) · Gut · doi:10.1136/gut.2007.134817 · Cited by 254

American Gastroenterological Association Consensus Development Conference on the Use of Biologics in the Treatment of Inflammatory Bowel Disease, June 21–23, 2006

Clark, M., Colombel, J.-F., Feagan, B. C., Fedorak, R. N., Hanauer, S. B., Kamm, M. A., Mayer, L., Regueiro, C., Rutgeerts, P., Sandborn, W. J., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.006 · Cited by 224

Current best practice for disease activity assessment in IBD

Walsh, A. J., Bryant, R. V., & Travis, S. P. L. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.128 · Cited by 223

Converging goals of treatment of inflammatory bowel disease from clinical trials and practice

Levesque, B. G., Sandborn, W. J., Ruel, J., Feagan, B. G., Sands, B. E., & Colombel, J.-F. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.08.003 · Cited by 217

Biomarkers in inflammatory bowel disease: current practices and recent advances.

Iskandar, H. N., & Ciorba, M. A. (2012) · Translational Research · doi:10.1016/j.trsl.2012.01.001 · Cited by 210

A meta-analysis of the placebo rates of remission and response in clinical trials of active crohn’s disease

Su, C., Lichtenstein, G. R., Krok, K., Brensinger, C. M., & Lewis, J. D. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.01.024 · Cited by 212

Validity, reliability, and responsiveness of the work productivity and activity impairment questionnaire in Crohn’s disease

Reilly, M. C., Gerlier, L., Brabant, Y., & Brown, M. (2008) · Clinical Therapeutics · doi:10.1016/j.clinthera.2008.02.016 · Cited by 196

Psychological Distress, Social Support, and Disease Activity in Patients With Inflammatory Bowel Disease

Sewitch, M. J., Abrahamowicz, M., Bitton, A., Daly, D., Wild, G. E., Cohen, A., Katz, S., Szego, P. L., & Dobkin, P. L. (2001) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2001.03800.x · Cited by 192

Do NSAIDs, Antibiotics, Infections, or Stress Trigger Flares in IBD?

Singh, S., Graff, L. A., & Bernstein, C. N. (2009) · The American Journal of Gastroenterology · doi:10.1038/ajg.2009.15 · Cited by 181

Do psychosocial factors define symptom severity and patient status in irritable bowel syndrome?

Drossman, D. A. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00081-9 · Cited by 168

Inflammatory bowel disease versus irritable bowel syndrome: a hospital‐based, case‐control study of disease impact on quality of life

Pace, F., Molteni, P., Bollani, S., Sarzi‐Puttini, P., Stockbrügger, R., Porro, G. B., & Drossman, D. A. (2003) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520310004524 · Cited by 157

The assessment of faecal flora in patients with inflammatory bowel disease by a simplified bacteriological technique

GIAFFER, M. H., HOLDSWORTH, C. D., & DUERDEN, B. I. (1991) · Journal of Medical Microbiology · doi:10.1099/00222615-35-4-238 · Cited by 151

Clinical relevance of serum interleukin-6 in Crohn’s disease: single point measurements, therapy monitoring, and prediction of clinical relapse

Reinisch, W., Gasché, C., Tillinger, W., Wyatt, J., Lichtenberger, C., Willheim, M., Dejaco, C., Waldhör, T., Bakos, S., Vogelsang, H., et al. (1999) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1999.01288.x · Cited by 150

Changes in the Abundance of Faecalibacterium prausnitzii Phylogroups I and II in the Intestinal Mucosa of Inflammatory Bowel Disease and Patients with Colorectal Cancer

Lopez-Siles, M., Martinez-Medina, M., Surís-Valls, R., Aldeguer, X., Sabat-Mir, M., Duncan, S. H., Flint, H. J., & Garcia-Gil, L. J. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000590 · Cited by 144

Short CDAI: Development and validation of a shortened and simplified Crohnʼs disease activity index

Thia, K., Faubion, W. A., Loftus, E. V., Persson, T., Persson, A., & Sandborn, W. J. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21400 · Cited by 134

Bone disease in patients with primary sclerosing cholangitis

Angulo, P., Grandison, G. A., Fong, D. G., Keach, J. C., Lindor, K. D., Bjornsson, E., & Koch, A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2010.10.014 · Cited by 133

Randomized, double-blind, placebo-controlled trial of the oral interleukin-12/23 inhibitor apilimod mesylate for treatment of active Crohn’s disease

Sands, B. E., Jacobson, E. W., Sylwestrowicz, T., Younes, Z., Dryden, G., Fedorak, R., & Greenbloom, S. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21159 · Cited by 114

Preliminary examination of the relations between disease activity, illness perceptions, coping strategies, and psychological morbidity in Crohnʼs disease guided by the common sense model of illness

Knowles, S. R., Wilson, J. L., Connell, W. R., & Kamm, M. A. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21650 · Cited by 113

The relation between daily stress and Crohn's disease

Garrett, V. D., Brantley, P. J., Jones, G. N., & McKnight, G. T. (1991) · Journal of Behavioral Medicine · doi:10.1007/bf00844770 · Cited by 112

Virulence properties of Escherichia coli strains isolated from patients with inflammatory bowel disease.

Giaffer, M. H., Holdsworth, C. D., & Duerden, B. I. (1992) · Gut · doi:10.1136/gut.33.5.646 · Cited by 109

Total parenteral nutrition as the sole therapy in Crohn's disease—a prospective study

Müller, J. M., Keller, H. W., Erasmi, H., & Pichlmaier, H. (1983) · Journal of British Surgery · doi:10.1002/bjs.1800700116 · Cited by 101

Cognitive-behavioural therapy has no effect on disease activity but improves quality of life in subgroups of patients with inflammatory bowel disease: a pilot randomised controlled trial

Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. M. (2015) · BMC Gastroenterology · doi:10.1186/s12876-015-0278-2 · Cited by 86

Which patients with IBD need psychological interventions? A controlled study

Miehsler, W., Weichselberger, M., Öfferlbauer-Ernst, A., Dejaco, C., Reinisch, W., Vogelsang, H., Machold, K., Stamm, T., Gangl, A., & Moser, G. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20462 · Cited by 82

Enteral nutrition for the maintenance of remission in Crohnʼs disease: a systematic review

Yamamoto, T., Nakahigashi, M., Umegae, S., & Matsumoto, K. (2010) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32832c788c · Cited by 81

A Controlled Study of a Group Mindfulness Intervention for Individuals Living With Inflammatory Bowel Disease

Neilson, K., Ftanou, M., Monshat, K., Salzberg, M., Bell, S., Kamm, M. A., Connell, W., Knowles, S. R., Sevar, K., Mancuso, S. G., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000629 · Cited by 80

Cognitive-Behavioural Therapy for Inflammatory Bowel Disease: 24-Month Data from a Randomised Controlled Trial

Mikocka-Walus, A., Bampton, P., Hetzel, D., Hughes, P., Esterman, A., & Andrews, J. M. (2017) · International Journal of Behavioral Medicine · doi:10.1007/s12529-016-9580-9 · Cited by 78

Psychological problems in gastroenterology outpatients: A South Australian experience. Psychological co-morbidity in IBD, IBS and hepatitis C

Mikocka-Walus, A. A., Turnbull, D. A., Andrews, J. M., Moulding, N. T., Wilson, I. G., Harley, H. A., Hetzel, D. J., & Holtmann, G. J. (2008) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-4-15 · Cited by 76

ECCO position on harmonisation of Crohn's disease mucosal histopathology

Magro, F., Sabino, J., Rosini, F., Tripathi, M., Borralho, P., Baldin, P., Danese, S., Driessen, A., Gordon, I. O., Iacucci, M., et al. (2022) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjac006 · Cited by 76

Gut lavage fluid protein concentrations: Objective measures of disease activity in inflammatory bowel disease

Choudari, C. P., O'Mahony, S., Brydon, G., Mwantembe, O., & Ferguson, A. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90275-h · Cited by 71

Concerns and worries in people living with inflammatory bowel disease (IBD): A mixed methods study

Keeton, R. L., Mikocka-Walus, A., & Andrews, J. M. (2015) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2014.12.004 · Cited by 72

Mood and nonmood components of perceived stress and exacerbation of Crohnʼs disease

Cámara, R. J. A., Schoepfer, A. M., Pittet, V., Begré, S., & von Känel, R. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21623 · Cited by 67

Degradation of the extracellular matrix components by bacterial-derived metalloproteases: Implications for inflammatory bowel diseases

Pruteanu, M., Hyland, N. P., Clarke, D. J., Kiely, B., & Shanahan, F. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21475 · Cited by 67

A Randomised, Double-blind, Placebo-controlled Trial of Trichuris suis ova in Active Crohn’s disease

Schölmerich, J., Fellermann, K., Seibold, F. W., Rogler, G., Langhorst, J., Howaldt, S., Novacek, G., Petersen, A. M., Bachmann, O., Matthes, H., et al. (2016) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjw184 · Cited by 66

Autonomic dysfunctions in patients with inflammatory bowel disease in clinical remission

Sharma, P., Makharia, G. K., Ahuja, V., Dwivedi, S. N., & Deepak, K. K. (2009) · Digestive Diseases and Sciences · doi:10.1007/s10620-008-0424-6 · Cited by 64

Clinical disease activity is associated with anxiety and depressive symptoms in adolescents and young adults with inflammatory bowel disease

van den Brink, G., Stapersma, L., Vlug, L. E., Rizopolous, D., Bodelier, A. G., van Wering, H., Hurkmans, P. C. W. M., Stuyt, R. J. L., Hendriks, D. M., van der Burg, J. A. T., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14832 · Cited by 61

Active Crohn's Disease Patients Show a Distinctive Expansion of Circulating Memory CD4+CD45RO+CD28null T Cells

De Tena, J. G., Manzano, L., Leal, J. C., Antonio, E. S., Sualdea, V., & Álvarez-Mon, M. (2004) · Journal of Clinical Immunology · doi:10.1023/b:joci.0000019784.20191.7f · Cited by 59

Serum Hepcidin in Inflammatory Bowel Diseases: Biological and Clinical Significance

Bergamaschi, G., Di Sabatino, A., Albertini, R., Costanzo, F., Guerci, M., Masotti, M., Pasini, A., Massari, A., Campostrini, N., Corbella, M., et al. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e31829a6e43 · Cited by 56

Reconsidering the methodology of “stress” research in inflammatory bowel disease

Keefer, L., Keshavarzian, A., & Mutlu, E. (2008) · Journal of Crohn's and Colitis · doi:10.1016/j.crohns.2008.01.002 · Cited by 56

Impaired Sleep Quality in Crohn’s Disease Depends on Disease Activity

Gingold-Belfer, R., Peled, N., Levy, S., Katz, N., Niv, Y., Fass, R., Fraser, G., & Dickman, R. (2014) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2890-8 · Cited by 46

Effectiveness of disease-specific cognitive behavioral therapy on anxiety, depression, and quality of life in youth with inflammatory bowel disease: a randomized controlled trial

Stapersma, L., van den Brink, G., van der Ende, J., Szigethy, E. M., Beukers, R., Korpershoek, T. A., Theuns-Valks, S. D. M., Hillegers, M. H. J., Escher, J. C., & Utens, E. M. W. J. (2018) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsy029 · Cited by 46

Common functional alterations identified in blood transcriptome of autoimmune cholestatic liver and inflammatory bowel diseases

Ostrowski, J., Goryca, K., Lazowska, I., Rogowska, A., Paziewska, A., Dabrowska, M., Ambrozkiewicz, F., Karczmarski, J., Balabas, A., Kluska, A., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43699-1 · Cited by 36

Deep learning analysis of histologic images from intestinal specimen reveals adipocyte shrinkage and mast cell infiltration to predict postoperative crohn disease

Kiyokawa, H., Abe, M., Matsui, T., Kurashige, M., Ohshima, K., Tahara, S., Nojima, S., Ogino, T., Sekido, Y., Mizushima, T., et al. (2022) · The American Journal of Pathology · doi:10.1016/j.ajpath.2022.03.006 · Cited by 32

Assessment of hypothalamic-pituitary-adrenal axis function after corticosteroid therapy in inflammatory bowel disease

Desramé, J., Sabaté, J. M., Agher, R., Bremont, C., Gaudric, M., Couturier, D., & Chaussade, S. (2002) · American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05786.x · Cited by 26

Psychological mediators of psychological distress and quality of life in inflammatory bowel disease

Kantidakis, J. D., Moulding, R., & Knowles, S. R. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110596 · Cited by 26

Kallikrein-kinin system activation in Crohn's disease: differences in intestinal and systemic markers

Devani, M., Cugno, M., Vecchi, M., Ferrero, S., Berardino, F., Avesani, E. C., Franchis, R., & Colman, R. W. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05919.x · Cited by 31

Everyday stress and crohn’s disease activity: A time series analysis of 20 single cases

Traue, H. C., & Kosarz, P. (1999) · International Journal of Behavioral Medicine · doi:10.1207/s15327558ijbm0602_1 · Cited by 21

The Placebo Response Rate in Irritable Bowel Syndrome and Inflammatory Bowel Disease

Sands, B. E. (2009) · Digestive Diseases · doi:10.1159/000268123 · Cited by 17

Cognitive behaviour therapy for distress in people with inflammatory bowel disease: A benchmarking study

Jordan, C., Hayee, B., & Chalder, T. (2019) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.2326 · Cited by 14

Administration of testosterone to elderly hypogonadal men with Crohn's disease improves their Crohn's Disease Activity Index: a pilot study

Haider, A., Kurtz, W., Giltay, E. J., Gooren, L. J., & Saad, F. (2010) · hmbci · doi:10.1515/hmbci.2010.033 · Cited by 10