Cited by 254Skin Protection and AgingAntioxidant Activity and Oxidative Stressmelanin and skin pigmentation

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Photoprotective potential of lycopene, β-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts

Offord, Elizabeth A., Gautier, Jean-Charles, Avanti, Ornella, Scaletta, Corinne, Runge, Frank, Krämer, Klaus, Applegate, Lee Ann·2002·Free Radical Biology and Medicine

DOI 10.1016/s0891-5849(02)00831-6

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Abstract

The photoprotective potential of the dietary antioxidants vitamin C, vitamin E, lycopene, beta-carotene, and the rosemary polyphenol, carnosic acid, was tested in human dermal fibroblasts exposed to ultraviolet-A (UVA) light. The carotenoids were prepared in special nanoparticle formulations together with vitamin C and/or vitamin E. Nanoparticle formulations, in contrast to dimethylsulphoxide, stablized lycopene in the cell culture medium and allowed efficient cellular uptake. The presence of vitamin E in the formulation further increased the stability and cellular uptake of lycopene. UVA irradiation of the human skin fibroblasts led to a 10-15-fold rise in metalloproteinase 1 (MMP-1) mRNA. This rise was suppressed in the presence of low microM concentrations of vitamin E, vitamin C, or carnosic acid but not with beta-carotene or lycopene. Indeed, in the presence of 0.5-1.0 microM beta-carotene or lycopene, the UVA-induced MMP-1 mRNA was further increased by 1.5-2-fold. This increase was totally suppressed when vitamin E was included in the nanoparticle formulation. Heme-oxygenase 1 (HO-1) mRNA expression was strongly induced by UVA irradiation but none of the antioxidants inhibited this effect at the concentrations used in this study. Indeed, beta-carotene or lycopene (0.5-1.0 microM) led to a further 1.5-fold rise in the UVA-induced HO-1 mRNA levels. In conclusion, vitamin C, vitamin E, and carnosic acid showed photoprotective potential. Lycopene and beta-carotene did not protect on their own but in the presence of vitamin E, their stability in culture was improved and the rise in MMP-1 mRNA expression was suppressed, suggesting a requirement for antioxidant protection of the carotenoids against formation of oxidative derivatives that can influence the cellular and molecular responses.

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Authors: Offord, E. A., Gautier, J.-C., Avanti, O., Scaletta, C., Runge, F., Krämer, K., & Applegate, L. A.
Affiliations: Nestlé (Switzerland) (CH)
Centre Hospitalier Universitaire Vaudois (CH)
BASF (Germany) (DE)
Corresponding author: Offord, Elizabeth A.
ORCID: Offord, Elizabeth A.
Scaletta, Corinne
Krämer, Klaus
Applegate, Lee Ann
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 2002-06
Volume: 32
Issue: 12
Pages: 1293-1303
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/s0891-5849(02)00831-6
OpenAlex: W2052373472
Cited by: 254
References: 63
Citations by year: 2026: 5 · 2025: 8 · 2024: 10 · 2023: 5 · 2022: 8 · 2021: 8 · 2020: 9 · 2019: 9 · 2018: 9 · 2017: 8 · 2016: 17 · 2015: 11 · 2014: 5 · 2013: 12 · 2012: 12
FWCI: 10.77
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
IRIS (submittedVersion)
SERVAL (Université de Lausanne) (submittedVersion)
Topics: Health Sciences › Medicine › Dermatology › Skin Protection and Aging
Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Keywords: photoprotection, lycopene, beta-carotene, vitamin E, vitamin C, carnosic acid, UVA irradiation, human dermal fibroblasts, MMP-1, heme oxygenase-1, carotenoid stability, nanoparticle formulation, dietary antioxidants, oxidative stress
MeSH terms: Lycopene, Adult, Antioxidants, Ascorbic Acid, Carotenoids, Cells, Cultured, Chromatography, High Pressure Liquid, Diterpenes, DNA Damage, Fibroblasts, Heme Oxygenase (Decyclizing), Humans, Male, Membrane Proteins, Plant Extracts, Radiation-Protective Agents, Skin, Ultraviolet Rays, Vitamin E, Blotting, Northern, Biomarkers, beta Carotene, Cytoprotection, Matrix Metalloproteinase 1, Abietanes, Heme Oxygenase-1

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Photoprotective potential of lycopene, β-carotene, vitamin E, vitamin C and carnosic acid in UVA-irradiated human skin fibroblasts

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