MALDI Imaging of Lipid Biochemistry in Tissues by Mass Spectrometry

Intracellular Signaling by Hydrolysis of Phospholipids and Activation of Protein Kinase C

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Evidence for the Formation of Symmetric and Asymmetric DLPC-DAPC Lipid Bilayer Domains

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Phosphoinositides in cell regulation and membrane dynamics

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Fourier transform ion cyclotron resonance mass spectrometry: A primer

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A comprehensive classification system for lipids

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Synthesis and Function of 3-Phosphorylated Inositol Lipids

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Efficacy of a New Tonic Containing Urea, Lactate, Polidocanol, and Glycyrrhiza inflata Root Extract in the Treatment of a Dry, Itchy, and Subclinically Inflamed Scalp

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The biologically active isomers of conjugated linoleic acid

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Electrospray mass spectrometry of phospholipids

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The regulation and cellular functions of phosphatidylcholine hydrolysis

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The Kennedy pathway—De novo synthesis of phosphatidylethanolamine and phosphatidylcholine

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Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions

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The role of lipids in pulmonary surfactant

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Mass Spectrometric Imaging for Biomedical Tissue Analysis

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Sphingolipids—The Enigmatic Lipid Class: Biochemistry, Physiology, and Pathophysiology

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De Novo Sphingolipid Biosynthesis: A Necessary, but Dangerous, Pathway

Merrill, A. H. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r200009200 · Cited by 617

Sublimation as a method of matrix application for mass spectrometric imaging

Hankin, J. A., Barkley, R. M., & Murphy, R. C. (2007) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2007.06.010 · Cited by 598

Ceramide: an intracellular signal for apoptosis

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Sphingolipidomics: High-throughput, structure-specific, and quantitative analysis of sphingolipids by liquid chromatography tandem mass spectrometry

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Phospholipase D: a lipid centric review

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Metabolism and functions of phosphatidylserine

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Acyl-CoA:Lysophospholipid Acyltransferases

Shindou, H., & Shimizu, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.r800046200 · Cited by 478

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

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Electrospray ionization mass spectroscopic analysis of human erythrocyte plasma membrane phospholipids.

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Cardiolipin, the heart of mitochondrial metabolism

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Properties of the Group IV phospholipase A2 family

GHOSH, M., TUCKER, D., BURCHETT, S., & LESLIE, C. (2006) · Progress in Lipid Research · doi:10.1016/j.plipres.2006.05.003 · Cited by 397

The ins and outs of phospholipid asymmetry in the plasma membrane: roles in health and disease

Fadeel, B., & Xue, D. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409230903193307 · Cited by 392

The Kennedy pathway—De novo synthesis of phosphatidylethanolamine and phosphatidylcholine

Gibellini, F., & Smith, T. K. (2010) · IUBMB Life · doi:10.1002/iub.354 · Cited by 376

Ozone-Induced Dissociation: Elucidation of Double Bond Position within Mass-Selected Lipid Ions

Thomas, M. C., Mitchell, T. W., Harman, D. G., Deeley, J. M., Nealon, J. R., & Blanksby, S. J. (2008) · Analytical Chemistry · doi:10.1021/ac7017684 · Cited by 375

Phospholipid biosynthesis in mammalian cells

Vance, J. E., & Vance, D. E. (2004) · Biochemistry and Cell Biology · doi:10.1139/o03-073 · Cited by 373

A comprehensive classification system for lipids

Fahy, E., Subramaniam, S., Brown, H. A., Glass, C. K., Merrill, A. H., Murphy, R. C., Raetz, C. R. H., Russell, D. W., Seyama, Y., Shaw, W., et al. (2005) · European Journal of Lipid Science and Technology · doi:10.1002/ejlt.200405001 · Cited by 371

Electrospray ionization with low-energy collisionally activated dissociation tandem mass spectrometry of glycerophospholipids: Mechanisms of fragmentation and structural characterization

Hsu, F.-F., & Turk, J. (2009) · Journal of Chromatography B · doi:10.1016/j.jchromb.2009.02.033 · Cited by 346

MALDI-FTICR Imaging Mass Spectrometry of Drugs and Metabolites in Tissue

Cornett, D. S., Frappier, S. L., & Caprioli, R. M. (2008) · Analytical Chemistry · doi:10.1021/ac800617s · Cited by 343

Detection of Individual Phospholipids in Lipid Mixtures by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry: Phosphatidylcholine Prevents the Detection of Further Species

Petković, M., Schiller, J., Müller, M., Benard, S., Reichl, S., Arnold, K., & Arnhold, J. (2001) · Analytical Biochemistry · doi:10.1006/abio.2000.4926 · Cited by 312

Thematic Review Series: Skin Lipids. Antimicrobial lipids at the skin surface

Drake, D. R., Brogden, K. A., Dawson, D. V., & Wertz, P. W. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r700016-jlr200 · Cited by 305

Imaging of lipid species by MALDI mass spectrometry

Murphy, R. C., Hankin, J. A., & Barkley, R. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800051-jlr200 · Cited by 299

Structural determination of picomole amounts of phospholipids via electrospray ionization tandem mass spectrometry

Han, X., & Gross, R. W. (1995) · Journal of the American Society for Mass Spectrometry · doi:10.1016/1044-0305(95)00568-4 · Cited by 289

Chemistry and functional distribution of sulfoglycolipids

Ishizuka, I. (1997) · Progress in Lipid Research · doi:10.1016/s0163-7827(97)00011-8 · Cited by 289

Changes in electric charge and phospholipids composition in human colorectal cancer cells

Dobrzyńska, I., Szachowicz-Petelska, B., Sulkowski, S., & Figaszewski, Z. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-3557-3 · Cited by 285

Gold-Enhanced Biomolecular Surface Imaging of Cells and Tissue by SIMS and MALDI Mass Spectrometry

Altelaar, A. F. M., Klinkert, I., Jalink, K., de Lange, R. P. J., Adan, R. A. H., Heeren, R. M. A., & Piersma, S. R. (2006) · Analytical Chemistry · doi:10.1021/ac0513111 · Cited by 278

Characterization of phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate by electrospray ionization tandem mass spectrometry: A mechanistic study

Hsu, F.-F., & Turk, J. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(00)00172-0 · Cited by 275

Structural characterization of triacylglycerols as lithiated adducts by electrospray ionization mass spectrometry using low-energy collisionally activated dissociation on a triple stage quadrupole instrument

Hsu, F., & TURK, J. W. (1999) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(99)00035-5 · Cited by 260

Sulfatide is essential for the maintenance of CNS myelin and axon structure

Marcus, J., Honigbaum, S., Shroff, S., Honke, K., Rosenbluth, J., & Dupree, J. L. (2006) · Glia · doi:10.1002/glia.20292 · Cited by 250

Mass spectrometric analysis of long‐chain lipids

Murphy, R. C., & Axelsen, P. H. (2011) · Mass Spectrometry Reviews · doi:10.1002/mas.20284 · Cited by 242

Intracellular transport and metabolism of sphingomyelin

Koval, M., & Pagano, R. E. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90184-j · Cited by 234

Solvent-free matrix dry-coating for MALDI imaging of phospholipids

Puolitaival, S. M., Burnum, K. E., Cornett, D. S., & Caprioli, R. M. (2008) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2008.02.013 · Cited by 228

Lysophospholipid Acyltransferases and Arachidonate Recycling in Human Neutrophils

Gijón, M. A., Riekhof, W. R., Zarini, S., Murphy, R. C., & Voelker, D. R. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806194200 · Cited by 226

Formation of lithiated adducts of glycerophosphocholine lipids facilitates their identification by electrospray ionization tandem mass spectrometry

Hsu, F.-F., Bohrer, A., & Turk, J. (1998) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(98)00012-9 · Cited by 219

On-tissue protein identification and imaging by MALDI-Ion mobility mass spectrometry

Stauber, J., MacAleese, L., Franck, J., Claude, E., Snel, M., Kaletas, B. K., Wiel, I. M. V. D., Wisztorski, M., Fournier, I., & Heeren, R. M. A. (2010) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2009.09.016 · Cited by 209

Sphingomyelin metabolism at the plasma membrane: Implications for bioactive sphingolipids

Milhas, D., Clarke, C. J., & Hannun, Y. A. (2010) · FEBS Letters · doi:10.1016/j.febslet.2009.10.058 · Cited by 204

Automated MALDI Matrix Deposition Method with Inkjet Printing for Imaging Mass Spectrometry

Baluya, D. L., Garrett, T. J., & Yost, R. A. (2007) · Analytical Chemistry · doi:10.1021/ac070958d · Cited by 202

Visualization of the cell-selective distribution of PUFA-containing phosphatidylcholines in mouse brain by imaging mass spectrometry

Sugiura, Y., Konishi, Y., Zaima, N., Kajihara, S., Nakanishi, H., Taguchi, R., & Setou, M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900047-jlr200 · Cited by 201

Colloidal Graphite-Assisted Laser Desorption/Ionization Mass Spectrometry and MSn of Small Molecules. 1. Imaging of Cerebrosides Directly from Rat Brain Tissue

Cha, S., & Yeung, E. S. (2007) · Analytical Chemistry · doi:10.1021/ac062251h · Cited by 196

MALDI-based imaging mass spectrometry revealed abnormal distribution of phospholipids in colon cancer liver metastasis

Shimma, S., Sugiura, Y., Hayasaka, T., Hoshikawa, Y., Noda, T., & Setou, M. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.02.037 · Cited by 194

Phospholipid meets all-trans-retinal: the making of RPE bisretinoids

Sparrow, J. R., Wu, Y., Kim, C. Y., & Zhou, J. (2010) · Journal of Lipid Research · doi:10.1194/jlr.r000687 · Cited by 193

Study of latent fingermarks by matrix‐assisted laser desorption/ionisation mass spectrometry imaging of endogenous lipids

Wolstenholme, R., Bradshaw, R., Clench, M. R., & Francese, S. (2009) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4218 · Cited by 187

Identification of Markers of Taxane Sensitivity Using Proteomic and Genomic Analyses of Breast Tumors from Patients Receiving Neoadjuvant Paclitaxel and Radiation

Bauer, J. A., Chakravarthy, A. B., Rosenbluth, J. M., Mi, D., Seeley, E. H., De Matos Granja-Ingram, N., Olivares, M. G., Kelley, M. C., Mayer, I. A., Meszoely, I. M., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1091 · Cited by 187

Matrix vapor deposition/recrystallization and dedicated spray preparation for high‐resolution scanning microprobe matrix‐assisted laser desorption/ionization imaging mass spectrometry (SMALDI‐MS) of tissue and single cells

Bouschen, W., Schulz, O., Eikel, D., & Spengler, B. (2010) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.4401 · Cited by 186

Imaging mass spectrometry for lipidomics

Goto‐Inoue, N., Hayasaka, T., Zaima, N., & Setou, M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.03.004 · Cited by 173

Pulmonary surfactant phosphatidylglycerol inhibits respiratory syncytial virus–induced inflammation and infection

Numata, M., Chu, H. W., Dakhama, A., & Voelker, D. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909361107 · Cited by 172

Molecular Analysis of Tumor Margins by MALDI Mass Spectrometry in Renal Carcinoma

Oppenheimer, S. R., Mi, D., Sanders, M. E., & Caprioli, R. M. (2010) · Journal of Proteome Research · doi:10.1021/pr900936z · Cited by 167

Quantitation of cardiolipin molecular species in spontaneously hypertensive heart failure rats using electrospray ionization mass spectrometry

Sparagna, G. C., Johnson, C. A., McCune, S. A., Moore, R. L., & Murphy, R. C. (2005) · Journal of Lipid Research · doi:10.1194/jlr.m500031-jlr200 · Cited by 166

Imaging of peptides in the rat brain using MALDI-FTICR mass spectrometry

Taban, I. M., Altelaar, A. F. M., van der Burgt, Y. E. M., McDonnell, L. A., Heeren, R. M. A., Fuchser, J., & Baykut, G. (2007) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.09.017 · Cited by 164

Direct qualitative analysis of triacylglycerols by electrospray mass spectrometry using a linear ion trap

McAnoy, A. M., Wu, C. C., & Murphy, R. C. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.04.017 · Cited by 164

Mass Imaging and Identification of Biomolecules with MALDI-QIT-TOF-Based System

Shimma, S., Sugiura, Y., Hayasaka, T., Zaima, N., Matsumoto, M., & Setou, M. (2008) · Analytical Chemistry · doi:10.1021/ac071301v · Cited by 160

Imaging MALDI Mass Spectrometry Using an Oscillating Capillary Nebulizer Matrix Coating System and Its Application to Analysis of Lipids in Brain from a Mouse Model of Tay−Sachs/Sandhoff Disease

Chen, Y., Allegood, J. C., Liu, Y., Wang, E. L., Cachón-González, B., Cox, T. M., Merrill, A. H., & Sullards, M. C. (2008) · Analytical Chemistry · doi:10.1021/ac702350g · Cited by 160

Imaging of small molecules in tissue sections with a new intermediate-pressure MALDI linear ion trap mass spectrometer

Garrett, T. J., Prieto-Conaway, M. C., Kovtoun, V., Bui, H., Izgarian, N., Stafford, G., & Yost, R. A. (2007) · International Journal of Mass Spectrometry · doi:10.1016/j.ijms.2006.09.019 · Cited by 160

Spatial and temporal alterations of phospholipids determined by mass spectrometry during mouse embryo implantation

Burnum, K. E., Cornett, D. S., Puolitaival, S. M., Milne, S. B., Myers, D. S., Tranguch, S., Brown, H. A., Dey, S. K., & Caprioli, R. M. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m900100-jlr200 · Cited by 158

High-Spatial and High-Mass Resolution Imaging of Surface Metabolites of Arabidopsis thaliana by Laser Desorption-Ionization Mass Spectrometry Using Colloidal Silver

Jun, J. H., Song, Z., Liu, Z., Nikolau, B. J., Yeung, E. S., & Lee, Y. (2010) · Analytical Chemistry · doi:10.1021/ac902990p · Cited by 157

Lipidomic analyses of Mycobacterium tuberculosis based on accurate mass measurements and the novel “Mtb LipidDB”

Sartain, M. J., Dick, D. L., Rithner, C. D., Crick, D. C., & Belisle, J. T. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m010363 · Cited by 156

Discovery and Characterization of a Ca2+-independent Phosphatidylethanolamine N-Acyltransferase Generating the Anandamide Precursor and Its Congeners

Jin, X.-H., Okamoto, Y., Morishita, J., Tsuboi, K., Tonai, T., & Ueda, N. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606369200 · Cited by 155

Unique molecular signatures of glycerophospholipid species in different rat tissues analyzed by tandem mass spectrometry

Hicks, A. M., DeLong, C. J., Thomas, M. J., Samuel, M. P., & Cui, Z. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2006.05.010 · Cited by 149

Profiling and Imaging of Lipids on Brain and Liver Tissue by Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Using 2-Mercaptobenzothiazole as a Matrix

Astigarraga, E., Barreda‐Gómez, G., Lombardero, L., Fresnedo, O., Castaño, F., Giralt, M. T., Ochoa, B., Rodríguez‐Puertas, R., & Fernández, J. A. (2008) · Analytical Chemistry · doi:10.1021/ac801662n · Cited by 145

Studies on phosphatidylserine by tandem quadrupole and multiple stage quadrupole ion-trap mass spectrometry with electrospray ionization: Structural characterization and the fragmentation processes

Hsu, F., & TURK, J. W. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2005.04.018 · Cited by 145

Imaging Mass Spectrometry Technology and Application on Ganglioside Study; Visualization of Age-Dependent Accumulation of C20-Ganglioside Molecular Species in the Mouse Hippocampus

Sugiura, Y., Shimma, S., Konishi, Y., Yamada, M., & Setou, M. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003232 · Cited by 141

MALDI Mass Spectrometric Imaging of Lipids in Rat Brain Injury Models

Hankin, J. A., Farias, S., Barkley, R. M., Heidenreich, K. A., Frey, L. C., Hamazaki, K., Kim, H., & Murphy, R. C. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0122-z · Cited by 132

Elevation of sulfatides in ovarian cancer: An integrated transcriptomic and lipidomic analysis including tissue-imaging mass spectrometry

Liu, Y., Chen, Y., Momin, A. A., et al. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-186 · Cited by 130

Three dimensional mapping of neuropeptides and lipids in crustacean brain by mass spectral imaging

Chen, R., Hui, L., Sturm, R. M., & Li, L. (2009) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2009.01.017 · Cited by 129

Imaging mass spectrometry revealed the production of lyso-phosphatidylcholine in the injured ischemic rat brain

Koizumi, S., Yamamoto, S., Hayasaka, T., Konishi, Y., Yamaguchi‐Okada, M., Goto‐Inoue, N., Sugiura, Y., Setou, M., & Namba, H. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.03.056 · Cited by 128

In situ structural characterization of glycerophospholipids and sulfatides in brain tissue using MALDI-MS/MS

Jackson, S. N., Wang, H. Y. J., & Woods, A. S. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.08.015 · Cited by 126

Structural characterization of cardiolipin by tandem quadrupole and multiple-stage quadrupole ion-trap mass spectrometry with electrospray ionization

Hsu, F., TURK, J. W., Rhoades, E. R., Russell, D. G., Shi, Y., & Groisman, E. A. (2005) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2004.12.015 · Cited by 125

Matrix‐assisted laser desorption/ionization quadrupole ion trap time‐of‐flight (MALDI‐QIT‐TOF)‐based imaging mass spectrometry reveals a layered distribution of phospholipid molecular species in the mouse retina

Hayasaka, T., Goto-Inoue, N., Sugiura, Y., Zaima, N., Nakanishi, H., Ohishi, K., Nakanishi, S., Naito, T., Taguchi, R., & Setou, M. (2008) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.3751 · Cited by 125

Liquid ionic matrixes for MALDI mass spectrometry imaging of lipids

Mériaux, C., Franck, J., Wisztorski, M., Salzet, M., & Fournier, I. (2010) · Journal of Proteomics · doi:10.1016/j.jprot.2010.02.010 · Cited by 124

Direct MALDI-MS analysis of cardiolipin from rat organs sections

Wang, H.-Y. J., Jackson, S. N., & Woods, A. S. (2006) · Journal of the American Society for Mass Spectrometry · doi:10.1016/j.jasms.2006.10.023 · Cited by 118

Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids

Mueller, H. W., O’Flaherty, J. T., & Wykle, R. L. (1982) · Lipids · doi:10.1007/bf02535178 · Cited by 116

Localization of Fatty Acyl and Double Bond Positions in Phosphatidylcholines Using a Dual Stage CID Fragmentation Coupled with Ion Mobility Mass Spectrometry

Castro‐Perez, J. M., Roddy, T. P., Nibbering, N. M. M., Shah, V., McLaren, D. G., Previs, S. F., Attygalle, A. B., Herath, K. B., Chen, Z., Wang, S., et al. (2011) · Journal of the American Society for Mass Spectrometry · doi:10.1007/s13361-011-0172-2 · Cited by 112

Correlation between enzyme activity and substrate storage in a cell culture model system for Gaucher disease

Schueler, U., Kolter, T., Kaneski, C. R., Zirzow, G. C., Sandhoff, K., & Brady, R. O. (2004) · Journal of Inherited Metabolic Disease · doi:10.1023/b:boli.0000042959.44318.7c · Cited by 111

Imaging mass spectrometry of myxoid sarcomas identifies proteins and lipids specific to tumour type and grade, and reveals biochemical intratumour heterogeneity

Willems, S. M., van Remoortere, A., van Zeijl, R. J. M., Deelder, A. M., McDonnell, L. A., & Hogendoorn, P. C. W. (2010) · The Journal of Pathology · doi:10.1002/path.2771 · Cited by 111

Requirement of Seminolipid in Spermatogenesis Revealed by UDP-galactose:Ceramide Galactosyltransferase-deficient Mice

Fujimoto, H., Tadano‐Aritomi, K., Tokumasu, A., Ito, K., Hikita, T., Suzuki, K., & Ishizuka, I. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.c000200200 · Cited by 111

Imaging of Lipids in Spinal Cord Using Intermediate Pressure Matrix-Assisted Laser Desorption-Linear Ion Trap/Orbitrap MS

Landgraf, R. R., Conaway, M. C. P., Garrett, T. J., et al. (2009) · Analytical Chemistry · doi:10.1021/ac901387u · Cited by 106

Analysis of stem cell lipids by offline HPTLC-MALDI-TOF MS

Fuchs, B., Schiller, J., Süß, R., Zscharnack, M., Bader, A., Müller, P. K., Schürenberg, M., Becker, M. S., & Suckau, D. (2008) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-008-2301-8 · Cited by 105

MALDI mass spectrometry imaging of gangliosides in mouse brain using ionic liquid matrix

Chan, K. H., Lanthier, P. H., Liu, X., Sandhu, J. K., Stanimirovic, D. B., & Li, J. (2009) · Analytica Chimica Acta · doi:10.1016/j.aca.2009.02.051 · Cited by 104

Lipid glycation and protein glycation in diabetes and atherosclerosis

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Apoptotic Cell Recognition: Will the Real Phosphatidylserine Receptor(s) Please Stand up?

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