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Cited by 308

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

De Novo Design of Chemical Stability Near-Infrared Molecular Probes for High-Fidelity Hepatotoxicity Evaluation In Vivo

Cheng, Dan, Peng, Juanjuan, Lv, Yun, Su, Dongdong, Liu, Dongjie, Chen, Mei, Yuan, Lin, Zhang, Xiaobing·2019·Journal of the American Chemical Society
DOI 10.1021/jacs.9b01374
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Abstract

Near-infrared (NIR) fluorescence imaging technique is garnering increasing research attention due to various advantages. However, most NIR fluorescent probes still suffer from a false signals problem owing to their instability in real application. Especially in a pathological environment, many NIR probes can be easily destroyed due to the excessive generation of highly reactive species and causing a distorted false signal. Herein, we proposed an approach for developing a new stable NIR dye platform with an optically tunable group to eliminate false signals using the combination of dyes screening and rational design strategy. The conception is validated by the construction of two high-fidelity NIR fluorescent probes ( NIR-LAP and NIR-ONOO – ) sensing leucine aminopeptidase (LAP) and peroxynitrite (ONOO – ), the markers of hepatotoxicity. These probes ( NIR-LAP and NIR-ONOO – ) were demonstrated to sensitively and accurately monitor LAP and ONOO – (detection limit: 80 mU/L for LAP and 90 nM for ONOO – ), thereby allowing one to precisely evaluate drug-induced hepatotoxicity. In addition, based on the fluctuation of LAP, the therapeutic efficacy of six hepatoprotective medicines for acetaminophen-induced hepatotoxicity was analyzed in vivo. We anticipate the high-fidelity NIR dye platform with an optically tunable group could provide a convenient and efficient tool for the development of future probes applied in the pathological environment.

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Metadata

Authors
Cheng, D., Peng, J., Lv, Y., Su, D., Liu, D., Chen, M., Yuan, L., & Zhang, X.
Venue
Journal of the American Chemical Society
Publisher
American Chemical Society (ACS)
Published
2019-03-22
Volume
141
Issue
15
Pages
6352-6361
ISSN
  • 0002-7863 (ISSN-L)
  • 1520-5126
DOI
10.1021/jacs.9b01374
OpenAlex
W2925268815
Cited by
308
References
56
FWCI
15.94
Type
journal article
Language
en
Open access
closed

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