Cited by 733Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

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Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia

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Treadway, Michael T., Bossaller, Nicholas A., Shelton, Richard C., Zald, David H.·2012·Journal of Abnormal Psychology

DOI 10.1037/a0028813PMC PMC3730492

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Abstract

Anhedonia is a core feature of major depressive disorder (MDD), but the precise nature of anhedonic symptoms is unknown. Whereas anhedonia has traditionally been viewed as a deficit in the experience of pleasure, more recent evidence suggests that reduced anticipation and motivation may also be a core feature of this symptom. Here, we provide data from a study in MDD patients and healthy controls using a translational measure of reward motivation, the Effort Expenditure for Rewards Task (EEfRT or "effort"). This task offers subjects a series of trials where they may choose to expend more or less effort for the opportunity to win varying amounts of monetary rewards. We found that MDD patients were less willing to expend effort for rewards than controls. Additionally, we observed that patients were less able to effectively use information about magnitude and probability of rewards to guide their choice behavior. Finally, within the MDD patient group, duration of the current episode was a significant negative predictor of EEfRT task performance. These findings offer novel support for theoretical models proposing that anhedonia in MDD may reflect specific impairments in motivation and reward-based decision-making.

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Authors: Treadway, M. T., Bossaller, N. A., Shelton, R. C., & Zald, D. H.
Affiliations: Vanderbilt University (US)
ORCID: Treadway, Michael T.
Bossaller, Nicholas A.
Shelton, Richard C.
Zald, David H.
Venue: Journal of Abnormal Psychology
Publisher: American Psychological Association (APA)
Published: 2012-08
Volume: 121
Issue: 3
Pages: 553-558
ISSN: 0021-843X (ISSN-L)
1939-1846
DOI: 10.1037/a0028813
PMC: PMC3730492
OpenAlex: W2123089523
Cited by: 733
References: 40
Citations by year: 2026: 59 · 2025: 69 · 2024: 48 · 2023: 53 · 2022: 78 · 2021: 58 · 2020: 68 · 2019: 47 · 2018: 58 · 2017: 42 · 2016: 51 · 2015: 54 · 2014: 32 · 2013: 15
FWCI: 16.53
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Journal of Abnormal Psychology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Mental Health (R21 MH092751; F31MH087015)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: major depressive disorder, anhedonia, effort-based decision making, reward motivation, reward anticipation, effort expenditure, depressive episode duration, translational model
MeSH terms: Adult, Decision Making, Major Depressive Disorder, Female, Humans, Male, Middle Aged, Motivation, Psychiatric Status Rating Scales, Reward, Anhedonia

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Effort-based decision-making in major depressive disorder: a translational model of motivational anhedonia

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