The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Antioxidant supplements for prevention of gastrointestinal cancers: a systematic review and meta-analysis
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552
Quantifying heterogeneity in a meta‐analysis
Higgins, J. P. T., & Thompson, S. G. (2002) · Statistics in Medicine · doi:10.1002/sim.1186 · Cited by 36,763
Schulz (1995) · doi:10.1001/jama.1995.03520290060030 · Cited by 5,634
(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638
Moher, D., Pham, B., Jones, A., Cook, D. J., Jadad, A. R., Moher, M., Tugwell, P., & Klassen, T. P. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01085-x · Cited by 3,560
Assessing the quality of controlled clinical trials
Jüni, P., Altman, D. G., & Egger, M. (2001) · BMJ · doi:10.1136/bmj.323.7303.42 · Cited by 3,309
Vegetables, Fruit, and Cancer Prevention
STEINMETZ, K. A., & POTTER, J. D. (1996) · Journal of the American Dietetic Association · doi:10.1016/s0002-8223(96)00273-8 · Cited by 2,118
Vivekananthan, D. P., Penn, M. S., Sapp, S. K., Hsu, A., & Topol, E. J. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13637-9 · Cited by 1,083
Research works printed but not linked: 54
- Ames, 1995, The causes and prevention of cancer, Proc Natl Acad Sci USA, 92, 5258, 10.1073/pnas.92.12.5258 · DOI · Paper page
- Halliwell, 2000, The gastrointestinal tract: a major site of antioxidant action?, Free Radic Res, 33, 819, 10.1080/10715760000301341 · DOI · Paper page
- Poppel, 1997, Vitamins and cancer, Cancer Lett, 114, 195, 10.1016/S0304-3835(97)04662-4 · DOI
- Diplock, 1994, Antioxidants and disease prevention, Mol Aspects Med, 15, 293, 10.1016/0098-2997(94)90005-1 · DOI · Paper page
- Sporn, 2000, Chemoprevention of cancer, Carcinogenesis, 21, 525, 10.1093/carcin/21.3.525 · DOI · Paper page
- Salganik, 2001, The benefits and hazards of antioxidants: controlling apoptosis and other protective mechanisms in cancer patients and the human population, J Am Coll Nutr, 20, 464S, 10.1080/07315724.2001.10719185 · DOI · Paper page
- Thomson, 1998, Oxidative stress and antioxidants in intestinal disease, Dig Dis, 16, 152, 10.1159/000016859 · DOI
- Tamimi, 2002, Prospect for chemoprevention of cancer, J Intern Med, 251, 286, 10.1046/j.1365-2796.2002.00969.x · DOI
- Pritchard, 1996, Apoptosis and gastrointestinal pharmacology, Pharmacol Ther, 72, 149, 10.1016/S0163-7258(96)00102-7 · DOI
- Sihvo, 2002, Oxidative stress has a role in malignant transformation in Barrett's oesophagus, Int J Cancer, 102, 551, 10.1002/ijc.10755 · DOI
- Boyle, 1985, Descriptive epidemiology of colorectal cancer, Int J Cancer, 36, 9, 10.1002/ijc.2910360103 · DOI
- Weisburger, 1991, Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants, and carotenoids, Am J Clin Nutr, 53, S226, 10.1093/ajcn/53.1.226S · DOI
- Poppel, 1996, Epidemiological evidence for beta-carotene in prevention of cancer and cardiovascular disease, Eur J Clin Nutr, 50, S57
- Lee, 2003, Beneficial and adverse effects of chemopreventive agents, Mutat Res, 523–24, 265, 10.1016/S0027-5107(02)00342-1 · DOI
- Paolini, 2003, Beta-carotene: a cancer chemopreventive agent or a co-carcinogen?, Mutat Res, 543, 195, 10.1016/S1383-5742(03)00002-4 · DOI
- Bjelakovic, 2003, Antioxidants for preventing gastrointestinal cancers (protocol for a Cochrane Review)
- Kjaergard, 2001, Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses, Ann Intern Med, 135, 982, 10.7326/0003-4819-135-11-200112040-00010 · DOI · Paper page
- DeMets, 1987, Methods for combining randomized clinical trials: strengths and limitations, Stat Med, 66, 341, 10.1002/sim.4780060325 · DOI · Paper page
- Altman, 2003, Interaction revisited: the difference between two estimates, BMJ, 326, 219, 10.1136/bmj.326.7382.219 · DOI · Paper page
- Munoz, 1985, No effect of riboflavine, retinol, and zinc on prevalence of precancerous lesions of oesophagus: randomised double-blind intervention study in high-risk population of China, Lancet, 326, 111, 10.1016/S0140-6736(85)90223-5 · DOI
- Yu, 1991, A preliminary report on the intervention trials of primary liver cancer in high-risk populations with nutritional supplementation of selenium in China, Biol Trace Elem Res, 29, 289, 10.1007/BF03032685 · DOI
- Blot, 1993, Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population, J Natl Cancer Inst, 85, 1483, 10.1093/jnci/85.18.1483 · DOI · Paper page
- Li, 1993, Nutrition intervention trials in Linxian, China: multiple vitamin/mineral supplementation, cancer incidence, and disease-specific mortality among adults with esophageal dysplasia, J Natl Cancer Inst, 85, 1492, 10.1093/jnci/85.18.1492 · DOI · Paper page
- Clark, 1996, Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. A randomized controlled trial, JAMA, 276, 1957, 10.1001/jama.1996.03540240035027 · DOI · Paper page
- Hennekens, 1996, Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease, N Engl J Med, 334, 1145, 10.1056/NEJM199605023341801 · DOI · Paper page
- Yu, 1997, Protective role of selenium against hepatitis B virus and primary liver cancer in Qidong, Biol Trace Elem Res, 56, 117, 10.1007/BF02778987 · DOI · Paper page
- Lee, 1999, Randomised beta-carotene supplementation and incidence of cancer and cardiovascular disease in women: the Women's Health Study, J Natl Cancer Inst, 91, 2102, 10.1093/jnci/91.24.2102 · DOI · Paper page
- Li, 2000, The prevention of primary liver cancer by selenium in high-risk populations, Zhonghua Yu Fang Yi Xue Za Zhi, 34, 336
- Correa, 2000, Chemoprevention of gastric dysplasia: randomized trial of antioxidant supplements and anti- Helicobacter pylori therapy, J Natl Cancer Inst, 92, 1881, 10.1093/jnci/92.23.1881 · DOI · Paper page
- Zhu, 2002, The interventional effect of folic acid on the development of gastric and other gastrointestinal cancers—clinical trial and follow-up for seven years, Chin J Gastroenterol, 7, 73
- Caraballoso, 2004, Drugs for preventing lung cancer in healthy people (Cochrane Review)
- van den Broek, 2003, Vitamin A supplementation during pregnancy (Cochrane Review)
- Darlow, 2003, Vitamin A supplementation for preventing morbidity and mortality in very low birthweight infants (Cochrane Review)
- Glasziou, 1993, Vitamin A supplementation in infectious diseases: a meta-analysis, BMJ, 306, 366, 10.1136/bmj.306.6874.366 · DOI · Paper page
- Hercberg, 1999, “The SU.VI.MAX Study”: a primary prevention trial using nutritional doses of antioxidant vitamins and minerals in cardiovascular diseases and cancers, Food Chem Toxicol, 37, 925, 10.1016/S0278-6915(99)00078-2 · DOI
- Klein, 2003, SELECT: the selenium and vitamin E cancer prevention trial, Urol Oncol, 21, 59, 10.1016/S1078-1439(02)00301-0 · DOI
- McKeown-Eyssen, 1988, A randomized trial of vitamins C and E in the prevention of recurrence of colorectal polyps, Cancer Res, 48, 4701
- Roncucci, 1993, Antioxidant vitamins or lactulose for the prevention of the recurrence of colorectal adenomas. Colorectal Cancer Study Group of the University of Modena and the health-care district 16, Dis Colon Rectum, 36, 227, 10.1007/BF02053502 · DOI
- Greenberg, 1994, A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group, New Eng J Med, 331, 141, 10.1056/NEJM199407213310301 · DOI · Paper page
- MacLennan, 1995, Randomized trial of intake of fat, fiber, and beta carotene to prevent colorectal adenomas. The Australian Polyp Prevention Project. J, Natl Cancer Inst, 87, 1760, 10.1093/jnci/87.23.1760 · DOI · Paper page
- Ponz de Leon, 1997, Chemoprevention of colorectal tumors: role of lactulose and of other agents, Scand J Gastroenterol, 222, 72, 10.1080/00365521.1997.11720724 · DOI
- Hofstad, 1998, Growth and recurrence of colorectal polyps: a double-blind 3-year intervention with calcium and antioxidants, Digestion, 59, 148, 10.1159/000007480 · DOI
- Malila, 1999, The effect of alpha-tocopherol and beta-carotene supplementation on colorectal adenomas in middle-aged male smokers, Cancer Epidemiol Biomarkers Prev, 8, 489
- Janne, 2000, Chemoprevention of colorectal cancer, N Engl J Med, 342, 1960, 10.1056/NEJM200006293422606 · DOI · Paper page
- Shikany, 2003, Antioxidant supplement use in Women's Health Initiative, Prev Med, 36, 379, 10.1016/S0091-7435(02)00050-6 · DOI
- Karakaya, 1999, Antimutagenic activities of some foods, J Agricultur Food Chem, 79, 237, 10.1002/(SICI)1097-0010(199902)79:2<237::AID-JSFA178>3.0.CO;2-K · DOI
- Greenwald, 2001, Diet and cancer prevention, Eur J Cancer, 37, 948, 10.1016/S0959-8049(01)00070-3 · DOI · Paper page
- Kaur, 2001, Antioxidants in fruits and vegetables—the millennium's health, Int J Food Science Technol, 36, 703, 10.1046/j.1365-2621.2001.00513.x · DOI · Paper page
- Camire, 1999, Dietary supplements: nutritional and legal considerations, Food Technol, 53, 87
- Halliwell, 1997, Antioxidants and human disease: a general introduction, Nutr Rev, 55, S44, 10.1111/j.1753-4887.1997.tb06100.x · DOI · Paper page
- Michels, 2000, Prospective study of fruit and vegetable consumption and incidence of colon and rectal cancers, J Natl Cancer Inst, 92, 1740, 10.1093/jnci/92.21.1740 · DOI · Paper page
- Botterweck, 1998, A prospective cohort study on vegetable and fruit consumption and stomach cancer risk in the Netherlands, Am J Epidemiol, 148, 842, 10.1093/oxfordjournals.aje.a009709 · DOI
- Schatzkin, 2000, Lack of effect of a low-fat, high-fiber diet on the recurrence of colorectal adenomas. Polyp Prevention Trial Study Group, N Engl J Med, 342, 1149, 10.1056/NEJM200004203421601 · DOI · Paper page
- Omenn, 1998, Chemoprevention of lung cancer: the rise and demise of beta-carotene, Annu Rev Public Health, 19, 73, 10.1146/annurev.publhealth.19.1.73 · DOI
Cited by
Rayman, M. P. (2012) · The Lancet · doi:10.1016/s0140-6736(11)61452-9 · Cited by 3,563
Meta-Analysis: High-Dosage Vitamin E Supplementation May Increase All-Cause Mortality
Miller, E. R., Pastor-Barriuso, R., Dalal, D., Riemersma, R. A., Appel, L. J., & Guallar, E. (2005) · Annals of Internal Medicine · doi:10.7326/0003-4819-142-1-200501040-00110 · Cited by 2,577
Oxidative Stress: An Essential Factor in the Pathogenesis of Gastrointestinal Mucosal Diseases
Bhattacharyya, A., Chattopadhyay, R., Mitra, S., & Crowe, S. E. (2014) · Physiological Reviews · doi:10.1152/physrev.00040.2012 · Cited by 2,484
Bjelakovic, G., Nikolova, D., Gluud, L. L., Simonetti, R. G., & Gluud, C. (2007) · JAMA · doi:10.1001/jama.297.8.842 · Cited by 2,275
Self-citationTrial sequential analysis may establish when firm evidence is reached in cumulative meta-analysis
Wetterslev, J., Thorlund, K., Brok, J., & Gluud, C. (2008) · Journal of Clinical Epidemiology · doi:10.1016/j.jclinepi.2007.03.013 · Cited by 1,881
Self-citationOxidative stress and cancer: Have we moved forward?
Halliwell, B. (2007) · Biochemical Journal · doi:10.1042/bj20061131 · Cited by 1,302
Achieving the Balance between ROS and Antioxidants: When to Use the Synthetic Antioxidants
Poljsak, B., Šuput, D., & Milisav, I. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/956792 · Cited by 1,301
Autier, P. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.16.1730 · Cited by 1,104
The role of mitochondria in aging
Bratic, A., & Larsson, N.-G. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64125 · Cited by 1,087
Moderate exercise is an antioxidant: Upregulation of antioxidant genes by training
Gomez-Cabrera, M.-C., Domenech, E., & Viña, J. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.02.001 · Cited by 1,020
Role of ROS and Nutritional Antioxidants in Human Diseases
Liu, Z., Ren, Z., Zhang, J., Chuang, C.-C., Kandaswamy, E., Zhou, T., & Zuo, L. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00477 · Cited by 860
Ristow, M., & Zarse, K. (2010) · Experimental Gerontology · doi:10.1016/j.exger.2010.03.014 · Cited by 789
Selenium: its role as antioxidant in human health
Tinggi, U. (2008) · Environmental Health and Preventive Medicine · doi:10.1007/s12199-007-0019-4 · Cited by 607
Schleicher, R. L., Carroll, M. D., Ford, E. S., & Lacher, D. A. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27016 · Cited by 504
Effect of a Traditional Mediterranean Diet on Lipoprotein Oxidation: A Randomized Controlled Trial
Fitó, M., Guxens, M., Corella, D., Sáez, G., Estruch, R., de la Torre, R., Francés, F., Cabezas, C., López-Sabater, M. D. C., Marrugat, J., et al. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.11.1195 · Cited by 448
Health benefits of nuts: potential role of antioxidants
Blomhoff, R., Carlsen, M. H., Andersen, L. F., & Jacobs, D. R. (2006) · British Journal Of Nutrition · doi:10.1017/bjn20061864 · Cited by 430
Antioxidants of Edible Mushrooms
Kozarski, M., Klaus, A., Jakovljevic, D., Todorovic, N., Vunduk, J., Petrović, P., Niksic, M., Vrvic, M., & Van Griensven, L. (2015) · Molecules · doi:10.3390/molecules201019489 · Cited by 413
Antioxidants: Molecules, medicines, and myths
Gutteridge, J. M. C., & Halliwell, B. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.02.071 · Cited by 405
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Scheurer, P., Rob Hermans, J. J., Schiffers, P., Ho, H., Wingler, K., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1010-9 · Cited by 371
Micronutrients in Health and Disease
Shenkin, A. (2006) · Postgraduate Medical Journal · doi:10.1136/pgmj.2006.047670 · Cited by 357
Vitamins C and E and beta carotene supplementation and cancer risk: a randomized controlled trial
Lin, J., Cook, N. R., Albert, C., Zaharris, E., Gaziano, J. M., Van Denburgh, M., Buring, J. E., & Manson, J. E. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djn438 · Cited by 309
Skeie, G., Braaten, T., Hjartåker, A., Lentjes, M., Amiano, P., Jakszyn, P., Pala, V, Palanca, A., Niekerk, E. M., Verhagen, H., et al. (2009) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2009.83 · Cited by 242
Antioxidant supplements and mortality
Bjelakovic, G., Nikolova, D., & Gluud, C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0000000000000009 · Cited by 234
Self-citationVitamin E and All-Cause Mortality: A Meta-Analysis
L. Abner, E., A. Schmitt, F., S. Mendiondo, M., L. Marcum, J., & J. Kryscio, R. (2011) · Current Aging Sciencee · doi:10.2174/1874609811104020158 · Cited by 209
The neglected significance of “antioxidative stress”
Poljsak, B., & Milisav, I. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/480895 · Cited by 177
Selenius, M., Rundlöf, A.-K., Olm, E., Fernandes, A. P., & Björnstedt, M. (2010) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2884 · Cited by 170
The sodium-dependent ascorbic acid transporter family SLC23
Bürzle, M., Suzuki, Y., Ackermann, D., Miyazaki, H., Maeda, N., Clémençon, B., Burrier, R., & Hediger, M. A. (2013) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.12.002 · Cited by 158
Systematic reviews and meta‐analyses in coloproctology: interpretation and potential pitfalls
Wille‐Jørgensen, P., & Renehan, A. G. (2008) · Colorectal Disease · doi:10.1111/j.1463-1318.2007.01421.x · Cited by 19
Metadata
- Authors
- Bjelakovic, G., Nikolova, D., Simonetti, R. G., & Gluud, C.
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 364
- Issue
- 9441
- Pages
- 1219-1228
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2002956860
- Cited by
- 612
- References
- 11
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.