AP-1 function and regulation

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937

Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain.

Hibi, M., Lin, A., Smeal, T., Minden, A., & Karin, M. (1993) · Genes & Development · doi:10.1101/gad.7.11.2135 · Cited by 1,886

Independent Human MAP-Kinase Signal Transduction Pathways Defined by MEK and MKK Isoforms

Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Science · doi:10.1126/science.7839144 · Cited by 1,555

Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction

Yang-Yen, H.-F., Chambard, J.-C., Sun, Y.-L., Smeal, T., Schmidt, T. J., Drouin, J., & Karin, M. (1990) · Cell · doi:10.1016/0092-8674(90)90396-v · Cited by 1,553

Nuclear protein CBP is a coactivator for the transcription factor CREB

Kwok, R. P. S., Lundblad, J. R., Chrivia, J. C., Richards, J. P., Bächinger, H. P., Brennan, R. G., Roberts, S. G. E., Green, M. R., & Goodman, R. H. (1994) · Nature · doi:10.1038/370223a0 · Cited by 1,443

JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation.

Kallunki, T., Su, B., Tsigelny, I., Sluss, H. K., Dérijard, B., Moore, G., Davis, R., & Karin, M. (1994) · Genes & Development · doi:10.1101/gad.8.24.2996 · Cited by 642

E1A-associated p300 and CREB-associated CBP belong to a conserved family of coactivators

Arany, Z. (1994) · Cell · doi:10.1016/0092-8674(94)90127-9 · Cited by 444

Heterodimer formation of cJun and ATF‐2 is responsible for induction of c‐jun by the 243 amino acid adenovirus E1A protein.

van Dam, H., Duyndam, M., Rottier, R., Bosch, A., de Vries‐Smits, L., Herrlich, P., Zantema, A., Angel, P., & van der Eb, A. J. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05680.x · Cited by 375

Cellular Transformation and Malignancy Induced by ras Require c-jun

Johnson, R., Spiegelman, B., Hanahan, D., & Wisdom, R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4504 · Cited by 282

Reactive oxygen species: Metabolism, oxidative stress, and signal transduction

Apel, K., & Hirt, H. (2004) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.55.031903.141701 · Cited by 11,723

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143

AP-1 as a regulator of cell life and death

Shaulian, E., & Karin, M. (2002) · Nature Cell Biology · doi:10.1038/ncb0502-e131 · Cited by 2,961

Mechanisms of photoaging and chronological skin aging

Fisher, G. J., Kang, S., Varani, J., Bata-Csorgo, Z., Wan, Y., Datta, S., & Voorhees, J. J. (2002) · Archives of Dermatology · doi:10.1001/archderm.138.11.1462 · Cited by 1,849

Multiple control of interleukin-8 gene expression

Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.5.847 · Cited by 1,058

The Interplay between the Glucocorticoid Receptor and Nuclear Factor-κB or Activator Protein-1: Molecular Mechanisms for Gene Repression

De Bosscher, K., Vanden Berghe, W., & Haegeman, G. (2003) · Endocrine Reviews · doi:10.1210/er.2002-0006 · Cited by 898

An integrated view of oxidative stress in aging: basic mechanisms, functional effects, and pathological considerations

Kregel, K. C., & Zhang, H. J. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00327.2006 · Cited by 883

The Aryl Hydrocarbon Receptor Complex and the Control of Gene Expression

Beischlag, T. V., Morales, J. L., Hollingshead, B. D., & Perdew, G. H. (2008) · Critical Reviews™ in Eukaryotic Gene Expression · doi:10.1615/critreveukargeneexpr.v18.i3.20 · Cited by 727

Genetic Control of Bone Formation

Karsenty, G., Kronenberg, H. M., & Settembre, C. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113308 · Cited by 667

The enhanceosome and transcriptional synergy.

Carey, M. (1998) · Cell · doi:10.1016/s0092-8674(00)80893-4 · Cited by 553

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

Leppä, S., & Bohmann, D. (1999) · Oncogene · doi:10.1038/sj.onc.1203173 · Cited by 522

Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium

Stewart, D., Killeen, E., Naquin, R., Alam, S., & Alam, J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m209195200 · Cited by 463

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

Buteau, J., Roduit, R., Susini, S., & Prentki, M. (1999) · Diabetologia · doi:10.1007/s001250051238 · Cited by 413

Aberrantly expressed c‐Jun and JunB are a hallmark of Hodgkin lymphoma cells, stimulate proliferation and synergize with NF‐κB

Mathas, S., Hinz, M., Anagnostopoulos, I., Krappmann, D., Lietz, A., Jundt, F., Bommert, K., Mechta‐Grigoriou, F., Stein, H., Dörken, B., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf389 · Cited by 375

Thiol-based redox switches in eukaryotic proteins

Brandes, N., Schmitt, S., & Jakob, U. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2285 · Cited by 373

Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions

Di Meglio, P., Duarte, J. H., Ahlfors, H., Owens, N. D. L., Li, Y., Villanova, F., Tosi, I., Hirota, K., Nestle, F. O., Mrowietz, U., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.04.019 · Cited by 373

Raw Single-Wall Carbon Nanotubes Induce Oxidative Stress and Activate MAPKs, AP-1, NF-κB, and Akt in Normal and Malignant Human Mesothelial Cells

Pacurari, M., Yin, X. J., Zhao, J., Ding, M., Leonard, S. S., Schwegler-Berry, D., Ducatman, B. S., Sbarra, D., Hoover, M. D., Castranova, V., et al. (2008) · Environmental Health Perspectives · doi:10.1289/ehp.10924 · Cited by 372

Cadherins and catenins at synapses: Roles in synaptogenesis and synaptic plasticity.

Arikkath, J., & Reichardt, L. F. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.07.001 · Cited by 289

Nrf2 Mediates the Induction of Ferritin H in Response to Xenobiotics and Cancer Chemopreventive Dithiolethiones

Pietsch, E. C., Chan, J. Y., Torti, F. M., & Torti, S. V. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210664200 · Cited by 284

Dopaminergic stimulation of local protein synthesis enhances surface expression of GluR1 and synaptic transmission in hippocampal neurons

Smith, W. B., Starck, S. R., Roberts, R. W., & Schuman, E. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.01.015 · Cited by 252

25-Hydroxycholesterol acts as an amplifier of inflammatory signaling

Gold, E. S., Diercks, A. H., Podolsky, I., Podyminogin, R. L., Askovich, P. S., Treuting, P. M., & Aderem, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1404271111 · Cited by 250

Expression of inflammatory genes induced by beta-amyloid peptides in human brain endothelial cells and in Alzheimer's brain is mediated by the JNK-AP1 signaling pathway

Vukic, V., Callaghan, D., Walker, D., Lue, L.-F., Liu, Q. Y., Couraud, P.-O., Romero, I. A., Weksler, B., Stanimirovic, D. B., & Zhang, W. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.007 · Cited by 232

Amyloid-β Peptides Are Cytotoxic to Oligodendrocytes

Xu, J., Chen, S., Ahmed, S. H., Chen, H., Ku, G., Goldberg, M. P., & Hsu, C. Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-j0001.2001 · Cited by 230

The Two NF-κB Pathways Regulating Bacterial and WSSV Infection of Shrimp

Li, C., Wang, S., & He, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01785 · Cited by 230

The c‐myc Promoter: Still MysterY and Challenge

(2008) · Advances in Cancer Research · doi:10.1016/s0065-230x(07)99004-1 · Cited by 211

Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1

Aikawa, Y., Morimoto, K., Yamamoto, T., Chaki, H., Hashiramoto, A., Narita, H., Hirono, S., & Shiozawa, S. (2008) · Nature Biotechnology · doi:10.1038/nbt1412 · Cited by 214

Reactive oxygen species are downstream products of TRAF-mediated signal transduction

Chandel, N. S., Schumacker, P. T., & Arch, R. H. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103074200 · Cited by 203

Discovery of a Functional Covalent Ligand Targeting an Intrinsically Disordered Cysteine within MYC

Boike, L., Cioffi, A. G., Majewski, F. C., Co, J., Henning, N. J., Jones, M. D., Liu, G., McKenna, J. M., Tallarico, J. A., Schirle, M., et al. (2021) · Cell Chemical Biology · doi:10.1016/j.chembiol.2020.09.001 · Cited by 154

P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways

Shiratori, M., Tozaki‐Saitoh, H., Yoshitake, M., Tsuda, M., & Inoue, K. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06809.x · Cited by 153

Cellular effects of long wavelength UV light (UVA) in mammalian cells

McMillan, T. J., Leatherman, E., Ridley, A., Shorrocks, J., Tobi, S. E., & Whiteside, J. R. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.8.0004 · Cited by 146

Leishmania-Induced Inactivation of the Macrophage Transcription Factor AP-1 Is Mediated by the Parasite Metalloprotease GP63

Contreras, I., Gómez, M. A., Nguyen, O., Shio, M. T., McMaster, R. W., & Olivier, M. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001148 · Cited by 143

Current knowledge on the acute regulation of steroidogenesis

Selvaraj, V., Stocco, D. M., & Clark, B. J. (2018) · Biology of Reproduction · doi:10.1093/biolre/ioy102 · Cited by 118

The response of c-Jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1α dependent

Laderoute, K. R., Calaoagan, J. M., Gustafson-Brown, C., Knapp, A. M., Li, G.-C., Mendonca, H. L., Ryan, H. E., Wang, Z., & Johnson, R. S. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2515-2523.2002 · Cited by 105

Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging

Karakaslar, E. O., Katiyar, N., Hasham, M., Youn, A., Sharma, S., Chung, C., Marches, R., Korstanje, R., Banchereau, J., & Ucar, D. (2023) · Aging Cell · doi:10.1111/acel.13792 · Cited by 98

Characterization of Keratinocyte Differentiation Induced by Ascorbic Acid: Protein Kinase C Involvement and Vitamin C Homeostasis11The authors declared not to have a conflict of interest.

Savini, I., Rossi, A., Duranti, G., Avigliano, L., Catani, M. V., & Melino, G. (2002) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01624.x · Cited by 91

ATF3 drives senescence by reconstructing accessible chromatin profiles

Zhang, C., Zhang, X., Huang, L., Guan, Y., Huang, X., Tian, X., Zhang, L., & Tao, W. (2021) · Aging Cell · doi:10.1111/acel.13315 · Cited by 84

Fucoidan inhibits UVB-induced MMP-1 promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts

Moon, H. J., Lee, S. H., Ku, M. J., Yu, B. C., Jeon, M. J., Jeong, S. H., Stonik, V. A., Zvyagintseva, T. N., Ermakova, S. P., & Lee, Y. H. (2009) · European Journal of Dermatology · doi:10.1684/ejd.2008.0611 · Cited by 81

GEF-H1 Signaling upon Microtubule Destabilization Is Required for Dendritic Cell Activation and Specific Anti-tumor Responses

Kashyap, A. S., Fernandez-Rodriguez, L., Zhao, Y., Monaco, G., Trefny, M. P., Yoshida, N., Martin, K., Sharma, A., Olieric, N., Shah, P., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.057 · Cited by 76

Ethanol-induced Modulation of Hepatocellular Extracellular Signal-regulated Kinase-1/2 Activity via 4-Hydroxynonenal

Sampey, B. P., Stewart, B. J., & Petersen, D. R. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610602200 · Cited by 64

Expression of Jun family members in human colorectal adenocarcinoma

Wang, H., Birkenbach, M., & Hart, J. (2000) · Carcinogenesis · doi:10.1093/carcin/21.7.1313 · Cited by 64

Vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide inhibit the MEKK1/MEK4/JNK signaling pathway in endotoxin-activated microglia

Delgado, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)00283-8 · Cited by 53

Persistent activation of ERK1/2 by lead acetate increases nucleotide excision repair synthesis and confers anti-cytotoxicity and anti-mutagenicity

Lin, Y.-W. (2003) · Carcinogenesis · doi:10.1093/carcin/24.1.53 · Cited by 51

Requirement of an E1A-sensitive Coactivator for Long-range Transactivation by the β-Globin Locus Control Region

Forsberg, E. C., Johnson, K., Zaboikina, T. N., Mosser, E. A., & Bresnick, E. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.38.26850 · Cited by 46

ERK1/2 signaling pathways involved in VEGF release in diabetic rat retina

Ye, X., Xu, G., Chang, Q., Fan, J., Sun, Z., Qin, Y., & Jiang, A. C. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-4899 · Cited by 47

ERK1/2 signaling pathway in the release of VEGF from Müller cells in diabetes

Ye, X., Ren, H., Zhang, M., Sun, Z., Jiang, A. C., & Xu, G. (2012) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.11-9076 · Cited by 44

CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras andjunD

Nicolaou, F., Teodoridis, J. M., Park, H., Georgakis, A., Farokhzad, O. C., Böttinger, E. P., Da Silva, N., Rousselot, P., Chomienne, C., Ferenczi, K., et al. (2003) · Blood · doi:10.1182/blood-2002-01-0324 · Cited by 39

MiR-155 Induction by Microbes/Microbial Ligands Requires NF-κB-Dependent de novo Protein Synthesis

Cremer, T. J., Fatehchand, K., Shah, P., Gillette, D., Patel, H., Marsh, R. L., Besecker, B. Y., Rajaram, M. V. S., Cormet-Boyaka, E., Kanneganti, T.-D., et al. (2012) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2012.00073 · Cited by 29

Integration of ATAC-seq and RNA-seq identifies MX1-mediated AP-1 transcriptional regulation as a therapeutic target for Down syndrome

Guo, Z., Zhu, Y., Xiao, H., Dai, R., Yang, W., Xue, W., Zhang, X., Hao, B., & Liao, S. (2023) · Biological Research · doi:10.1186/s40659-023-00474-x · Cited by 15

In vitro evaluation of the effects of human umbilical cord extracts on human fibroblasts, keratinocytes, and melanocytes

Van Pham, P., Dang, L. T.-T., Dinh, U. T., Truong, H. T.-T., Huynh, B. N., Van Le, D., & Phan, N. K. (2014) · In Vitro Cellular & Developmental Biology - Animal · doi:10.1007/s11626-013-9706-1 · Cited by 8

Design and evaluation of a tripartite chemogenetic fluorescent reporter for visualizing ternary protein complexes

(2025) · doi:10.1038/s41467-025-62241-8 · Cited by 5

Hepa-ToxMOA: a pathway-screening method for evaluating cellular stress and hepatic metabolic-dependent toxicity of natural products

Park, S.-M., Choi, M.-S., Kim, S., Jegal, H., Han, H.-Y., Chun, H. S., Kim, S. K., & Oh, J.-H. (2024) · Scientific Reports · doi:10.1038/s41598-024-54634-4 · Cited by 4

CauTrigger: deciphering biological system state transitions by hierarchical causal decomposition

Zhang, C., Cai, D., Aihara, K., & Chen, L. (2026) · Nature Methods · doi:10.1038/s41592-026-03274-9