The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index; 29 of the 54 sources its claims cite were checked for support.
Cognitive reserve in ageing and Alzheimer's disease
Open accessAbstract
The concept of cognitive reserve provides an explanation for differences between individuals in susceptibility to age-related brain changes or pathology related to Alzheimer's disease, whereby some people can tolerate more of these changes than others and maintain function. Epidemiological studies suggest that lifelong experiences, including educational and occupational attainment, and leisure activities in later life, can increase this reserve. For example, the risk of developing Alzheimer's disease is reduced in individuals with higher educational or occupational attainment. Reserve can conveniently be divided into two types: brain reserve, which refers to differences in the brain structure that may increase tolerance to pathology, and cognitive reserve, which refers to differences between individuals in how tasks are performed that might enable some people to be more resilient to brain changes than others. Greater understanding of the concept of cognitive reserve could lead to interventions to slow cognitive ageing or reduce the risk of dementia.
Overview
AI snapshot
Written from the paper’s full text.
TL;DR
This review argues that cognitive reserve explains why people differ in how much Alzheimer’s disease pathology or age-related brain change they can tolerate while still functioning. It synthesizes epidemiologic, neuroimaging, postmortem, and intervention evidence, and concludes that reserve is modifiable but that causal interventions remain unproven.
Key findings
- Reserve is split into brain reserve, a more passive quantitative tolerance tied to brain size or neurons/synapses, and cognitive reserve, an active functional process in which pre-existing or compensatory networks help cope with damage.
- Epidemiologic studies cited found that fewer than 8 years of education carried 2.2 times higher dementia risk, low occupational attainment carried 2.25 times higher risk, and greater leisure activity was linked to 38% lower risk; a review of 22 cohort studies estimated higher reserve reduced dementia risk by 46%.
- After Alzheimer’s disease becomes clinically apparent, higher reserve is associated with faster decline: memory scores fell about one point yearly on average, with an additional point yearly in those with higher education or occupation.
- Imaging and autopsy evidence indicated that at matched clinical severity, higher education was linked to greater parietotemporal blood-flow deficit and, in 130 elders, each additional year of education reduced the pathology–cognition association by 0.088 standard units; fMRI work distinguished neural reserve from neural compensation.
Methods
- Narrative review by the author, integrating his group’s and others’ epidemiologic cohort studies, functional and resting neuroimaging studies, postmortem analyses, and cognitive or exercise intervention trials.
- Cited samples include 593 non-demented adults aged 60 or older followed for 4 years, 130 elders who had cognitive evaluation before autopsy, and a preliminary 90-person older-adult Space Fortress training study.
- Main analysis is conceptual synthesis rather than a new primary study or formal meta-analysis; it draws on a cited systematic review of 22 cohort studies for one pooled estimate.
Limitations
- Stated: epidemiologic evidence is correlational and cannot establish causation; controlled intervention studies are needed, and no study to date has shown changes in the key endpoints of slowed cognitive decline or reduced Alzheimer’s disease risk.
- Stated: clinical use of biomarkers and imaging for reserve is premature because prognostic implications are not fully established, and cognitive training evidence is mixed.
- Evident from the text: this is a narrative review without formal risk-of-bias assessment, many findings come from the author’s own research program, and the interaction between brain reserve and cognitive reserve remains unresolved.
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Claims the paper makes
39 Own interpretation · 14 No full text of the sources · 12 No basis given · 10 Supported · 10 Own result · 8 Partly supported · 5 Supported so far · 3 Not checked yet · 2 Couldn’t confirm · 1 Sources not found · accuracy not yet measured
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“This idea is supported by a set of studies that suggest that prevalence or incidence of dementia is lower in individuals with larger brains13, 14.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
What the sources say
- Not checked — no full text of the sourcecites [13] Katzman, 1988, Clinical, pathological, and neurochemical changes in dementia: a subgroup with preserved mental status and numerous neocortical plaques, Ann Neurol source
- Supportedcites [14] Schofield, 1997, An association between head circumference and Alzheimer's disease in a population-based study of aging, Neurology source
The Discussion (p. 5) reports that smaller head circumference was associated with higher prevalence of Alzheimer’s disease. The paper uses head circumference as an index of premorbid brain size (p. 1), so its finding supports the citing sentence’s hedged association. This study measured prevalence of Alzheimer’s disease, not incidence of dementia generally. (LLM, conf=0.88)
hedgedstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“Second, compared to individuals with lower CR, those with higher CR performed better even when they use the second network.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [42] Steffener, 2011, Supporting performance in the face of age-related neural changes: testing mechanistic roles of cognitive reserve, Brain Imaging Behav source
The Results (Model C) report that, in older adults, higher cognitive reserve reduced the negative effect of network 2 expression on task performance. The Discussion likewise says older adults with greater reserve maintained performance better as network 2 expression increased. (LLM, conf=0.88)
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Those who engaged in more leisure activities had 38% less risk of developing dementia.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
What the sources say
- Supportedcites [24] Scarmeas, 2001, Influence of leisure activity on the incidence of Alzheimer's disease, Neurology source
The Discussion explicitly states that subjects with high leisure activity had 38% less risk of developing dementia. The Results report a relative risk of 0.62 (95% CI 0.46–0.83), consistent with that figure. (LLM, conf=0.95)
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The rate of decline is more rapid in individuals with high reserve than those with low reserve, even when accounting for a multitude of other factors that may contribute to disease course27, 28, 46.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
What the sources say
- Supportedcites [27] Stern, 1999, Rate of memory decline in AD is related to education and occupation: cognitive reserve?, Neurology sourceExperimental — accuracy not yet measured
The DOI was not indexed for paper-scoped Semantic Scholar search, so the cited paper’s full text could not be checked directly. A systematic review, “Education and Dementia in the Context of the Cognitive Reserve Hypothesis” (search score 0.789), explicitly attributes more rapid memory decline in Alzheimer’s patients with higher education and occupational attainment to Stern et al. (1999). This supports the central claim, though the retrieved passage does not verify which other factors the original analysis accounted for. (LLM, conf=0.81)
- Supportedcites [28] Scarmeas, 2006, Education and rates of cognitive decline in incident Alzheimer's disease, J Neurol Neurosurg Psychiatry sourceExperimental — accuracy not yet measured
No paper-scoped Semantic Scholar snippets were available for Scarmeas et al. (2006). However, “Higher education affects accelerated cortical thinning in Alzheimer's disease” explicitly cites Scarmeas et al. (2006) among studies finding more rapid cognitive decline after Alzheimer’s onset in patients with higher education (snippet score 0.534). This supports the claim through a secondary citation, although the available evidence does not independently verify which other factors Scarmeas et al. adjusted for. (LLM, conf=0.76)
- Supportedcites [46] Hall, 2007, Education delays accelerated decline on a memory test in persons who develop dementia, Neurology sourceExperimental — accuracy not yet measured
Hall’s (2007) title establishes the finding of delayed accelerated memory decline in people who develop dementia. A Semantic Scholar snippet from “Episodic memory performance in a multi-ethnic longitudinal study of 13,037 elderly” describes the same pattern: education is associated with a delayed change point followed by faster decline (score 0.52). Hall’s full text was unavailable in the paper-scoped search, so the specific assertion about accounting for other factors could not be checked directly; the available evidence supports the core paraphrase, not every qualification. (LLM, conf=0.72)
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“In a young group of subjects we identified an activation network that was expressed during the stimulus presentation phase of both tasks and whose increase in expression with increasing load correlated with CR.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [43] Stern, 2008, A common neural network for cognitive reserve in verbal and object working memory in young but not old, Cereb Cortex source
The Discussion identifies a pattern in young subjects during stimulus presentation whose load-related activation had a similar relationship with cognitive reserve in both the letter and shape tasks. The Canonical Variates Analysis reports significant expression of that pattern in both tasks and relates its load-related expression to cognitive-reserve scores. (LLM, conf=0.91)
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Similar analysis demonstrated a comparable protective effect of occupational attainment33 and leisure activities34.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Not checked — no full text of the sourcecites [33] Stern, 1995, Relationship between lifetime occupation and parietal flow: implications for a reserve against Alzheimer's disease pathology, Neurology source
- Supportedcites [34] Scarmeas, 2003, Association of life activities with cerebral blood flow in Alzheimer disease: implications for the cognitive reserve hypothesis, Arch Neurol source
The cited paper’s Results report an inverse association between activity scores and cerebral blood flow after controlling for clinical severity, which the authors interpret as consistent with cognitive reserve. The Conclusions describe analogous findings for occupational attainment and note evidence linking leisure activities to reduced dementia risk. The citation supports the leisure-activities part of the sentence; occupational attainment has a separate citation. (LLM, conf=0.85)
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“For example, at a given level of clinical severity, AD patients with higher education have a more severe pattern of AD-related changes on PET scan than those with lower education44, 45.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
What the sources say
- Not checked — no full text of the sourcecites [44] Garibotto, 2008, Education and occupation as proxies for reserve in aMCI converters and AD: FDG-PET evidence, Neurology source
- Supportedcites [45] Kemppainen, 2008, Cognitive reserve hypothesis: Pittsburgh Compound B and fluorodeoxyglucose positron emission tomography in relation to education in mild Alzheimer's disease, Ann Neurol source
The Abstract reports that high- and low-educated patients with mild Alzheimer’s disease had the same degree of cognitive deterioration, while the high-educated group showed greater amyloid-tracer uptake and lower glucose metabolism on PET. The Discussion likewise describes more pronounced amyloid accumulation and neuronal dysfunction in the high-educated group. (LLM, conf=0.93)
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Every source the paper cites for this claim was checked and supports it.
In the paper
“In AD patients matched for clinical severity, we found an inverse relationship between resting rCBF and years of education32.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Supportedcites [32] Stern, 1992, Inverse relationship between education and parietotemporal perfusion deficit in Alzheimer's disease, Ann Neurol source
The Procedures (p. 2) state that rCBF was measured under resting conditions. The Results (pp. 2–3) report greater parietotemporal flow reductions with more education in AD groups that did not differ on clinical measures; the relationship at the P3 detector remained significant after controlling for dementia severity. (LLM, conf=0.92)
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“The neural implementation of CR might take two forms: neural reserve and neural compensation16, 38.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [16] Stern, 2009, Cognitive reserve, Neuropsychologia source
In “Neural Mechanisms Underlying CR,” Stern explicitly says that the neural implementation of cognitive reserve might take two forms: neural reserve and neural compensation. The “Brain Reserve and Cognitive Reserve” section also describes them as two proposed components. (LLM, conf=0.95)
- Supportedcites [38] Stern, 2005, Brain networks associated with cognitive reserve in healthy young and old adults, Cereb Cortex source
The Introduction (p. 1) explicitly proposes two complementary facets of the neural implementation of cognitive reserve: neural reserve and neural compensation. The paper then defines and contrasts them in the Introduction (pp. 1–2). (LLM, conf=0.95)
hedgedstates a possible cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Supported
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“These observations using cerebral blood flow have been replicated by other groups as well35, 36.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Scans Acquired at Rest
What the sources say
- Not checked — no full text of the sourcecites [35] Alexander, 1997, Association of premorbid intellectual function with cerebral metabolism in Alzheimer's disease: implications for the cognitive reserve hypothesis, Am J Psychiatry source
- Supportedcites [36] Perneczky, 2006, Schooling mediates brain reserve in Alzheimer's disease: findings of fluoro-deoxy-glucose-positron emission tomography, J Neurol Neurosurg Psychiatry source
The Results report an inverse association between schooling and glucose metabolism in patients with Alzheimer’s disease. The Discussion says these findings are supported by other groups’ cerebral-blood-flow studies, while noting that the results do not match exactly because of differences in samples and methods. This paper used FDG-PET rather than measuring cerebral blood flow itself. (LLM, conf=0.86)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Probably not a substantial claim. 15
- It may state two separate claims as one. 17
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“In contrast, the concept of CR suggests that the brain actively attempts to cope with brain damage by using pre-existing cognitive processing approaches or by enlisting compensatory approaches15, 16.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
What the sources say
- Not checked — no full text of the sourcecites [15] Stern, 2002, What is cognitive reserve? Theory and research application of the reserve concept, J Int Neuropsychol Soc source
- Supportedcites [16] Stern, 2009, Cognitive reserve, Neuropsychologia source
The “Brain Reserve and Cognitive Reserve” section states that active models such as CR propose that the brain copes with damage using pre-existing cognitive processes or enlisting compensatory processes. This directly supports the paraphrase; no page number is provided in our copy. (LLM, conf=0.95)
hedgedstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“We replicated this observation in patients with incident AD28 and also found more rapid decline in cognitive function in AD patients who engaged in more leisure activities prior to dementia onset29.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
What the sources say
- Partly supportedcites [28] Scarmeas, 2006, Education and rates of cognitive decline in incident Alzheimer's disease, J Neurol Neurosurg Psychiatry sourceExperimental — accuracy not yet measured
Split into 2 atoms — 1 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 1 unverifiable. Expand the claim to see per-atom verdicts.
- Supportedcites [29] Helzner, 2007, Leisure activity and cognitive decline in incident Alzheimer disease, Arch Neurol source
Split into 2 atoms — 2 confirmed, 0 partially supported, 0 disputed, 0 misattributed, 0 unverifiable. Expand the claim to see per-atom verdicts.
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
Every source the paper cites for this claim was checked and supports it.
In the paper
“Using a covariance method to analyze the imaging data, we identified a spatial pattern of fMRI activation that was expressed by both groups and whose expression increased as the task became more difficult.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Supportedcites [39] Stern, 2012, Task difficulty modulates young-old differences in network expression, Brain Res source
The Functional imaging section identifies a spatial pattern common to young and old participants. The Discussion states that its expression increased logarithmically with task difficulty. Page numbers are not provided in our copy. (LLM, conf=0.94)
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In a follow-up analysis41, we found that atrophy in a key area within the first network (i.e. the one that was used by both young and old) was associated with decreased efficiency in that network and increased utilization of the second network.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
What the sources say
- Partly supportedcites [41] Steffener, 2009, The impact of age-related changes on working memory functional activity, Brain Imaging Behav sourceExperimental — accuracy not yet measured
The Abstract and Conclusion report that lower grey-matter volume in a region of the primary network was associated with greater secondary-network recruitment. The Discussion interprets this as compensation for an affected primary network, but the Results report no significant association between regional grey-matter volume and primary-network expression; decreased efficiency of that network was not demonstrated. (LLM, conf=0.86)
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“For example, Basak et al.50 had elders play a complex role-playing game,”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Partly supportedcites [50] Basak, 2008, Can training in a real-time strategy video game attenuate cognitive decline in older adults?, Psychol Aging sourceExperimental — accuracy not yet measured
The Method > Participants section says older adults were assigned to play Rise of Nations, and the General Discussion reports transfer benefits after 23.5 hours of training. The paper identifies Rise of Nations as a complex real-time strategy game, not a role-playing game. Its Abstract reports improvement on a subset of cognitive tasks, rather than across the entire battery (page numbers unavailable in our copy). (LLM, conf=0.90)
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“In research with young adults, one particular training approach produced excellent improvement in gameplay, but, more importantly, also showed transfer of training to other tasks.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [55] Gopher, 1994, Transfer of skill from a computer game trainer to flight, Hum Factors source
- Not checked — no full text of the sourcecites [56] Gopher, 1989, Practice under changing priorities: an approach to the training of complex skills, Acta Psychol source
- Partly supportedcites [57] Blumen, 2010, Training cognitive control in older adults with the space fortress game: the role of training instructions and basic motor ability, Front Aging Neurosci sourceExperimental — accuracy not yet measured
The Introduction (‘The space fortress game and emphasis change instructions’; page unavailable) reports that emphasis-change instructions improved Space Fortress performance in younger adults compared with standard instructions. It says those instructions *may* be important for transfer, but does not report that this approach demonstrated transfer to other tasks. The General Discussion (page unavailable) says future studies will determine whether such transfer occurs. (LLM, conf=0.86)
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Those who rely more on this alternate network can still perform the task, but do so more poorly.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“On the average scores on a memory test decline by about one point yearly, but in those with higher educational or occupational attainment scores decline by an additional point each year.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“The first network was used by both young and old subjects, and consisted of areas often associated with working memory.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“In contrast, the second network was primarily characterized by activation in parahippocampal areas and was used consistently only by the older subjects.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“Interestingly, although the game itself was very challenging for the elders, there were few dropouts and performance improved over time.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [58] Orrell, 1995, Education and dementia, BMJ source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“Interestingly, although the game itself was very challenging for the elders, there were few dropouts and performance improved over time.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [58] Orrell, 1995, Education and dementia, BMJ source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Each of these networks is a group of brain areas that seem to work together as the task is harder.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
hedgedstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Given these assumptions, individuals with higher CR will begin their cognitive decline when pathology is more advanced and thus have less time until they reach the point where pathology overwhelms function.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- The authors state this as an assumption: There is a common point in all people where pathology is so severe that function cannot be maintained.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Still, while in some ways interdependent, brain reserve and CR make independent in addition to synergistic contributions to understanding individual differences in clinical resilience to brain pathology.”
§ Cognitive reserve in ageing and Alzheimer's disease > Cognitive and Brain Reserve
plainstates an association- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: unclear — It is unclear why the paper says it holds.
It may state two separate claims as one.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“However, the cognitive or neural mechanism that underlies this reserve is unknown.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, clinicians must be aware that in the presence of pathology there should still be a period of time during which even the most sensitive measures would fail to detect cognitive change.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Individuals with high reserve, by definition, will not demonstrate disease-related clinical symptoms as early as individuals with low levels of reserve.”
§ Cognitive reserve in ageing and Alzheimer's disease > Application Of Cognitive Reserve In Clinical Practice
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Since people with greater reserve should be able to tolerate more AD pathology, the onset of clinical dementia should be delayed.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plainstates a causen = 593- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“It is possible that individuals with more efficient or higher capacity networks could have more resilience in the face of age- or disease-related changes.”
§ Cognitive reserve in ageing and Alzheimer's disease > Neuroimaging Studies of Cognitive Reserve > Neural Mechanisms Underlying CR
hedgedstates a possible cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper may give no reason why it holds.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Only controlled studies can truly establish that some set of interventions or experiences are beneficial.”
§ Cognitive reserve in ageing and Alzheimer's disease > Epidemiologic evidence for reserve
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence. The paper may give no reason why it holds.
In the paper
“In schizophrenia, small effects of cognitive remediation were noted, particularly in stable patients and when combined with adjunctive rehabilitation52.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not matchedcites [52]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
- Not matched
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“While the original observations concern easily measurable variables like education or occupational attainment, more recent studies have delved more deeply into lifestyle factors, cognitively stimulating behaviors, personality factors and the like.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“However, the exact”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These findings support the possibility that it may be possible to intervene even later in life in order to impart reserve, slow age-related cognitive decline, and prolonged healthy aging.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
hedgedstates a possible cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“This is a hopeful idea, since it suggests that changes in lifestyle even later in life might impart reserve against age-related cognitive decline or dementia.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
hedgedstates a possible cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
In the paper
“Similarly, focused training has improved working memory capacity and shown transfer of training to nontrained working memory tasks51.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
What the sources say
- Not checked — no full text of the sourcecites [51] Klingberg, 2010, Training and plasticity of working memory, Trends Cogn Sci source
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Studies using these endpoints will be very expensive because they will require a large number of participants and will have to be conducted over several years.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“While epidemiologic studies can only describe correlations and do not directly test causation, they are useful for deriving hypotheses and exploring ideas.”
§ Cognitive reserve in ageing and Alzheimer's disease > Conclusion
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“By shifting emphasis from game to game, participants cannot fall into a fixed strategy. They must develop the ability to deal with the entire task as a whole – skills that might be termed attentional allocation or executive control.”
§ Cognitive reserve in ageing and Alzheimer's disease > Implications of Cognitive Reserve for Remediation and Prevention
plainstates a cause- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The authors state this as an assumption.
Disease pathology slowly develops over time independently of cognitive reserve, and pathology begins many years before the onset of clinically diagnosed Alzheimer's disease.
“The assumption is that disease pathology slowly develops over time independently of CR, and that the pathology begins many years before the onset of clinically diagnosed AD.”
The authors state this as an assumption.
There is a common point in all people where pathology is so severe that function cannot be maintained.
“However, we reasoned that there is common point in all people where the pathology is so severe that function cannot be maintained.”
The paper relies on this without support.
No study to date has shown change in slowed rate of cognitive decline in aging or reduced risk of developing Alzheimer's disease.
“No study to date has shown change in either of these endpoints.”
The paper relies on this without support.
The brain both passively and actively attempts to cope with brain changes or pathology.
“Since the brain both passively and actively attempts to cope with brain changes or pathology, it is important to understand the factors that contribute to this resilience.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Researchers have long reported that people with more years of formal education are at lower risk for Alzheimer's and other dementias than those with fewer years of formal education.80,[144][145][146][147][148][149]”
From 2023 Alzheimer's disease facts and figures (2023) · cites this paper as [146]
The cited source says what the claim attributes to it.
In the citing paper
“This concept was theoretically framed by Park and Bischof (2013) as “scaffolding,” similar to the closely related cognitive reserve theory proposed by Stern (2012).”
In the citing paper
“supporting the theory that a greater cognitive reserve could help protect against development of LOAD117.”
From Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing (2019) · cites this paper as [117]
In the citing paper
“The level of education, a surrogate marker of cognitive reserves (Stern, 2012), is an important determinant of the expression of VCI, such that for a given level of neuropathology higher education is associated with less cognitive deficits (Zieren et al., 2013).”
From The Pathobiology of Vascular Dementia (2013) · cites this paper as Stern, 2012
In the citing paper
“These findings lead to the suggestion that higher social engagement and support experienced both before and during lockdown due to the COVID-19 pandemic might have had a protective/mitigating role by contributing to cognitive (51) and affective reserve (52).”
From The impact of COVID-19 infection and enforced prolonged social isolation on neuropsychiatric symptoms in older adults with and without dementia: A review (2020) · cites this paper as [51]
In the citing paper
“Cognitive reserve theory suggests that individuals differ in their level of resilience against brain pathology and hence may exhibit differences in cognitive function despite equivalent levels of pathology (Stern, 2002(Stern, , 2012)).”
From Living alone and cognitive function in later life (2019) · cites this paper as Stern, 2012
In the citing paper
“The theory suggests that individuals differ in their degree of resilience against age-related brain pathology and hence may show differences in cognitive function in relation to an equivalent level of pathology [8, 9].”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
In the citing paper
“Cognitive reserve is a theoretical concept that may account for the role of social isolation and its association with cognitive outcomes in later life.”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
In the citing paper
“Such individuals are likely to receive less cognitive stimulation through social contact, resulting in lower cognitive reserve and hence poorer cognitive function [8, 9].”
From Social isolation, cognitive reserve, and cognition in healthy older people (2018) · cites this paper as [9]
Citations
Cites
What is cognitive reserve? Theory and research application of the reserve concept
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Self-citationRunning increases cell proliferation and neurogenesis in the adult mouse dentate gyrus
van Praag, H., Kempermann, G., & Gage, F. H. (1999) · Nature Neuroscience · doi:10.1038/6368 · Cited by 3,880
Stern, Y. (2009) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2009.03.004 · Cited by 2,943
Self-citationRunning enhances neurogenesis, learning, and long-term potentiation in mice
van Praag, H., Christie, B. R., Sejnowski, T. J., & Gage, F. H. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13427 · Cited by 2,904
Neural consequences of enviromental enrichment
van Praag, H., Kempermann, G., & Gage, F. H. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044558 · Cited by 2,468
A Meta-Analysis of Cognitive Remediation for Schizophrenia: Methodology and Effect Sizes
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Training and plasticity of working memory
Klingberg, T. (2010) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.05.002 · Cited by 1,585
Influence of education and occupation on the incidence of Alzheimer's disease
Stern, Y. (1994) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1994.03510370056032 · Cited by 1,434
Self-citationAgeing, fitness and neurocognitive function
Kramer, A. F., Hahn, S., Cohen, N. J., Banich, M. T., McAuley, E., Harrison, C. R., Chason, J., Vakil, E., Bardell, L., Boileau, R. A., et al. (1999) · Nature · doi:10.1038/22682 · Cited by 1,394
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Cited by
Sorted by citations
Items 901–1,000 of 3,536
Ihle, A., Grotz, C., Adam, S., Oris, M., Fagot, D., Gabriel, R., & Kliegel, M. (2016) · International Psychogeriatrics · doi:10.1017/s1041610216000958 · Cited by 29
“This confirms the conceptual perspective that cognitive stimulation throughout the life course may contribute to cognitive reserve thereby being related to better cognitive functioning in old age (Stern, 2009, 2012; see also Hertzog et al., 2008; Opdebeeck et al., 2016).”
BackgroundInfluentialKaup, A. R., Xia, F., Launer, L. J., Sidney, S., Nasrallah, I. M., Erus, G., Allen, N. B., & Yaffe, K. S. (2018) · Neuropsychology · doi:10.1037/neu0000474 · Cited by 29
“While the above interpretations fit within the larger literature on cognitive reserve in aging (Stern, 2012), an alternative explanation for our results that we cannot rule out is that unmeasured, preexisting differences may have influenced individuals’ occupational cognitive complexity, such as…”
InfluentialSocioeconomic factors and the risk of cognitive decline among the elderly population in Japan
Okamoto, S. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5015 · Cited by 29
“Particularly, the cognitive reserve hypothesis suggests that there might be two forms of the neural implementation: neural reserve (less sensitive brain networks or cognitive paradigms to disruption) and neural compensation (the process to compensate for brain damage by using brain structures or networks).(4) The conc…”
BackgroundIhle, A., Rimmele, U., Oris, M., Maurer, J., & Kliegel, M. (2019) · Gerontology · doi:10.1159/000501293 · Cited by 29
Ortner, M., Drost, R., Hedderich, D. M., Goldhardt, O., Müller‐Sarnowski, F., Diehl‐Schmid, J., Förstl, H., Yakushev, I. Y., & Grimmer, T. (2019) · BMC Neurology · doi:10.1186/s12883-019-1498-9 · Cited by 31
Epidemiology and Risk Factors of Alzheimer’s disease in Iran: A Systematic Review
Navipour, E., Neamatshahi, M., Barabadi, Z., Neamatshahi, M., & Keykhosravi, A. (2020) · Iranian Journal of Public Health · doi:10.18502/ijph.v48i12.3544 · Cited by 31
“Alzheimer's family history in first-degree relatives and a history of head injury with loss of consciousness were also risk factors (29).”
BackgroundRecent advances in understanding frontotemporal degeneration
Borroni, B., & Benussi, A. (2019) · F1000Research · doi:10.12688/f1000research.20330.1 · Cited by 30
Canosa, A., Palumbo, F., Iazzolino, B., Peotta, L., Pede, F. D., Manera, U., Vasta, R., Grassano, M., Solero, L., Arena, V., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.11.010 · Cited by 29
Mejía-Arango, S., Garcia-Cifuentes, E. R., Samper‐Ternent, R., Borda, M. G., & Cano, C. A. (2020) · Journal of Cross-Cultural Gerontology · doi:10.1007/s10823-020-09418-4 · Cited by 29
Cognitive reserve hypothesis in frontotemporal dementia: A FDG-PET study
Beyer, L., Meyer-Wilmes, J., Schönecker, S., Schnabel, J., Sauerbeck, J., Scheifele, M., Prix, C., Unterrainer, M., Catak, C., Pogarell, O. M., et al. (2020) · NeuroImage Clinical · doi:10.1016/j.nicl.2020.102535 · Cited by 28
“Support for the hypothesis of protective effects of education has been best established in AD so far (Stern, 2012).”
Curiosity–tourism interaction promotes subjective wellbeing among older adults in Japan
Totsune, T., Matsudaira, I. Y., & Taki, Y. (2021) · Humanities and Social Sciences Communications · doi:10.1057/s41599-021-00748-3 · Cited by 37
Cano‐López, I., Aliño, M., Duque, A., Martínez, P., Almela, M., García-Rubio, M. J., & Puig‐Pérez, S. (2021) · International Psychogeriatrics · doi:10.1017/s1041610221000272 · Cited by 27
“Thus, cognitive reservemay be amoderator factor between pathology and clinical outcomes (Stern, 2012), accounting for differences in trajectories of latelife cognition (Siedlecki et al., 2009).”
BackgroundResultInfluentialAyesa‐Arriola, R., Miguel‐Corredera, M., de la Foz, V. O., Neergaard, K. D., Correa‐Ghisays, P., Setién‐Suero, E., & Crespo‐Facorro, B. (2021) · Psychological Medicine · doi:10.1017/s0033291721001112 · Cited by 29
“CR, as defined by Stern (2012), assumes that people develop a reserve of thinking abilities during their lives and that this protects them against losses that can occur through ageing and disease.”
BackgroundLi, X., Zhang, J., Hou, R., Zheng, M., Singh, M., Li, H., Li, C., Zhang, X., Yang, X., Wu, L., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.031 · Cited by 29
Ghezzi, E. S., Greaves, D., Boord, M. S., Davis, D. H. J., Knayfati, S., Astley, J. M., Sharman, R. L. S., Goodwin, S. I., & Keage, H. A. D. (2022) · Age and Ageing · doi:10.1093/ageing/afac200 · Cited by 30
Lai, K. Y., Webster, C. J., Kumari, S., Gallacher, J., & Sarkar, C. (2023) · Scientific Reports · doi:10.1038/s41598-023-32974-x · Cited by 30
Ourry, V., Binette, A. P., St‐Onge, F., Strikwerda‐Brown, C., Chagnot, A., Poirier, J., Breitner, J. C. S., Arenaza‐Urquijo, E. M., Rabin, J. S., Buckley, R. F., et al. (2023) · Biological Psychiatry · doi:10.1016/j.biopsych.2023.09.003 · Cited by 30
MacDonald, S. W. S., Hundza, S. R., Love, J., et al. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00017 · Cited by 29
Hasselgren, C., Dellve, L., Ekbrand, H., Zettergren, A., Zetterberg, H., Blennow, K., Skoog, I. G., & Halleröd, B. (2018) · SSM - Population Health · doi:10.1016/j.ssmph.2018.06.009 · Cited by 34
“…with regard to occupations in which decision latitude, skill discretion and/or psychological demands are high, the cognitive reserve hypothesis (Stern, 2002, 2012) proposes that activities containing intellectual stimulation could increase compensatory abilities in the neuronal networks and…”
BackgroundDubbelman, M. A., Hendriksen, H. M. A., Harrison, J., Vijverberg, E. G. B., Prins, N. D., Kroeze, L. A., Ottenhoff, L., van Leeuwenstijn, M. S. S. A., Verberk, I. M. W., Teunissen, C. E., et al. (2023) · Neurology · doi:10.1212/wnl.0000000000207978 · Cited by 27
Holland, C., Dravecz, N., Owens, L., Benedetto, A., Dias, I. H. K., Gow, A. J., & Broughton, S. J. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102461 · Cited by 32
Lorenzo‐López, L., Millán-Calentí, J. C., López‐López, R., Diego‐Díez, C., Laffón, B., Pásaro, E., Valdiglesias, V., & Maseda, A. (2017) · Frontiers in Psychology · doi:10.3389/fpsyg.2017.00162 · Cited by 28
“These factors, which seemingly have protective effects, have been termed “cognitive reserve” (Scarmeas and Stern, 2003; Stern, 2012).”
BackgroundSung, J. E., Yoo, J. K., Lee, S. E., & Eom, B. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217000047 · Cited by 28
“…changes of cognitive and linguistic tasks, based on the assumption that those who have greater cognitive reserve are less vulnerable to age-related decline in various cognitive measures and address tasks more efficiently than those with less available cognitive reserve (Stern, 2002, 2009, 2012).”
BackgroundKrieger, S. C., & Sumowski, J. F. (2017) · Neurologic Clinics · doi:10.1016/j.ncl.2017.08.003 · Cited by 34
Cognitive Performance among Cognitively Healthy Adults Aged 30–100 Years
Alenius, M., Koskinen, S. K., Hallikainen, I. T., Ngandu, T., Lipsanen, J. O., Sainio, P., Tuulio‐Henriksson, A., & Hänninen, T. (2019) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000495657 · Cited by 28
Iacono, D., & Feltis, G. C. (2019) · Aging · doi:10.18632/aging.101757 · Cited by 36
“Moreover, these clinicopathologic discrepancies between brain pathology and clinical manifestations (of absence of them) in AD or generally in dementia, support, among others, the general concept of the “cognitive/brain reserve” [22-24].”
BackgroundN-of-1 Clinical Trials in Nutritional Interventions Directed at Improving Cognitive Function
Soldevila‐Domenech, N., Boronat, A., Langohr, K., & de la Torre, R. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00110 · Cited by 27
“This, in turn, increases cognitive reserve, defined as the capacity to perform cognitive tasks properly despite neuropathological damage to the brain (178, 179).”
BackgroundEstimated age of first exposure to American football and outcome from concussion
Caccese, J. B., Houck, Z. M., Kaminski, T. W., Clugston, J. R., Iverson, G. L., Bryk, K. N., Oldham, J. R., Pasquina, P. F., Broglio, S. P., McAllister, T. W., et al. (2020) · Neurology · doi:10.1212/wnl.0000000000010672 · Cited by 28
Metabolic brain changes across different levels of cognitive impairment in ALS: a18F-FDG-PET study
Canosa, A., Moglia, C., Manera, U., Vasta, R., Torrieri, M. C., Arena, V., D’Ovidio, F., Palumbo, F., Zucchetti, J. P., Iazzolino, B., et al. (2020) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2020-323876 · Cited by 28
Babiloni, C., Ferri, R., Noce, G., Lizio, R., Lopez, S., Lorenzo, I., Panzavolta, A., Soricelli, A., Nobili, F. M., Arnaldi, D., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa356 · Cited by 28
“The so-called “neuroprotective mechanism” was supposed to postpone the onset of clinical manifestations in ADD patients with high CR (Valenzuela and Sachdev 2006; Garibotto et al. 2008; Reed et al. 2010; Buchman and Bennett 2012; Stern 2012; Zahodne et al. 2013, 2015; Bennett et al. 2014;Morbelli andNobili 2014; Arena…”
BackgroundYu, W., Chen, R., Zhang, M., Li, Z., Gao, F., Yu, S., & Zhang, X. (2021) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2021.104381 · Cited by 30
Anatürk, M., Suri, S., Smith, S. M., Ebmeier, K. P., & Sexton, C. E. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.734866 · Cited by 30
“Leisure activities (e.g., visiting friends and family, reading, and going to the cinema or museum) represent one set of modifiable factors that potentially support healthy cognitive aging, by promoting brain plasticity (Stern, 2012).”
BackgroundResultChern, A., Irace, A. L., Sharma, R. K., Zhang, Y., Chen, Q., & Golub, J. S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.789515 · Cited by 29
“Medical Research Council Cognitive Function and Aging Study, 2001; Savva et al., 2009; Stern, 2012).”
Backgroundde la Fuente, J., Grotzinger, A. D., Marioni, R. E., Nivard, M. G., & Tucker–Drob, E. M. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010208 · Cited by 30
“This assumption is supported by a large body of work indicating that ancillary factors, such as educational attainment, are associated with clinical AD rates among individuals with equivalent levels of brain pathology [20].”
BackgroundLu, H., Chan, S. S. M., Ma, S., Lin, C., Mok, V., Shi, L., Wang, D., Mak, A. D. P., & LAM, L. C. W. (2022) · Human Brain Mapping · doi:10.1002/hbm.26032 · Cited by 30
“education is thought to reflect a higher level of cognitive reserve and possibly protects against the accumulating brain pathology and related cognitive impairment during ageing (Stern, 2012).”
BackgroundSkirbekk, V., Bowen, C. E., Haberg, A. K., Jugessur, A., Engdahl, B., Bratsberg, B., Zotcheva, E., Selbæk, G., Kohler, H., Weiss, J., et al. (2022) · Journal of Aging and Health · doi:10.1177/08982643221131926 · Cited by 29
“Marriage might affect social interaction, which in turn might build cognitive reserve, which reduces dementia risk (Guner et al., 2018a; Stern, 2012; Tosi & van den Broek, 2020; Tumin & Zheng, 2018).”
BackgroundSelf-citationConnectome‐based predictive modelling of cognitive reserve using task‐based functional connectivity
Boyle, R. T., Connaughton, M., McGlinchey, E., Knight, S. P., Looze, C. D., Carey, D., Stern, Y., Robertson, I. H., Kenny, R. A., & Whelan, R. (2022) · European Journal of Neuroscience · doi:10.1111/ejn.15896 · Cited by 27
“Accurate measurement of CR could improve the clinical diagnosis of dementia (Stern, 2012), the measurement of intervention efficacy in clinical trials (Mondini et al., 2016), the stratification of participants in intervention studies (Stern, 2012), and the development of interventions designed to…”
BackgroundSelf-citationNew horizons in understanding oral health and swallowing function within the context of frailty
Robison, R., Garand, K. L., Affoo, R. H., Yeh, C., Chin, N. A., McArthur, C., Pulia, M. S., & Rogus‐Pulia, N. M. (2023) · Age and Ageing · doi:10.1093/ageing/afac276 · Cited by 34
The A-to-Z factors associated with cognitive impairment. Results of the DeCo study
Gil‐Peinado, M., Alacreu, M., Ramos, H., Sendra‐Lillo, J., García-García, C., García‐Lluch, G., de Coca, T. L., Sala‐Climent, M., & Moreno, L. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2023.1152527 · Cited by 29
“Cognitive reserve refers to the varying susceptibility to exhibit dementia symptoms during the same phases of the disease (Stern, 2013; Stern and Barulli, 2019; Stern et al., 2021).”
BackgroundNovel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer’s Disease
Fà, M., Zhang, H., Staniszewski, A., Saeed, F., Shen, L. W., Schiefer, I. T., Siklos, M. I., Tapadar, S., Litosh, V. A., Libien, J. M., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150618 · Cited by 30
Durazzo, T. C., Mattsson, N., Weiner, M. W., Korecka, M., Trojanowski, J. Q., & Shaw, L. M. J. (2014) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2014.06.030 · Cited by 29
“However, it is possible the isoprostane findings for these smokers may be, at least partially, related to unrecorded differences between smokers and never-smokers in brain reserve (Stern, 2012), diet and physical activity (Barnes and Yaffe, 2011; Durazzo et al.”
BackgroundOkonkwo, O. C., Oh, J. M., Koscik, R. L., Jonaitis, E. M., Cleary, C. A., Dowling, N. M., Bendlin, B. B., LaRue, A. A., Hermann, B. P., Barnhart, T. E., et al. (2014) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617714000113 · Cited by 31
“Literacy is considered a proxy for cognitive reserve (Stern, 2012), and several studies have now shown that higher cognitive reserve delays the onset of clinical impairments even in the context of marked neuropathological changes (Rentz et al., 2010).”
BackgroundTautvydaitė, D., Kukreja, D., Antonietti, J., Henry, H., von Gunten, A., & Popp, J. (2017) · Alzheimer s Research & Therapy · doi:10.1186/s13195-017-0235-0 · Cited by 28
Agarwal, S., Presciutti, A., Verma, J., Pavol, M. A., Anbarasan, D., Brodie, D., Rabbani, L. E., Roh, D. J., Park, S., Claassen, J., et al. (2018) · Resuscitation · doi:10.1016/j.resuscitation.2018.01.036 · Cited by 28
“This higher reserve could enable men to either withstand more damage to the brain or compensate for existing damage better than women [20].”
BackgroundSelf-citationJi, L., Pearlson, G. D., Zhang, X., Steffens, D. C., Ji, X., Guo, H., & Wang, L. (2018) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4909 · Cited by 28
“A robust neural compensatory mechanism has been considered as part of cognitive reserve.(30) We conclude that physical exercise may benefit cognition, motor function, as well as cognitive reserve in older adults.”
BackgroundFuncionamiento cognitivo en adultos mayores: rol de la reserva cognitiva, apoyo social y depresión
Cancino, M., Rehbein, L., & Ortíz, M. S. (2018) · Revista médica de Chile · doi:10.4067/s0034-98872018000300315 · Cited by 43
Impaired brain plasticity as a potential therapeutic target for treatment and prevention of dementia
Rajji, T. K. (2018) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2019.1550074 · Cited by 30
The role of cognitive and brain reserve in late-life depressive events: The Rotterdam Study
Zijlmans, J. L., Vernooij, M. W., Ikram, M. A., et al. (2022) · Journal of Affective Disorders · doi:10.1016/j.jad.2022.09.145 · Cited by 27
Yang, Y., Chen, Y., Yang, C., Chen, K., Li, X., & Zhang, Z. (2022) · BMC Geriatrics · doi:10.1186/s12877-022-03530-5 · Cited by 29
“Various types of intellectual engagements serve as proxy measures of cognitive reserve [49, 50], which continues to accumulate during the lifespan and in old age by participating in mental activities and cognitive training [46].”
BackgroundYang, W., Wang, J., Dove, A. E., Dunk, M. M., Qi, X., Bennett, D. A., & Xu, W. (2024) · The British Journal of Psychiatry · doi:10.1192/bjp.2024.13 · Cited by 29
“…reserve might not affect age-related brain changes or pathologies directly but represent other pathways to compensate for or cope with these changes, 4,22 such as enhancing brain network efficiency 22 and contributing to neurotrophic effects in the mid-prefrontal lobe and greater neuronal density.”
BackgroundContador, I., Buch-Vicente, B., del Ser, T., Velasco, S. L., Villarejo‐Galende, A., Benito‐León, J., & Bermejo‐Pareja, F. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13144100 · Cited by 31
“…synapses may withstand a more significant neuropathological load before manifesting dementia symptoms [298]; CR refers to the active capacity of the brain to deal with brain damage, essentially activating compensation mechanisms (i.e., alternative brain networks and/or cognitive strategies) [299].”
BackgroundKetone body metabolism and cardiometabolic implications for cognitive health
Fulghum, K., Salathe, S. F., Davis, X. C., Thyfault, J. P., Puchalska, P., & Crawford, P. A. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00029-y · Cited by 30
Yen, T. E., Allen, J. C., Rivelli, S. K., Patterson, S. C., Metcalf, M., Flink, B. J., Mirrakhimov, A. E., Lagoo, S. A., Vail, T. P., Young, C. C., et al. (2016) · Scientific Reports · doi:10.1038/srep20736 · Cited by 27
Rheenen, T. E. V., Cropley, V., Fagerlund, B., Wannan, C., Bruggemann, J. M., Lenroot, R., Sundram, S., Weickert, C. S., Weickert, T. W., Zalesky, A., et al. (2019) · Psychological Medicine · doi:10.1017/s0033291719001417 · Cited by 27
“CR has been studied extensively in the context of neurological illness, where patients with the same disease burden (brain pathology) show marked variability in the expression of disease symptoms as a function of high or low levels of crystallized intelligence (Sumowski et al., 2010a; Stern, 2012).”
BackgroundThe long-term consequences of repetitive head impacts: Chronic traumatic encephalopathy
Alosco, M. L., & Stern, R. A. (2019) · Handbook of clinical neurology · doi:10.1016/b978-0-12-804766-8.00018-2 · Cited by 28
Initial motor reserve and long-term prognosis in Parkinson's disease
Chung, S. J., Yoo, H. S., Lee, Y. H., Lee, H. S., Lee, P. H., & Sohn, Y. H. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.02.028 · Cited by 27
Aschenbrenner, A., Petros, J., McDade, E., Wang, G.-Q., Balota, D., Benzinger, T., Cruchaga, C., Goate, A., Xiong, C., Perrin, R., et al. (2020) · Alzheimer's & Dementia · doi:10.1002/dad2.12038 · Cited by 19
Mejía-Arango, S., Avila, J. C., Downer, B. G., García, M. A., Michaels-Obregón, A., Saenz, J. L., Samper‐Ternent, R., & Wong, R. (2021) · Geriatrics · doi:10.3390/geriatrics6030063 · Cited by 28
“anisms that shape how the brain copes with age-related changes and pathology such as dementia [23].”
BackgroundJutten, R. J., Thompson, L., Sikkes, S. A. M., Maruff, P., Molinuevo, J. L., Zetterberg, H., Alber, J., Faust, D., Gauthier, S. G., Gold, M., et al. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-215098 · Cited by 32
Spinelli, G., on behalf of the INSIGHT-preAD Study Group, Bakardjian, H., Schwartz, D., Potier, M., Habert, M., Lévy, M., Dubois, B., & George, N. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220204 · Cited by 32
“, the so-called “cognitive reserve” hypothesis; [4, 5]) or other forms of cognitive impairment [6–8], but no decisive solution has emerged yet.”
BackgroundLee, Y., & Chi, I. (2015) · Aging & Mental Health · doi:10.1080/13607863.2015.1011081 · Cited by 28
“Based on cognitive reserve theory (Stern, 2012) and the extant literature, we specified three research questions to guide our analysis.”
BackgroundMethodImpact of Pharmacotherapy on Cognitive Dysfunction in Patients with Multiple Sclerosis
Roy, S., Benedict, R. H. B., Drake, A. S., & Weinstock‐Guttman, B. (2016) · CNS Drugs · doi:10.1007/s40263-016-0319-6 · Cited by 30
“Research on AD has shown that people with high levels of reserve are less likely to develop dementia [107].”
BackgroundIhle, A., Oris, M., Baeriswyl, M., & Kliegel, M. (2018) · International Psychogeriatrics · doi:10.1017/s1041610218000789 · Cited by 27
“To address this issue, the cognitive reserve concept postulates that interindividual differences in the effective recruitment of neural networks and cognitive processes explain differences in individuals’ capacity to cope with or compensate for age-related decline (Stern, 2009, 2012).”
BackgroundAvalon Genomics (HK) Limited, S., Yee, A., Tsui, N. B. Y., Chang, Y., Au, C. S., Fok, M., Lau, L. T., Chung, T., Cheng, G. Y.-M., Kwan, R. Y. C., et al. (2018) · Hong Kong Medical Journal · doi:10.12809/hkmj187244 · Cited by 26
Chess Practice as a Protective Factor in Dementia
Lillo‐Crespo, M., Forner-Ruiz, M., Riquelme-Galindo, J., et al. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16122116 · Cited by 27
“In other words, there is a reduced risk of developing Alzheimer’s disease in individuals with a higher level of education and, therefore, they will also be able to maintain their activities of daily living for longer [7].”
BackgroundEnhanced temporal complexity of EEG signals in older individuals with high cognitive functions
Iinuma, Y., Nobukawa, S., Mizukami, K., Kawaguchi, M., Higashima, M., Tanaka, Y., Yamanishi, T., & Takahashi, T. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.878495 · Cited by 24
“However, individual differences in the symptoms of cognitive decline depend on various environmental factors, such as lifestyle and other personal factors (Stern, 2012; Gates et al., 2019).”
BackgroundNa, M., Dou, N., Brown, M. J., Chen-Edinboro, L. P., Anderson, L. R., & Wennberg, A. M. V. (2022) · Journal of Nutrition · doi:10.1016/j.tjnut.2022.12.012 · Cited by 28
“Educational attainment is a leading factor in promoting cognitive reserve [31].”
BackgroundNeuroglia in cognitive reserve
Verkhratsky, A., & Zorec, R. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02644-z · Cited by 34
Huijbers, W., Papp, K., Lapoint, M. R., Wigman, S. E., Dagley, A. S., Hedden, T., Rentz, D., Schultz, A., & Sperling, R. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw234 · Cited by 28
“In that case, TOT experiences might be a sign of compensation (Stern 2012).”
BackgroundNation, D. A., Ho, J. K., Dutt, S., Han, S. D., Lai, M. H. C., & Initiative, A. D. N. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-180525 · Cited by 28
“Cognitive reserve and other genetic, psychological and environmental factors are also known to limit the relationship between underlying pathology and its clinical manifestation [31, 32].”
BackgroundJoannette, M., Bocti, C., Sévigny-Dupont, P., Lavallée, M. M., Nikelski, J., Vallet, G. T., Chertkow, H. M., & Joubert, S. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz235 · Cited by 27
“In other words, individuals with higher education can better compensate the effects of advancing AD brain pathology (10,13).”
BackgroundKuang, W., Gao, M., Tian, L., Wan, Y., & Qiu, P. (2019) · International Health · doi:10.1093/inthealth/ihz114 · Cited by 28
Yao, T., Sweeney, E. M., Nagorski, J., Shulman, J. M., & Allen, G. I. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241707 · Cited by 24
Bermejo‐Pareja, F., Contador, I., del Ser, T., Olazarán, J., Velasco, S. L., Vega, S., & Benito‐León, J. (2020) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5474 · Cited by 29
Tsapekos, D., Strawbridge, R., Cella, M., Wykes, T., & Young, A. H. (2021) · Journal of Affective Disorders · doi:10.1016/j.jad.2021.07.036 · Cited by 26
Status and Factors of Cognitive Function Among Older Adults in Urban China
Shen, L., Tang, X., Li, C., Qian, Z., Wang, J., & Liu, W. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.728165 · Cited by 28
“The cognitive reserve hypothesis points out that educational level is an important factor in improving cognitive reserve and plays a positive compensatory role in the cognitive aging process (Stern, 2012).”
BackgroundJansen, M. G., Geerligs, L., Claassen, J. A. H. R., Overdorp, E. J., Brazil, I. A., Kessels, R. P. C., & Oosterman, J. M. (2021) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2021.723728 · Cited by 28
“It has been suggested that disease state may attenuate such effects (Stern, 2012; Gregory et al., 2017; Mungas et al., 2021), and previous studies have demonstrated that the benefits of higher education become less pronounced or disappear entirely as disease severity increases (Ye et al., 2013;…”
BackgroundInfluentialChen, C., Kuo, M., Chen, P., Tung, Y.-H., Hsu, Y., Huang, C.-W. C., Chan, W. P., & Tseng, W. I. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2022.03.006 · Cited by 27
Gerstorf, D., Ram, N., Drewelies, J., Duezel, S., Eibich, P., Steinhagen-Thiessen, E., Liebig, S., Goebel, J., Demuth, I., Villringer, A., et al. (2023) · Psychological Science · doi:10.1177/09567976221118541 · Cited by 26
“Expectations about a postponed onset of cognitive decline among later-born cohorts can be derived from the cognitive-reserve hypothesis (Stern, 2012).”
BackgroundCOMMUNITY-BASED INTERVENTION FOR PREVENTION OF DEMENTIA IN JAPAN
Suzuki, T., Makizako, H., Doi, T., Park, H., Lee, S., Tsutsumimoto, K., Umemura, K., Maki, Y., & Shimada, H. (2015) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2015.42 · Cited by 26
“Previous studies reported that regular exercise is beneficial in reducing the risk of cognitive decline in elderly individuals (21-24).”
BackgroundMiddle age self-report risk score predicts cognitive functioning and dementia in 20–40 years
Vuoksimaa, E., Rinne, J., Lindgren, N., Heikkilä, K., Koskenvuo, M., & Kaprio, J. (2016) · Alzheimer's & Dementia · doi:10.1016/j.dadm.2016.08.003 · Cited by 27
“CR hypothesis states that those with higher levels of reserve can tolerate aging-related pathology and risk factors better and develop dementias later than those with lower levels of reserve [16].”
BackgroundMethodCohort Differences in Cognitive Aging in the Longitudinal Aging Study Amsterdam
Brăilean, A., Huisman, M. A., Prince, M. J., Prina, M. A., Deeg, D. J. H., & Comijs, H. C. (2016) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbw129 · Cited by 33
“Alternatively, cohort differences in cognitive decline may be better accounted for by factors such as occupational attainment or leisure activities that also contribute to increasing cognitive reserve and delaying cognitive impairment in later life (Scarmeas, Levy, Tang, Manly, & Stern, 2001; Stern, 2012; Stern et al.…”
BackgroundHan, Y., Wang, K., Jia, J., & Wei-ping, W. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00107 · Cited by 25
“The neural compensation demonstrated that brain actively attempts to recruit alternative structures which are not normally used to compensate for brain damage (Stern, 2009, 2012, 2013; Risacher and Saykin, 2013).”
BackgroundZhang, Z., Liu, Z., Deng, H., & Chen, Q. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2345-z · Cited by 27
Lifestyle intervention to prevent Alzheimer’s disease
Ko, Y., & Chye, S. M. (2020) · Reviews in the Neurosciences · doi:10.1515/revneuro-2020-0072 · Cited by 29
Linking Late Life Depression and Alzheimer’s Disease: Mechanisms and Resilience
Weisenbach, S. L., Kim, J. U., Hammers, D. B., Konopacki, K. L., & Koppelmans, V. (2019) · Current Behavioral Neuroscience Reports · doi:10.1007/s40473-019-00180-7 · Cited by 28
Cognitive reserve and cognition in mood disorders: A systematic review and meta-analysis
Camprodon‐Boadas, P., Prisco, M. D., Rabelo‐da‐Ponte, F. D., Sugranyes, G., Clougher, D., Baeza, I., Torrent, C., Castro‐Fornieles, J., Tosetti, Y., Vieta, E., et al. (2024) · Psychiatry Research · doi:10.1016/j.psychres.2024.116083 · Cited by 28
Cognitive resilience in Alzheimer’s disease: Mechanism and potential clinical intervention
Jia, B., Xu, Y., & Zhu, X. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102711 · Cited by 30
Heser, K., Wagner, M., Wiese, B., Prokein, J., Ernst, A., König, H., Brettschneider, C., Riedel-Heller, S. G., Luppa, M., Weyerer, S. B., et al. (2014) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000368189 · Cited by 26
Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer’s model
Stuart, K., King, A., Fernandez-Martos, C. M., Summers, M., & Vickers, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-03016-0 · Cited by 22
Incidence and risk factors of subsyndromal delirium after curative resection of gastric cancer
Hwang, H., Lee, K.-M., Son, K., Jung, D., Kim, W., Lee, J.-Y., Kong, S., Suh, Y., Lee, H., Yang, H., et al. (2018) · BMC Cancer · doi:10.1186/s12885-018-4681-2 · Cited by 25
Preventing Alzheimer’s: Our Most Urgent Health Care Priority
Sherzai, D., & Sherzai, A. Z. (2019) · American Journal of Lifestyle Medicine · doi:10.1177/1559827619843465 · Cited by 27
Cheng, G. H. ‐., Chan, A. W.-M., Østbye, T., & Malhotra, R. (2019) · Aging & Mental Health · doi:10.1080/13607863.2019.1686458 · Cited by 26
Gender Differences in Superior-memory SuperAgers and Associated Factors in an Australian Cohort
Maccora, J., Peters, R. K., & Anstey, K. J. (2020) · Journal of Applied Gerontology · doi:10.1177/0733464820902943 · Cited by 29
“It is possible that this analysis adds weight to the cognitive reserve hypothesis, which suggests that resilience to age-related cognitive decline can be developed through activities that stimulate neural activity, such as education and investigative activities (Stern, 2002, 2012).”
BackgroundLi, M., Reisman, J. I., Morris-Eppolito, B., Qian, S. X., Kazis, L. E., Wolozin, B. L., Goldstein, L. E., & Xia, W. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00589-3 · Cited by 65
Influence of Lifestyles on Mild Cognitive Impairment: A Decision Tree Model Study
Wang, Z., Hou, J., Shi, Y., Tan, Q., Lin, P., Deng, Z., Wang, Z., & Guo, Z. (2020) · Clinical Interventions in Aging · doi:10.2147/cia.s265839 · Cited by 27
Jester, D. J., Andel, R., Čechová, K., Laczó, J., Lerch, O., Marková, H., Nikolai, T., Vyhnálek, M., & Hort, J. (2020) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617720001046 · Cited by 25
“Another possible explanation revolves around cognitive reserve, as the interaction between age and cognitive reserve may explain the differences seen in cognitive phenotypes (Stern, 2012), especially given the high level of educational attainment across all SCD profiles.”
BackgroundOlder Workers with Physically Demanding Jobs and their Cognitive Functioning
Choi, E., Kim, S., Zahodne, L. B., & Albert, S. M. (2021) · Ageing International · doi:10.1007/s12126-020-09404-8 · Cited by 27
“Similarly, less physically demanding jobs usually involve more intellectual engagement, which promotes cognitive function (Andel et al. 2011; Stern 2012).”
BackgroundValidity and reliability of "Cognitive Reserve Index Questionnaire" for the Turkish Population.
Ozakbas, S., Yiğit, P., Akyuz, Z., Sagıcı, O., Abasıyanık, Z., Ozdogar, A. T., Kahraman, T., Bozan, H. R., & Hosgel, I. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.102817 · Cited by 23
Lee, Y. J., Gonzales, E. G., & Andel, R. (2021) · The Journals of Gerontology Series B · doi:10.1093/geronb/gbab087 · Cited by 23
Metadata
- Authors
- Stern, Y.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Stern, Yaakov
- ORCID
- Stern, Yaakov
- Venue
- The Lancet Neurology
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 11
- Issue
- 11
- Pages
- 1006-1012
- ISSN
- 1474-4422 (ISSN-L)
- PMC
- PMC3507991
- OpenAlex
- W2144907160
- Cited by
- 3,557
- References
- 59
- Citations by year
- 2026: 412 · 2025: 352 · 2024: 311 · 2023: 343 · 2022: 281 · 2021: 303 · 2020: 350 · 2019: 292 · 2018: 244 · 2017: 213 · 2016: 176 · 2015: 125 · 2014: 93 · 2013: 58 · 2012: 1
- FWCI
- 12.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- The Lancet Neurology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institute on Aging (R01AG026158, R01AG014671)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- cognitive reserve, brain reserve, Alzheimer's disease, cognitive aging, dementia risk, educational attainment, occupational attainment, leisure
- MeSH terms
- Aging, Alzheimer Disease, Animals, Humans, Cognitive Reserve
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