Meta-Analysis of Cognitive-Behavioral Treatments for Generalized Anxiety Disorder: A Comparison With Pharmacotherapy.
Abstract
The efficacy of (cognitive) behavioral therapy ([C]BT) for generalized anxiety disorder was investigated and compared with the efficacy of pharmacological therapy using meta-analytic techniques. A total of 65 (C)BT studies and pharmacological studies were included. (C)BT was more effective than control conditions. The results of the comparison between (C)BT and pharmacotherapy varied according to the meta-analytic methods used. Conclusions about differences in efficacy between therapy approaches are limited when all available studies are included owing to a number of factors that influence effect sizes. When only those studies that directly compared both therapies were included in the analysis, there were no significant differences in efficacy. Attrition rates were lower for (C)BT, indicating that it is better tolerated by patients.
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CBT has been shown to be a highly effective treatment for GAD.
“By far the most extensively researched psychological treatment for GAD is cognitive-behavior therapy (CBT) which has been shown to be a highly effective treatment for GAD [22].”
From Low-intensity internet-delivered treatment for generalized anxiety symptoms in routine care: protocol for a randomized controlled trial (2014) · cites this paper as [22]
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- Authors
- Mitte, K.
- Affiliations
- Friedrich Schiller University Jena (DE)
- Corresponding author
- Mitte, Kristin
- ORCID
- Mitte, Kristin
- Venue
- Psychological Bulletin
- Published
- 2005
- Volume
- 131
- Issue
- 5
- Pages
- 785-795
- ISSN
- 0033-2909 (ISSN-L)
- 1939-1455
- OpenAlex
- W1998351820
- Semantic Scholar
- 2d83d21bf41faf87e4501603548b126f73934a96
- Cited by
- 239
- References
- 77
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 5 · 2022: 5 · 2021: 10 · 2020: 6 · 2019: 6 · 2018: 14 · 2017: 21 · 2016: 11 · 2015: 11 · 2014: 16 · 2013: 20 · 2012: 20
- FWCI
- 1.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychological Bulletin (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Psychological Treatments and Assessments
- Keywords
- generalized anxiety disorder, cognitive behavioral therapy, pharmacotherapy, psychotherapy versus medication, treatment efficacy, attrition rates, treatment tolerability, meta-analytic methods
- MeSH terms
- Anxiety Disorders, Drug Therapy, Humans, Cognitive Behavioral Therapy
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