Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

Dissection of TNF Receptor 1 Effector Functions: JNK Activation Is Not Linked to Apoptosis While NF-κB Activation Prevents Cell Death

Liu, Z.-G., Hsu, H., Goeddel, D. V., & Karin, M. (1996) · Cell · doi:10.1016/s0092-8674(00)81375-6 · Cited by 1,937

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543

A Cytoplasmic Inhibitor of the JNK Signal Transduction Pathway

Dickens, M., Rogers, J. S., Cavanagh, J., Raitano, A., Xia, Z., Halpern, J. R., Greenberg, M. E., Sawyers, C. L., & Davis, R. J. (1997) · Science · doi:10.1126/science.277.5326.693 · Cited by 675

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

Chow, C.-W., Rincón, M., Cavanagh, J., Dickens, M., & Davis, R. J. (1997) · Science · doi:10.1126/science.278.5343.1638 · Cited by 357

Free Radicals in the Physiological Control of Cell Function

Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855

Oxyl radicals, redox-sensitive signalling cascades and antioxidants

Genestra, M. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.04.009 · Cited by 4,930

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237

MAP kinase signalling pathways in cancer

Dhillon, A. S., Hagan, S., Rath, O., & Kolch, W. (2007) · Oncogene · doi:10.1038/sj.onc.1210421 · Cited by 2,995

MAPK signal pathways in the regulation of cell proliferation in mammalian cells

ZHANG, W., & LIU, H. T. (2002) · Cell Research · doi:10.1038/sj.cr.7290105 · Cited by 2,845

Critical nodes in signalling pathways: insights into insulin action

Taniguchi, C. M., Emanuelli, B., & Kahn, C. R. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1837 · Cited by 2,760

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728

Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers

Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600

The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307

Aguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487

The MAPK signalling pathways and colorectal cancer

Fang, J. Y., & Richardson, B. C. (2005) · The Lancet Oncology · doi:10.1016/s1470-2045(05)70168-6 · Cited by 1,185

Multiple control of interleukin-8 gene expression

Hoffmann, E., Dittrich-Breiholz, O., Holtmann, H., & Kracht, M. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.72.5.847 · Cited by 1,058

Ras and Rap control AMPA receptor trafficking during synaptic plasticity

Zhu, J. J., Qin, Y., Zhao, M., Van Aelst, L., & Malinow, R. (2002) · Cell · doi:10.1016/s0092-8674(02)00897-8 · Cited by 769

A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J. (1998) · Science · doi:10.1126/science.281.5383.1671 · Cited by 652

Targeting JNK for therapeutic benefit: from junk to gold?

Manning, A. M., & Davis, R. J. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1132 · Cited by 585

Diverse functions of JNK signaling and c-Jun in stress response and apoptosis

Leppä, S., & Bohmann, D. (1999) · Oncogene · doi:10.1038/sj.onc.1203173 · Cited by 522

Signal transduction by the TCR for antigen

Kane, L. P., Lin, J., & Weiss, A. (2000) · Current Opinion in Immunology · doi:10.1016/s0952-7915(00)00083-2 · Cited by 498

The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins

Yasuda, J., Whitmarsh, A. J., Cavanagh, J., Sharma, M., & Davis, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7245 · Cited by 458

MEK and the inhibitors: from bench to bedside

Akinleye, A., Furqan, M., Mukhi, N., Ravella, P., & Liu, D. (2013) · Journal of Hematology & Oncology · doi:10.1186/1756-8722-6-27 · Cited by 291

Identification of a docking groove on ERK and p38 MAP kinases that regulates the specificity of docking interactions

Tanoue, T., Maeda, R., Adachi, M., & Nishida, E. (2001) · The EMBO Journal · doi:10.1093/emboj/20.3.466 · Cited by 285

Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3

Kelkar, N., Gupta, S., Dickens, M., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1030-1043.2000 · Cited by 281

The reelin receptor ApoER2 recruits JNK-interacting proteins-1 and -2

Stockinger, W., Brandes, C., Fasching, D., Hermann, M., Gotthardt, M., Herz, J., Schneider, W. J., & Nimpf, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004119200 · Cited by 239

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration

Xia, Y., Makris, C., Su, B., Li, E., Yang, J., Nemerow, G. R., & Karin, M. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.10.5243 · Cited by 238

Molecular Mechanisms Underlying β-Adrenergic Receptor-Mediated Cross-Talk between Sympathetic Neurons and Immune Cells

Lorton, D., & Bellinger, D. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms16035635 · Cited by 221

Dietary grape seed proanthocyanidins inhibit UVB-induced oxidative stress and activation of mitogen-activated protein kinases and nuclear factor-κB signaling in in vivo SKH-1 hairless mice

Sharma, S. D., Meeran, S. M., & Katiyar, S. K. (2007) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0661 · Cited by 219

Transcriptional characterizations of differences between eutopic and ectopic endometrium

Wu, Y., Kajdacsy-Balla, A., Strawn, E., Basir, Z., Halverson, G., Jailwala, P., Wang, Y., Wang, X., Ghosh, S., & Guo, S.-W. (2006) · Endocrinology · doi:10.1210/en.2005-0426 · Cited by 208

Strategies for the Selective Regulation of Kinases with Allosteric Modulators: Exploiting Exclusive Structural Features

Fang, Z., Grütter, C., & Rauh, D. (2013) · ACS Chemical Biology · doi:10.1021/cb300663j · Cited by 197

Identification of a new JNK inhibitor targeting the JNK-JIP interaction site

Stebbins, J. L., De, S. K., Machleidt, T., Becattini, B., Vazquez, J., Kuntzen, C., Chen, L.-H., Cellitti, J. F., Riel-Mehan, M., Emdadi, A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805677105 · Cited by 186

Alzheimer-like amyloid and tau alterations associated with cognitive deficit in temporal lobe epilepsy.

Gourmaud, S., Shou, H., Irwin, D. J., Sansalone, K., Jacobs, L. M., Lucas, T. H., Marsh, E. D., Davis, K. A., Jensen, F. E., & Talos, D. M. (2020) · Brain · doi:10.1093/brain/awz381 · Cited by 155

Non-cell-autonomous induction of tissue overgrowth by JNK/Ras cooperation in a Drosophila tumor model

Uhlirova, M., Jasper, H., & Bohmann, D. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504170102 · Cited by 134

Docking interactions in the mitogen-activated protein kinase cascades

Tanoue, T., & Nishida, E. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00188-2 · Cited by 134

MOM-4, a MAP Kinase Kinase Kinase–Related Protein, Activates WRM-1/LIT-1 Kinase to Transduce Anterior/Posterior Polarity Signals in C. elegans

Shin, T. H., Yasuda, J., Rocheleau, C. E., Lin, R., Soto, M., Bei, Y., Davis, R. J., & Mello, C. C. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80375-5 · Cited by 123

Axonal degeneration as a therapeutic target in the CNS

Lingor, P., Koch, J. C., Tönges, L., & Bähr, M. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1362-3 · Cited by 119

The JNK Are Important for Development and Survival of Macrophages

Himes, S. R., Sester, D. P., Ravasi, T., Cronau, S. L., Sasmono, T., & Hume, D. A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.4.2219 · Cited by 117

Back to the future: oral targeted therapy for RA and other autoimmune diseases

O'Shea, J. J., Laurence, A., & McInnes, I. B. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.7 · Cited by 115

Multiple pathways of apolipoprotein E signaling in primary neurons

Hoe, H., Harris, D. C., & Rebeck, G. W. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.03007.x · Cited by 111

Alzheimer’s amyloid β-peptide (1–42) induces cell death in human neuroblastoma via bax/bcl-2 ratio increase: An intriguing role for methionine 35

Clementi, M. E., Pezzotti, M., Orsini, F., Sampaolese, B., Mezzogori, D., Grassi, C., Giardina, B., & Misiti, F. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.01.137 · Cited by 105

A Drosophila MAPKKK, D‐MEKK1, mediates stress responses through activation of p38 MAPK

Inoue, H., Tateno, M., Fujimura‐Kamada, K., Takaesu, G., Adachi‐Yamada, T., Ninomiya‐Tsuji, J., Irie, K., Nishida, Y., & Matsumoto, K. (2001) · The EMBO Journal · doi:10.1093/emboj/20.19.5421 · Cited by 99

Direct inhibition of c‐Jun N‐terminal kinase in sympathetic neurones prevents c‐jun promoter activation and NGF withdrawal‐induced death

Eilers, A., Whitfield, J., Shah, B., Spadoni, C., Desmond, H., & Ham, J. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00150.x · Cited by 96

Cells Preconditioned with Mild, Transient UVA Irradiation Acquire Resistance to Oxidative Stress and UVA-induced Apoptosis

Yang, Y., Sharma, A., Sharma, R., Patrick, B., Singhal, S. S., Zimniak, P., Awasthi, S., & Awasthi, Y. C. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305766200 · Cited by 90

c-Jun N-terminal kinase-dependent mechanisms in respiratory disease

Bennett, B. L. (2006) · European Respiratory Journal · doi:10.1183/09031936.06.00012106 · Cited by 63

Phosphorylated Protein Kinases Associated with Neuronal and Glial Tau Deposits in Argyrophilic Grain Disease

Ferrer, I., Barrachina, M., Tolnay, M., Rey, M. J., Vidal, N., Carmona, M., Blanco, R., & Puig, B. (2003) · Brain Pathology · doi:10.1111/j.1750-3639.2003.tb00007.x · Cited by 60

Spatial, temporal and subcellular localization of islet-brain 1 (IB1), a homologue of JIP-1, in mouse brain

Pellet, J., Haefliger, J., Staple, J. K., Widmann, C., Welker, E., Hirling, H., Bonny, C., Nicod, P., Catsicas, S., Waeber, G., et al. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00945.x · Cited by 55

Src Homology Region 2 Domain-Containing Phosphatase 1 Positively Regulates B Cell Receptor-Induced Apoptosis by Modulating Association of B Cell Linker Protein with Nck and Activation of c-Jun NH2-Terminal Kinase

Mizuno, K., Tagawa, Y., Mitomo, K., Watanabe, N., Katagiri, T., Ogimoto, M., & Yakura, H. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.2.778 · Cited by 34

Subconjunctival Injection of XG-102, a c-Jun N-Terminal Kinase Inhibitor Peptide, in the Treatment of Endotoxin-Induced Uveitis in Rats

El Zaoui, I., Touchard, E., Berdugo, M., Abadie, C., Kowalczuk, L., Deloche, C., Zhao, M., Naud, M.-C., Combette, J.-M., & Behar-Cohen, F. (2015) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2014.0019 · Cited by 31

Coffee Polyphenols Change the Expression of STAT5B and ATF-2 Modifying Cyclin D1 Levels in Cancer Cells

Oleaga, C., Ciudad, C. J., Noé, V., & Izquierdo-Pulido, M. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/390385 · Cited by 25

Kinetic Mechanism and Inhibitor Characterization for c-jun-N-Terminal Kinase 3α1

Ember, B., Kamenecka, T., & LoGrasso, P. (2008) · Biochemistry · doi:10.1021/bi701852z · Cited by 22