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Cited by 267

The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.

“Electron Transport Chain Interference” Strategy of Amplified Mild-Photothermal Therapy and Defect-Engineered Multi-Enzymatic Activities for Synergistic Tumor-Personalized Suppression

Dong, Shuming, Dong, Yushan, Zhao, Zhiyu, Liu, Jing, Liu, Shikai, Feng, Lili, He, Fei, Gai, Shili, Xie, Ying, Yang, Piaoping·2023·Journal of the American Chemical Society
DOI 10.1021/jacs.2c09608
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Abstract

Arming activatable mild-photothermal therapy (PTT) with the property of relieving tumor thermotolerance holds great promise for overcoming traditional mild PTT limitations such as thermoresistance, insufficient therapeutic effect, and off-target heating. Herein, a mitochondria-targeting, defect-engineered AFCT nanozyme with enhanced multi-enzymatic activity was elaborately designed as a tumor microenvironment (TME)-activatable phototheranostic agent to achieve remarkable anti-tumor therapy via “electron transport chain (ETC) interference and synergistic adjuvant therapy”. Density functional theory calculations revealed that the synergistic effect among multi-enzyme active centers endows the AFCT nanozymes with excellent catalytic activity. In TME, open sources of H 2 O 2 can be achieved by superoxide dismutase-mimicking AFCT nanozymes. In response to the dual stimuli of H 2 O 2 and mild acidity, the peroxidase-mimicking activity of AFCT nanozymes not only catalyzes the accumulation of H 2 O 2 to generate ·OH but also converts the loaded 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) into its oxidized form with strong near-infrared absorption, specifically unlocking its photothermal and photoacoustic imaging properties. Intriguingly, the undesired thermoresistance of tumor cells can be greatly alleviated owing to the reduced expression of heat shock proteins enabled by NADH POD-mimicking AFCT-mediated NADH depletion and consequent restriction of ATP supply. Meanwhile, the accumulated ·OH can facilitate both apoptosis and ferroptosis in tumor cells, resulting in synergistic therapeutic outcomes in combination with TME-activated mild PTT.

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Crossref · 10.1021/jacs.2c09608

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Citations

Cites

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Metadata

Authors
Dong, S., Dong, Y., Zhao, Z., Liu, J., Liu, S., Feng, L., He, F., Gai, S., Xie, Y., & Yang, P.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2023-03-31
Volume
145
Issue
17
Pages
9488-9507
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
DOI
10.1021/jacs.2c09608
OpenAlex
W4361257309
Cited by
267
References
67
FWCI
19.59
Type
journal article
Language
en
Open access
closed

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.