Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naive clinically depressed adolescents
Abstract
Background: Depression is prevalent and typically has its onset in adolescence. Resting‐state fMRI could help create a better understanding of the underlying neurobiological mechanisms during this critical period. In this study, resting‐state functional connectivity ( RSFC ) is examined using seed regions‐of‐interest ( ROI s) associated with three networks: the limbic network, the default mode network ( DMN ) and the salience network. Methods: Twenty‐six treatment‐naïve, clinically depressed adolescents of whom 18 had comorbid anxiety, and 26 pair‐wise matched healthy controls underwent resting‐state fMRI . The three networks were investigated using a seed‐based ROI approach with seeds in the bilateral amygdala (limbic network), bilateral dorsal anterior cingulate cortex (d ACC ; salience network) and bilateral posterior cingulate cortex (default mode network). Results: Compared to healthy controls, clinically depressed adolescents showed increased RSFC of the left amygdala with right parietal cortical areas, and decreased right amygdala RSFC with left frontal cortical areas including the ACC , as well as with right occipito‐parietal areas. The bilateral dACC showed decreased RSFC with the right middle frontal gyrus, frontal pole, and inferior frontal gyrus in clinically depressed adolescents. No abnormalities in DMN RSFC were found, and differences in RSFC did not correlate with clinical measures. Conclusions: The aberrant RSFC of the amygdala network and the d ACC network may be related to altered emotion processing and regulation in depressed adolescents. Our results provide new insights into RSFC in clinically depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network.
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Studies of children and adolescents with major depressive disorder found increased connectivity between the amygdala and parietal and occipital cortices.
“Notably, studies that have examined amygdalar RSFC in children and adolescents with major depressive disorder have found increased connectivity of the amygdala with parietal and occipital cortices (Cullen et al., 2014, Jacobs et al., 2014, Pannekoek et al., 2014);”
From Developmental sex differences in resting state functional connectivity of amygdala sub-regions (2015) · cites this paper as Pannekoek et al., 2014
Cites
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630 · see citing works
Jenkinson, M., Bannister, P., Brady, M., & Smith, S. (2002) · NeuroImage · doi:10.1006/nimg.2002.1132 · Cited by 11,888 · see citing works
Functional connectivity in the motor cortex of resting human brain using echo‐planar mri
Biswal, B., Zerrin Yetkin, F., Haughton, V. M., & Hyde, J. S. (1995) · Magnetic Resonance in Medicine · doi:10.1002/mrm.1910340409 · Cited by 9,812 · see citing works
(1991) · Medical Entomology and Zoology · Cited by 8,071 · see citing works
Power, J. D., Barnes, K. A., Snyder, A. Z., Schlaggar, B. L., & Petersen, S. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.018 · Cited by 7,429 · see citing works
Dissociable intrinsic connectivity networks for salience processing and executive control
Seeley, W. W., Menon, V., Schatzberg, A. F., Keller, J., Glover, G. H., Kenna, H., Reiss, A. L., & Greicius, M. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5587-06.2007 · Cited by 7,426 · see citing works
Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
Fox, M. D., & Raichle, M. E. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2201 · Cited by 6,700 · see citing works
Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0135058100 · Cited by 6,358 · see citing works
Wechsler Adult Intelligence Scale-III
Ryan, J. J., & Lopez, S. J. (2001) · Springer eBooks · doi:10.1007/978-1-4615-1185-4_2 · Cited by 3,680 · see citing works
Contributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · cited 2× · see citing works
“…studies have indicated that the ACC is involved in emotion regulation by having an inhibitory e!ect on amygdala function, which is consistent with the hypothesis that decreased cortical regulation of limbic activation may be present in depression (Phelps and LeDoux, 2005, Anand et al., 2005).”
BackgroundEmotional processing in anterior cingulate and medial prefrontal cortex
Etkin, A., Egner, T., & Kalisch, R. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.11.004 · Cited by 3,059 · cited 1× · see citing works
“"is is in line with previous literature linking connectivity between the amygdala and the pregenual ACC to the regulation of a!ective processing (Etkin et al., 2011b).”
ResultThapar, A., Collishaw, S., Pine, D. S., & Thapar, A. K. (2012) · The Lancet · doi:10.1016/s0140-6736(11)60871-4 · Cited by 2,365 · see citing works
The influence of head motion on intrinsic functional connectivity MRI
Van Dijk, K. R. A., Sabuncu, M. R., & Buckner, R. L. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.07.044 · Cited by 2,344 · see citing works
Greicius, M. D., Flores, B. H., Menon, V., Glover, G. H., Solvason, H. B., Kenna, H., Reiss, A. L., & Schatzberg, A. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.09.020 · Cited by 2,214 · see citing works
Chorpita, B. F., Yim, L., Moffitt, C., Umemoto, L. A., & Francis, S. E. (2000) · Behaviour Research and Therapy · doi:10.1016/s0005-7967(99)00130-8 · Cited by 1,966 · see citing works
Satterthwaite, T., Elliott, M., Gerraty, R. T., Ruparel, K., Loughead, J., Calkins, M., Eickhoff, S., Hakonarson, H., Gur, R., Gur, R. E., et al. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.08.052 · Cited by 1,900 · see citing works
The Neural Bases of Emotion Regulation: Reappraisal and Suppression of Negative Emotion
Goldin, P. R., McRae, K., Ramel, W., & Gross, J. J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.05.031 · Cited by 1,886 · see citing works
Beesdo, K., Knappe, S., & Pine, D. S. (2009) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.06.002 · Cited by 1,703 · see citing works
Default-mode brain dysfunction in mental disorders: A systematic review
Broyd, S. J., Demanuele, C., Debener, S., Helps, S. K., James, C. J., & Sonuga-Barke, E. J. S. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.002 · Cited by 1,675 · see citing works
Limbic-cortical dysregulation: a proposed model of depression
(1997) · The Journal of Neuropsychiatry and Clinical Neurosciences · doi:10.1176/jnp.9.3.471 · Cited by 1,585 · see citing works
Functional brain networks develop from a local to distributed organization
Fair, D. A., Cohen, A. L., Power, J. D., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Schlaggar, B. L., & Petersen, S. E. (2009) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000381 · Cited by 1,530 · see citing works
The maturing architecture of the brain's default network
Fair, D. A., Cohen, A. L., Dosenbach, N. U. F., Church, J. A., Miezin, F. M., Barch, D. M., Raichle, M. E., Petersen, S. E., & Schlaggar, B. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800376105 · Cited by 1,314 · see citing works
Development of distinct control networks through segregation and integration
Fair, D. A., Dosenbach, N. U. F., Church, J. A., Cohen, A. L., Brahmbhatt, S., Miezin, F. M., Barch, D. M., Raichle, M. E., Petersen, S. E., & Schlaggar, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705843104 · Cited by 1,244 · see citing works
Sheline, Y. I., Price, J. L., Yan, Z., & Mintun, M. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000446107 · Cited by 1,196 · see citing works
SILVERMAN, W. K., SAAVEDRA, L. M., & PINA, A. A. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200108000-00016 · Cited by 1,190 · see citing works
Satterthwaite, T. D., Wolf, D. H., Loughead, J., Ruparel, K., Elliott, M. A., Hakonarson, H., Gur, R. C., & Gur, R. E. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.12.063 · Cited by 1,125 · see citing works
Advances and pitfalls in the analysis and interpretation of resting-state FMRI data
Cole, D. M. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00008 · Cited by 950 · see citing works
Attentional biases for negative interpersonal stimuli in clinical depression
Gotlib, I. H., Krasnoperova, E., Yue, D. N., & Joormann, J. (2004) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.113.1.121 · Cited by 911 · see citing works
Garnefski, N., & Kraaij, V. (2006) · Personality and Individual Differences · doi:10.1016/j.paid.2005.12.009 · Cited by 908 · see citing works
Statistical analysis of activation images
Worsley, K. J. (2001) · doi:10.1093/acprof:oso/9780192630711.003.0014 · Cited by 825 · see citing works
Zahn‐Waxler, C., Klimes‐Dougan, B., & Slattery, M. J. (2000) · Development and Psychopathology · doi:10.1017/s0954579400003102 · Cited by 809 · see citing works
Development of large-scale functional brain networks in children
Supekar, K., Musen, M., & Menon, V. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000157 · Cited by 807 · see citing works
Anand, A., Li, Y., Wang, Y., Wu, J., Gao, S., Bukhari, L., Mathews, V. P., Kalnin, A., & Lowe, M. J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.02.021 · Cited by 787 · see citing works
Mapping the functional connectivity of anterior cingulate cortex
Margulies, D. S., Kelly, C. A. M., Uddin, L. Q., Biswal, B. B., Castellanos, F. X., & Milham, M. P. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.05.019 · Cited by 751 · see citing works
Functional connectivity of the human amygdala using resting state fMRI
Roy, A. K., Shehzad, Z., Margulies, D. S., Kelly, A. M. C., Uddin, L. Q., Gotimer, K., Biswal, B. B., Castellanos, F. X., & Milham, M. P. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.11.030 · Cited by 749 · see citing works
Imaging brain development: The adolescent brain
Blakemore, S.-J. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.11.080 · Cited by 649 · see citing works
Amygdala Response to Fearful Faces in Anxious and Depressed Children
Thomas, K. M. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.11.1057 · Cited by 582 · see citing works
Functional network dysfunction in anxiety and anxiety disorders
Sylvester, C. M., Corbetta, M., Raichle, M. E., Rodebaugh, T. L., Schlaggar, B. L., Sheline, Y. I., Zorumski, C. F., & Lenze, E. J. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.04.012 · Cited by 579 · see citing works
Development of Anterior Cingulate Functional Connectivity from Late Childhood to Early Adulthood
Kelly, A. M. C., Di Martino, A., Uddin, L. Q., Shehzad, Z., Gee, D. G., Reiss, P. T., Margulies, D. S., Castellanos, F. X., & Milham, M. P. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhn117 · Cited by 572 · see citing works
Etkin, A., Prater, K. E., Hoeft, F., Menon, V., & Schatzberg, A. F. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.09070931 · Cited by 550 · see citing works
Supekar, K., Uddin, L. Q., Prater, K. E., Amin, H., Greicius, M. D., & Menon, V. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.009 · Cited by 524 · see citing works
Abnormal attention modulation of fear circuit function in pediatric generalized anxiety disorder
McClure, E. B., Monk, C. S., Nelson, E. E., Parrish, J. M., Adler, A., Blair, R. J. R., Fromm, S., Charney, D. S., Leibenluft, E., Ernst, M., et al. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.97 · Cited by 431 · see citing works
A validated network of effective amygdala connectivity
Stein, J. L., Wiedholz, L. M., Bassett, D. S., Weinberger, D. R., Zink, C. F., Mattay, V. S., & Meyer-Lindenberg, A. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.03.022 · Cited by 392 · see citing works
Guyer, A. E., Lau, J. Y. F., McClure-Tone, E. B., Parrish, J., Shiffrin, N. D., Reynolds, R. C., Chen, G., Blair, R. J. R., Leibenluft, E., Fox, N. A., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.11.1303 · Cited by 371 · see citing works
Connolly, C. G., Wu, J., Ho, T. C., Hoeft, F., Wolkowitz, O., Eisendrath, S., Frank, G., Hendren, R., Max, J. E., Paulus, M. P., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.05.036 · Cited by 356 · see citing works
A systematic review of resting-state functional-MRI studies in major depression
Wang, L., Hermens, D. F., Hickie, I. B., & Lagopoulos, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.04.013 · Cited by 333 · see citing works
Metaanalytic connectivity modeling: Delineating the functional connectivity of the human amygdala
Robinson, J. L., Laird, A. R., Glahn, D. C., Lovallo, W. R., & Fox, P. T. (2010) · Human Brain Mapping · doi:10.1002/hbm.20854 · Cited by 327 · see citing works
LYNEHAM, H. J., ABBOTT, M. J., & RAPEE, R. M. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180465a09 · Cited by 307 · see citing works
Neuroimaging in social anxiety disorder: a systematic review of the literature
Freitas-Ferrari, M. C., Hallak, J. E. C., Trzesniak, C., Filho, A. S., Machado-de-Sousa, J. P., Chagas, M. H. N., Nardi, A. E., & Crippa, J. A. S. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.02.028 · Cited by 298 · see citing works
Personality Is Reflected in the Brain's Intrinsic Functional Architecture
Adelstein, J. S., Shehzad, Z. E., Mennes, M., DeYoung, C. G., Zuo, X., Kelly, C. A. M., Margulies, D. S., Bloomfield, A., Gray, J. R., Castellanos, F. X., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027633 · Cited by 286 · see citing works
Research Review: A neuroscience framework for pediatric anxiety disorders
Pine, D. S. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01751.x · Cited by 277 · see citing works
Roy, A. K., Fudge, J. L., Kelly, C. A. M., Perry, J. S. A., Daniele, T., Carlisi, C. O., Benson, B. E., Castellanos, F. X., Milham, M. P., Pine, D. S., et al. (2013) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.12.010 · Cited by 267 · see citing works
Grimm, S., Ernst, J., Boesiger, P., Schuepbach, D., Hell, D., Boeker, H., & Northoff, G. (2008) · Human Brain Mapping · doi:10.1002/hbm.20693 · Cited by 254 · see citing works
Integrating VBM into the General Linear Model with voxelwise anatomical covariates
Oakes, T. R., Fox, A. S., Johnstone, T., Chung, M. K., Kalin, N. H., & Davidson, R. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.10.007 · Cited by 247 · see citing works
A preliminary study of functional connectivity in comorbid adolescent depression
Cullen, K. R., Gee, D. G., Klimes‐Dougan, B., Gabbay, V., Hulvershorn, L. A., Mueller, B. A., Camchong, J., Bell, C. J., Houri, A. K., Kumra, S., et al. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.05.022 · Cited by 226 · see citing works
Boeker, H. (2009) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-18088 · Cited by 208 · see citing works
Avenevoli, S. (2012) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2011.1603 · Cited by 206 · see citing works
Grecucci, A., Giorgetta, C., Bonini, N., & Sanfey, A. G. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00523 · Cited by 203 · see citing works
Veer, I. M., Oei, N. Y. L., Spinhoven, P., van Buchem, M. A., Elzinga, B. M., & Rombouts, S. A. R. B. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.074 · Cited by 199 · see citing works
Self-citationA comprehensive study of whole-brain functional connectivity in children and young adults
Jolles, D. D., van Buchem, M. A., Crone, E. A., & Rombouts, S. A. R. B. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq104 · Cited by 181 · see citing works
Functional Connectivity Bias of the Orbitofrontal Cortex in Drug-Free Patients with Major Depression
Frodl, T., Bokde, A. L. W., Scheuerecker, J., Lisiecka, D., Schoepf, V., Hampel, H., Möller, H.-J., Brückmann, H., Wiesmann, M., & Meisenzahl, E. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.08.022 · Cited by 174 · see citing works
Hulvershorn, L. A., Cullen, K. R., & Anand, A. (2011) · Brain Imaging and Behavior · doi:10.1007/s11682-011-9134-3 · Cited by 170 · see citing works
Functional connectivity of emotional processing in depression
Carballedo, A., Scheuerecker, J., Meisenzahl, E., Schoepf, V., Bokde, A., Möller, H.-J., Doyle, M., Wiesmann, M., & Frodl, T. (2011) · Journal of Affective Disorders · doi:10.1016/j.jad.2011.06.021 · Cited by 156 · see citing works
Pannekoek, J. N., Veer, I. M., van Tol, M., van der Werff, S. J. A., Demenescu, L. R., Aleman, A., Veltman, D. J., Zitman, F. G., Rombouts, S. A. R. B., & van der Wee, N. J. A. (2012) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2012.04.018 · Cited by 145 · see citing works
Self-citationHalari, R., Simic, M., Pariante, C. M., Papadopoulos, A., Cleare, A., Brammer, M., Fombonne, E., & Rubia, K. (2009) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2008.01972.x · Cited by 139 · cited 1× · see citing works
“"ese brain regions were also implicated in task studies investigating depression and social anxiety in children and adolescents (Guyer et al., 2008, Halari et al., 2009).”
BackgroundJin, C., Gao, C., Chen, C., Ma, S., Netra, R., Wang, Y., Zhang, M., & Li, D. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.08.017 · Cited by 136 · see citing works
The structure of depression, anxiety and somatic symptoms in primary care
Simms, L. J., Prisciandaro, J. J., Krueger, R. F., & Goldberg, D. P. (2011) · Psychological Medicine · doi:10.1017/s0033291711000985 · Cited by 133 · see citing works
Functional Connectivity of the Amygdala in Early-Childhood-Onset Depression
Luking, K. R., Repovš, G., Belden, A. C., Gaffrey, M. S., Botteron, K. N., Luby, J. L., & Barch, D. M. (2011) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2011.07.019 · Cited by 121 · see citing works
Dyck, M., Loughead, J., Kellermann, T., Boers, F., Gur, R. C., & Mathiak, K. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.10.013 · Cited by 112 · see citing works
van Tol, M.-J., Demenescu, L. R., van der Wee, N. J. A., Kortekaas, R., Marjan M.A., N., Boer, J. A. D., Renken, R. J., van Buchem, M. A., Zitman, F. G., Aleman, A., et al. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.11.016 · Cited by 105 · see citing works
Self-citationPannekoek, J. N., Veer, I. M., van Tol, M., van der Werff, S. J. A., Demenescu, L. R., Aleman, A., Veltman, D. J., Zitman, F. G., Rombouts, S. A. R. B., & van der Wee, N. J. A. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.07.006 · Cited by 102 · see citing works
Self-citationAltered white-matter architecture in treatment-naive adolescents with clinical depression
Aghajani, M., Veer, I. M., van Lang, N. D. J., Meens, P. H. F., van den Bulk, B. G., Rombouts, S. A. R. B., Vermeiren, R. R. J. M., & van der Wee, N. J. (2013) · Psychological Medicine · doi:10.1017/s0033291713003000 · Cited by 89 · see citing works
Self-citationIncreased Activity Imbalance in Fronto-Subcortical Circuits in Adolescents with Major Depression
Jiao, Q., Ding, J., Lu, G., Su, L., Zhang, Z., Wang, Z., Zhong, Y., Li, K., Ding, M., & Liu, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025159 · Cited by 83 · see citing works
Default mode network connectivity in children with a history of preschool onset depression
Gaffrey, M. S., Luby, J. L., Botteron, K., Repovš, G., & Barch, D. M. (2012) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2012.02552.x · Cited by 78 · see citing works
Maalouf, F. T., Clark, L., Tavitian, L., Sahakian, B. J., Brent, D. A., & Phillips, M. L. (2012) · Psychiatry Research · doi:10.1016/j.psychres.2012.01.030 · Cited by 63 · see citing works
Subgenual cingulate connectivity in children with a history of preschool-depression
Gaffrey, M. S., Luby, J. L., Repovš, G., Belden, A. C., Botteron, K. N., Luking, K. R., & Barch, D. M. (2010) · Neuroreport · doi:10.1097/wnr.0b013e32834127eb · Cited by 52 · see citing works
Reduced anterior cingulate gray matter volume in treatment-naïve clinically depressed adolescents
Pannekoek, J. N., van der Werff, S. J. A., van den Bulk, B. G., van Lang, N. D. J., Rombouts, S. A. R. B., van Buchem, M. A., Vermeiren, R. R. J. M., & van der Wee, N. J. A. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.01.007 · Cited by 43 · see citing works
Self-citationPI-3 Kinase and IP3: Partners in NT3-Induced Synaptic Transmission
Kaplan, D. R., & Cooper, E. (2001) · Nature Neuroscience · doi:10.1038/82897 · Cited by 20 · see citing works
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Kaiser, R. H., Andrews-Hanna, J. R., Wager, T. D., & Pizzagalli, D. A. (2015) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.0071 · Cited by 2,281 · see citing works
Resting-state functional connectivity in major depressive disorder: A review
Mulders, P. C., van Eijndhoven, P. F., Schene, A. H., Beckmann, C. F., & Tendolkar, I. (2015) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2015.07.014 · Cited by 884 · see citing works
Emotion-dependent functional connectivity of the default mode network in adolescent depression
Ho, T. C., Connolly, C. G., Henje Blom, E., LeWinn, K. Z., Strigo, I. A., Paulus, M. P., Frank, G., Max, J. E., Wu, J., Chan, M., et al. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.09.002 · Cited by 227 · see citing works
Li, J., Duan, X., Cui, Q., Chen, H., & Liao, W. (2019) · Psychological Medicine · doi:10.1017/s0033291718001502 · Cited by 208 · see citing works
Alterations in amygdala–prefrontal circuits in infants exposed to prenatal maternal depression
Posner, J., Cha, J., Roy, A. K., Peterson, B. S., Bansal, R., Gustafsson, H. C., Raffanello, E., Gingrich, J., & Monk, C. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.146 · Cited by 184 · see citing works
Connolly, C. G., Ho, T. C., Blom, E. H., LeWinn, K. Z., Sacchet, M. D., Tymofiyeva, O., Simmons, A. N., & Yang, T. T. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.09.026 · Cited by 177 · see citing works
Developmental sex differences in resting state functional connectivity of amygdala sub-regions
Alarcón, G., Cservenka, A., Rudolph, M. D., Fair, D. A., & Nagel, B. J. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2015.04.013 · Cited by 105 · see citing works
Li, H., Wei, D., Browning, M., Du, X., Zhang, Q., & Qiu, J. (2016) · Psychological Medicine · doi:10.1017/s003329171500238x · Cited by 59 · see citing works
Arnaldo, I., Corcoran, A. W., Friston, K. J., & Ramstead, M. J. D. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104590 · Cited by 56 · see citing works
van Hoof, M.-J., Riem, M. M. E., Garrett, A. S., van der Wee, N. J. A., van IJzendoorn, M. H., & Vermeiren, R. R. J. M. (2019) · European Journal of Psychotraumatology · doi:10.1080/20008198.2019.1583525 · Cited by 14 · see citing works
Self-citation
- Authors
- Pannekoek, J. N., van der Werff, S. J. A., Meens, P. H. F., van den Bulk, B. G., Jolles, D. D., Veer, I. M., van Lang, N. D. J., Rombouts, S. A. R. B., van der Wee, N. J. A., & Vermeiren, R. R. J. M.
- Affiliations
- Leiden University (NL)
- Department of Psychiatry Leiden University Medical Center Leiden The Netherlands
- Leiden Institute for Brain and Cognition Leiden University Leiden The Netherlands
- Corresponding author
- Pannekoek, Justine Nienke
- ORCID
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 2014-05-15
- Volume
- 55
- Issue
- 12
- Pages
- 1317-1327
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- OpenAlex
- W1976295108
- Cited by
- 150
- References
- 78
- Citations by year
- 2026: 8 · 2025: 15 · 2024: 16 · 2023: 7 · 2022: 14 · 2021: 12 · 2020: 12 · 2019: 13 · 2018: 14 · 2017: 9 · 2016: 13 · 2015: 13 · 2014: 4
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Child Psychology and Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Leiden Repository (Leiden University) (submittedVersion)
- Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (056-25-010)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Mental Health Research Topics
- Keywords
- adolescent depression, resting-state functional connectivity, limbic network, salience network, default mode network, amygdala, dorsal anterior cingulate cortex, posterior cingulate cortex, anxiety comorbidity, emotion regulation
- MeSH terms
- Adolescent, Amygdala, Anxiety Disorders, Brain Mapping, Cerebral Cortex, Depressive Disorder, Female, Gyrus Cinguli, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Comorbidity
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