The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index; 29 of the 54 sources its claims cite were checked for support.
Cognitive reserve in ageing and Alzheimer's disease
Open accessAbstract
The concept of cognitive reserve provides an explanation for differences between individuals in susceptibility to age-related brain changes or pathology related to Alzheimer's disease, whereby some people can tolerate more of these changes than others and maintain function. Epidemiological studies suggest that lifelong experiences, including educational and occupational attainment, and leisure activities in later life, can increase this reserve. For example, the risk of developing Alzheimer's disease is reduced in individuals with higher educational or occupational attainment. Reserve can conveniently be divided into two types: brain reserve, which refers to differences in the brain structure that may increase tolerance to pathology, and cognitive reserve, which refers to differences between individuals in how tasks are performed that might enable some people to be more resilient to brain changes than others. Greater understanding of the concept of cognitive reserve could lead to interventions to slow cognitive ageing or reduce the risk of dementia.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This review argues that cognitive reserve explains why people differ in how much Alzheimer’s disease pathology or age-related brain change they can tolerate while still functioning. It synthesizes epidemiologic, neuroimaging, postmortem, and intervention evidence, and concludes that reserve is modifiable but that causal interventions remain unproven.
Key findings
- Reserve is split into brain reserve, a more passive quantitative tolerance tied to brain size or neurons/synapses, and cognitive reserve, an active functional process in which pre-existing or compensatory networks help cope with damage.
- Epidemiologic studies cited found that fewer than 8 years of education carried 2.2 times higher dementia risk, low occupational attainment carried 2.25 times higher risk, and greater leisure activity was linked to 38% lower risk; a review of 22 cohort studies estimated higher reserve reduced dementia risk by 46%.
- After Alzheimer’s disease becomes clinically apparent, higher reserve is associated with faster decline: memory scores fell about one point yearly on average, with an additional point yearly in those with higher education or occupation.
- Imaging and autopsy evidence indicated that at matched clinical severity, higher education was linked to greater parietotemporal blood-flow deficit and, in 130 elders, each additional year of education reduced the pathology–cognition association by 0.088 standard units; fMRI work distinguished neural reserve from neural compensation.
Methods
- Narrative review by the author, integrating his group’s and others’ epidemiologic cohort studies, functional and resting neuroimaging studies, postmortem analyses, and cognitive or exercise intervention trials.
- Cited samples include 593 non-demented adults aged 60 or older followed for 4 years, 130 elders who had cognitive evaluation before autopsy, and a preliminary 90-person older-adult Space Fortress training study.
- Main analysis is conceptual synthesis rather than a new primary study or formal meta-analysis; it draws on a cited systematic review of 22 cohort studies for one pooled estimate.
Limitations
- Stated: epidemiologic evidence is correlational and cannot establish causation; controlled intervention studies are needed, and no study to date has shown changes in the key endpoints of slowed cognitive decline or reduced Alzheimer’s disease risk.
- Stated: clinical use of biomarkers and imaging for reserve is premature because prognostic implications are not fully established, and cognitive training evidence is mixed.
- Evident from the text: this is a narrative review without formal risk-of-bias assessment, many findings come from the author’s own research program, and the interaction between brain reserve and cognitive reserve remains unresolved.
Model-written summary. Check it against the paper before relying on it.
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Claims the paper makes
39 Own interpretation · 14 No full text of the sources · 12 No basis given · 10 Supported · 10 Own result · 8 Partly supported · 5 Supported so far · 3 Not checked yet · 2 Couldn’t confirm · 1 Sources not found · accuracy not yet measured
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“This idea is supported by a set of studies that suggest that prevalence or incidence of dementia is lower in individuals with larger brains13, 14.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
What the sources say
- Not checked — no full text of the sourcecites [13] Katzman, 1988, Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques, Ann Neurol source
- Supportedcites [14] Schofield, 1997, An association between head circumference and Alzheimer's disease in a population-based study of aging, Neurology source
The Discussion (p. 5) reports that smaller head circumference was associated with higher prevalence of Alzheimer’s disease. The paper uses head circumference as an index of premorbid brain size (p. 1), so its finding supports the citing sentence’s hedged association. This study measured prevalence of Alzheimer’s disease, not incidence of dementia generally. (LLM, conf=0.88)
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Second, compared to individuals with lower CR, those with higher CR performed better even when they use the second network.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [42] Steffener, 2011, Supporting performance in the face of age-related neural changes: testing mechanistic roles of cognitive reserve, Brain Imaging Behav source
The Results (Model C) report that, in older adults, higher cognitive reserve reduced the negative effect of network 2 expression on task performance. The Discussion likewise says older adults with greater reserve maintained performance better as network 2 expression increased. (LLM, conf=0.88)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Those who engaged in more leisure activities had 38% less risk of developing dementia.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
What the sources say
- Supportedcites [24] Scarmeas, 2001, Influence of leisure activity on the incidence of Alzheimer's disease, Neurology source
The Discussion explicitly states that subjects with high leisure activity had 38% less risk of developing dementia. The Results report a relative risk of 0.62 (95% CI 0.46–0.83), consistent with that figure. (LLM, conf=0.95)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The rate of decline is more rapid in individuals with high reserve than those with low reserve, even when accounting for a multitude of other factors that may contribute to disease course27, 28, 46.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
What the sources say
- Supportedcites [27] Stern, 1999, Rate of memory decline in AD is related to education and occupation: cognitive reserve?, Neurology sourceExperimental — accuracy not yet measured
The DOI was not indexed for paper-scoped Semantic Scholar search, so the cited paper’s full text could not be checked directly. A systematic review, “Education and Dementia in the Context of the Cognitive Reserve Hypothesis” (search score 0.789), explicitly attributes more rapid memory decline in Alzheimer’s patients with higher education and occupational attainment to Stern et al. (1999). This supports the central claim, though the retrieved passage does not verify which other factors the original analysis accounted for. (LLM, conf=0.81)
- Supportedcites [28] Scarmeas, 2006, Education and rates of cognitive decline in incident Alzheimer's disease, J Neurol Neurosurg Psychiatry sourceExperimental — accuracy not yet measured
No paper-scoped Semantic Scholar snippets were available for Scarmeas et al. (2006). However, “Higher education affects accelerated cortical thinning in Alzheimer's disease” explicitly cites Scarmeas et al. (2006) among studies finding more rapid cognitive decline after Alzheimer’s onset in patients with higher education (snippet score 0.534). This supports the claim through a secondary citation, although the available evidence does not independently verify which other factors Scarmeas et al. adjusted for. (LLM, conf=0.76)
- Supportedcites [46] Hall, 2007, Education delays accelerated decline on a memory test in persons who develop dementia, Neurology sourceExperimental — accuracy not yet measured
Hall’s (2007) title establishes the finding of delayed accelerated memory decline in people who develop dementia. A Semantic Scholar snippet from “Episodic memory performance in a multi-ethnic longitudinal study of 13,037 elderly” describes the same pattern: education is associated with a delayed change point followed by faster decline (score 0.52). Hall’s full text was unavailable in the paper-scoped search, so the specific assertion about accounting for other factors could not be checked directly; the available evidence supports the core paraphrase, not every qualification. (LLM, conf=0.72)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“In a young group of subjects we identified an activation network that was expressed during the stimulus presentation phase of both tasks and whose increase in expression with increasing load correlated with CR.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [43] Stern, 2008, A common neural network for cognitive reserve in verbal and object working memory in young but not old, Cereb Cortex source
The Discussion identifies a pattern in young subjects during stimulus presentation whose load-related activation had a similar relationship with cognitive reserve in both the letter and shape tasks. The Canonical Variates Analysis reports significant expression of that pattern in both tasks and relates its load-related expression to cognitive-reserve scores. (LLM, conf=0.91)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Similar analysis demonstrated a comparable protective effect of occupational attainment33 and leisure activities34.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Not checked — no full text of the sourcecites [33] Stern, 1995, Relationship between lifetime occupation and parietal flow: implications for a reserve against Alzheimer's disease pathology, Neurology source
- Supportedcites [34] Scarmeas, 2003, Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis, Arch Neurol source
The cited paper’s Results report an inverse association between activity scores and cerebral blood flow after controlling for clinical severity, which the authors interpret as consistent with cognitive reserve. The Conclusions describe analogous findings for occupational attainment and note evidence linking leisure activities to reduced dementia risk. The citation supports the leisure-activities part of the sentence; occupational attainment has a separate citation. (LLM, conf=0.85)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“For example, at a given level of clinical severity, AD patients with higher education have a more severe pattern of AD-related changes on PET scan than those with lower education44, 45.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
What the sources say
- Not checked — no full text of the sourcecites [44] Garibotto, 2008, Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence, Neurology source
- Supportedcites [45] Kemppainen, 2008, Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease, Ann Neurol source
The Abstract reports that high- and low-educated patients with mild Alzheimer’s disease had the same degree of cognitive deterioration, while the high-educated group showed greater amyloid-tracer uptake and lower glucose metabolism on PET. The Discussion likewise describes more pronounced amyloid accumulation and neuronal dysfunction in the high-educated group. (LLM, conf=0.93)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“In AD patients matched for clinical severity, we found an inverse relationship between resting rCBF and years of education32.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Supportedcites [32] Stern, 1992, Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease, Ann Neurol source
The Procedures (p. 2) state that rCBF was measured under resting conditions. The Results (pp. 2–3) report greater parietotemporal flow reductions with more education in AD groups that did not differ on clinical measures; the relationship at the P3 detector remained significant after controlling for dementia severity. (LLM, conf=0.92)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The neural implementation of CR might take two forms: neural reserve and neural compensation16, 38.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [16] Stern, 2009, Cognitive reserve, Neuropsychologia source
In “Neural Mechanisms Underlying CR,” Stern explicitly says that the neural implementation of cognitive reserve might take two forms: neural reserve and neural compensation. The “Brain Reserve and Cognitive Reserve” section also describes them as two proposed components. (LLM, conf=0.95)
- Supportedcites [38] Stern, 2005, Brain networks associated with cognitive reserve in healthy young and old adults, Cereb Cortex source
The Introduction (p. 1) explicitly proposes two complementary facets of the neural implementation of cognitive reserve: neural reserve and neural compensation. The paper then defines and contrasts them in the Introduction (pp. 1–2). (LLM, conf=0.95)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“These observations using cerebral blood flow have been replicated by other groups as well35, 36.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Not checked — no full text of the sourcecites [35] Alexander, 1997, Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis, Am J Psychiatry source
- Supportedcites [36] Perneczky, 2006, Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography, J Neurol Neurosurg Psychiatry source
The Results report an inverse association between schooling and glucose metabolism in patients with Alzheimer’s disease. The Discussion says these findings are supported by other groups’ cerebral-blood-flow studies, while noting that the results do not match exactly because of differences in samples and methods. This paper used FDG-PET rather than measuring cerebral blood flow itself. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Probably not a substantial claim. 15
- It may state two separate claims as one. 17
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“In contrast, the concept of CR suggests that the brain actively attempts to cope with brain damage by using pre-existing cognitive processing approaches or by enlisting compensatory approaches15, 16.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
What the sources say
- Not checked — no full text of the sourcecites [15] Stern, 2002, What is cognitive reserve? Theory and research application of the reserve concept, J Int Neuropsychol Soc source
- Supportedcites [16] Stern, 2009, Cognitive reserve, Neuropsychologia source
The “Brain Reserve and Cognitive Reserve” section states that active models such as CR propose that the brain copes with damage using pre-existing cognitive processes or enlisting compensatory processes. This directly supports the paraphrase; no page number is provided in our copy. (LLM, conf=0.95)
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“We replicated this observation in patients with incident AD28 and also found more rapid decline in cognitive function in AD patients who engaged in more leisure activities prior to dementia onset29.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
What the sources say
- Partly supportedcites [28] Scarmeas, 2006, Education and rates of cognitive decline in incident Alzheimer's disease, J Neurol Neurosurg Psychiatry sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
- Supportedcites [29] Helzner, 2007, Leisure activity and cognitive decline in incident Alzheimer disease, Arch Neurol source
Split into 2 atoms — 2 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Using a covariance method to analyze the imaging data, we identified a spatial pattern of fMRI activation that was expressed by both groups and whose expression increased as the task became more difficult.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [39] Stern, 2012, Task difficulty modulates young-old differences in network expression, Brain Res source
The Functional imaging section identifies a spatial pattern common to young and old participants. The Discussion states that its expression increased logarithmically with task difficulty. Page numbers are not provided in our copy. (LLM, conf=0.94)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In a follow-up analysis41, we found that atrophy in a key area within the first network (i.e. the one that was used by both young and old) was associated with decreased efficiency in that network and increased utilization of the second network.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Partly supportedcites [41] Steffener, 2009, The impact of age-related changes on working memory functional activity, Brain Imaging Behav sourceExperimental — accuracy not yet measured
The Abstract and Conclusion report that lower grey-matter volume in a region of the primary network was associated with greater secondary-network recruitment. The Discussion interprets this as compensation for an affected primary network, but the Results report no significant association between regional grey-matter volume and primary-network expression; decreased efficiency of that network was not demonstrated. (LLM, conf=0.86)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“For example, Basak et al.50 had elders play a complex role-playing game,”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Partly supportedcites [50] Basak, 2008, Can training in a real-time strategy video game attenuate cognitive decline in older adults?, Psychol Aging sourceExperimental — accuracy not yet measured
The Method > Participants section says older adults were assigned to play Rise of Nations, and the General Discussion reports transfer benefits after 23.5 hours of training. The paper identifies Rise of Nations as a complex real-time strategy game, not a role-playing game. Its Abstract reports improvement on a subset of cognitive tasks, rather than across the entire battery (page numbers unavailable in our copy). (LLM, conf=0.90)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In research with young adults, one particular training approach produced excellent improvement in gameplay, but, more importantly, also showed transfer of training to other tasks.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [55] Gopher, 1994, Transfer of skill from a computer game trainer to flight, Hum Factors source
- Not checked — no full text of the sourcecites [56] Gopher, 1989, Practice under changing priorities: an approach to the training of complex skills, Acta Psychol source
- Partly supportedcites [57] Blumen, 2010, Training cognitive control in older adults with the space fortress game: the role of training instructions and basic motor ability, Front Aging Neurosci sourceExperimental — accuracy not yet measured
The Introduction (‘The space fortress game and emphasis change instructions’; page unavailable) reports that emphasis-change instructions improved Space Fortress performance in younger adults compared with standard instructions. It says those instructions *may* be important for transfer, but does not report that this approach demonstrated transfer to other tasks. The General Discussion (page unavailable) says future studies will determine whether such transfer occurs. (LLM, conf=0.86)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Those who rely more on this alternate network can still perform the task, but do so more poorly.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“On the average scores on a memory test decline by about one point yearly, but in those with higher educational or occupational attainment scores decline by an additional point each year.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The first network was used by both young and old subjects, and consisted of areas often associated with working memory.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast, the second network was primarily characterized by activation in parahippocampal areas and was used consistently only by the older subjects.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Interestingly, although the game itself was very challenging for the elders, there were few dropouts and performance improved over time.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [58] Orrell, 1995, Education and dementia, BMJ source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Interestingly, although the game itself was very challenging for the elders, there were few dropouts and performance improved over time.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [58] Orrell, 1995, Education and dementia, BMJ source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Each of these networks is a group of brain areas that seem to work together as the task is harder.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Given these assumptions, individuals with higher CR will begin their cognitive decline when pathology is more advanced and thus have less time until they reach the point where pathology overwhelms function.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- The authors state this as an assumption: There is a common point in all people where pathology is so severe that function cannot be maintained.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Still, while in some ways interdependent, brain reserve and CR make independent in addition to synergistic contributions to understanding individual differences in clinical resilience to brain pathology.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: unclear — It is unclear why the paper says it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, the cognitive or neural mechanism that underlies this reserve is unknown.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, clinicians must be aware that in the presence of pathology there should still be a period of time during which even the most sensitive measures would fail to detect cognitive change.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Individuals with high reserve, by definition, will not demonstrate disease-related clinical symptoms as early as individuals with low levels of reserve.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
plaindirect- Asserted: passes — The authors put it forward as true.
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A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Since people with greater reserve should be able to tolerate more AD pathology, the onset of clinical dementia should be delayed.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaindirectn = 593- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper may give no reason why it holds. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“It is possible that individuals with more efficient or higher capacity networks could have more resilience in the face of age- or disease-related changes.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper may give no reason why it holds.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Only controlled studies can truly establish that some set of interventions or experiences are beneficial.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
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Probably not a substantial claim. It may be too vague to check against evidence. The paper may give no reason why it holds.
In the paper
“In schizophrenia, small effects of cognitive remediation were noted, particularly in stable patients and when combined with adjunctive rehabilitation52.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not matchedcites [52]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
- Not matched
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“While the original observations concern easily measurable variables like education or occupational attainment, more recent studies have delved more deeply into lifestyle factors, cognitively stimulating behaviors, personality factors and the like.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
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In the paper
“However, the exact”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These findings support the possibility that it may be possible to intervene even later in life in order to impart reserve, slow age-related cognitive decline, and prolonged healthy aging.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This is a hopeful idea, since it suggests that changes in lifestyle even later in life might impart reserve against age-related cognitive decline or dementia.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Similarly, focused training has improved working memory capacity and shown transfer of training to nontrained working memory tasks51.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [51] Klingberg, 2010, Training and plasticity of working memory, Trends Cogn Sci source
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
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It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Studies using these endpoints will be very expensive because they will require a large number of participants and will have to be conducted over several years.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“While epidemiologic studies can only describe correlations and do not directly test causation, they are useful for deriving hypotheses and exploring ideas.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“By shifting emphasis from game to game, participants cannot fall into a fixed strategy. They must develop the ability to deal with the entire task as a whole – skills that might be termed attentional allocation or executive control.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The authors state this as an assumption.
Disease pathology slowly develops over time independently of cognitive reserve, and pathology begins many years before the onset of clinically diagnosed Alzheimer's disease.
“The assumption is that disease pathology slowly develops over time independently of CR, and that the pathology begins many years before the onset of clinically diagnosed AD.”
The authors state this as an assumption.
There is a common point in all people where pathology is so severe that function cannot be maintained.
“However, we reasoned that there is common point in all people where the pathology is so severe that function cannot be maintained.”
The paper relies on this without support.
No study to date has shown change in slowed rate of cognitive decline in aging or reduced risk of developing Alzheimer's disease.
“No study to date has shown change in either of these endpoints.”
The paper relies on this without support.
The brain both passively and actively attempts to cope with brain changes or pathology.
“Since the brain both passively and actively attempts to cope with brain changes or pathology, it is important to understand the factors that contribute to this resilience.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Researchers have long reported that people with more years of formal education are at lower risk for Alzheimer's and other dementias than those with fewer years of formal education.80,[144][145][146][147][148][149]”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [146]
The cited source says what the claim attributes to it.
In the citing paper
“This concept was theoretically framed by Park and Bischof (2013) as “scaffolding,” similar to the closely related cognitive reserve theory proposed by Stern (2012).”
In the citing paper
“supporting the theory that a greater cognitive reserve could help protect against development of LOAD117.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [117]
In the citing paper
“The level of education, a surrogate marker of cognitive reserves (Stern, 2012), is an important determinant of the expression of VCI, such that for a given level of neuropathology higher education is associated with less cognitive deficits (Zieren et al., 2013).”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as Stern, 2012
In the citing paper
“These findings lead to the suggestion that higher social engagement and support experienced both before and during lockdown due to the COVID-19 pandemic might have had a protective/mitigating role by contributing to cognitive (51) and affective reserve (52).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [51]
In the citing paper
“Cognitive reserve theory suggests that individuals differ in their level of resilience against brain pathology and hence may exhibit differences in cognitive function despite equivalent levels of pathology (Stern, 2002(Stern, , 2012)).”
From Living alone and cognitive function in later life (2019) · cites this paper as Stern, 2012
In the citing paper
“The theory suggests that individuals differ in their degree of resilience against age-related brain pathology and hence may show differences in cognitive function in relation to an equivalent level of pathology [8, 9].”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
In the citing paper
“Cognitive reserve is a theoretical concept that may account for the role of social isolation and its association with cognitive outcomes in later life.”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
In the citing paper
“Such individuals are likely to receive less cognitive stimulation through social contact, resulting in lower cognitive reserve and hence poorer cognitive function [8, 9].”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
Citations
Cites
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Self-citationRunning enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Neural consequences of enviromental enrichment
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Cited by
Sorted by citations
Items 1,301–1,400 of 3,537
Hou, X., Luo, Y., Yang, F., Zhu, X., Gao, X., Wang, W., Qiao, G., & Zhou, J. W. (2024) · BMC Public Health · doi:10.1186/s12889-024-18106-8 · Cited by 16
“…of physical and mental work, such as assisting with school or homework, instructing and teaching grandchildren skills, which helps to enhance their mental stimulation by exercising their cognitive skills such as learning, thinking, and reasoning, thus improving cognitive function [49, 50].”
BackgroundFonseca, L. M., Schmidt, J. J., Snoek, F. J., Weinstock, R. S., Chaytor, N. S., Stuckey, H. L., Ryan, C. M., & van Duinkerken, E. (2024) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s410363 · Cited by 20
Kobayashi, G., Hirata, K., Ono, M., Kasuga, K., & Takado, Y. (2026) · Frontiers in Dementia · doi:10.3389/frdem.2026.1736297 · Cited by 22
“In empirical studies, CR is commonly operationalized using sociobehavioral proxies such as early age IQ, educational attainment, occupational complexity, and cognitively stimulating leisure activities, which modulate the relationship between biomarker burden and clinical expression (Stern, 2012).”
The importance of bilingualism for the aging brain
Sullivan, M. D., & Bialystok, E. (2017) · Studies in bilingualism · doi:10.1075/sibil.53.01sul · Cited by 16
Naming in Older Adults: Complementary Auditory and Visual Assessment
Hamberger, M. J., Heydari, N. D., Caccappolo, E., & Seidel, W. T. (2021) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617721000552 · Cited by 19
“The correlation between education and cognitive performance in older adults has been framed within “cognitive reserve theory,” which suggests that environmental enrichment promotes an increase in synapses and vascularization, resulting in better performance (Speisman et al., 2013; Stern, 2012).”
Nunes, I., & Nunes, M. V. S. (2021) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2021.2014788 · Cited by 16
“These factors appear to act as a protective effect against normal and pathological aging and brain injury (Levi et al., 2013; Liu et al., 2013; Stern, 2002, 2012).”
BackgroundHow Welfare Regimes Moderate the Associations Between Cognitive Aging, Education, and Occupation
Orsholits, D., Cullati, S., Ghisletta, P., Aartsen, M., Oris, M., Studer, M., Maurer, J., Perna, L., Gouveia, É. R., de Gouveia, B. R. F. O., et al. (2022) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbac013 · Cited by 20
Karantonis, J. A., Carruthers, S. P., Burdick, K. E., Pantelis, C., Green, M. J., Rossell, S. L., Hughes, M. E., Cropley, V., & Rheenen, T. E. V. (2022) · Neuropsychology Review · doi:10.1007/s11065-021-09533-0 · Cited by 15
“…in psychiatric disorders, and used to explain findings in in which more severe underlying brain pathology has been found in individuals with relatively minor clinical indicators of illness compared to those with much more severe symptoms (Leeson et al., 2011; Stern, 2012; Van Rheenen et al., 2019).”
BackgroundResultLeisure Participation and Cognitive Impairment Among Healthy Older Adults in China
Zhang, W., Feng, Q., Fong, J. H. Y., & Chen, H. (2022) · Research on Aging · doi:10.1177/01640275221082151 · Cited by 16
Potential Link Between Cognition and Motor Reserve in Patients With Parkinson’s Disease
Chung, S. J., Kim, Y. J., Kim, Y. J., et al. (2022) · Journal of Movement Disorders · doi:10.14802/jmd.22063 · Cited by 16
Barbieri, G. F., Real, E., Lopez, J., García-Justicia, J. M., Satorres, E., & Meléndez, J. C. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph191912757 · Cited by 18
“Thus, the participants’ preserved emotion recognition abilities could be attributed to Stern’s cognitive reserve concept, which explains individual differences in the susceptibility to age-related changes and brain pathologies, such as those observed in Alzheimer’s disease [57].”
BackgroundDobyns, L., Zhuang, K., Baker, S. L., Mungas, D., Jagust, W. J., & Harrison, T. M. (2023) · Nature Aging · doi:10.1038/s43587-022-00353-2 · Cited by 16
Gazes, Y., Lee, S., Fang, Z., Mensing, A., Noofoory, D., Nazario, G. H., Babukutty, R. S., Chen, B. B., Habeck, C. G., & Stern, Y. (2023) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbad044 · Cited by 17
Self-citationLin, H., Chung, C., Chen, L., Wang, J., Chen, C., Huang, K., Tsai, M.-H., Chien, W., & Lin, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-33674-2 · Cited by 17
Neighborhood Cohesion Across the Life Course and Effects on Cognitive Aging
Choi, J., Han, S. H., Ng, Y. T., & Muñoz, E. (2023) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbad095 · Cited by 15
Timing of Alzheimer’s Disease by Intellectual Disability Level in Down Syndrome
Hartley, S. L., Fleming, V., Schworer, E. K., Peven, J. C., Handen, B. L., Krinsky‐McHale, S. J., Hom, C. L., Lee, L., Tudorascu, D., Laymon, C. M., et al. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230200 · Cited by 18
“Alternatively, variability in premorbid ID may impact the trajectory of AD in DS through cognitive reserve, or the concept that those with higher premorbid intelligence can better recruit alternate neural networks or more efficiently use existing networks to cope with early AD-related pathology [20].”
PET imaging of synaptic density in Parkinsonian disorders
Martin, S. L., Uribe, C., & Strafella, A. P. (2023) · Journal of Neuroscience Research · doi:10.1002/jnr.25253 · Cited by 19
“…et al., 2014], exercise [Binda et al., 2021; Li et al., 2021; Yang et al., 2022], environment [Frick & Fernandez, 2003; Hui et al., 2020; Saito et al., 1994]) and internal (cognitive reserve [Pettigrew & Soldan, 2019; Stern, 2012]) factors that may alter synaptic density in healthy aging of humans.”
BackgroundRaimo, S., Cropano, M., Gaita, M., Maggi, G., Cavallo, N. D., Roldán-Tapia, L., & Santangelo, G. (2023) · Brain Sciences · doi:10.3390/brainsci13111510 · Cited by 16
Xia, X., Yuan, P., Zhao, X., Jia, F. R., Li, B., & Cai, P. (2024) · Journal of Alzheimer s Disease Reports · doi:10.3233/adr-230137 · Cited by 16
Rajagopal, S. K., Beltz, A. M., Hampstead, B. M., & Polk, T. A. (2024) · Scientific Reports · doi:10.1038/s41598-024-63301-7 · Cited by 16
Plini, E. R. G., Melnychuk, M. C., Andrews, R., Boyle, R. T., Whelan, R., Spence, J. S., Chapman, S. B., Robertson, I. H., & Dockree, P. M. (2024) · Acta Physiologica · doi:10.1111/apha.14191 · Cited by 20
High cognitive reserve attenuates the risk of dementia associated with cardiometabolic diseases
Dove, A. E., Yang, W., Dekhtyar, S., Guo, J., Wang, J., Marseglia, A., Vetrano, D. L., Whitmer, R. A., & Xu, W. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01528-2 · Cited by 19
“This may be explained by the concept of cognitive reserve (CR), the ability of lifelong engagement in cognitively stimulating activities to increase the adaptability of cognitive processes, thereby enhancing the brain’s capacity to with-stand age-and pathology-related damage [10, 11].”
BackgroundInflammation and olfactory loss are associated with at least 139 medical conditions
Leon, M., Troscianko, E. T., & Woo, C. C. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1455418 · Cited by 17
“Cognitive reserve in humans comes from leading a life filled with environmental enrichment, with a high level of education, a cognitively engaging career, and a high level of socializing (Stern, 2012).”
BackgroundPlayful brains: a possible neurobiological pathway to cognitive health in aging
Golland, Y., Ben‐David, B. M., Mather, M., & Keisari, S. (2025) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2025.1490864 · Cited by 15
“It has long been observed that factors such as social engagement and learning seem to protect against cognitive impairment even when Alzheimer’s disease neuropathology is present in the brain (Stern, 2012).”
Does bilingualism protect against cognitive aging?
Watson, C. W., Manly, J. J., & Zahodne, L. B. (2016) · Linguistic Approaches to Bilingualism · doi:10.1075/lab.15043.wat · Cited by 16
“Risk for AD is associated with genetic factors, vascular disease, and lifestyle factors, while higher levels of education, greater occupational complexity, and other cognitively-stimulating activities are protective against AD (Stern, 2012).”
BackgroundSartor‐Pfeiffer, J., Bettecken, K., Bernhard, F. P., Hofmann, M., Gladow, T., Lindig, T. M., Ciliz, M., ten Kate, M., Geritz, J., Heinzel, S., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00213 · Cited by 17
“This effect has been shown to be, at least partly, driven by cognitive reserve (Scarmeas et al., 2003; Steffener et al., 2009; Brickman et al., 2011; Tucker and Stern, 2011; Stern, 2012; Stern et al., 2012; Fernandez-Cabello et al., 2016).”
BackgroundGarber, A., Csizmadi, I., Friedenreich, C. M., Sajobi, T. T., Longman, R. S., Tyndall, A. V., Drogos, L. L., Davenport, M. H., & Poulin, M. J. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2017.07.011 · Cited by 18
Walsh, E., Shaw, M. E., Sachdev, P. S., Anstey, K. J., & Cherbuin, N. (2018) · European Journal of Neurology · doi:10.1111/ene.13780 · Cited by 16
“Conversely, larger brain volumes may constitute protective reserve [11].”
BackgroundPudas, S., & Rönnlund, M. (2018) · The Journals of Gerontology Series B · doi:10.1093/geronb/gby137 · Cited by 18
Ihle, A., Oris, M., Sauter, J., Spini, D., Rimmele, U., Maurer, J., & Kliegel, M. (2018) · Aging & Mental Health · doi:10.1080/13607863.2018.1531370 · Cited by 16
“…basis in early life, midlife, and old age has found to be related to better cognitive functioning such as memory and executive functioning in old age (GuzmanVelez & Tranel, 2015; Hertzog, Kramer, Wilson, & Lindenberger, 2008; Newson & Kemps, 2005; Opdebeeck, Martyr, & Clare, 2016; Stern, 2012).”
BackgroundInfluentialHighlighting the Role of Cognitive and Brain Reserve in the Substance use Disorder Field
Cutuli, D., de Guevara-Miranda, D. L., Castilla-Ortega, E., Santín, L. J., & Sampedro-Piquero, P. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190617100707 · Cited by 14
Androgen deprivation therapy increases brain ageing
Bello, J. P., Plata-Bello, A., Pérez-Martín, Y., Fajardo, V., & Concepción-Massip, T. (2019) · Aging · doi:10.18632/aging.102142 · Cited by 16
“Cognitive reserve explains the differences between individuals susceptible to age-related cognitive changes and pathology [29].”
Personality Traits are Related to Selective Cognitive Impairment in Early Alzheimer’s Disease
Rouch, I., Padovan, C., Pongan, É., Boublay, N., Laurent, B., Dorey, J., & Krolak‐Salmon, P. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190459 · Cited by 15
Egroo, M. V., Narbutas, J., Chylinski, D., González, P. V., Ghaemmaghami, P., Muto, V., Schmidt, C., Gaggioni, G., Besson, G., Pépin, X., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0693-y · Cited by 21
Goudsmit, M., van Campen, J., Franzen, S., van den Berg, E., Schilt, T., & Schmand, B. A. (2020) · The Clinical Neuropsychologist · doi:10.1080/13854046.2020.1711967 · Cited by 16
“Educational level is hypothesized to protect against cognitive decline by forming a ‘cognitive reserve’ against pathological changes (Stern, 2012).”
BackgroundAuditory Agnosia for Environmental Sounds in Alzheimer’s Disease: Not Hearing and Not Listening?
Coebergh, J., McDowell, S., van Woerkom, T. C. A. M., Koopman, J., Mulder, J., & Bruijn, S. D. (2020) · Journal of Alzheimer's Disease · doi:10.3233/jad-190431 · Cited by 10
APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer’s disease spectrum
Initiative, A. D. N., Li, T., Wang, B., Gao, Y., Wang, X., Yan, T., Xiang, J., Niu, Y., Liu, T., Chen, D., et al. (2020) · Brain Imaging and Behavior · doi:10.1007/s11682-020-00283-w · Cited by 16
“For example, individuals with higher education have a greater capacity to counteract impacts on gray matter integrity and cortical thickness in normal aging, MCI and AD (Franzmeier et al. 2018; Liu et al. 2012; Serra et al. 2011; Stern 2012).”
BackgroundTreyer, V., Meyer, R., Buchmann, A., Crameri, G. A. G., Studer, S. T., Saake, A., Gruber, E., Unschuld, P. G., Nitsch, R. M., Höck, C., et al. (2021) · PLoS ONE · doi:10.1371/journal.pone.0247225 · Cited by 18
Armstrong, N. M., Tom, S. E., Harrati, A., Casaletto, K. B., Pa, J., Rentería, M. A., Gu, Y., Rajan, K. B., Schupf, N., Fieo, R. A., et al. (2021) · The Gerontologist · doi:10.1093/geront/gnab046 · Cited by 16
“The protective effects of educational attainment, occupation, and LAE may reflect increased cognitive reserve, a hypothetical construct that prevents clinical decline in the face of pathological injury (Stern, 2012).”
BackgroundSelf-citationCyprien, F., Berr, C., Maller, J. J., Meslin, C., Gentreau, M., Mura, T., Gabelle, A., Courtet, P., Ritchie, K. A., Ancelin, M., et al. (2021) · Psychological Medicine · doi:10.1017/s0033291721000416 · Cited by 16
“Personality traits influence lifestyle patterns such as health behavior, dietary habits, cognitive activity, and social relationships (Roberts, Kuncel, Shiner, Caspi, & Goldberg, 2007; Stephan, Boiché, Canada, & Terracciano, 2014; Weston, Edmonds, & Hill, 2020), and these factors in turn are related to the risk of dev…”
BackgroundUse of Hormone Therapy in Postmenopausal Women with Alzheimer’s Disease: A Systematic Review
Cardinali, C. A. E. F., Martins, Y. A., & Torrão, A. D. S. (2021) · Drugs & Aging · doi:10.1007/s40266-021-00878-y · Cited by 16
Ham, M.-J., Kim, S., Jo, Y.-J., Park, C., Nam, Y., Yoo, D., & Moon, M. (2021) · Biomedicines · doi:10.3390/biomedicines9121951 · Cited by 16
“In particular, cognitive reserve is the one of the important concepts of brain changes in neurodegenerative diseases, such as AD [50].”
BackgroundKouraki, A., Bast, T., Ferguson, E., & Valdes, A. M. (2022) · Scientific Reports · doi:10.1038/s41598-022-04781-3 · Cited by 18
Cognitive Impairment in Alzheimer’s and Metabolic Diseases: A Catecholaminergic Hypothesis
Guzmán-Ramos, K. R., Osorio‐Gómez, D., & Bermúdez‐Rattoni, F. (2022) · Neuroscience · doi:10.1016/j.neuroscience.2022.05.031 · Cited by 15
Is There More to Subjective Cognitive Impairment than Meets the Eye? A Perspective
Tales, A., Wilcock, G. K., Phillips, J. E., & Bayer, A. J. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132414 · Cited by 16
“Another factor influencing the early diagnosis of dementia in MCI and SCI is that cognitive function may be maintained, namely performance on standard neuropsychological measures may be within the normal range despite underlying pathology, due to cognitive reserve and re-organizational and compensatory strategies [83,…”
BackgroundEvaluation of Cognitive Impairment in Older Adults
Scharre, D. W., & Trzepacz, P. T. (2013) · FOCUS The Journal of Lifelong Learning in Psychiatry · doi:10.1176/appi.focus.11.4.482 · Cited by 17
Effect size for the main cognitive function determinants in a large cross‐sectional study
Mura, T., Amieva, H., Goldberg, M., Dartigues, J., Ankri, J., Zins, M., & Berr, C. (2016) · European Journal of Neurology · doi:10.1111/ene.13087 · Cited by 16
“The association between education and cognitive performances can be explained by brain development and lifelong experiences, such as lifestyle choices, health behaviors, social interactions and type of occupation [12,46].”
BackgroundNutrition as a component of dementia risk reduction strategies
Greenwood, C. E., & Parrott, M. D. (2016) · Healthcare Management Forum · doi:10.1177/0840470416662885 · Cited by 16
“Some factors, such as higher education, occupational complexity, and social networking, may primarily help sustain cognitive function with aging by promoting the development of cognitive reserves.(33) By contrast, diet may play more of a supportive role through its ability to maintain brain structure, neural connectiv…”
BackgroundGuzmán‐Vélez, E., Jaimes, S. Y., Aguirre–Acevedo, D. C., Norton, D. J., Papp, K. V., Amariglio, R. E., Rentz, D. M., Baena, A. Y., Henao, E., Tirado, V., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180078 · Cited by 16
Disentangling Heterogeneity in Alzheimer’s Disease: Two Empirically-Derived Subtypes
Blanken, A. E., Dutt, S., Li, Y., Nation, D. A., & Initiative, A. D. N. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190230 · Cited by 16
“Cognitive reserve may convey resilience in the context of both agerelated and AD-related neurocognitive decline due to greater efficiency in use of cognitive resources [38].”
Nishizawa, T., Morita, A., Fujiwara, T., & Kondo, K. (2019) · International Psychogeriatrics · doi:10.1017/s1041610219000814 · Cited by 16
“According to the brain and cognitive reserve hypotheses, lifetime “reserve” (i.e. increased brain volume and synaptic connections) can help people cope with neuropathology anddelay the clinical diagnosis of dementia (Stern, 2012).”
BackgroundThe Association Between Cognitive Reserve and Cognitive Trajectories Among Older Adults
Khalaila, R., Dintica, C. S., & Yaffe, K. S. (2024) · Innovation in Aging · doi:10.1093/geroni/igae014 · Cited by 16
“…that attaining an active and cognitively stimulating lifestyle through higher education, higher occupational complexity, and leisure activities can increase CR (Cheng, 2016; Dekhtyar et al., 2016; Fritsch et al., 2007; Leon et al., 2014; Opdebeeck et al., 2016; Stern, 2012; Wilson et al., 2002).”
BackgroundResultInfluentialLiao, Z., Zhang, Q., Ren, N., Zhao, H., & Zheng, X. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1418939 · Cited by 15
“Patients with AD exhibit typical clinical attention de fi cit disorder with extensive cognitive de fi cits, which severely affects their normal life (2).”
BackgroundThe Role of Cognitive Reserve in Post-Stroke Rehabilitation Outcomes: A Systematic Review
Bertoni, D., Bruni, S., Saviola, D., TANTI, A. D., & Costantino, C. (2024) · Brain Sciences · doi:10.3390/brainsci14111144 · Cited by 17
“The notion of CR was first introduced in the context of Alzheimer’s disease, where it was observed that individuals with higher CR could tolerate greater degrees of brain pathology before exhibiting clinical symptoms [10,11].”
Jang, H., Yeo, M., Cho, J., Kim, S., Chin, J., Kim, H. J., Seo, S. W., & Na, D. L. (2021) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1002/trc2.12209 · Cited by 18
Migliore, S., D’Aurizio, G., Scaricamazza, E., Maffi, S., Ceccarelli, C., Ristori, G., Romano, S., Castaldo, A., Fichera, M., Curcio, G., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12010036 · Cited by 15
“Intellectual enrichment is generally evaluated in terms of educational attainment, vocabulary knowledge, and occupation level [9,10], and many studies have shown that premorbid engagement in leisure activities might increase CR and mitigate longitudinal cognitive impairment [11,12].”
BackgroundMethodBorelli, W. V., de Senna, P. N., Brum, W. S., Schuh, A. F. S., Zimmer, E. R., Chaves, M. L. F., & Castilhos, R. M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.789190 · Cited by 15
“Educational attainment is an important proxy of cognitive reserve, and it plays a significant influence on the pathophysiology of cognitive decline (Stern, 2012).”
BackgroundJoint Models for Estimating Determinants of Cognitive Decline in the Presence of Survival Bias
Davis-Plourde, K. L., Mayeda, E. R., Lodi, S., Filshtein, T., Beiser, A., Gross, A. L., Seshadri, S., Glymour, M. M., & Tripodis, Y. (2022) · Epidemiology · doi:10.1097/ede.0000000000001472 · Cited by 15
Associations between volunteering and cognitive impairment: The moderating role of race/ethnicity
Wang, Y., Wong, R., Amano, T., & Shen, H. (2022) · Health & Social Care in the Community · doi:10.1111/hsc.13847 · Cited by 14
“It is theorised that lifetime engagement in such activities may delay cognitive decline by building cognitive reserve, which is a property of the brain that allows for sustained cognitive performance in the presence of age- related changes or brain insults (Stern, 2012).”
BackgroundGaspar, P. M., Campos‐Magdaleno, M., Pereiro, A. X., Facal-Mayo, D., & Juncos‐Rabadán, O. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.968343 · Cited by 15
“…that social, cultural, family and free-time activities throughout life constitute important proxies or dimensions in the cognitive reserve model (Stern, 2012) and that these should be considered, together with education and professional activities, to be predictors of cognitive frailty.”
BackgroundWagle, J., Selbæk, G., Benth, J. Š., Gjøra, L., Rønqvist, T. K., Bekkhus‐Wetterberg, P., Persson, K., & Engedal, K. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220672 · Cited by 18
Modifiable risk factors of dementia linked to excitation-inhibition imbalance
Hafizi, S., & Rajji, T. K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101804 · Cited by 16
Khan, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-25563-x · Cited by 16
Felix, P. E. F., Vanzelli, S. R. C. B., Ribeiro, F. S., & Santos, F. H. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.985438 · Cited by 15
“) contribute to the formation of more resistant neural networks that protect cognitive function, even in neuropathological progress (Stern, 2012).”
BackgroundInfluentialRole of cognitive reserve in ischemic stroke prognosis: A systematic review
Tao, C.-H., Yuan, Y., Xu, Y.-J., Zhang, S., Wang, Z., Wang, S., Liang, J.-Y., & Wang, Y.-G. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1100469 · Cited by 13
“First, patients with a higher CR level may tolerate more pathology until reaching a critical threshold manifested by cognitive deficits despite comparable stroke severity (58).”
Yoo, S. S., Tyas, S. L., Maxwell, C. J., & Oremus, M. (2023) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2023.105076 · Cited by 15
Maddock, J., Gallo, F., Wolters, F. J., Stafford, J., Marseglia, A., Dekhtyar, S., Lenart‐Bugla, M., Verspoor, E., Perry, M., Samtani, S., et al. (2023) · Gerontology · doi:10.1159/000531969 · Cited by 14
“For example, participating in social activities involves cognitive and mental stimulation [22].”
BackgroundIn vivo cortical diffusion imaging relates to Alzheimer's disease neuropathology
Torso, M., Ridgway, G. R., Valotti, M., Hardingham, I., Chance, S. A., for the National Alzheimer’s Coordinating Center, Brewer, J., Lopez, O., Hyman, B., Grabowski, T., et al. (2023) · Alzheimer's Research & Therapy · doi:10.1186/s13195-023-01309-3 · Cited by 16
He, K., Li, B., Huang, L., Zhao, J., Hua, F., Wang, T., Li, J., Wang, J., Huang, Q., Chen, K., et al. (2023) · European Radiology · doi:10.1007/s00330-023-10366-z · Cited by 15
“These results indicated that higher education could help individuals “cope with” AD pathology and resist cognitive decline [53, 54].”
Characteristics and cognition of older adults engaged in lifelong learning
Wenzel, K. C., Puymbroeck, M. V., Lewis, S. T., McGuire, F. A., & Vidotto, J. (2024) · Educational Gerontology · doi:10.1080/03601277.2023.2299647 · Cited by 22
“The cognitive reserve hypothesis postulates that people with more education can better withstand pathological brain changes associated with aging and the dementia process (Scarmeas, 2007; Stern, 2012).”
BackgroundXu, S., Jesdale, W. M., Dube, C. E., Nielsen, N. N., McPhillips, E., & Lapane, K. L. (2024) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2024.105397 · Cited by 15
Li, Y., Dekhtyar, S., Grande, G., Kalpouzos, G., Gregorio, C., Laukka, E. J., & Qiu, C. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13910 · Cited by 21
“32,33 We also found that a high composite CR was related to a reduced risk of transition from normal cognition or CIND to death.”
Morganti, F. (2024) · Geriatrics · doi:10.3390/geriatrics9040093 · Cited by 19
“The new ideas that began to take hold at the end of the last century, such as the concept of “reserve”—whether cognitive [13], motor [14], or defined through the term “crystallized abilities” [15]—give due prominence to the path of aging as a possible future stage in life.”
BackgroundL., D. S. H., Thomas, S. M., & Kamath, S. S. (2024) · IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW) · doi:10.1109/cvprw63382.2024.00529 · Cited by 15
“However, most existing works typically focus on utilizing a single type of data like MRI or PET scans to visualize structural and functional changes in the brain associated with AD, while ignoring other data sources [14].”
BackgroundThe Hidden Dangers of Sedentary Living: Insights into Molecular, Cellular, and Systemic Mechanisms
Diniz, D. G., Bento‐Torres, J., da Costa, V. O., Carvalho, J. P. R., Tomás, A. M., de Oliveira, T. C. G., Soares, F. C., de Macedo, L. D. E. D., Jardim, N. Y. V., Bento-Torres, N. V. O., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910757 · Cited by 19
Ren, H., Feng, Q., Chen, L., Li, L., Wang, J., Wu, J., Dong, L., Liu, T., & Wang, Z. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1429934 · Cited by 17
“Epidemiological studies suggest that lifelong experiences, such as education and occupational accomplishments, contribute to an individual ’ s cognitive reserve (45).”
BackgroundResistance and resilience to Alzheimer's disease in Down syndrome
Boyle, R. T., Koops, E. A., Ances, B. M., Andrews, E. J., Arenaza‐Urquijo, E. M., Bejanin, A., Brickman, A. M., Buckley, R. F., Clas, G. S., Costello, E., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70151 · Cited by 14
“123 Furthermore, the possibility of targeting biological resistance and resilience factors, including the cholinergic system or genetic factors, via novel therapeutics should be explored.”
Paus, T., Pausová, Z., Abrahamowicz, M., Gaudet, D., Leonard, G. T., Pike, G. B., & Richer, L. (2014) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2014.10.003 · Cited by 16
A Quantitative Study of Network Robustness in Resting-State fMRI in Young and Elder Adults
Gómez‐Ramírez, J., Li, Y., Wu, Q., & Wu, J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00256 · Cited by 15
“…Sick Children, University of Toronto, Toronto, ON, Canada, 2 Key Laboratory of Adolescent Cyberpsychology and Behavior (CCNU), Ministry of Education, Wuhan, China, 3 School of Psychology, Central China Normal University, Wuhan, China, 4 Biomedical Engineering Laboratory, Okayama University,…”
BackgroundInfluentialHammers, D. B., Atkinson, T. J., Dalley, B. C. A., Suhrie, K. R., Horn, K. P., Rasmussen, K. M., Beardmore, B. E., Burrell, L. D., Duff, K. M., & Hoffman, J. M. (2017) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317517698795 · Cited by 16
Higher IQ in juvenile myoclonic epilepsy: Dodging cognitive obstacles and “masking” impairments
Rzezak, P., Moschetta, S. P., Mendonça, M., Paiva, M. L. M. N., Coan, A. C., Guerreiro, C. A. M., & Valente, K. D. R. (2018) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2018.05.029 · Cited by 15
Telles‐Longui, M., Mourelle, D., Schöwe, N. M., Cipolli, G. C., Malerba, H. N., Buck, H. S., & Viel, T. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14744 · Cited by 15
“However, many studies have shown that retaining cognitive function during the ageing process depends on the formation of cognitive and structural reserves (Balthazar, Schöwe, Cipolli, Buck, & Viel, 2018; Baraldi et al., 2013; Grant, Dennis, & Li, 2014; Lavrencic et al., 2018; Stern, 2012).”
Charness, N. H. (2019) · Gerontology · doi:10.1159/000502141 · Cited by 16
Brent, R. J. (2019) · OBM Geriatrics · doi:10.21926/obm.geriatr.1904079 · Cited by 16
“Under the brain reserve hypothesis, being educated gives the brain protective and compensating mechanisms making for greater resilience to the destructive pathologies of dementia [13].”
BackgroundDelpak, A., & Talebi, M. (2020) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2020.104090 · Cited by 16
Yang, H., Tng, G. Y. Q., Ng, W. Q., & Yang, S. (2020) · Clinical Gerontologist · doi:10.1080/07317115.2020.1799891 · Cited by 19
“…association between sense of control and dementia risk is significant only at working-memory scores of 5.26 and lower (i.e., 0.44 SD below the mean), as indicated by the solid vertical line. and neural mechanisms underlying these cognitivereserve factors remain relatively unknown (Stern, 2012).”
BackgroundInfluentialMorris, T. P., Ai, M., Chaddock‐Heyman, L., McAuley, E., Hillman, C. H., & Kramer, A. F. (2021) · Journal of Cognitive Enhancement · doi:10.1007/s41465-021-00208-5 · Cited by 17
“…mechanisms of plasticity (i.e., the nervous system’s ability to make adaptations to constantly changing environmental inputs) (Pascual-Leone, 2006) and the brain’s expression of compensatory responses in the face of pathological changes (i.e., brain resilience/cognitive reserve) (Stern, 2012).”
BackgroundYeverino-Castro, S. G., Mejía-Arango, S., Mimenza-Alvarado, A. J., Cantú-Brito, C. G., Ávila‐Funes, J. A., & Aguilar-Navarro, S. G. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253856 · Cited by 14
“A lack of cognitive reserve, where pre-existing mechanisms allow for neural compensation and favor resilience when coping with the damage caused by vascular pathology, can be a possible explanation in situations where a lower educational level is associated with greater dementia risk [36, 37].”
BackgroundPaolini, S., Devita, M., Epifania, O. M., Anselmi, P., Sergi, G., Mapelli, D., & Coin, A. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110584 · Cited by 16
“The second is to investigate the potential effects of PS and CE on participants’ cognitive functioning and whether these variables are modulated by cognitive reserve (CR), which is known to play an important role in the onset and evolution of neurodegenerative diseases [27].”
BackgroundPanico, F., Luciano, S. M., Sagliano, L., Santangelo, G., & Trojano, L. (2022) · Personality and Individual Differences · doi:10.1016/j.paid.2022.111703 · Cited by 17
“Since CR could protect against cognitive decline (Stern, 2012), interventions aimed at increasing CR might help also preventing onset of cognitive failures during the pandemic (Santangelo et al., 2021).”
Activity-dependent degeneration of axotomized neuromuscular synapses in WldS mice
Brown, R., Hynes-Allen, A. M., Swan, A., Dissanayake, K. N., Gillingwater, T. H., & Ribchester, R. R. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.01.018 · Cited by 15
“…of muscle function is associated with early signs of synaptic dysfunction and demise (Frey et al., 2000; Selkoe, 2002; Swaab et al., 2002; Fischer et al., 2004; Frick and Benoit, 2010; Power et al., 2010; Valdez et al., 2010; Li et al., 2011; Punga and Ruegg, 2012; Stern, 2012; Shors et al., 2012).”
Gurnani, A. S., John, S. E., & Gavett, B. E. (2015) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acv005 · Cited by 15
HLA-A2 Alleles Mediate Alzheimer’s Disease by Altering Hippocampal Volume
Initiative, A. D. N., Wang, Z.-X., Wang, H.-F., Tan, L., Sun, F.-R., Tan, C., Tan, C.-C., Jiang, T., Tan, L., & Yu, J. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9832-3 · Cited by 15
Quantitative multimodal multiparametric imaging in Alzheimer’s disease
Zhao, Q., Chen, X., & Zhou, Y. (2016) · Brain Informatics · doi:10.1007/s40708-015-0028-9 · Cited by 16
Kim, G. H., Im, K., Kwon, H., Seo, S. W., Ye, B. S., Cho, H., Noh, Y., Lee, J. M., Kim, S. T., Park, S. E., et al. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00198 · Cited by 18
Rolstad, S., Abé, C., Olsson, E., Eckerström, C., & Landén, M. (2016) · Psychological Medicine · doi:10.1017/s0033291716001641 · Cited by 15
“2013) and might yield more accurate estimates of CR than education when it is unclear if the latter can be considered representative (Stern, 2012).”
BackgroundMethodStudy on Cognitive Reserve in Korea Using Korean Version of Cognitive Reserve Index Questionnaire
Choi, C.-H., Park, S., Park, H.-J., Cho, Y., Sohn, B. K., & Lee, J. (2016) · 신경정신의학 · doi:10.4306/jknpa.2016.55.3.256 · Cited by 15
Construction and Analysis of Weighted Brain Networks from SICE for the Study of Alzheimer's Disease
Munilla, J., Ortíz, A., Górriz, J. M., Ramı́rez, J., & Initiative, T. A. D. N. (2017) · Frontiers in Neuroinformatics · doi:10.3389/fninf.2017.00019 · Cited by 15
“…the course of the disease and explain the increase of the connectivity with other brain regions as a compensatory reallocation of recruitment of cognitive resources that could help to preserve attention ability and memory (Saykin et al., 2004; Gould et al., 2006; Huang et al., 2010; Stern, 2012).”
BackgroundHistory-inspired reflections on the Bilingual Advantages Hypothesis
Titone, D. A., Gullifer, J. W., Subramaniapillai, S., Rajah, N., & Baum, S. R. (2017) · Studies in bilingualism · doi:10.1075/sibil.53.13tit · Cited by 15
Chiang, A. C. A., Fowler, S., Reddy, R., Pletniková, O., Troncoso, J. C., Sherman, M. A., Lesné, S., & Jankowsky, J. L. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.11.011 · Cited by 17
Metadata
- Authors
- Stern, Y.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Stern, Yaakov
- ORCID
- Stern, Yaakov
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 11
- Issue
- 11
- Pages
- 1006-1012
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC3507991
- OpenAlex
- W2144907160
- Cited by
- 3,557
- References
- 59
- Citations by year
- 2026: 412 · 2025: 352 · 2024: 311 · 2023: 343 · 2022: 281 · 2021: 303 · 2020: 350 · 2019: 292 · 2018: 244 · 2017: 213 · 2016: 176 · 2015: 125 · 2014: 93 · 2013: 58 · 2012: 1
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institute on Aging (R01AG026158, R01AG014671)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- cognitive reserve, brain reserve, Alzheimer's disease, cognitive aging, dementia risk, educational attainment, occupational attainment, leisure
- MeSH terms
- Aging, Alzheimer Disease, Animals, Humans, Cognitive Reserve
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