Cited by 249,961Bacteriophages and microbial interactionsEnzyme Structure and FunctionBacterial Genetics and Biotechnology

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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LAEMMLI, U. K.·1970·Nature

DOI 10.1038/227680a0

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The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis.
Weber, K., & Osborn, M. (1969) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94333-4 · Cited by 16,688
DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS *
Davis, B. J. (1964) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1964.tb14213.x · Cited by 16,129
Molecular weight estimation of polypeptide chains by electrophoresis in SDS-polyacrylamide gels
Shapiro, A. L., Viñuela, E., & Maizel, J. V. (1967) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(67)90391-9 · Cited by 3,775
Fundamental techniques in virology.
Habel, K., & Salzman, N. P. (1969) · Medical Entomology and Zoology · Cited by 1,762
Physiological Studies of Conditional Lethal Mutants of Bacteriophage T4DPreprint
Epstein, R. H., Bolle, A., Steinberg, C. M., Kellenberger, E., de la Tour, E. B., Chevalley, R., Edgar, R. S., Susman, M., Denhardt, G. H., & Lielausis, A. (1963) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1963.028.01.053 · Cited by 803
Analysis of C14-labeled proteins by disc electrophoresis
Fairbanks, G., Levinthal, C., & Reeder, R. H. (1965) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(65)90589-9 · Cited by 467
A factor preventing the major head protein of bacteriophage T4 from random aggregation
Laemmli, U. K., Béguin, F., & Gujer-Kellenberger, G. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90402-x · Cited by 387
Self-citation
Structure of crystalline α-chymotrypsin
Steitz, T. A., Hendekson, R., & Blow, D. M. (1969) · Journal of Molecular Biology · doi:10.1016/0022-2836(69)90426-4 · Cited by 378
Co-Linearity of the Gene with the Polypeptide Chain
Sarabhai, A., Stretton, A. O. W., Brenner, S., & Bolle, A. (1964) · Nature · doi:10.1038/201013a0 · Cited by 362
Form-determining function of the genes required for the assembly of the head of bacteriophage T4
Laemmll, U. K., Mölbert, E., Showe, M. K., & Kellenberger, E. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90379-7 · Cited by 264

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Maizel, J. V., Fundamental Techniques of Virology (edit. by Habel, K., and Salzman, N. P.), chap. 32, 334 (Academic Press, New York, 1969).
King, J., FEBS Symp. (edit. by Ochoa, S., Nachmansohn, D., Asensio, C., and Heredia, C. F.), 21, 156 (Academic Press, London, 1970).
Sternberg, N., and Champe, S. P., J. Mol. Biol., 46, 337 (1970).

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Authors: LAEMMLI, U. K.
Affiliations: MRC Laboratory of Molecular Biology (GB)
Corresponding author: LAEMMLI, U. K.
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1970-08
Volume: 227
Issue: 5259
Pages: 680-685
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/227680a0
OpenAlex: W2100837269
Cited by: 249,961
References: 21
Citations by year: 2026: 1249 · 2025: 1666 · 2024: 1888 · 2023: 2073 · 2022: 2397 · 2021: 2628 · 2020: 2933 · 2019: 2771 · 2018: 2930 · 2017: 3226 · 2016: 3362 · 2015: 3679 · 2014: 4166 · 2013: 4392 · 2012: 4509
FWCI: 333.16
Type: journal article
Language: en
Open access: green
archive-ouverte.unige.ch
Licence: cc-by
www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics: Life Sciences › Immunology and Microbiology › Virology › Bacteriophages and microbial interactions
Life Sciences › Biochemistry, Genetics and Molecular Biology › Structural Biology › Enzyme Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: bacteriophage T4, structural proteins, proteolytic cleavage, precursor protein, gene products, assembly intermediates
MeSH terms: Autoradiography, Carbon Isotopes, Coliphages, Electrophoresis, Disc, Genes, Genetics, Microbial, Kinetics, Viral Proteins

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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