The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index; 29 of the 54 sources its claims cite were checked for support.
Cognitive reserve in ageing and Alzheimer's disease
Open accessAbstract
The concept of cognitive reserve provides an explanation for differences between individuals in susceptibility to age-related brain changes or pathology related to Alzheimer's disease, whereby some people can tolerate more of these changes than others and maintain function. Epidemiological studies suggest that lifelong experiences, including educational and occupational attainment, and leisure activities in later life, can increase this reserve. For example, the risk of developing Alzheimer's disease is reduced in individuals with higher educational or occupational attainment. Reserve can conveniently be divided into two types: brain reserve, which refers to differences in the brain structure that may increase tolerance to pathology, and cognitive reserve, which refers to differences between individuals in how tasks are performed that might enable some people to be more resilient to brain changes than others. Greater understanding of the concept of cognitive reserve could lead to interventions to slow cognitive ageing or reduce the risk of dementia.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This review argues that cognitive reserve explains why people differ in how much Alzheimer’s disease pathology or age-related brain change they can tolerate while still functioning. It synthesizes epidemiologic, neuroimaging, postmortem, and intervention evidence, and concludes that reserve is modifiable but that causal interventions remain unproven.
Key findings
- Reserve is split into brain reserve, a more passive quantitative tolerance tied to brain size or neurons/synapses, and cognitive reserve, an active functional process in which pre-existing or compensatory networks help cope with damage.
- Epidemiologic studies cited found that fewer than 8 years of education carried 2.2 times higher dementia risk, low occupational attainment carried 2.25 times higher risk, and greater leisure activity was linked to 38% lower risk; a review of 22 cohort studies estimated higher reserve reduced dementia risk by 46%.
- After Alzheimer’s disease becomes clinically apparent, higher reserve is associated with faster decline: memory scores fell about one point yearly on average, with an additional point yearly in those with higher education or occupation.
- Imaging and autopsy evidence indicated that at matched clinical severity, higher education was linked to greater parietotemporal blood-flow deficit and, in 130 elders, each additional year of education reduced the pathology–cognition association by 0.088 standard units; fMRI work distinguished neural reserve from neural compensation.
Methods
- Narrative review by the author, integrating his group’s and others’ epidemiologic cohort studies, functional and resting neuroimaging studies, postmortem analyses, and cognitive or exercise intervention trials.
- Cited samples include 593 non-demented adults aged 60 or older followed for 4 years, 130 elders who had cognitive evaluation before autopsy, and a preliminary 90-person older-adult Space Fortress training study.
- Main analysis is conceptual synthesis rather than a new primary study or formal meta-analysis; it draws on a cited systematic review of 22 cohort studies for one pooled estimate.
Limitations
- Stated: epidemiologic evidence is correlational and cannot establish causation; controlled intervention studies are needed, and no study to date has shown changes in the key endpoints of slowed cognitive decline or reduced Alzheimer’s disease risk.
- Stated: clinical use of biomarkers and imaging for reserve is premature because prognostic implications are not fully established, and cognitive training evidence is mixed.
- Evident from the text: this is a narrative review without formal risk-of-bias assessment, many findings come from the author’s own research program, and the interaction between brain reserve and cognitive reserve remains unresolved.
Model-written summary. Check it against the paper before relying on it.
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Claims the paper makes
39 Own interpretation · 14 No full text of the sources · 12 No basis given · 10 Supported · 10 Own result · 8 Partly supported · 5 Supported so far · 3 Not checked yet · 2 Couldn’t confirm · 1 Sources not found · accuracy not yet measured
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“This idea is supported by a set of studies that suggest that prevalence or incidence of dementia is lower in individuals with larger brains13, 14.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
What the sources say
- Not checked — no full text of the sourcecites [13] Katzman, 1988, Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques, Ann Neurol source
- Supportedcites [14] Schofield, 1997, An association between head circumference and Alzheimer's disease in a population-based study of aging, Neurology source
The Discussion (p. 5) reports that smaller head circumference was associated with higher prevalence of Alzheimer’s disease. The paper uses head circumference as an index of premorbid brain size (p. 1), so its finding supports the citing sentence’s hedged association. This study measured prevalence of Alzheimer’s disease, not incidence of dementia generally. (LLM, conf=0.88)
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Second, compared to individuals with lower CR, those with higher CR performed better even when they use the second network.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [42] Steffener, 2011, Supporting performance in the face of age-related neural changes: testing mechanistic roles of cognitive reserve, Brain Imaging Behav source
The Results (Model C) report that, in older adults, higher cognitive reserve reduced the negative effect of network 2 expression on task performance. The Discussion likewise says older adults with greater reserve maintained performance better as network 2 expression increased. (LLM, conf=0.88)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Those who engaged in more leisure activities had 38% less risk of developing dementia.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
What the sources say
- Supportedcites [24] Scarmeas, 2001, Influence of leisure activity on the incidence of Alzheimer's disease, Neurology source
The Discussion explicitly states that subjects with high leisure activity had 38% less risk of developing dementia. The Results report a relative risk of 0.62 (95% CI 0.46–0.83), consistent with that figure. (LLM, conf=0.95)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The rate of decline is more rapid in individuals with high reserve than those with low reserve, even when accounting for a multitude of other factors that may contribute to disease course27, 28, 46.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
What the sources say
- Supportedcites [27] Stern, 1999, Rate of memory decline in AD is related to education and occupation: cognitive reserve?, Neurology sourceExperimental — accuracy not yet measured
The DOI was not indexed for paper-scoped Semantic Scholar search, so the cited paper’s full text could not be checked directly. A systematic review, “Education and Dementia in the Context of the Cognitive Reserve Hypothesis” (search score 0.789), explicitly attributes more rapid memory decline in Alzheimer’s patients with higher education and occupational attainment to Stern et al. (1999). This supports the central claim, though the retrieved passage does not verify which other factors the original analysis accounted for. (LLM, conf=0.81)
- Supportedcites [28] Scarmeas, 2006, Education and rates of cognitive decline in incident Alzheimer's disease, J Neurol Neurosurg Psychiatry sourceExperimental — accuracy not yet measured
No paper-scoped Semantic Scholar snippets were available for Scarmeas et al. (2006). However, “Higher education affects accelerated cortical thinning in Alzheimer's disease” explicitly cites Scarmeas et al. (2006) among studies finding more rapid cognitive decline after Alzheimer’s onset in patients with higher education (snippet score 0.534). This supports the claim through a secondary citation, although the available evidence does not independently verify which other factors Scarmeas et al. adjusted for. (LLM, conf=0.76)
- Supportedcites [46] Hall, 2007, Education delays accelerated decline on a memory test in persons who develop dementia, Neurology sourceExperimental — accuracy not yet measured
Hall’s (2007) title establishes the finding of delayed accelerated memory decline in people who develop dementia. A Semantic Scholar snippet from “Episodic memory performance in a multi-ethnic longitudinal study of 13,037 elderly” describes the same pattern: education is associated with a delayed change point followed by faster decline (score 0.52). Hall’s full text was unavailable in the paper-scoped search, so the specific assertion about accounting for other factors could not be checked directly; the available evidence supports the core paraphrase, not every qualification. (LLM, conf=0.72)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“In a young group of subjects we identified an activation network that was expressed during the stimulus presentation phase of both tasks and whose increase in expression with increasing load correlated with CR.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [43] Stern, 2008, A common neural network for cognitive reserve in verbal and object working memory in young but not old, Cereb Cortex source
The Discussion identifies a pattern in young subjects during stimulus presentation whose load-related activation had a similar relationship with cognitive reserve in both the letter and shape tasks. The Canonical Variates Analysis reports significant expression of that pattern in both tasks and relates its load-related expression to cognitive-reserve scores. (LLM, conf=0.91)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Similar analysis demonstrated a comparable protective effect of occupational attainment33 and leisure activities34.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Not checked — no full text of the sourcecites [33] Stern, 1995, Relationship between lifetime occupation and parietal flow: implications for a reserve against Alzheimer's disease pathology, Neurology source
- Supportedcites [34] Scarmeas, 2003, Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis, Arch Neurol source
The cited paper’s Results report an inverse association between activity scores and cerebral blood flow after controlling for clinical severity, which the authors interpret as consistent with cognitive reserve. The Conclusions describe analogous findings for occupational attainment and note evidence linking leisure activities to reduced dementia risk. The citation supports the leisure-activities part of the sentence; occupational attainment has a separate citation. (LLM, conf=0.85)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“For example, at a given level of clinical severity, AD patients with higher education have a more severe pattern of AD-related changes on PET scan than those with lower education44, 45.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
What the sources say
- Not checked — no full text of the sourcecites [44] Garibotto, 2008, Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence, Neurology source
- Supportedcites [45] Kemppainen, 2008, Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease, Ann Neurol source
The Abstract reports that high- and low-educated patients with mild Alzheimer’s disease had the same degree of cognitive deterioration, while the high-educated group showed greater amyloid-tracer uptake and lower glucose metabolism on PET. The Discussion likewise describes more pronounced amyloid accumulation and neuronal dysfunction in the high-educated group. (LLM, conf=0.93)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“In AD patients matched for clinical severity, we found an inverse relationship between resting rCBF and years of education32.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Supportedcites [32] Stern, 1992, Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease, Ann Neurol source
The Procedures (p. 2) state that rCBF was measured under resting conditions. The Results (pp. 2–3) report greater parietotemporal flow reductions with more education in AD groups that did not differ on clinical measures; the relationship at the P3 detector remained significant after controlling for dementia severity. (LLM, conf=0.92)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The neural implementation of CR might take two forms: neural reserve and neural compensation16, 38.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [16] Stern, 2009, Cognitive reserve, Neuropsychologia source
In “Neural Mechanisms Underlying CR,” Stern explicitly says that the neural implementation of cognitive reserve might take two forms: neural reserve and neural compensation. The “Brain Reserve and Cognitive Reserve” section also describes them as two proposed components. (LLM, conf=0.95)
- Supportedcites [38] Stern, 2005, Brain networks associated with cognitive reserve in healthy young and old adults, Cereb Cortex source
The Introduction (p. 1) explicitly proposes two complementary facets of the neural implementation of cognitive reserve: neural reserve and neural compensation. The paper then defines and contrasts them in the Introduction (pp. 1–2). (LLM, conf=0.95)
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“These observations using cerebral blood flow have been replicated by other groups as well35, 36.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Not checked — no full text of the sourcecites [35] Alexander, 1997, Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis, Am J Psychiatry source
- Supportedcites [36] Perneczky, 2006, Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography, J Neurol Neurosurg Psychiatry source
The Results report an inverse association between schooling and glucose metabolism in patients with Alzheimer’s disease. The Discussion says these findings are supported by other groups’ cerebral-blood-flow studies, while noting that the results do not match exactly because of differences in samples and methods. This paper used FDG-PET rather than measuring cerebral blood flow itself. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Probably not a substantial claim. 15
- It may state two separate claims as one. 17
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“In contrast, the concept of CR suggests that the brain actively attempts to cope with brain damage by using pre-existing cognitive processing approaches or by enlisting compensatory approaches15, 16.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
What the sources say
- Not checked — no full text of the sourcecites [15] Stern, 2002, What is cognitive reserve? Theory and research application of the reserve concept, J Int Neuropsychol Soc source
- Supportedcites [16] Stern, 2009, Cognitive reserve, Neuropsychologia source
The “Brain Reserve and Cognitive Reserve” section states that active models such as CR propose that the brain copes with damage using pre-existing cognitive processes or enlisting compensatory processes. This directly supports the paraphrase; no page number is provided in our copy. (LLM, conf=0.95)
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“We replicated this observation in patients with incident AD28 and also found more rapid decline in cognitive function in AD patients who engaged in more leisure activities prior to dementia onset29.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
What the sources say
- Partly supportedcites [28] Scarmeas, 2006, Education and rates of cognitive decline in incident Alzheimer's disease, J Neurol Neurosurg Psychiatry sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
- Supportedcites [29] Helzner, 2007, Leisure activity and cognitive decline in incident Alzheimer disease, Arch Neurol source
Split into 2 atoms — 2 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Using a covariance method to analyze the imaging data, we identified a spatial pattern of fMRI activation that was expressed by both groups and whose expression increased as the task became more difficult.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [39] Stern, 2012, Task difficulty modulates young-old differences in network expression, Brain Res source
The Functional imaging section identifies a spatial pattern common to young and old participants. The Discussion states that its expression increased logarithmically with task difficulty. Page numbers are not provided in our copy. (LLM, conf=0.94)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In a follow-up analysis41, we found that atrophy in a key area within the first network (i.e. the one that was used by both young and old) was associated with decreased efficiency in that network and increased utilization of the second network.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Partly supportedcites [41] Steffener, 2009, The impact of age-related changes on working memory functional activity, Brain Imaging Behav sourceExperimental — accuracy not yet measured
The Abstract and Conclusion report that lower grey-matter volume in a region of the primary network was associated with greater secondary-network recruitment. The Discussion interprets this as compensation for an affected primary network, but the Results report no significant association between regional grey-matter volume and primary-network expression; decreased efficiency of that network was not demonstrated. (LLM, conf=0.86)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“For example, Basak et al.50 had elders play a complex role-playing game,”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Partly supportedcites [50] Basak, 2008, Can training in a real-time strategy video game attenuate cognitive decline in older adults?, Psychol Aging sourceExperimental — accuracy not yet measured
The Method > Participants section says older adults were assigned to play Rise of Nations, and the General Discussion reports transfer benefits after 23.5 hours of training. The paper identifies Rise of Nations as a complex real-time strategy game, not a role-playing game. Its Abstract reports improvement on a subset of cognitive tasks, rather than across the entire battery (page numbers unavailable in our copy). (LLM, conf=0.90)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In research with young adults, one particular training approach produced excellent improvement in gameplay, but, more importantly, also showed transfer of training to other tasks.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [55] Gopher, 1994, Transfer of skill from a computer game trainer to flight, Hum Factors source
- Not checked — no full text of the sourcecites [56] Gopher, 1989, Practice under changing priorities: an approach to the training of complex skills, Acta Psychol source
- Partly supportedcites [57] Blumen, 2010, Training cognitive control in older adults with the space fortress game: the role of training instructions and basic motor ability, Front Aging Neurosci sourceExperimental — accuracy not yet measured
The Introduction (‘The space fortress game and emphasis change instructions’; page unavailable) reports that emphasis-change instructions improved Space Fortress performance in younger adults compared with standard instructions. It says those instructions *may* be important for transfer, but does not report that this approach demonstrated transfer to other tasks. The General Discussion (page unavailable) says future studies will determine whether such transfer occurs. (LLM, conf=0.86)
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Those who rely more on this alternate network can still perform the task, but do so more poorly.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“On the average scores on a memory test decline by about one point yearly, but in those with higher educational or occupational attainment scores decline by an additional point each year.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The first network was used by both young and old subjects, and consisted of areas often associated with working memory.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast, the second network was primarily characterized by activation in parahippocampal areas and was used consistently only by the older subjects.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Interestingly, although the game itself was very challenging for the elders, there were few dropouts and performance improved over time.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [58] Orrell, 1995, Education and dementia, BMJ source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Interestingly, although the game itself was very challenging for the elders, there were few dropouts and performance improved over time.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [58] Orrell, 1995, Education and dementia, BMJ source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Each of these networks is a group of brain areas that seem to work together as the task is harder.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Given these assumptions, individuals with higher CR will begin their cognitive decline when pathology is more advanced and thus have less time until they reach the point where pathology overwhelms function.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- The authors state this as an assumption: There is a common point in all people where pathology is so severe that function cannot be maintained.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Still, while in some ways interdependent, brain reserve and CR make independent in addition to synergistic contributions to understanding individual differences in clinical resilience to brain pathology.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: unclear — It is unclear why the paper says it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, the cognitive or neural mechanism that underlies this reserve is unknown.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, clinicians must be aware that in the presence of pathology there should still be a period of time during which even the most sensitive measures would fail to detect cognitive change.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Individuals with high reserve, by definition, will not demonstrate disease-related clinical symptoms as early as individuals with low levels of reserve.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
plaindirect- Asserted: passes — The authors put it forward as true.
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In the paper
“Since people with greater reserve should be able to tolerate more AD pathology, the onset of clinical dementia should be delayed.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaindirectn = 593- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper may give no reason why it holds. It may state two separate claims as one.
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In the paper
“It is possible that individuals with more efficient or higher capacity networks could have more resilience in the face of age- or disease-related changes.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
hedgedconditional- Asserted: passes — The authors put it forward as true.
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The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Only controlled studies can truly establish that some set of interventions or experiences are beneficial.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plaindirect- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may be too vague to check against evidence. The paper may give no reason why it holds.
In the paper
“In schizophrenia, small effects of cognitive remediation were noted, particularly in stable patients and when combined with adjunctive rehabilitation52.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not matchedcites [52]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
- Not matched
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“While the original observations concern easily measurable variables like education or occupational attainment, more recent studies have delved more deeply into lifestyle factors, cognitively stimulating behaviors, personality factors and the like.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
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In the paper
“However, the exact”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These findings support the possibility that it may be possible to intervene even later in life in order to impart reserve, slow age-related cognitive decline, and prolonged healthy aging.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
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It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This is a hopeful idea, since it suggests that changes in lifestyle even later in life might impart reserve against age-related cognitive decline or dementia.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
hedgedconditional- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim.
In the paper
“Similarly, focused training has improved working memory capacity and shown transfer of training to nontrained working memory tasks51.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [51] Klingberg, 2010, Training and plasticity of working memory, Trends Cogn Sci source
plaindirect- Asserted: passes — The authors put it forward as true.
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It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Studies using these endpoints will be very expensive because they will require a large number of participants and will have to be conducted over several years.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plaindirect- Asserted: passes — The authors put it forward as true.
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- Load-bearing: fails — The paper’s conclusions may not depend on it.
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Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“While epidemiologic studies can only describe correlations and do not directly test causation, they are useful for deriving hypotheses and exploring ideas.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
plain- Asserted: passes — The authors put it forward as true.
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Probably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“By shifting emphasis from game to game, participants cannot fall into a fixed strategy. They must develop the ability to deal with the entire task as a whole – skills that might be termed attentional allocation or executive control.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plaindirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The authors state this as an assumption.
Disease pathology slowly develops over time independently of cognitive reserve, and pathology begins many years before the onset of clinically diagnosed Alzheimer's disease.
“The assumption is that disease pathology slowly develops over time independently of CR, and that the pathology begins many years before the onset of clinically diagnosed AD.”
The authors state this as an assumption.
There is a common point in all people where pathology is so severe that function cannot be maintained.
“However, we reasoned that there is common point in all people where the pathology is so severe that function cannot be maintained.”
The paper relies on this without support.
No study to date has shown change in slowed rate of cognitive decline in aging or reduced risk of developing Alzheimer's disease.
“No study to date has shown change in either of these endpoints.”
The paper relies on this without support.
The brain both passively and actively attempts to cope with brain changes or pathology.
“Since the brain both passively and actively attempts to cope with brain changes or pathology, it is important to understand the factors that contribute to this resilience.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Researchers have long reported that people with more years of formal education are at lower risk for Alzheimer's and other dementias than those with fewer years of formal education.80,[144][145][146][147][148][149]”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [146]
The cited source says what the claim attributes to it.
In the citing paper
“This concept was theoretically framed by Park and Bischof (2013) as “scaffolding,” similar to the closely related cognitive reserve theory proposed by Stern (2012).”
In the citing paper
“supporting the theory that a greater cognitive reserve could help protect against development of LOAD117.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [117]
In the citing paper
“The level of education, a surrogate marker of cognitive reserves (Stern, 2012), is an important determinant of the expression of VCI, such that for a given level of neuropathology higher education is associated with less cognitive deficits (Zieren et al., 2013).”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as Stern, 2012
In the citing paper
“These findings lead to the suggestion that higher social engagement and support experienced both before and during lockdown due to the COVID-19 pandemic might have had a protective/mitigating role by contributing to cognitive (51) and affective reserve (52).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [51]
In the citing paper
“Cognitive reserve theory suggests that individuals differ in their level of resilience against brain pathology and hence may exhibit differences in cognitive function despite equivalent levels of pathology (Stern, 2002(Stern, , 2012)).”
From Living alone and cognitive function in later life (2019) · cites this paper as Stern, 2012
In the citing paper
“The theory suggests that individuals differ in their degree of resilience against age-related brain pathology and hence may show differences in cognitive function in relation to an equivalent level of pathology [8, 9].”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
In the citing paper
“Cognitive reserve is a theoretical concept that may account for the role of social isolation and its association with cognitive outcomes in later life.”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
In the citing paper
“Such individuals are likely to receive less cognitive stimulation through social contact, resulting in lower cognitive reserve and hence poorer cognitive function [8, 9].”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
Citations
Cites
What is cognitive reserve? Theory and research application of the reserve concept
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Self-citationRunning increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
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Self-citationRunning enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Neural consequences of enviromental enrichment
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A Meta-Analysis of Cognitive Remediation for Schizophrenia: Methodology and Effect Sizes
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Training and plasticity of working memory
Klingberg, T. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.05.002 · Cited by 1,585
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Cited by
Sorted by citations
Items 801–900 of 3,537
Wang, S., Wang, W., Li, X., Liu, Y., Wei, J., Zheng, J., Wang, Y., Ye, B., Zhao, R., Huang, Y., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.977034 · Cited by 34
“The cognitive reserve hypothesis suggests that an engaged lifestyle may enable related neural networks to be more efficient or plastic, resulting in the postponement of dementia onset or less cognitive deterioration (Stern, 2012).”
BackgroundCognitive reserve and the severity of Alzheimer’s disease
Sobral, M., Pestana, M. H. D. A. P. E., & Paúl, C. (2015) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20150044 · Cited by 35
The impact of cognitive reserve on neurocognitive performance in Major Depressive Disorder
Venezia, R., Gorlyn, M., Burke, A. K., Oquendo, M. A., Mann, J. J., & Keilp, J. G. (2018) · Psychiatry Research · doi:10.1016/j.psychres.2018.09.031 · Cited by 36
Education modulates brain maintenance in presymptomatic frontotemporal dementia
Gazzina, S., Grassi, M., Premi, E., Cosseddu, M., Alberici, A., Archetti, S., Gasparotti, R., Van Swieten, J., Galimberti, D., Sanchez-Valle, R., et al. (2019) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2019-320439 · Cited by 33
Berezuk, C., Scott, S. C., Black, S. E., & Zakzanis, K. K. (2021) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2022.2047160 · Cited by 37
“(Stern, 2012) it follows that memory may be deteriorating faster in individuals with high reserve (i.”
BackgroundUnifying framework for cognitive training interventions in brain aging
Turnbull, A. G., Seitz, A. R., Tadin, D., & Lin, F. V. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101724 · Cited by 34
“Individuals with high cognitive reserve can demonstrate a quick improvement in task performance without neuro-plasticity effectively taking place (Stern, 2012).”
BackgroundAn 18‐month multimodal intervention trial for preventing dementia: J‐MINT PRIME Tamba
Oki, Y., Osaki, T., Kumagai, R., Murata, S., Encho, H., Ono, R., Yasuda, H., & Kowa, H. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14170 · Cited by 41
“…5 our study shows that these factors can be overcome by multifacto-rialinterventionsprobablyduetoincreasingcognitivereserve, 30 training, and aerobic exercise, 34,35 but also the Cognicise.”
2026 Alzheimer's disease facts and figures
(2026) · Alzheimer s & Dementia · doi:10.1002/alz.71345 · Cited by 69
McGuinness, B., Barrett, S., McIlvenna, J., Passmore, A. P., & Shorter, G. W. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.10.003 · Cited by 36
“The cognitive reserve hypothesis postulates that cognitive reserve in the form of higher IQ, education, or occupational attainment reduces the prevalence of cognitive decline [38].”
BackgroundVemuri, P., Fields, J. A., Peter, J., & Klöppel, S. (2016) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000346 · Cited by 36
“Cognitive intervention is suggested to increase an individual’s cognitive reserve [16] and, therefore, mechanistic interpretations associated with higher vs.”
BackgroundVeličkaitė, V., Ferreira, D., Cavallin, L., Lind, L., Ahlström, H. K., Kilander, L., Westman, E., & Larsson, E. (2017) · European Radiology · doi:10.1007/s00330-017-5103-6 · Cited by 38
“This has also been shown in other studies with normal populations [34].”
ResultSerra, L., Gelfo, F., Petrosini, L., Domenico, C. D., Bozzali, M., & Caltagirone, C. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180609 · Cited by 32
“Conversely, the cognitive reserve (CR) refers to the differences in cognitive processing, and it is related to the lifetime physical, intellectual, and social activities [4].”
InfluentialPeterson, R. L., Fain, M. J., Butler, E. A., Ehiri, J. E., & Carvajal, S. C. (2019) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2019.1598539 · Cited by 33
“The concept of cognitive reserve emerged to help explain why some individuals have fewer clinical symptoms of Alzheimer’s disease in the presence of neuropathology compared with others (Stern, 2012).”
BackgroundCognitive activity, cognitive function, and brain diffusion characteristics in old age
Arfanakis, K., Wilson, R. S., Barth, C. M., Capuano, A. W., Vasireddi, A. K., Zhang, S., Fleischman, D. A., & Bennett, D. A. (2015) · Brain Imaging and Behavior · doi:10.1007/s11682-015-9405-5 · Cited by 37
“This suggests that late life cognitive activity influences cognition through an association with cognitive or neural reserve (Hall et al. 2009; Stern 2012; Wilson et al. 2007).”
BackgroundCognitive reserve proxies, Alzheimer pathologies, and cognition
Ko, K., Yi, D., Byun, M. S., Lee, J. H., Jeon, S. Y., Kim, W. J., Byeon, G., Sung, K., Han, D., Lee, Y., et al. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.10.005 · Cited by 34
“…analyses were conducted for each of CU and cognitively impaired (CI: MCI plus AD dementia) group using the same models, considering that the effect of CR measured by proxy variable may differently observed by cognitive status ( Pettigrew and Soldan, 2019 ; Soldan et al., 2017 ; Stern, 2012 ).”
InfluentialSocial support is linked to mental health, quality of life, and motor function in multiple sclerosis
Kever, A., Buyukturkoglu, K., Riley, C., Jager, P. L. D., & Leavitt, V. M. (2021) · Journal of Neurology · doi:10.1007/s00415-020-10330-7 · Cited by 37
Promise of metformin for preventing age-related cognitive dysfunction
Shetty, A. K., Madhu, L. N., & Kodali, M. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.320971 · Cited by 34
“Multiple structural and functional changes underlie age-related cognitive function, including reductions in white matter, altered structure and function of neurons without significant neurodegeneration, synapse loss, and dysfunctional neural networks (Stern, 2012; Harada et al., 2013).”
Effect of Cognitive Reserve on the Association of Vascular Brain Injury With Cognition
Durrani, R., Friedrich, M. G., Schulze, K. M., Awadalla, P., Balasubramanian, K., Black, S. E., Broët, P., Busseuil, D., Desai, D., Dummer, T., et al. (2021) · Neurology · doi:10.1212/wnl.0000000000012765 · Cited by 35
Concussion and long‐term cognitive function among rugby players—The BRAIN Study
Gallo, V., McElvenny, D. M., Seghezzo, G., Kemp, S. P. T., Williamson, E., Lu, K., Mian, S., James, L., Hobbs, C., Davoren, D., et al. (2021) · Alzheimer s & Dementia · doi:10.1002/alz.12455 · Cited by 31
“55) 30 (28, 30) 68 (49,79) 9 (6, 11) 51 (45, 55)”
InfluentialLifelong bilingualism and mechanisms of neuroprotection in Alzheimer dementia
Sala, A., Malpetti, M., Farsad, M., Lubian, F., Magnani, G., Polara, G. F., Epiney, J., Abutalebi, J., Assal, F., Garibotto, V., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25605 · Cited by 36
“Many studies, for examples, reported more severe hypometabolism in AD in subject with higher education, who are able to compensate longer for brain neurodegeneration compared to subjects with lower education (Garibotto et al., 2008; Stern, 2012).”
BackgroundWare, C., Dautricourt, S., Gonneaud, J., & Chételat, G. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.706672 · Cited by 53
“These interventions aim to boost or maintain cognitive and brain reserve (Stern, 2012).”
BackgroundEvaluation of Compensation Strategies for Gait Impairment in Patients With Parkinson Disease
Tosserams, A., Keijsers, N., Kapelle, W., Kessels, R. P. C., Weerdesteyn, V., Bloem, B. R., & Nonnekes, J. H. (2022) · Neurology · doi:10.1212/wnl.0000000000201159 · Cited by 38
Hogervorst, E., Temple, S., & O’Donnell, E. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_408 · Cited by 35
Bermejo‐Pareja, F., & del Ser, T. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13020536 · Cited by 39
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“There are useful papers for further discussion of cognitive reserve as some property such as higher education or occupational attainment that decreases the likelihood of development of dementia or AD (Stern, 2012; Pettigrew and Soldan, 2019).”
BackgroundWaser, M., Benke, T., Dal‐Bianco, P., Garn, H., Mosbacher, J. A., Ransmayr, G. N., Schmidt, R., Seiler, S., Sørensen, H. B. D., & Jennum, P. (2018) · Brain and Behavior · doi:10.1002/brb3.1197 · Cited by 34
“AD invariably affects episodic memory and other complex cognitive processes, but the perceived onset and early course of the symptoms are highly subjective and depend on the individual cognitive reserve (Stern, 2012).”
BackgroundBrain biomarkers and cognition across adulthood
Tsapanou, A., Habeck, C. G., Gazes, Y., Razlighi, Q. R., Sakhardande, J., Stern, Y., & Salthouse, T. A. (2019) · Human Brain Mapping · doi:10.1002/hbm.24634 · Cited by 30
“The CR study was designed to elucidate the neural underpinnings of CR and the concept of brain reserve (Stern, 2012).”
MethodSelf-citationBessi, V., Mazzeo, S., Bagnoli, S., Padiglioni, S., Carraro, M., Piaceri, I., Bracco, L., Sorbi, S., & Nacmias, B. (2019) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-019-01069-y · Cited by 34
Reserve in Alzheimer's disease: update on the concept, functional mechanisms and sex differences.
Ewers, M. (2019) · Current Opinion in Psychiatry · doi:10.1097/yco.0000000000000574 · Cited by 29
Lin, C., Huang, C., Fan, Y., Liu, H., Chen, Y.-L., Aizenstein, H. J., Lee, T. M.-C., & Lee, S. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00249 · Cited by 32
“Indicated by education, occupational attainment, or leisure activities, CR could reduce or delay the occurrence of dementia (15).”
BackgroundYasuno, F., Minami, H., Hattori, H., & Initiative, A. D. N. (2020) · Psychogeriatrics · doi:10.1111/psyg.12552 · Cited by 32
“6 12-14 Recently, the availability of radiotracers that bind to tau (e.g. 18 F-fl ortaucipir (AV-1451) 15 ) has allowed in vivo imaging of tau pathology.”
Pregnancy as a model for aging
Giller, A., Andrawus, M., Gutman, D., & Atzmon, G. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101093 · Cited by 33
Graham, E. K., James, B. D., Jackson, K., Willroth, E. C., Luo, J., Beam, C. R., Pedersen, N. L., Reynolds, C. A., Katz, M. J., Lipton, R. B., et al. (2021) · Journal of Research in Personality · doi:10.1016/j.jrp.2021.104100 · Cited by 34
Therapeutic Potential of Human Stem Cell Implantation in Alzheimer’s Disease
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“Another prominent protein in the pathogenesis of AD is tau [38], which is a microtubule-associated protein that aids in the assembly and stabilization of microtubules.”
BackgroundAschenbrenner, A. J., Hassenstab, J. J., Morris, J. C., Cruchaga, C., & Jackson, J. J. (2023) · Neuropsychology · doi:10.1037/neu0000905 · Cited by 32
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“In contrast to the traditional view, cognitive performance in these elderly subjects was substantially better than expected, indicating ‘‘some people to be more resilient to brain changes than others’’ [4], p.”
BackgroundResultSerum Testosterone and Cognitive Function in Ageing Male: Updating the Evidence
Giagulli, V. A., Guastamacchia, E., Licchelli, B., & Triggiani, V. (2016) · Recent Patents on Endocrine Metabolic & Immune Drug Discovery · doi:10.2174/1872214810999160603213743 · Cited by 32
Three midlife strategies to prevent cognitive impairment due to Alzheimer's disease
Henderson, V. W. (2014) · Climacteric · doi:10.3109/13697137.2014.929650 · Cited by 32
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Mild cognitive impairment in Parkinson’s disease: a distinct clinical entity?
Wen, M., Chan, L. L., Tan, L. C. S., & Tan, E. K. (2017) · Translational Neurodegeneration · doi:10.1186/s40035-017-0094-4 · Cited by 33
“The combination of these factors has been termed cognitive reserve [66].”
BackgroundKo, K., Byun, M. S., Yi, D., Lee, J. H., Kim, C. H., & Lee, D. Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00070 · Cited by 31
“CR refers to functional rather than structural or quantitative aspects of the brain, and may explain why some people are more resilient to cognitive decline than others who present with the same level of pathology (Stern, 2012).”
BackgroundPsychological resilience is linked to motor strength and gait endurance in early multiple sclerosis
Klineova, S., Brandstadter, R., Fabian, M. T., Sand, I. K., Krieger, S. C., Leavitt, V. M., Lewis, C., Riley, C., LUBLIN, F. D., Miller, A., et al. (2019) · Multiple Sclerosis Journal · doi:10.1177/1352458519852725 · Cited by 31
“car); (5) CANTAB Paired Associate Learning (PAL; Cambridge Cognition, Cambridge, UK) required subjects to recall the locations where visual stimuli were presented; (6) Brief Visuospatial Memory Test, Revised (BVMT-R) and (7) Selective Reminding Test (SRT) are the nonverbal (geometric shapes and locations) and verbal (…”
MethodDementia prevention and reserve against neurodegenerative disease
Perneczky, R. (2019) · Phlebolymphology · doi:10.31887/dcns.2019.21.1/rperneczky2 · Cited by 40
Centenarians as Models of Resistance and Resilience to Alzheimer’s Disease and Related Dementias
Andersen, S. L. (2020) · Advances in Geriatric Medicine and Research · doi:10.20900/agmr20200018 · Cited by 35
“Mechanisms underlying resilience to AD among long-lived individuals may include factors that confer brain reserve and/or cognitive reserve [58].”
BackgroundGan, S., Yu, Y., Wu, J., Tang, X., Zheng, Y., Wang, M., & Zhu, S. (2020) · BMC Anesthesiology · doi:10.1186/s12871-020-01096-6 · Cited by 32
Kim, B. R., Kwon, H., Chun, M. Y., Park, K. D., Lim, S. M., Jeong, J. H., & Kim, G. H. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.549983 · Cited by 35
Clinical relevance of brain atrophy subtypes categorization in memory clinics
Planche, V., Bouteloup, V., Mangin, J., Dubois, B., Delrieu, J., Pasquier, F., Blanc, F., Paquet, C., Hanon, O., Gabelle, A., et al. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12231 · Cited by 32
Role of plant-based diet in late-life cognitive decline: results from the Salus in Apulia Study
Zupo, R., Griseta, C., Battista, P., Donghia, R., Guerra, V., Castellana, F., Lampignano, L., Bortone, I., Lozupone, M., Giannelli, G., et al. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2020.1853416 · Cited by 31
Finlay, J., Yu, W., Clarke, P. J., Li, M., Judd, S. E., & Esposito, M. H. (2021) · Wellbeing Space and Society · doi:10.1016/j.wss.2021.100040 · Cited by 33
Chen, Y., Crimmins, E. M., Ferido, P., & Zissimopoulos, J. (2022) · The Lancet Regional Health - Americas · doi:10.1016/j.lana.2021.100179 · Cited by 33
Tian, G., Shuai, J., Li, R., Zhou, T., Shi, Y., Cheng, G., & Yan, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.966647 · Cited by 32
“Some studies had explored possible biological mechanisms for the association of cognitively stimulating activities with cognitive function (Stern, 2012).”
BackgroundHuang, Y., Zhu, X., Liu, X., & Li, J. (2022) · Aging & Mental Health · doi:10.1080/13607863.2022.2116396 · Cited by 32
Nicolini, P., Lucchi, T. A., Abbate, C., Inglese, S., Tomasini, E., Mari, D., Rossi, P. D., & Vicenzi, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.886023 · Cited by 31
“, closer to the threshold beyond which reserve is depleted and compensation is no longer possible (Sperling et al., 2010; Stern, 2012).”
BackgroundResultInfluentialNon-affective psychotic disorders and risk of dementia: a systematic review and meta-analysis
Miniawi, S. E., Orgeta, V., & Stafford, J. (2022) · Psychological Medicine · doi:10.1017/s0033291722002781 · Cited by 32
“Lower educational attainment and impairments in cognitive functioning which are important markers of psychotic disorders could also lead to increased risk by limiting individuals’ cognitive reserve, thereby increasing vulnerability to exhibiting dementia symptoms (Stern, 2012).”
Effects of exergames on mood and cognition in healthy older adults: A randomized pilot study
Moret, B., Nucci, M., & Campana, G. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1018601 · Cited by 31
“Moreover, the cognitive-motor intervention might support the growth of cognitive reserve, the ability to make flexible and efficient use of cognitive networks when performing tasks (Stern, 2002), by increasing the efficiency of the cognitive networks underlying executive control (Stern, 2012).”
BackgroundIndividual reserve in aging and neurological disease
Holtzer, R., Choi, J., Motl, R. W., Foley, F. W., Picone, M. A., Lipton, M. L., İzzetoğlu, M., Hernandez, M. E., & Wagshul, M. E. (2023) · Journal of Neurology · doi:10.1007/s00415-023-11656-8 · Cited by 31
“The literature devoted to this hypothetical construct is extensive [12, 13] and recent meta-analytic studies demonstrate robust protective CR effects against cognitive decline in older adults [14] and persons with multiple sclerosis (MS) [15].”
Misiura, M. B., Butts, B., Hammerschlag, B. L., Munkombwe, C., Bird, A., Fyffe, M., Hemphill, A., Dotson, V. M., & Wharton, W. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01408-x · Cited by 35
“Greater education levels can preserve cognitive function by compensating for memory deficits by relying on skills from other cognitive domains, otherwise known as cognitive reserve [71].”
BackgroundWard, D. D., Summers, M. J., Saunders, N. L., & Vickers, J. C. (2014) · International Psychogeriatrics · doi:10.1017/s1041610214002075 · Cited by 30
“However, participation in leisure activities in adult life is susceptible to change over time, and CR-based interventions that determine the effect of modulation in cognitive activities are eagerly awaited (Stern, 2012).”
BackgroundDelphin‐Combe, F., Bathsavanis, A., Rouch, I., Liles, T., Vannier-Nitenberg, C., Fantino, B., Dauphinot, V., & Krolak‐Salmon, P. (2016) · European Journal of Neurology · doi:10.1111/ene.13004 · Cited by 31
“On the other hand, according to the theory of cognitive reserve [23], this anxiety could also have a negative influence on cognitive reserve and thus may expose patients to a greater risk of cognitive impairment.”
BackgroundIhle, A., Oris, M., Fagot, D., Chicherio, C., van der Linden, B. W. A., Sauter, J., & Kliegel, M. (2017) · Applied Neuropsychology Adult · doi:10.1080/23279095.2017.1306525 · Cited by 31
“Notably, empirical evidence showed that longer education in early life and cognitively demanding occupation in midlife are related to better cognitive functioning such as verbal ability and processing speed in old age (Adam, Bonsang, Grotz, & Perelman, 2013; Gatz et al., 2001; Hertzog, Kramer, Wilson, & Lindenberger,…”
BackgroundIhle, A., Gouveia, É. R., de Gouveia, B. R. F. O., Freitas, D. L., Jurema, J., Tinôco, M. A., & Kliegel, M. (2017) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000477846 · Cited by 31
Potts, C., Richardson, J., Bond, R., Price, R. K., Mulvenna, M. D., Zvolský, P., Harvey, M., Hughes, C., & Duffy, F. (2021) · European Journal of Ageing · doi:10.1007/s10433-021-00652-4 · Cited by 31
“Studies have linked this to better cognitive performance in people with dementia (Stern 2012), but also in other neurological diseases including Parkinson’s (Hindle et al.”
BackgroundLiu, Y., Liu, Z., Liang, R., & Luo, Y. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-02946-3 · Cited by 31
“Second, higher SES individuals, particularly those who are well educated, have a greater capacity for cognitive reserve than people with lower SES [17, 49].”
BackgroundResultRisk factors and predictive markers of post-stroke cognitive decline–A mini review
Guo, X., Phan, C., Batarseh, S., Wei, M., & Dye, J. A. (2024) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2024.1359792 · Cited by 35
“The theory of Cognitive Reserve (CR) describes individual differences, such as enriched environments and life experiences, in susceptibility to both age-related brain changes and pathologic changes (Stern, 2012).”
BackgroundPérez, R. F., Tezanos, P., Peñarroya, A., González-Ramón, A., Urdinguio, R. G., Gancedo-Verdejo, J., Tejedor, J. R., Santamarina‐Ojeda, P., Alba‐Linares, J. J., Sainz‐Ledo, L., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49608-z · Cited by 34
Song, Y., Yuan, Q., Liu, H., Gu, K., & Liu, Y. (2024) · Journal of Affective Disorders · doi:10.1016/j.jad.2024.09.059 · Cited by 31
Riley, D., Robbins, C. A., Cantu, R. C., & Stern, R. A. (2015) · Brain Injury · doi:10.3109/02699052.2014.965215 · Cited by 32
Pathogenesis and Treatment of Vascular Cognitive Impairment
Jellinger, K. A. (2014) · Neurodegenerative Disease Management · doi:10.2217/nmt.14.37 · Cited by 30
Ihle, A., Oris, M., Fagot, D., & Kliegel, M. (2016) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2016.1197184 · Cited by 30
“…to better cognitive functioning in old age (e.g., Adam, Bonsang, Grotz, & Perelman, 2013; Kröger et al., 2008; Schooler, Mulatu, & Oates, 1999; Stern, 2012; see Hertzog, Kramer, Wilson, & Lindenberger, 2008, for a review on enrichment effects in adulthood; see Opdebeeck, Martyr, & Clare,…”
BackgroundInfluentialKurth, F., Cherbuin, N., & Eileen Luders, A. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00860 · Cited by 33
“Similarly, factors such as educational attainment have been proposed to stimulate neuroplasticity and neurotrophic mechanisms, thereby enhancing brain and cognitive reserves, which may ultimately manifest as more age-resilient brains (Stern, 2012).”
BackgroundMalek‐Ahmadi, M. H., Lu, S., Chan, Y., Perez, S. E., Chen, K., & Mufson, E. J. (2017) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000390 · Cited by 34
“Cognitive reserve (CR) refers to an individual’s ability to maintain cognitive function in the presence of damaging brain pathology [1].”
BackgroundDementia incidence — the times, they are a-changing
Skoog, I. G. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.55 · Cited by 30
Maiovis, P., Ioannidis, P., Gerasimou, G., Gotzamani-Psarrakou, A., & Karacostas, D. (2018) · Neurodegenerative Diseases · doi:10.1159/000486621 · Cited by 30
Berginström, N., Nordström, P., Nyberg, L. H., & Nordström, A. (2020) · Brain Injury · doi:10.1080/02699052.2020.1725124 · Cited by 30
Oremus, M., Tyas, S. L., Maxwell, C. J., Konnert, C. A., O’Connell, M. E., & Law, J. (2019) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2019.103962 · Cited by 31
Shall We Dance? Dancing Modulates Executive Functions and Spatial Memory
Noguera, C., Carmona, D., Rueda, A., García, R. F., & Cimadevilla, J. M. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17061960 · Cited by 33
“It is hypothesized that aerobic sports ultimately contribute to increase the cognitive reserve which is considered a neuroprotective factor from cognitive decline [37].”
BackgroundEffects of bilingualism on age at onset in two clinical Alzheimer's disease variants
de Leon, J., Grasso, S. M., Welch, A. E., Miller, Z., Shwe, W., Rabinovici, G. D., Miller, B. L., Henry, M. L., & Gorno‐Tempini, M. L. (2020) · Alzheimer s & Dementia · doi:10.1002/alz.12170 · Cited by 34
Kępińska, A. P., MacCabe, J. H., Cadar, D., Steptoe, A., Murray, R. M., & Ajnakina, O. (2020) · Translational Psychiatry · doi:10.1038/s41398-020-01114-8 · Cited by 30
Age-Related Hearing Loss, Neuropsychological Performance, and Incident Dementia in Older Adults
Brewster, K., Hu, M., Wall, M. M., Brown, P. J., Zilcha‐Mano, S., Roose, S. P., Stein, A., Golub, J. S., & Rutherford, B. R. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-200908 · Cited by 37
“Our results may provide insights into the pathophysiologic mechanisms linking ARHL to dementia, as it has been proposed that HL may has-ten cognitive decline by depleting cognitive reserve [13], which has been associated with impairment in working memory [14] and increased risk for dementia [31].”
Alzheimer’s disease: a tale of two diseases?
Nardini, E., Hogan, R., Flamier, A., & Bernier, G. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.308070 · Cited by 33
“Similarly, lifestyle habits such as lack of sleep, high blood pressure and sedentary behavior affect AD risk (Reitz and Mayeux, 2014), while education and intellectual engagement in old age are protective factors (Sando et al., 2008; Stern, 2012).”
BackgroundSimultaneous modeling of Alzheimer's disease progression via multiple cognitive scales
Kühnel, L., Berger, A., Markussen, B., & Rakêt, L. L. (2021) · Statistics in Medicine · doi:10.1002/sim.8932 · Cited by 29
“14 Consequently, the patients that are later in disease (with an associated faster rate of decline) but better able to compensate on cognitive tests will look like the fastest progressors.”
Effects of Cognitive Reserve in Alzheimer’s Disease and Cognitively Unimpaired Individuals
Lee, D. H., Seo, S. W., Roh, J. H., Oh, M., Oh, J. S., Oh, S. J., Kim, J. S., & Jeong, Y. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.784054 · Cited by 35
“The reserve concept accounts for individual susceptibility to age-related brain changes or AD-related brain neuropathology (Stern, 2012).”
The Role of Incarceration as a Risk Factor for Cognitive Impairment
Cox, R. J. A., & Wallace, R. B. (2022) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbac138 · Cited by 28
“The findings also align with research investigating the cognitive reserve hypothesis (Greenfield et al., 2020; Meng & D’Arcy, 2012; Schmand et al., 1997; Stern, 2012).”
Social cognition is not associated with cognitive reserve in older adults
Lavrencic, L. M., Kurylowicz, L., Valenzuela, M., Churches, O. F., & Keage, H. A. D. (2015) · Aging Neuropsychology and Cognition · doi:10.1080/13825585.2015.1048773 · Cited by 32
“…engagement (Marioni, Van Den Hout, Valenzuela, Brayne, & Matthews, 2012) or education, occupation, and premorbid IQ (Roldán-Tapia, García, Cánovas, & León, 2012), display better general cognitive performance and have lower risk for dementia (for a general discussion see Stern, 2002, 2009, 2012).”
BackgroundInfluentialBeyond cognitive reserve: Behavioural reserve hypothesis in Frontotemporal Dementia
Premi, E., Garibotto, V., Gazzina, S., Grassi, M., Cosseddu, M., Paghera, B., Turla, M., Padovani, A., & Borroni, B. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.01.030 · Cited by 30
Sumowski, J. F., Rocca, M. A., Leavitt, V. M., et al. (2016) · Multiple Sclerosis Journal · doi:10.1177/1352458516630822 · Cited by 30
“Note that patients endorsed the frequency with which each activity was performed during their early 20s as daily (5), several times per week (4), several times per month (3), several times per year (2), or once per year or less (1).”
BackgroundVaqué‐Alcázar, L., Sala‐Llonch, R., Valls‐Pedret, C., Dídac Vidal-piñeiro, A., Fernández‐Cabello, S., Bargalló, N., Ros, E., & Bartrés‐Faz, D. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9584-8 · Cited by 30
Tang, X., Varma, V. R., Miller, M. I., & Carlson, M. C. (2016) · Brain Structure and Function · doi:10.1007/s00429-016-1287-9 · Cited by 33
“This approach is consistent with that used by Stern and colleagues in prior work on CR (Stern et al. 1992, 1994; Stern 2009, 2012).”
MethodDimitriadis, S. I., Tarnanas, I., Wiederhold, M. D., Wiederhold, B. K., Tsolaki, M., & Fleisch, E. (2016) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2016.08.004 · Cited by 31
“Both the cognitive and the neural reserve seem to make independent and synergistic contributions to an individual’s clinical resilience, and the mechanisms that underlie both reserves are currently under investigation [4].”
BackgroundPark, S., Ryu, S., Yoo, Y., Yang, J.-J., Kwon, H., Youn, J. H., Lee, J., Cho, S.-J., & Lee, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-19390-2 · Cited by 30
Yano, Y., Griswold, M., Wang, W., Greenland, P., Lloyd-Jones, D., Heiss, G., Gottesman, R., & Mosley, T. (2018) · Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease · doi:10.1161/jaha.118.009578 · Cited by 25
Genetic meta-analysis identifies 9 novel loci and functional pathways for Alzheimer’s disease riskPreprint
Jansen, I. E., Savage, J. E., Watanabe, K., Bryois, J., Williams, D. M., Steinberg, S., Sealock, J., Karlsson, I., Hägg, S., Athanasiu, L., et al. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/258533 · Cited by 33
“proposed as a protective mechanism in which the brain aims to control brain damage with prior 395 existing cognitive processing strategies.(34) Our findings imply that some component of the 396 genetic factors for AD might affect cognitive reserve, rather than being involved in AD397 pathology-related damaging process…”
LaPlume, A. A., McKetton, L., Levine, B., Troyer, A. K., & Anderson, N. D. (2022) · Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring · doi:10.1002/dad2.12337 · Cited by 29
Brunelle-Hamann, L., Thivierge, S., & Simard, M. (2015) · Neuropsychological Rehabilitation · doi:10.1080/09602011.2014.964731 · Cited by 29
“…apathy, facilitate social interactions in homes for the elderly, and offer an opportunity of physical activity, with potential benefits on health (Potter, Ellard, Rees, & Thorogood, 2011; Venturelli, Scarsini, & Schena, 2011) and cognition (Littbrand, Stenval, & Rosendahl, 2011; Stern, 2012).”
BackgroundWhen I'm 64: A review of instrumental music-making and brain health in later life
Jordan, C. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.05.006 · Cited by 32
Phonological and Semantic Fluency in Alzheimer’s Disease: A Systematic Review and Meta-Analysis
Olmos-Villaseñor, R., Sepulveda-Silva, C., Julio–Ramos, T., Fuentes–López, E., Toloza–Ramirez, D., Santibañez, R. A., Copland, D. A., & Méndez‐Orellana, C. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221272 · Cited by 36
Li, Y., Liu, C., Sun, J., Zhang, J., Li, X., & Zhang, Z. (2024) · Journal of Medical Internet Research · doi:10.2196/59684 · Cited by 32
“…to the adoption of a less engaging lifestyle throughout older adults’ lifespans, which may diminish their “cognitive reserve” (the resource of the brain can get to tolerate the age-related changes or pathology related to dementia) and ultimately hasten the deterioration of cognitive function [6].”
Akter, S., Liu, Z., Simões, E. J., & Rao, P. R. (2025) · The Journal of Prevention of Alzheimer s Disease · doi:10.1016/j.tjpad.2025.100169 · Cited by 37
“The 80–90 yrs age group had the strongest positive influence, followed by 70–80 yrs age group, aligning with research showing ADRD risk accelerates beyond age 80 due to neurodegeneration, amyloid accumulation, and vascular dysfunction [ 54 ].”
Santangelo, R., Coppi, E., Ferrari, L. D., Bernasconi, M. P., Pinto, P., Passerini, G., Comı, G., & Magnani, G. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-141122 · Cited by 29
“Considering the groups altogether, there was a negative correlation between CSF tau and MMSE, as already observed in previous studies [33, 35].”
Age and Vascular Burden Determinants of Cortical Hemodynamics Underlying Verbal Fluency
Heinzel, S., Metzger, F. G., Ehlis, A., Korell, R., Alboji, A., Haeussinger, F. B., Wurster, I., Brockmann, K., Suenkel, U., Eschweiler, G. W., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138863 · Cited by 31
“This may indicate aspects of a neural basis of cognitive reserve [9], however whether compensatory reorganization might delay cognitive decline due to age/neurodegenerative processes or increase resilience of some individuals needs is still unclear.”
Background
Metadata
- Authors
- Stern, Y.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Stern, Yaakov
- ORCID
- Stern, Yaakov
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 11
- Issue
- 11
- Pages
- 1006-1012
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC3507991
- OpenAlex
- W2144907160
- Cited by
- 3,557
- References
- 59
- Citations by year
- 2026: 412 · 2025: 352 · 2024: 311 · 2023: 343 · 2022: 281 · 2021: 303 · 2020: 350 · 2019: 292 · 2018: 244 · 2017: 213 · 2016: 176 · 2015: 125 · 2014: 93 · 2013: 58 · 2012: 1
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institute on Aging (R01AG026158, R01AG014671)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- cognitive reserve, brain reserve, Alzheimer's disease, cognitive aging, dementia risk, educational attainment, occupational attainment, leisure
- MeSH terms
- Aging, Alzheimer Disease, Animals, Humans, Cognitive Reserve
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